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Papers Published

1. Truskey, George A. and Pirone, John S., Effect of fluid shear stress upon cell adhesion to fibronectin-treated surfaces, Journal of Biomedical Materials Research, vol. 24 no. 10 (1990), pp. 1333 - 1353 .
   (last updated on 2007/04/12)

   Abstract:
   The role of fibronectin in maintaining cell adhesion was examined by measuring cell attachment following exposure of cells to laminar flow in a parallel-plate flow channel. 3T3 fibroblasts were allowed to adhere to glass slides with or without preadsorbed fibronectin for 2 h before exposure to shear stresses ranging from 5 to 140 dyne/cm². It is shown that preadsorbed fibronectin resulted in a greater number of bonds between the surface and the cell, which in turn promoted cell spreading and increased the adhesive strength of the cell.

   Keywords:
   Biological Materials--Cells;Proteins;Flow of Fluids--Laminar;Stresses--Shear;