Papers Published

1. Roy, S; Bhattacharya, BB; Chakrabarti, PP; Chakrabarty, K, Layout-aware solution preparation for biochemical analysis on a digital microfluidic biochip, Proceedings of the Ieee International Conference on Vlsi Design (March, 2011), pp. 171-176, IEEE [doi] .
   (last updated on 2022/12/30)

   Abstract:
   A biochemical analysis is based on several laboratory protocols that require repeated mixing of samples with reagents. Sample preparation and analyte identification steps in such bioassays often involve mixing for solution preparation, i.e., various fluids are to be mixed in a certain volumetric ratio in their resulting mixture. We present an efficient approach for automated mixing of three or more fluids on a droplet-based digital microfluidic biochip and design a layout for implementing this algorithm. The proposed method reduces the droplet transportation time from boundary reservoirs to on-chip mixers as well as cross-contamination among overlapping droplet routing paths. Simulation of several example solutions reveals encouraging results. © 2011 IEEE.