Papers Published

1. WD Taylor, JR MacFall, DC Steffens, ME Payne, JM Provenzale, KR Krishnan, Localization of age-associated white matter hyperintensities in late-life depression., Progress in neuro-psychopharmacology & biological psychiatry, vol. 27 no. 3 (May, 2003), pp. 539-44 [doi] .
   (last updated on 2013/05/16)

   Abstract:
   OBJECTIVE: Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects. METHODS: Eighty-seven depressed subjects and 47 control subjects underwent 1.5 T cranial magnetic resonance imaging (MRI). Utilizing a semiautomated method, a segmented image was created containing only white matter lesions. We created a statistical parametric map (SPM) separately for each subject group that displayed the association between lesions in any voxel and advanced age. RESULTS: The SPM analysis in depressed subjects demonstrates a significant association between age and lesions found in bilateral, frontal, and left parietal regions. The analysis in control subjects found significant associations only in bilateral parieto-temporal regions, not frontal regions. CONCLUSIONS: This study demonstrates a different pattern of age-related lesion location between depressed and control subjects. It further supports the theory that frontostriatal disconnection contributes to late-life depression.

   Keywords:
   Age Factors • Aged • Aged, 80 and over • Depressive Disorder, Major • Female • Humans • Magnetic Resonance Imaging • Male • Middle Aged • Nerve Fibers, Myelinated • Prefrontal Cortex • methods • pathology* • psychology • statistics & numerical data