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Papers Published

1. Perperidis, D; Bucholz, E; Johnson, GA; Constantinides, C, Morphological studies of the murine heart based on probabilistic and statistical atlases., Comput Med Imaging Graph, vol. 36 no. 2 (March, 2012), pp. 119-129 [21820867], [doi] .
   (last updated on 2025/02/12)

   Abstract:
   This study directly compares morphological features of the mouse heart in its end-relaxed state based on constructed morphometric maps and atlases using principal component analysis in C57BL/6J (n=8) and DBA (n=5) mice. In probabilistic atlases, a gradient probability exists for both strains in longitudinal locations from base to apex. Based on the statistical atlases, differences in size (49.8%), apical direction (15.6%), basal ventricular blood pool size (13.2%), and papillary muscle shape and position (17.2%) account for the most significant modes of shape variability for the left ventricle of the C57BL/6J mice. For DBA mice, differences in left ventricular size and direction (67.4%), basal size (15.7%), and position of papillary muscles (16.8%) account for significant variability.

   Keywords:
   Algorithms* • Animals • Contrast Media • Data Interpretation, Statistical • Gadolinium DTPA • Heart • Image Enhancement • Image Interpretation, Computer-Assisted • Magnetic Resonance Imaging • Male • Mice • Mice, Inbred C57BL • Reproducibility of Results • Sensitivity and Specificity • Subtraction Technique* • anatomy & histology* • diagnostic use* • methods • methods*