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Papers Published

1. GA Johnson, GP Cofer, B Fubara, SL Gewalt, LW Hedlund, RR Maronpot, Magnetic resonance histology for morphologic phenotyping., Journal of magnetic resonance imaging : JMRI, United States, vol. 16 no. 4 (October, 2002), pp. 423-9 .
   (last updated on 2005/08/03)

   Abstract:
   Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100-micron isotropic resolution at 2.0 T with image arrays of 256 x 256 x 1024. Higher resolution (50 x 50 x 50 microns) of limited volumes has been acquired at 7.1T with image arrays of 512 x 512 x 512. Even higher resolution images (20 x 20 x 20 microns) of isolated organs have been acquired at 9.4 T. The volume resolution represents an increase of 625000 x over conventional clinical MRI. The technological basis is summarized that will allow basic scientists to begin using MRH as a routine method for morphologcic phenotyping of the mouse. MRH promises four unique attributes over conventional histology: 1). MRH is non-destructive; 2). MRH exploits the unique contrast mechanisms that have made MRI so successful clinically; 3). MRH is 3-dimensional; and 4). the data are inherently digital. We demonstrate the utility in morphologic phenotyping a whole C57BL/6J mouse.

   Keywords:
   Animals • Magnetic Resonance Imaging* • Mice • Mice, Inbred C57BL • Phenotype • methods