Papers Published

1. Obeid, I; Morizio, JC; Moxon, KA; Nicolelis, MAL; Wolf, PD, Two multichannel integrated circuits for neural recording and signal processing., Ieee Transactions on Bio Medical Engineering, vol. 50 no. 2 (February, 2003), pp. 255-258 [12665041], [doi] .
   (last updated on 2023/06/01)

   Abstract:
   We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage analog signal processor with differential amplification and high-pass filtering. It features selectable gains of 250 and 500 V/V as well as reference channel selection. The resulting amplifiers on Device A had a mean gain of 1.99 V/V with an equivalent input noise of 10 microV(rms). Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 microV(rms). Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex.

   Keywords:
   Action Potentials • Amplifiers* • Animals • Artifacts • Electrodes, Implanted • Electrophysiology • Equipment Design • Feasibility Studies • Haplorhini • Miniaturization • Neurons • Pilot Projects • Quality Control • Rats • Semiconductors • Somatosensory Cortex • instrumentation* • physiology • physiology*