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Papers Published

1. Callahan, DJ; Liu, W; Li, X; Dreher, MR; Hassouneh, W; Kim, M; Marszalek, P; Chilkoti, A, Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution., Nano letters, vol. 12 no. 4 (April, 2012), pp. 2165-2170 [22417133], [doi] .
   (last updated on 2024/07/16)

   Abstract:
   To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.