Papers Published

1. McCain, S.T. and Gehm, M.E. and Wang, Y. and Pitsianis, N.P. and Brady, D.J., Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom, Applied Spectroscopy, vol. 60 no. 6 (2006), pp. 663 - 671 [000370206777670693] .
   (last updated on 2007/04/11)

   Abstract:
   Coded aperture spectroscopy allows for sources of large etendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r ² > 0.98. Leave-one-out cross-validation demonstrates prediction errors of less than or equal 15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves less than or equal 12% error at this concentration. © 2006 Society for Applied Spectroscopy.

   Keywords:
   Raman spectroscopy;Tissue;Optimization;Spectrometers;Regression analysis;Multiplexing;