Papers Published

1. Hoffman, B. D. and Massiera, G. and Crocker, J. C., Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding, Physical Review E, vol. 76 no. 5 (2007) .
   (last updated on 2011/11/11)

   Abstract:
   We describe a model of cytoskeletal mechanics based on the force-induced conformational change of protein cross-links in a stressed polymer network. Slow deformation of simulated networks containing cross-links that undergo repeated, serial domain unfolding leads to an unusual state-with many cross-links accumulating near the critical force for further unfolding. This state is robust to thermalization and does not occur in similar protein unbinding based simulations. Moreover, we note that the unusual configuration of near-critical protein cross-links in the fragile state provides a physical mechanism for the chemical transduction of cell-level mechanical strain and extra-cellular matrix stiffness.

   Keywords:
   soft glassy materials mechanical-properties actin networks living cell microscopy spectroscopy dynamics filamins behavior