Papers Published

1. McCain, S.T. and Gehm, M.E. and Wang, Y. and Pitsianis, N.P. and Brady, D.J., Multimodal multiplex Raman spectroscopy optimized for in vivo chemometrics, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6093 (2006), pp. 60930 - [12.646755] .
   (last updated on 2007/04/11)

   Abstract:
   We have designed and constructed a multimodal multiplex Raman spectrometer which uses multi-wavelength excitation to better detect signals in the presence of fluorescence by taking advantage of the shift-variance of the Raman signal with respect to excitation frequency. Coupled with partial-least-squares (PLS) regression, the technique applied to ethanol estimation in a tissue phantom achieves root-mean-squared-cross-validation errors (RMSCVE) of 9.2 mmol/L with a model formed with 2 principal components, compared to a single wavelength data set with equivalent energy where 7 principal components were used to achieve an RMSCVE of 39.1 mmol/L.

   Keywords:
   Raman spectroscopy;Signal processing;Electric excitation;Regression analysis;