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Papers Published

1. Hyun, J; Kim, J; Craig, SL; Chilkoti, A, Enzymatic nanolithography of a self-assembled oligonucleotide monolayer on gold., Journal of the American Chemical Society, vol. 126 no. 15 (April, 2004), pp. 4770-4771 [15080668], [doi] .
   (last updated on 2024/07/16)

   Abstract:
   This paper describes a simple strategy to biochemically manipulate a surface at the nanoscale by enzyme dip-pen nanolithography using an endonuclease (DNase I) that is directly patterned on a self-assembled monolayer presenting a terminal oligonucleotide. Physisorbed nanopatterns of DNase I carried out nanoscale enzymology at the surface creating oligonucleotide patterns with the fidelity of the patterned enzyme because of the affinity of the enzyme for the immobilized, oligonucleotide substrate.