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Papers Published

1. Dreher, M; Raucher, D; Balu, N; Colvin, M; Ludeman, S; Chilkoti, A, Elastin-like polypeptide-doxorubicin conjugates for cancer therapy, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 1 (December, 2002), pp. 524-525 [IEMBS.2002.1136930] .
   (last updated on 2025/04/17)

   Abstract:
   Thermally responsive elastin-like polypeptides (ELP) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid labile bond. The thermal properties, release of doxorubicin, uptake of ELP, cytotoxicity and cellular localization of ELP-doxorubicin conjugates were investigated in this study.

   Keywords:
   biochemistry;biothermics;cancer;cellular transport;DNA;patient treatment;polymers;proteins;tumours;