search www.ncbi.nlm.nih.gov.

Papers Published

1. Johnson, GA; Maronpot, RR, Magnetic resonance microscopy of chemically-induced liver foci., Toxicol Pathol, vol. 17 no. 4 Pt 1 (1989), pp. 613-616 [2629098], [doi] .
   (last updated on 2025/02/12)

   Abstract:
   Magnetic resonance imaging (MRI) is a new imaging technique used in clinical diagnosis. This paper describes extension of the technique to basic research applications--specifically detecting and characterizing chemically-induced liver neoplasms and foci of cellular alteration. Two systems have been built that allow spatial microscopic resolution--more than 100,000 x greater than that of earlier efforts. Use of spin-lattice (T1) and spin-spin (T2) relaxation times permits detailed characterization of the tissue.

   Keywords:
   Animals • Carcinogenicity Tests • Diet • Female • Liver • Liver Neoplasms, Experimental • Magnetic Resonance Imaging • Rats • Rats, Inbred F344 • chemically induced • pathology* • ultrastructure