Harold P. Erickson, James B. Duke Distinguished Professor Emeritus of Cell Biology and Biomedical Engineering  


Harold P. Erickson
Contact Info:
Office Location:  367 Nanaline H Duke
Email Address:   send me a message
Web Page: http://note.cellbio.duke.edu/Faculty/Research/Erickson.html

Education:

Ph.D., Johns Hopkins University, 1968
Research Interests:

Erickson's lab works on extracellular matrix and cytoskeleton, with an emphasis on protein biochemistry and structure.

Specialties:

Contraception, Biofluid Mechanics
Representative Publications   (More Publications)

  1. M Osawa, HP Erickson, Inside-out Z rings--constriction with and without GTP hydrolysis., Molecular microbiology, vol. 81 no. 2 (July, 2011), pp. 571-9 [doi]  [abs].
  2. CA Lemmon, T Ohashi, HP Erickson, Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility., The Journal of biological chemistry, vol. 286 no. 30 (July, 2011), pp. 26375-82 [doi]  [abs].
  3. Y Chen, HP Erickson, Conformational changes of FtsZ reported by tryptophan mutants., Biochemistry, vol. 50 no. 21 (May, 2011), pp. 4675-84 [doi]  [abs].
  4. HP Erickson, DE Anderson, M Osawa, FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one., Microbiology and molecular biology reviews : MMBR, vol. 74 no. 4 (December, 2010), pp. 504-28 [doi]  [abs].
  5. HP Erickson, M Osawa, Cell division without FtsZ--a variety of redundant mechanisms., Molecular microbiology, vol. 78 no. 2 (October, 2010), pp. 267-70 .
  6. D Popp, M Iwasa, HP Erickson, A Narita, Y Maéda, RC Robinson, Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ., The Journal of biological chemistry, vol. 285 no. 15 (April, 2010), pp. 11281-9 [doi]  [abs].
  7. R Kenjale, G Meng, DL Fink, T Juehne, T Ohashi, HP Erickson, G Waksman, JW St Geme 3rd, Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter., Infection and immunity, vol. 77 no. 11 (November, 2009), pp. 4704-13 [doi]  [abs].
  8. M Osawa, DE Anderson, HP Erickson, Curved FtsZ protofilaments generate bending forces on liposome membranes., The EMBO journal, vol. 28 no. 22 (November, 2009), pp. 3476-84 [doi]  [abs].
  9. Y Chen, HP Erickson, FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis., Biochemistry, vol. 48 no. 28 (July, 2009), pp. 6664-73 [doi]  [abs].
  10. HP Erickson, Modeling the physics of FtsZ assembly and force generation., Proceedings of the National Academy of Sciences of the United States of America, vol. 106 no. 23 (June, 2009), pp. 9238-43 [doi]  [abs].
  11. T Ohashi, AM Augustus, HP Erickson, Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin., Biochemistry, vol. 48 no. 19 (May, 2009), pp. 4189-97 [doi]  [abs].
  12. T Ohashi, HP Erickson, Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds., Matrix biology : journal of the International Society for Matrix Biology, vol. 28 no. 3 (April, 2009), pp. 170-5 [doi]  [abs].
  13. D Popp, M Iwasa, A Narita, HP Erickson, Y Maéda, FtsZ condensates: an in vitro electron microscopy study., Biopolymers, vol. 91 no. 5 (May, 2009), pp. 340-50 [doi]  [abs].
  14. HP Erickson, Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy., Biological procedures online, vol. 11 (2009), pp. 32-51 [doi]  [abs].
  15. M Osawa, HP Erickson, Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings., Methods in enzymology, vol. 464 (2009), pp. 3-17 [doi]  [abs].
  16. CA Sontag, H Sage, HP Erickson, BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly., PloS one, vol. 4 no. 9 (2009), pp. e7253 [doi]  [abs].
  17. GE White, HP Erickson, The coiled coils of cohesin are conserved in animals, but not in yeast., PloS one, vol. 4 no. 3 (2009), pp. e4674 [doi]  [abs].
  18. J Xu, E Bae, Q Zhang, DS Annis, HP Erickson, DF Mosher, Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin., PloS one, vol. 4 no. 1 (2009), pp. e4113 [doi]  [abs].
  19. HP Erickson, Evolution of the cytoskeleton., BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 29 no. 7 (July, 2007), pp. 668-77 [doi]  [abs].
  20. T Ohashi, SD Galiacy, G Briscoe, HP Erickson, An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins., Protein science : a publication of the Protein Society, vol. 16 no. 7 (July, 2007), pp. 1429-38 [doi]  [abs].
  21. S Takahashi, M Leiss, M Moser, T Ohashi, T Kitao, D Heckmann, A Pfeifer, H Kessler, J Takagi, HP Erickson, R Fässler, The RGD motif in fibronectin is essential for development but dispensable for fibril assembly., The Journal of cell biology, vol. 178 no. 1 (July, 2007), pp. 167-78 [doi]  [abs].
  22. -PDFs of most of my recent papers are available at
    http://www.cellbio.duke.edu/Faculty/Research/Erickson.html     .
  23. M Osawa, HP Erickson, FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli., Journal of bacteriology, vol. 188 no. 20 (October, 2006), pp. 7132-40 [doi]  [abs].
  24. GE White, HP Erickson, Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins., Journal of structural biology, vol. 154 no. 2 (May, 2006), pp. 111-21 [doi]  [abs].
  25. M Osawa, HP Erickson, Probing the domain structure of FtsZ by random truncation and insertion of GFP., Microbiology (Reading, England), vol. 151 no. Pt 12 (December, 2005), pp. 4033-43 [doi]  [abs].
  26. T Ohashi, HP Erickson, Domain unfolding plays a role in superfibronectin formation., The Journal of biological chemistry, vol. 280 no. 47 (November, 2005), pp. 39143-51 [doi]  [abs].
  27. Y Chen, HP Erickson, Rapid in vitro assembly dynamics and subunit turnover of FtsZ demonstrated by fluorescence resonance energy transfer., The Journal of biological chemistry, vol. 280 no. 23 (June, 2005), pp. 22549-54 [doi]  [abs].
  28. SD Redick, J Stricker, G Briscoe, HP Erickson, Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity., Journal of bacteriology, vol. 187 no. 8 (April, 2005), pp. 2727-36 [doi]  [abs].
  29. CA Sontag, JT Staley, HP Erickson, In vitro assembly and GTP hydrolysis by bacterial tubulins BtubA and BtubB., The Journal of cell biology, vol. 169 no. 2 (April, 2005), pp. 233-8 [doi]  [abs].
  30. Y Chen, K Bjornson, SD Redick, HP Erickson, A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus., Biophysical journal, vol. 88 no. 1 (January, 2005), pp. 505-14 [doi]  [abs].
  31. DE Anderson, FJ Gueiros-Filho, HP Erickson, Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins., Journal of bacteriology, vol. 186 no. 17 (September, 2004), pp. 5775-81 [doi]  [abs].
  32. T Ohashi, HP Erickson, The disulfide bonding pattern in ficolin multimers., The Journal of biological chemistry, vol. 279 no. 8 (February, 2004), pp. 6534-9 [doi]  [abs].
  33. J Stricker, HP Erickson, In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function., Journal of bacteriology, vol. 185 no. 16 (August, 2003), pp. 4796-805  [abs].
  34. T Ohashi, DP Kiehart, HP Erickson, Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants., Journal of cell science, vol. 115 no. Pt 6 (March, 2002), pp. 1221-9  [abs].
  35. J Stricker, P Maddox, ED Salmon, HP Erickson, Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching., Proceedings of the National Academy of Sciences of the United States of America, vol. 99 no. 5 (March, 2002), pp. 3171-5 [doi]  [abs].
  36. HP Erickson, Stretching fibronectin., Journal of muscle research and cell motility, vol. 23 no. 5-6 (2002), pp. 575-80  [abs].
  37. HP Erickson, Gamma-tubulin nucleation: template or protofilament?, Nature cell biology, vol. 2 no. 6 (June, 2000), pp. E93-6 [doi]  [abs].
  38. SD Redick, DL Settles, G Briscoe, HP Erickson, Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis., The Journal of cell biology, vol. 149 no. 2 (April, 2000), pp. 521-7  [abs].
  39. T Ohashi, DP Kiehart, HP Erickson, Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein., Proceedings of the National Academy of Sciences of the United States of America, vol. 96 no. 5 (March, 1999), pp. 2153-8  [abs].
  40. T Ohashi, HP Erickson, Oligomeric structure and tissue distribution of ficolins from mouse, pig and human., Archives of biochemistry and biophysics, vol. 360 no. 2 (December, 1998), pp. 223-32 [doi]  [abs].
  41. TE Melby, CN Ciampaglio, G Briscoe, HP Erickson, The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible hinge., The Journal of cell biology, vol. 142 no. 6 (September, 1998), pp. 1595-604  [abs].
  42. ET O'Brien, ED Salmon, HP Erickson, How calcium causes microtubule depolymerization., Cell motility and the cytoskeleton, vol. 36 no. 2 (1997), pp. 125-35 [doi]  [abs].
  43. HP Erickson, DW Taylor, KA Taylor, D Bramhill, Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers., Proceedings of the National Academy of Sciences of the United States of America, vol. 93 no. 1 (January, 1996), pp. 519-23  [abs].
  44. DJ Leahy, I Aukhil, HP Erickson, 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Cell, vol. 84 no. 1 (January, 1996), pp. 155-64  [abs].
  45. HP Erickson, Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin., Proceedings of the National Academy of Sciences of the United States of America, vol. 91 no. 21 (October, 1994), pp. 10114-8  [abs].
  46. HP Erickson, Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins., The Journal of cell biology, vol. 120 no. 5 (March, 1993), pp. 1079-81 .
  47. DJ Leahy, WA Hendrickson, I Aukhil, HP Erickson, Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein., Science (New York, N.Y.), vol. 258 no. 5084 (November, 1992), pp. 987-91  [abs].
  48. SH Northrup, HP Erickson, Kinetics of protein-protein association explained by Brownian dynamics computer simulation., Proceedings of the National Academy of Sciences of the United States of America, vol. 89 no. 8 (April, 1992), pp. 3338-42  [abs].
  49. HP Erickson, Co-operativity in protein-protein association. The structure and stability of the actin filament., Journal of molecular biology, vol. 206 no. 3 (April, 1989), pp. 465-74  [abs].
  50. RA Walker, ET O'Brien, NK Pryer, MF Soboeiro, WA Voter, HP Erickson, ED Salmon, Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies., The Journal of cell biology, vol. 107 no. 4 (October, 1988), pp. 1437-48  [abs].
  51. WA Voter, HP Erickson, The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism., The Journal of biological chemistry, vol. 259 no. 16 (August, 1984), pp. 10430-8  [abs].
  52. HP Erickson, JL Inglesias, A six-armed oligomer isolated from cell surface fibronectin preparations., Nature, vol. 311 no. 5983 (November, 1984), pp. 267-9  [abs].
  53. WE Fowler, HP Erickson, Trinodular structure of fibrinogen. Confirmation by both shadowing and negative stain electron microscopy., Journal of molecular biology, vol. 134 no. 2 (October, 1979), pp. 241-9 .
  54. HP Erickson, Microtubule surface lattice and subunit structure and observations on reassembly., The Journal of cell biology, vol. 60 no. 1 (January, 1974), pp. 153-67  [abs].
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