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Papers Published

1. McDaniel, JR; Macewan, SR; Dewhirst, M; Chilkoti, A, Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia., J Control Release, vol. 159 no. 3 (May, 2012), pp. 362-367 [22421424], [doi] .
   (last updated on 2024/07/16)

   Abstract:
   This paper reports the design, physicochemical characterization and in vitro cytotoxicity of a thermally responsive chimeric polypeptide (CP), derived from an elastin-like polypeptide (ELP). The CP self-assembles into ~40 nm diameter nanoparticles upon conjugation of multiple copies of doxorubicin (Dox), and displays a nanoparticle-to-aggregate phase transition between 39 and 42 °C in media, a temperature range suitable for mild hyperthermia of solid tumors. The CP-Dox nanoparticle is stable upon dilution to low micromolar concentrations, and is cytotoxic at both 37 and 42 °C. A thermally responsive nanoparticle formulation of Dox may prove to be broadly useful in hyperthermia targeted chemotherapy of a variety of solid tumors.