Papers Published

1. DP Barboriak, JR MacFall, BL Viglianti, MW Dewhirst Dvm, Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging., Journal of magnetic resonance imaging : JMRI, vol. 27 no. 6 (June, 2008), pp. 1388-98 [doi] .
   (last updated on 2013/05/13)

   Abstract:
   OBJECTIVE: To compare the performance of three physiologically-based pharmacokinetic (PBPK) models for predicting gadolinium contrast agent concentration-time curves (Gd-CTCs) obtained in superior sagittal sinus (SSS), cerebral cortex, and psoas muscle. METHODS: Three published whole-body PBPK models were modified to predict Gd-CTCs in normal-appearing tissue. The models differed in the number of organs modeled and total number of compartments, and were designated as the "well-mixed," "delay," and "dispersion" models. The suitability of the three models to predict Gd-CTC was studied using data from dynamic contrast-enhanced MR perfusion imaging obtained at 1.5T from 10 patients with glioblastoma multiforme and at 3.0T from five patients with liver metastases. RESULTS: The dispersion model produced better fits than the delay model in the SSS (P < 0.0001) and cerebral cortex (P < 0.0001), and better fits than the well-mixed model in psoas muscle (P < 0.005). No model produced better fits than the dispersion model at any of the three locations. CONCLUSIONS: In this evaluation, the dispersion model was most robust for prediction of Gd-CTCs derived from dynamic contrast-enhanced (DCE)-MRI. This represents a preliminary step in the development of a PBPK model useful for predicting Gd-CTCs at a time resolution appropriate for dynamic MRI applications.

   Keywords:
   Adult • Cerebral Cortex • Colorectal Neoplasms • Contrast Media • Female • Glioblastoma* • Glioma* • Humans • Image Enhancement • Imaging, Three-Dimensional • Liver Neoplasms • Magnetic Resonance Imaging • Male • Middle Aged • Models, Biological* • Predictive Value of Tests • Psoas Muscles • Superior Sagittal Sinus • Tissue Distribution • metabolism • methods • methods* • pathology* • pharmacokinetics* • secondary*