Papers Published

1. Zhao, Y; Sturmer, R; Chakrabarty, K; Pamula, VK, Optimization of droplet routing for an n-plex bioassay on a digital microfluidic lab-on-chip, 2009 Ieee Biomedical Circuits and Systems Conference, Biocas 2009 (December, 2009), pp. 241-244, IEEE [doi] .
   (last updated on 2022/12/30)

   Abstract:
   The multiplexed in-vitro measurement of glucose and other metabolites in human physiological fluids is of great importance for the clinical diagnosis of metabolic disorders. We present a design technique for optimizing an n-plex bioassay on an electrowetting-based digital microfluidic lab-on-chip. The n product droplets of the n-plex bioassay are detected using a photomultiplier tube located at the transport bus of the lab-on-chip. We optimize the routing of the droplets and prove that this approach minimizes the assay completion time. The effectiveness of the proposed droplet-routing schedule is shown via an on-chip experiment for a 3-plex assay. We compare the completion time of the proposed routing schedule to an unoptimized baseline schedule for the n-plex assay. ©2009 IEEE.