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Papers Published
- Ibrahim, M; Sridhar, A; Chakrabarty, K; Schlichtmann, U, Sortex: Efficient timing-driven synthesis of reconfigurable flow-based biochips for scalable single-cell screening,
Ieee/Acm International Conference on Computer Aided Design, Digest of Technical Papers, Iccad, vol. 2017-November
(December, 2017),
pp. 623-630, IEEE [doi] .
(last updated on 2022/12/30)Abstract:
Single-cell screening is used to sort a stream of cells into clusters (or types) based on pre-specified biomarkers, thus supporting type-driven biochemical analysis. Reconfigurable flow-based microfluidic biochips (RFBs) can be utilized to screen hundreds of heterogeneous cells within a few minutes, but they are overburdened with the control of a large number of valves. To address this problem, we present a pin-constrained RFB design methodology for single-cell screening. The proposed design is analyzed using computational fluid dynamics simulations, mapped to an RC-lumped model, and combined with a high-level synthesis framework, referred to as Sortex. Simulation results show that Sortex significantly reduces the number of control pins and fulfills the timing requirements of single-cell screening.