Papers Published

1. Chakrabarty, K; Zhao, Y, Digital Microfluidic Biochips: A Vision for Functional Diversity and More than Moore, Lecture Notes in Electrical Engineering, vol. 105 LNEE (December, 2011), pp. 263-285, Springer Netherlands [doi] .
   (last updated on 2022/12/30)

   Abstract:
   Microfluidics-based biochips are revolutionizing high-throughput sequencing, parallel immunoassayš blood chemistry for clinical diagnostics, and drug discovery. These emerging devices enable the precise control of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and they integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. Compared to conventional laboratory procedures, which are cumbersome and expensive, miniaturized biochips offer the advantages of higher sensitivity, lower cost due to smaller sample and reagent volumes, system integration, and less likelihood of human error. This chapter provides an overview of droplet-based "digital" microfluidic biochips. It describes emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips from bioassay protocols. Recent advances in fluidic-operation scheduling, module placement, droplet routing, pin-constrained chip design, and testing are presented. These CAD techniques allow biochip users to concentrate on the development of nanoscale bioassays, leaving chip optimization and implementation details to design-automation tools. © 2011 Springer Science+Business Media B.V.