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Papers Published

1. Shofer, S; Badea, C; Auerbach, S; Schwartz, DA; Johnson, GA, A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice., Exp Lung Res, vol. 33 no. 3-4 (2007), pp. 169-183 [17558678], [doi] .
   (last updated on 2025/02/12)

   Abstract:
   Micro-computed tomography (microCT) is being increasingly used to examine small animal models of pulmonary injury. The authors have developed a microCT technique suitable for the determination of pulmonary compliance in injured mice. Lung volumes in normal mice were radiographically determined at end-inspiration and end-expiration and pulmonary compliance was calculated at 2 time points 2 weeks apart, whereas a second group of mice were given bleomycin and imaged 3 weeks following drug administration. Compliance measurements were validated using a commercially available ventilator system. MicroCT pulmonary compliance measurements are suitable for longitudinal measurements, and correlate with physiologic measurements of pulmonary compliance.

   Keywords:
   Animals • Bleomycin • Disease Models, Animal • Female • Image Processing, Computer-Assisted • Lung • Lung Compliance* • Male • Mice • Mice, Inbred C57BL • Pulmonary Fibrosis • Reproducibility of Results • Time Factors • Tomography, X-Ray Computed • chemically induced • methods* • pathology • physiopathology • radiography*