Michael D Lynch, Assistant Research Professor
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| Office Phone: | (919) 681-3812 |
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- Education:
- M.D., University of Colorado, School of Medicine, 2007
- Ph.D., University of Colorado, Boulder, 2005
- Research Interests:
Dr. Lynch’s research focuses on genetically engineering microbes to shut off their growth circuits and turn on new pathways to produce different compounds. By focusing their energy, he seeks to improve production of biofuels, pharmacological molecules and industrial chemicals.
- Recent Publications
(More Publications)
- Yang, T; Ye, Z; Lynch, MD, "Multiagent" Screening Improves Directed Enzyme Evolution by Identifying Epistatic Mutations., Acs Synthetic Biology, vol. 11 no. 5 (May, 2022), pp. 1971-1983 [doi] [abs].
- Decker, JS; Menacho-Melgar, R; Lynch, MD, Integrated autolysis, DNA hydrolysis and precipitation enables an improved bioprocess for Q-Griffithsin, a broad-spectrum antiviral and clinical-stage anti-COVID-19 candidate., Biochemical Engineering Journal, vol. 181 (April, 2022), pp. 108403 [doi] [abs].
- Moreb, EA; Lynch, MD, A Meta-Analysis of gRNA Library Screens Enables an Improved Understanding of the Impact of gRNA Folding and Structural Stability on CRISPR-Cas9 Activity., The Crispr Journal, vol. 5 no. 1 (February, 2022), pp. 146-154 [doi] [abs].
- Decker, JS; Menacho-Melgar, R; Lynch, MD, Integrated Autolysis, DNA Hydrolysis and Precipitation Enables an Improved Bioprocess for Q-Griffithsin, a Broad-Spectrum Antiviral and Clinical-Stage anti-COVID-19 Candidate., Biorxiv (January, 2022) [doi] [abs].
- Menacho-Melgar, R; Lynch, MD, Simple Scalable Protein Expression and Extraction Using Two-stage Autoinducible Cell Autolysis and DNA/RNA Autohydrolysis in Escherichia coli., Bio Protocol, vol. 12 no. 2 (January, 2022), pp. e4297 [doi] [abs].