Papers Published

1. JP Vallée, HD Sostman, JR MacFall, T Wheeler, LW Hedlund, CE Spritzer, RE Coleman, MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 38 no. 6 (December, 1997), pp. 981-9 .
   (last updated on 2003/08/22)

   Abstract:
   K1 (first-order transfer constant from arterial plasma to myocardium for Gd-DTPA) and Vd (distribution volume of Gd-DTPA in myocardium) were measured in vivo in a canine model (n = 5) using MRI-derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd-DTPA (0.04 mM/kg) with an inversion-prepared fast gradient echo sequence. Myocardium and blood signal intensity were converted to a concentration of Gd-DTPA, according to a model appropriate for short (<1 s) interimage intervals characteristic of cardiac-triggered acquisitions. Before dipyridamole-induced stress, K1 and Vd, obtained from the fit of the MRI-derived perfusion curves, were 6.2 +/- 1.4 (mHz) and 17.5 +/- 4.2%, respectively. After dipyridamole infusion, a K1 increase of a factor of 2.82 +/- 0.72 was measured (P = 0.003). No change was observed in Vd (P = 0.98). These results suggest that the K1 increase after dipyridamole reflects a flow-related effect that can be useful to quantify the MRI-derived perfusion curves.

   Keywords:
   Animals • Contrast Media • Coronary Circulation • Dipyridamole • Dogs • Gadolinium DTPA • Heart • Magnetic Resonance Imaging* • Models, Theoretical • Perfusion • Rest • Stress • Vasodilator Agents • administration & dosage • diagnostic use • drug effects • pharmacology • physiology*