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Papers Published

1. RE TenBrink, DT Pals, DW Harris, GA Johnson, Renin inhibitors containing psi[CH2O] pseudopeptide inserts., Journal of medicinal chemistry, vol. 31 no. 3 (March, 1988), pp. 671-7 .
   (last updated on 2010/04/30)

   Abstract:
   Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1' site, were of a comparable potency to RIP. N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.

   Keywords:
   Amino Acid Sequence • Angiotensinogen • Chemistry, Physical • Humans • Molecular Sequence Data • Physicochemical Phenomena • Renin • Structure-Activity Relationship • analogs & derivatives* • antagonists & inhibitors* • chemical synthesis • pharmacology