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Papers Published

1. Hyun, J; Ma, H; Zhang, Z; Beebe Jr, TP; Chilkoti, A, Universal route to cell micropatterning using an amphiphilic comb polymer, Advanced Materials, vol. 15 no. 7-8 (2003), pp. 576-579, WILEY [adma.200304496], [doi] .
   (last updated on 2025/04/17)

   Abstract:
   Micropatterning of localized chemical or biochemical domains has the potential to become a powerful tool to control the behavior of anchorage-dependent cells. However, several problems, such as the limited types of substrates that can be successfully patterned with cells and the lack of reliable, long-term retention of cellular patterns under physiological conditions need to be solved for cellular patterning to become widely applicable for cell-based biosensors, biomaterials, and high-throughput drug screening assay. This paper reports on a simple and generic method to micropattern surfaces with an amphiphilic comb polymer presenting short oligoethylene glycol side chains that enables long-term, spatially resolved attachment and growth of mammalian cells in a biologically relevant milieu on a variety of substrates.

   Keywords:
   Cells;Growth kinetics;Oligomers;Biomaterials;Surfaces;Proteins;Cell culture;Adsorption;Secondary ion mass spectrometry;Polystyrenes;Positive ions;