Publications [#151621] of Walter T Lee

Papers Published

1. LM Akst, W Lee, C Discolo, D Knott, A Younes, PJ Koltai, Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children., Archives of otolaryngology--head & neck surgery, vol. 129 no. 8 (August, 2003), pp. 841-6, ISSN 0886-4470
   (last updated on 2013/05/16)

   Abstract:
   OBJECTIVE: To evaluate a stepped-dose protocol for intralesional injection of cidofovir in children with recurrent respiratory papillomatosis (RRP). METHODS: Prospective, nonrandomized case series. METHODS: Tertiary care children's hospital. METHODS: Eleven children undergoing evaluation for RRP from June 1, 2000, through December 31, 2001. METHODS: Intralesional injection of cidofovir was performed after microlaryngoscopy and carbon dioxide laser treatment. Patients received 4 monthly injections at a concentration of 5 mg/mL and returned 1 month after the last injection for follow-up. Patients with recurrent or recalcitrant disease then started a series of 4 monthly injections at a concentration of 10 mg/mL. METHODS: Papilloma stage (0-3) documented at multiple subsites by means of serial microlaryngoscopy. We calculated a severity score by summing the scores at all affected subsites. RESULTS: The severity score decreased in each of the 11 patients during the course of therapy, from a mean +/- SD of 13.7 +/- 6.0 at enrollment to 2.1 +/- 3.4 at 1-month follow-up. Six patients experienced complete resolution (stage 0) and 4 others had mild disease (stage, Keywords:
   Adolescent • Antineoplastic Agents • Child • Child, Preschool • Combined Modality Therapy • Cytosine • Female • Humans • Injections, Intralesional • Laryngoscopy • Laser Therapy • Male • Organophosphonates* • Organophosphorus Compounds • Papilloma • Prospective Studies • Respiratory Tract Neoplasms • Severity of Illness Index • Statistics, Nonparametric • Treatment Outcome • analogs & derivatives* • drug therapy* • surgery • therapeutic use*