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Papers Published

1. Meyer, DE; Kong, G; Dewhirst, M; Chilkoti, A, Genetically-engineered polypeptide carrier for thermal targeting of therapeutics, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 2 (December, 1999), pp. 1289 .
   (last updated on 2024/07/16)

   Abstract:
   We report the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. We hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. We report preliminary in vivo results which support this hypothesis.