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Papers Published

1. MacEwan, SR; Callahan, DJ; Chilkoti, A, Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery., Nanomedicine (London, England), vol. 5 no. 5 (July, 2010), pp. 793-806 [20662649], [doi] .
   (last updated on 2024/04/23)

   Abstract:
   Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in 'smart' - stimulus-responsive - peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.