Papers Published

1. Li, Z; Lai, KYT; Chakrabarty, K; Ho, TY; Lee, CY, Sample Preparation on Micro-Electrode-Dot-Array Digital Microfluidic Biochips, Proceedings of Ieee Computer Society Annual Symposium on Vlsi, Isvlsi, vol. 2017-July (July, 2017), pp. 146-151, IEEE [doi] .
   (last updated on 2022/12/30)

   Abstract:
   Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for onchip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain one major problem associated with sample preparation on a conventional DMFB. For conventional DMFBs, only a (1:1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. To overcome the drawback, we adopt a next generation DMFB platform, referred to as micro-electrode-dot-array (MEDA), for sample preparation. We propose the first sample preparation method that exploits the MEDA-specific advantages of fine-grained control of droplet sizes and real-time droplet sensing. Experimental demonstration using a fabricated MEDA biochip and simulation results highlight the effectiveness of the proposed sample-preparation method.