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Papers Published

1. GA Johnson, G Cates, XJ Chen, GP Cofer, B Driehuys, W Happer, LW Hedlund, B Saam, MD Shattuck, J Swartz, Dynamics of magnetization in hyperpolarized gas MRI of the lung., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 38 no. 1 (July, 1997), pp. 66-71 .
   (last updated on 2005/08/03)

   Abstract:
   The magnetization in hyperpolarized gas (HP) MRI is generated by laser polarization that is independent of the magnet and imaging process. As a consequence, there is no equilibrium magnetization during the image acquisition. The competing processes of gas inflow and depolarization of the spins lead to large changes in signal as one samples k-space. A model is developed of dynamic changes in polarization of hyperpolarized 3He during infusion and in vivo imaging of the lung and verified experimentally in a live guinea pig. Projection encoding is used to measure the view-to-view variation with temporal resolution < 4 ms. Large excitation angles effectively sample the magnetization in the early stages of inflow, highlighting larger airways, while smaller excitation angles produce images of the more distal spaces. The work provides a basis for pulse sequences designed to effectively exploit HP MRI in the lung.

   Keywords:
   Animals • Guinea Pigs • Helium • Isotopes • Lung • Magnetic Resonance Imaging • Male • Respiration • anatomy & histology* • diagnostic use* • methods*