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Papers Published

1. GD Tourassi, B Harrawood, S Singh, JY Lo, CE Floyd, Evaluation of information-theoretic similarity measures for content-based retrieval and detection of masses in mammograms., Medical physics, United States, vol. 34 no. 1 (January, 2007), pp. 140-50 .
   (last updated on 2009/07/03)

   Abstract:
   The purpose of this study was to evaluate image similarity measures employed in an information-theoretic computer-assisted detection (IT-CAD) scheme. The scheme was developed for content-based retrieval and detection of masses in screening mammograms. The study is aimed toward an interactive clinical paradigm where physicians query the proposed IT-CAD scheme on mammographic locations that are either visually suspicious or indicated as suspicious by other cuing CAD systems. The IT-CAD scheme provides an evidence-based, second opinion for query mammographic locations using a knowledge database of mass and normal cases. In this study, eight entropy-based similarity measures were compared with respect to retrieval precision and detection accuracy using a database of 1820 mammographic regions of interest. The IT-CAD scheme was then validated on a separate database for false positive reduction of progressively more challenging visual cues generated by an existing, in-house mass detection system. The study showed that the image similarity measures fall into one of two categories; one category is better suited to the retrieval of semantically similar cases while the second is more effective with knowledge-based decisions regarding the presence of a true mass in the query location. In addition, the IT-CAD scheme yielded a substantial reduction in false-positive detections while maintaining high detection rate for malignant masses.

   Keywords:
   Algorithms* • Artificial Intelligence* • Breast Neoplasms • Humans • Information Storage and Retrieval • Information Theory • Mammography • Pattern Recognition, Automated • Radiographic Image Enhancement • Radiographic Image Interpretation, Computer-Assisted • Reproducibility of Results • Sensitivity and Specificity • Subtraction Technique • methods • methods* • radiography*