Publications of Matthew Scult    :chronological  alphabetical  combined listing:

%% Journal Articles   
@article{fds342777,
   Author = {Davies, G and Lam, M and Harris, SE and Trampush, JW and Luciano, M and Hill, WD and Hagenaars, SP and Ritchie, SJ and Marioni, RE and Fawns-Ritchie, C and Liewald, DCM and Okely, JA and Ahola-Olli, AV and Barnes, CLK and Bertram, L and Bis, JC and Burdick, KE and Christoforou,
             A and DeRosse, P and Djurovic, S and Espeseth, T and Giakoumaki, S and Giddaluru, S and Gustavson, DE and Hayward, C and Hofer, E and Ikram,
             MA and Karlsson, R and Knowles, E and Lahti, J and Leber, M and Li, S and Mather, KA and Melle, I and Morris, D and Oldmeadow, C and Palviainen,
             T and Payton, A and Pazoki, R and Petrovic, K and Reynolds, CA and Sargurupremraj, M and Scholz, M and Smith, JA and Smith, AV and Terzikhan, N and Thalamuthu, A and Trompet, S and van der Lee, SJ and Ware, EB and Windham, BG and Wright, MJ and Yang, J and Yu, J and Ames, D and Amin, N and Amouyel, P and Andreassen, OA and Armstrong, NJ and Assareh,
             AA and Attia, JR and Attix, D and Avramopoulos, D and Bennett, DA and Böhmer, AC and Boyle, PA and Brodaty, H and Campbell, H and Cannon, TD and Cirulli, ET and Congdon, E and Conley, ED and Corley, J and Cox, SR and Dale, AM and Dehghan, A and Dick, D and Dickinson, D and Eriksson, JG and Evangelou, E and Faul, JD and Ford, I and Freimer, NA and Gao, H and Giegling, I and Gillespie, NA and Gordon, SD and Gottesman, RF and Griswold, ME and Gudnason, V and Harris, TB and Hartmann, AM and Hatzimanolis, A and Heiss, G and Holliday, EG and Joshi, PK and Kähönen, M and Kardia, SLR and Karlsson, I and Kleineidam, L and Knopman, DS and Kochan, NA and Konte, B and Kwok, JB and Le Hellard and S and Lee, T and Lehtimäki, T and Li, S-C and Lill, CM and Liu, T and Koini, M and London, E and Longstreth, WT and Lopez, OL and Loukola, A and Luck, T and Lundervold, AJ and Lundquist, A and Lyytikäinen, L-P and Martin, NG and Montgomery, GW and Murray, AD and Need, AC and Noordam, R and Nyberg, L and Ollier, W and Papenberg, G and Pattie, A and Polasek, O and Poldrack,
             RA and Psaty, BM and Reppermund, S and Riedel-Heller, SG and Rose, RJ and Rotter, JI and Roussos, P and Rovio, SP and Saba, Y and Sabb, FW and Sachdev, PS and Satizabal, CL and Schmid, M and Scott, RJ and Scult, MA and Simino, J and Slagboom, PE and Smyrnis, N and Soumaré, A and Stefanis,
             NC and Stott, DJ and Straub, RE and Sundet, K and Taylor, AM and Taylor,
             KD and Tzoulaki, I and Tzourio, C and Uitterlinden, A and Vitart, V and Voineskos, AN and Kaprio, J and Wagner, M and Wagner, H and Weinhold, L and Wen, KH and Widen, E and Yang, Q and Zhao, W and Adams, HHH and Arking, DE and Bilder, RM and Bitsios, P and Boerwinkle, E and Chiba-Falek, O and Corvin, A and De Jager and PL and Debette, S and Donohoe, G and Elliott, P and Fitzpatrick, AL and Gill, M and Glahn, DC and Hägg, S and Hansell, NK and Hariri, AR and Ikram, MK and Jukema, JW and Vuoksimaa, E and Keller, MC and Kremen, WS and Launer, L and Lindenberger, U and Palotie, A and Pedersen, NL and Pendleton, N and Porteous, DJ and Räikkönen, K and Raitakari, OT and Ramirez, A and Reinvang, I and Rudan, I and Dan
             Rujescu, and Schmidt, R and Schmidt, H and Schofield, PW and Schofield,
             PR and Starr, JM and Steen, VM and Trollor, JN and Turner, ST and Van
             Duijn, CM and Villringer, A and Weinberger, DR and Weir, DR and Wilson,
             JF and Malhotra, A and McIntosh, AM and Gale, CR and Seshadri, S and Mosley, TH and Bressler, J and Lencz, T and Deary,
             IJ},
   Title = {Author Correction: Study of 300,486 individuals identifies
             148 independent genetic loci influencing general cognitive
             function.},
   Journal = {Nature Communications},
   Volume = {10},
   Number = {1},
   Pages = {2068},
   Year = {2019},
   Month = {May},
   url = {http://dx.doi.org/10.1038/s41467-019-10160-w},
   Abstract = {Christina M. Lill, who contributed to analysis of data, was
             inadvertently omitted from the author list in the originally
             published version of this article. This has now been
             corrected in both the PDF and HTML versions of the
             article.},
   Doi = {10.1038/s41467-019-10160-w},
   Key = {fds342777}
}

@article{fds329571,
   Author = {Miller, JA and Scult, MA and Conley, ED and Chen, Q and Weinberger, DR and Hariri, AR},
   Title = {Effects of Schizophrenia Polygenic Risk Scores on Brain
             Activity and Performance During Working Memory Subprocesses
             in Healthy Young Adults.},
   Journal = {Schizophrenia Bulletin},
   Volume = {44},
   Number = {4},
   Pages = {844-853},
   Year = {2018},
   Month = {June},
   url = {http://dx.doi.org/10.1093/schbul/sbx140},
   Abstract = {Recent work has begun to shed light on the neural correlates
             and possible mechanisms of polygenic risk for schizophrenia.
             Here, we map a schizophrenia polygenic risk profile score
             (PRS) based on genome-wide association study significant
             loci onto variability in the activity and functional
             connectivity of a frontoparietal network supporting the
             manipulation versus maintenance of information during a
             numerical working memory (WM) task in healthy young adults
             (n = 99, mean age = 19.8). Our analyses revealed that higher
             PRS was associated with hypoactivity of the dorsolateral
             prefrontal cortex (dlPFC) during the manipulation but not
             maintenance of information in WM (r2 = .0576, P = .018).
             Post hoc analyses revealed that PRS-modulated dlPFC
             hypoactivity correlated with faster reaction times during WM
             manipulation (r2 = .0967, P = .002), and faster processing
             speed (r2 = .0967, P = .003) on a separate behavioral task.
             These PRS-associated patterns recapitulate dlPFC
             hypoactivity observed in patients with schizophrenia during
             central executive manipulation of information in WM on this
             task.},
   Doi = {10.1093/schbul/sbx140},
   Key = {fds329571}
}

@article{fds335713,
   Author = {Davies, G and Lam, M and Harris, SE and Trampush, JW and Luciano, M and Hill, WD and Hagenaars, SP and Ritchie, SJ and Marioni, RE and Fawns-Ritchie, C and Liewald, DCM and Okely, JA and Ahola-Olli, AV and Barnes, CLK and Bertram, L and Bis, JC and Burdick, KE and Christoforou,
             A and DeRosse, P and Djurovic, S and Espeseth, T and Giakoumaki, S and Giddaluru, S and Gustavson, DE and Hayward, C and Hofer, E and Ikram,
             MA and Karlsson, R and Knowles, E and Lahti, J and Leber, M and Li, S and Mather, KA and Melle, I and Morris, D and Oldmeadow, C and Palviainen,
             T and Payton, A and Pazoki, R and Petrovic, K and Reynolds, CA and Sargurupremraj, M and Scholz, M and Smith, JA and Smith, AV and Terzikhan, N and Thalamuthu, A and Trompet, S and van der Lee, SJ and Ware, EB and Windham, BG and Wright, MJ and Yang, J and Yu, J and Ames, D and Amin, N and Amouyel, P and Andreassen, OA and Armstrong, NJ and Assareh,
             AA and Attia, JR and Attix, D and Avramopoulos, D and Bennett, DA and Böhmer, AC and Boyle, PA and Brodaty, H and Campbell, H and Cannon, TD and Cirulli, ET and Congdon, E and Conley, ED and Corley, J and Cox, SR and Dale, AM and Dehghan, A and Dick, D and Dickinson, D and Eriksson, JG and Evangelou, E and Faul, JD and Ford, I and Freimer, NA and Gao, H and Giegling, I and Gillespie, NA and Gordon, SD and Gottesman, RF and Griswold, ME and Gudnason, V and Harris, TB and Hartmann, AM and Hatzimanolis, A and Heiss, G and Holliday, EG and Joshi, PK and Kähönen, M and Kardia, SLR and Karlsson, I and Kleineidam, L and Knopman, DS and Kochan, NA and Konte, B and Kwok, JB and Le Hellard and S and Lee, T and Lehtimäki, T and Li, S-C and Lill, CM and Liu, T and Koini, M and London, E and Longstreth, WT and Lopez, OL and Loukola, A and Luck, T and Lundervold, AJ and Lundquist, A and Lyytikäinen, L-P and Martin, NG and Montgomery, GW and Murray, AD and Need, AC and Noordam, R and Nyberg, L and Ollier, W and Papenberg, G and Pattie, A and Polasek, O and Poldrack,
             RA and Psaty, BM and Reppermund, S and Riedel-Heller, SG and Rose, RJ and Rotter, JI and Roussos, P and Rovio, SP and Saba, Y and Sabb, FW and Sachdev, PS and Satizabal, CL and Schmid, M and Scott, RJ and Scult, MA and Simino, J and Slagboom, PE and Smyrnis, N and Soumaré, A and Stefanis,
             NC and Stott, DJ and Straub, RE and Sundet, K and Taylor, AM and Taylor,
             KD and Tzoulaki, I and Tzourio, C and Uitterlinden, A and Vitart, V and Voineskos, AN and Kaprio, J and Wagner, M and Wagner, H and Weinhold, L and Wen, KH and Widen, E and Yang, Q and Zhao, W and Adams, HHH and Arking, DE and Bilder, RM and Bitsios, P and Boerwinkle, E and Chiba-Falek, O and Corvin, A and De Jager and PL and Debette, S and Donohoe, G and Elliott, P and Fitzpatrick, AL and Gill, M and Glahn, DC and Hägg, S and Hansell, NK and Hariri, AR and Ikram, MK and Jukema, JW and Vuoksimaa, E and Keller, MC and Kremen, WS and Launer, L and Lindenberger, U and Palotie, A and Pedersen, NL and Pendleton, N and Porteous, DJ and Räikkönen, K and Raitakari, OT and Ramirez, A and Reinvang, I and Rudan, I and Dan
             Rujescu, and Schmidt, R and Schmidt, H and Schofield, PW and Schofield,
             PR and Starr, JM and Steen, VM and Trollor, JN and Turner, ST and Van
             Duijn, CM and Villringer, A and Weinberger, DR and Weir, DR and Wilson,
             JF and Malhotra, A and McIntosh, AM and Gale, CR and Seshadri, S and Mosley, TH and Bressler, J and Lencz, T and Deary,
             IJ},
   Title = {Study of 300,486 individuals identifies 148 independent
             genetic loci influencing general cognitive
             function.},
   Journal = {Nature Communications},
   Volume = {9},
   Number = {1},
   Pages = {2098},
   Year = {2018},
   Month = {May},
   url = {http://dx.doi.org/10.1038/s41467-018-04362-x},
   Abstract = {General cognitive function is a prominent and relatively
             stable human trait that is associated with many important
             life outcomes. We combine cognitive and genetic data from
             the CHARGE and COGENT consortia, and UK Biobank (total
             N = 300,486; age 16-102) and find 148 genome-wide
             significant independent loci (P < 5 × 10-8)
             associated with general cognitive function. Within the novel
             genetic loci are variants associated with neurodegenerative
             and neurodevelopmental disorders, physical and psychiatric
             illnesses, and brain structure. Gene-based analyses find 709
             genes associated with general cognitive function. Expression
             levels across the cortex are associated with general
             cognitive function. Using polygenic scores, up to 4.3% of
             variance in general cognitive function is predicted in
             independent samples. We detect significant genetic overlap
             between general cognitive function, reaction time, and many
             health variables including eyesight, hypertension, and
             longevity. In conclusion we identify novel genetic loci and
             pathways contributing to the heritability of general
             cognitive function.},
   Doi = {10.1038/s41467-018-04362-x},
   Key = {fds335713}
}

@article{fds331650,
   Author = {Olmeta-Schult, F and Segal, LM and Tyner, S and Moon, TA and Chow, RD-W and Chakrabarty, P and Pacesa, M and Podgornaia, AI and Chen, J and Singh,
             B and Cao, B and Sidhu, RRS and Tan, BWQ and Sood, P and Parker, S and Scult,
             MA and Van Haute and D and Konstantinides, N and Schwendimann, BA and Srivastava, S and Fiorenza, R and Dutton-Regester, K and Hale, R and Polat, EO and Lau, E and Mayer, AL and White, ER},
   Title = {NextGen VOICES: Research resolutions.},
   Journal = {Science (New York, N.Y.)},
   Volume = {359},
   Number = {6371},
   Pages = {26-28},
   Year = {2018},
   Month = {January},
   url = {http://dx.doi.org/10.1126/science.aar7504},
   Doi = {10.1126/science.aar7504},
   Key = {fds331650}
}

@article{fds329570,
   Author = {Scult, MA and Knodt, AR and Radtke, SR and Brigidi, BD and Hariri,
             AR},
   Title = {Prefrontal Executive Control Rescues Risk for Anxiety
             Associated with High Threat and Low Reward Brain
             Function},
   Journal = {Cerebral Cortex (New York, N.Y. : 1991)},
   Volume = {29},
   Number = {1},
   Pages = {70-76},
   Year = {2017},
   Month = {November},
   url = {http://dx.doi.org/10.1093/cercor/bhx304},
   Abstract = {Compared with neural biomarkers of risk for mental illness,
             little is known about biomarkers of resilience. We explore
             if greater executive control-related prefrontal activity may
             function as a resilience biomarker by “rescuing” risk
             associated with higher threat-related amygdala and lower
             reward-related ventral striatum activity. Functional MRI was
             used to assay baseline threat-related amygdala,
             reward-related ventral striatum, and executive
             control-related prefrontal activity in 120 young adult
             volunteers. Participants provided self-reported mood and
             anxiety ratings at baseline and follow-up. A moderation
             model revealed a significant three-way interaction wherein
             higher amygdala and lower ventral striatum activity
             predicted increases in anxiety in those with average or low
             but not high prefrontal activity. This effect was specific
             to anxiety, with the neural biomarkers explaining ~10% of
             the variance in change over time, above and beyond baseline
             symptoms, sex, age, IQ, presence or absence of DMS-IV
             diagnosis, and both early and recent stress. Our findings
             are consistent with the importance of top-down executive
             control in adaptive regulation of negative emotions, and
             highlight a unique combination of neural biomarkers that may
             identify at-risk individuals for whom the adoption of
             strategies to improve executive control of negative emotions
             may prove particularly beneficial.},
   Doi = {10.1093/cercor/bhx304},
   Key = {fds329570}
}

@article{fds325909,
   Author = {Scult, MA and Knodt, AR and Hanson, JL and Ryoo, M and Adcock, RA and Hariri, AR and Strauman, TJ},
   Title = {Individual differences in regulatory focus predict neural
             response to reward.},
   Journal = {Soc Neurosci},
   Volume = {12},
   Number = {4},
   Pages = {419-429},
   Year = {2017},
   Month = {August},
   url = {http://dx.doi.org/10.1080/17470919.2016.1178170},
   Abstract = {Although goal pursuit is related to both functioning of the
             brain's reward circuits and psychological factors, the
             literatures surrounding these concepts have often been
             separate. Here, we use the psychological construct of
             regulatory focus to investigate individual differences in
             neural response to reward. Regulatory focus theory proposes
             two motivational orientations for personal goal pursuit: (1)
             promotion, associated with sensitivity to potential gain,
             and (2) prevention, associated with sensitivity to potential
             loss. The monetary incentive delay task was used to
             manipulate reward circuit function, along with instructional
             framing corresponding to promotion and prevention in a
             within-subject design. We observed that the more promotion
             oriented an individual was, the lower their ventral striatum
             response to gain cues. Follow-up analyses revealed that
             greater promotion orientation was associated with decreased
             ventral striatum response even to no-value cues, suggesting
             that promotion orientation may be associated with relatively
             hypoactive reward system function. The findings are also
             likely to represent an interaction between the cognitive and
             motivational characteristics of the promotion system with
             the task demands. Prevention orientation did not correlate
             with ventral striatum response to gain cues, supporting the
             discriminant validity of regulatory focus theory. The
             results highlight a dynamic association between individual
             differences in self-regulation and reward system
             function.},
   Doi = {10.1080/17470919.2016.1178170},
   Key = {fds325909}
}

@article{fds325905,
   Author = {Scult, MA},
   Title = {Flexible Adaptation of Brain Networks during
             Stress.},
   Journal = {The Journal of Neuroscience : the Official Journal of the
             Society for Neuroscience},
   Volume = {37},
   Number = {15},
   Pages = {3992-3994},
   Year = {2017},
   Month = {April},
   url = {http://dx.doi.org/10.1523/JNEUROSCI.0224-17.2017},
   Doi = {10.1523/JNEUROSCI.0224-17.2017},
   Key = {fds325905}
}

@article{fds325906,
   Author = {Trampush, JW and Yang, MLZ and Yu, J and Knowles, E and Davies, G and Liewald, DC and Starr, JM and Djurovic, S and Melle, I and Sundet, K and Christoforou, A and Reinvang, I and DeRosse, P and Lundervold, AJ and Steen, VM and Espeseth, T and Räikkönen, K and Widen, E and Palotie,
             A and Eriksson, JG and Giegling, I and Konte, B and Roussos, P and Giakoumaki, S and Burdick, KE and Payton, A and Ollier, W and Horan, M and Chiba-Falek, O and Attix, DK and Need, AC and Cirulli, ET and Voineskos,
             AN and Stefanis, NC and Avramopoulos, D and Hatzimanolis, A and Arking,
             DE and Smyrnis, N and Bilder, RM and Freimer, NA and Cannon, TD and London,
             E and Poldrack, RA and Sabb, FW and Congdon, E and Conley, ED and Scult,
             MA and Dickinson, D and Straub, RE and Donohoe, G and Morris, D and Corvin,
             A and Gill, M and Hariri, AR and Weinberger, DR and Pendleton, N and Bitsios, P and Rujescu, D and Lahti, J and Le Hellard and S and Keller, MC and Andreassen, OA and Deary, IJ and Glahn, DC and Malhotra, AK and Lencz,
             T},
   Title = {GWAS meta-analysis reveals novel loci and genetic correlates
             for general cognitive function: a report from the COGENT
             consortium.},
   Journal = {Mol Psychiatry},
   Volume = {22},
   Number = {3},
   Pages = {336-345},
   Year = {2017},
   Month = {March},
   url = {http://dx.doi.org/10.1038/mp.2016.244},
   Abstract = {The complex nature of human cognition has resulted in
             cognitive genomics lagging behind many other fields in terms
             of gene discovery using genome-wide association study (GWAS)
             methods. In an attempt to overcome these barriers, the
             current study utilized GWAS meta-analysis to examine the
             association of common genetic variation (~8M
             single-nucleotide polymorphisms (SNP) with minor allele
             frequency ⩾1%) to general cognitive function in a sample
             of 35 298 healthy individuals of European ancestry across
             24 cohorts in the Cognitive Genomics Consortium (COGENT). In
             addition, we utilized individual SNP lookups and polygenic
             score analyses to identify genetic overlap with other
             relevant neurobehavioral phenotypes. Our primary GWAS
             meta-analysis identified two novel SNP loci (top SNPs:
             rs76114856 in the CENPO gene on chromosome 2 and rs6669072
             near LOC105378853 on chromosome 1) associated with cognitive
             performance at the genome-wide significance level (P<5 ×
             10-8). Gene-based analysis identified an additional three
             Bonferroni-corrected significant loci at chromosomes
             17q21.31, 17p13.1 and 1p13.3. Altogether, common variation
             across the genome resulted in a conservatively estimated SNP
             heritability of 21.5% (s.e.=0.01%) for general cognitive
             function. Integration with prior GWAS of cognitive
             performance and educational attainment yielded several
             additional significant loci. Finally, we found robust
             polygenic correlations between cognitive performance and
             educational attainment, several psychiatric disorders, birth
             length/weight and smoking behavior, as well as a novel
             genetic association to the personality trait of openness.
             These data provide new insight into the genetics of
             neurocognitive function with relevance to understanding the
             pathophysiology of neuropsychiatric illness.},
   Doi = {10.1038/mp.2016.244},
   Key = {fds325906}
}

@article{fds325907,
   Author = {Scult, MA and Paulli, AR and Mazure, ES and Moffitt, TE and Hariri, AR and Strauman, TJ},
   Title = {The association between cognitive function and subsequent
             depression: a systematic review and meta-analysis.},
   Journal = {Psychol Med},
   Volume = {47},
   Number = {1},
   Pages = {1-17},
   Year = {2017},
   Month = {January},
   url = {http://dx.doi.org/10.1017/S0033291716002075},
   Abstract = {Despite a growing interest in understanding the cognitive
             deficits associated with major depressive disorder (MDD), it
             is largely unknown whether such deficits exist before
             disorder onset or how they might influence the severity of
             subsequent illness. The purpose of the present study was to
             conduct a systematic review and meta-analysis of
             longitudinal datasets to determine whether cognitive
             function acts as a predictor of later MDD diagnosis or
             change in depression symptoms. Eligible studies included
             longitudinal designs with baseline measures of cognitive
             functioning, and later unipolar MDD diagnosis or symptom
             assessment. The systematic review identified 29
             publications, representing 34 unique samples, and 121 749
             participants, that met the inclusion/exclusion criteria.
             Quantitative meta-analysis demonstrated that higher
             cognitive function was associated with decreased levels of
             subsequent depression (r = -0.088, 95% confidence interval.
             -0.121 to -0.054, p < 0.001). However, sensitivity analyses
             revealed that this association is likely driven by
             concurrent depression symptoms at the time of cognitive
             assessment. Our review and meta-analysis indicate that the
             association between lower cognitive function and later
             depression is confounded by the presence of contemporaneous
             depression symptoms at the time of cognitive assessment.
             Thus, cognitive deficits predicting MDD likely represent
             deleterious effects of subclinical depression symptoms on
             performance rather than premorbid risk factors for
             disorder.},
   Doi = {10.1017/S0033291716002075},
   Key = {fds325907}
}

@article{fds325908,
   Author = {Scult, MA and Knodt, AR and Swartz, JR and Brigidi, BD and Hariri,
             AR},
   Title = {Thinking and Feeling: Individual Differences in Habitual
             Emotion Regulation and Stress-Related Mood are Associated
             with Prefrontal Executive Control.},
   Journal = {Clinical Psychological Science : a Journal of the
             Association for Psychological Science},
   Volume = {5},
   Number = {1},
   Pages = {150-157},
   Year = {2017},
   Month = {January},
   url = {http://dx.doi.org/10.1177/2167702616654688},
   Abstract = {Calculating math problems from memory may seem unrelated to
             everyday processing of emotions, but they have more in
             common than one might think. Prior research highlights the
             importance of the dorsolateral prefrontal cortex (dlPFC) in
             executive control, intentional emotion regulation, and
             experience of dysfunctional mood and anxiety. While it has
             been hypothesized that emotion regulation may be related to
             'cold' (ie. not emotion-related) executive control, this
             assertion has not been tested. We address this gap by
             providing evidence that greater dlPFC activity during 'cold'
             executive control is associated with increased use of
             cognitive reappraisal to regulate emotions in everyday life.
             We then demonstrate that in the presence of increased life
             stress, increased dlPFC activity is associated with lower
             mood and anxiety symptoms and clinical diagnoses.
             Collectively, our results encourage ongoing efforts to
             understand prefrontal executive control as a possible
             intervention target for improving emotion regulation in mood
             and anxiety disorders.},
   Doi = {10.1177/2167702616654688},
   Key = {fds325908}
}

@article{fds325910,
   Author = {Scult, M and Haime, V and Jacquart, J and Takahashi, J and Moscowitz, B and Webster, A and Denninger, JW and Mehta, DH},
   Title = {A healthy aging program for older adults: effects on
             self-efficacy and morale.},
   Journal = {Advances in Mind Body Medicine},
   Volume = {29},
   Number = {1},
   Pages = {26-33},
   Year = {2015},
   Month = {December},
   Abstract = {As of 2012, 810 million people worldwide were older than 60
             y, accounting for 11% of the population. That number is
             expected to rise to 2 billion by 2050 or to 22% of the
             overall population. As a result, a growing need exists to
             understand the factors that promote mental and physical
             health in older populations.The purpose of this study was to
             develop a healthy aging program for older adults and to
             measure the changes from baseline to the end of the program
             in participants' relevant psychosocial outcomes (ie,
             self-efficacy and morale).The study's healthy aging
             mind-body intervention (MBI) was adapted from the Relaxation
             Response Resiliency Program (3RP) at the Benson-Henry
             Institute for Mind Body Medicine, which incorporates
             elements from the fields of stress management, cognitive
             behavioral therapy, and positive psychology. That program
             was modified with examples and exercises targeted to an
             older population and evaluated in the current single-arm
             pilot study.The program took place at the Massachusetts
             General Hospital (MGH).The 9-wk healthy aging MBI was
             developed for participants aged 65 y and older. Fifty-one
             older adults from the surrounding community participated in
             the study's groups.A new intervention group began the
             program every 3 mo, with a maximum of 12 individuals per
             group. For each group, the MBI consisted of weekly 90-min
             sessions for 9 consecutive wk, directed by a psychologist.
             The program included sessions that taught participants (1) a
             variety of methods to elicit the relaxation response (RR),
             (2) the practice of adaptive coping and cognitions, (3)
             behaviors necessary to create a healthy lifestyle, and (4)
             methods of building social support.The research team chose
             to focus on 2 psychological variables of interest for aging
             populations: morale and self-efficacy. The study used 2
             questionnaires to measure those outcomes, the Philadelphia
             Geriatric Center Morale Scale (PGCMS), a multidimensional
             measure of the psychological state of older people, and the
             Coping Self-efficacy Scale (CSES), a measure that addresses
             the multiple dimensions of self-efficacy.Data from 5
             intervention groups were combined for the current analysis.
             Forty-six participants enrolled and completed
             questionnaires. Of those participants, 41 attended at least
             7 of the 9 sessions. Significant increases in self-efficacy
             and morale were observed for program completers. After a
             highly conservative sensitivity analysis, the change for the
             measure of self-efficacy remained significant, and the
             change for the measure of morale trended toward
             significance.The study's healthy aging program appears to be
             a feasible intervention for older adults, with the potential
             to increase levels of self-efficacy and morale in
             participants. Further research is warranted to determine its
             effects on other psychosocial outcomes and health care
             utilization in aging populations.},
   Key = {fds325910}
}

@article{fds325911,
   Author = {Scult, MA and Trampush, JW and Zheng, F and Conley, ED and Lencz, T and Malhotra, AK and Dickinson, D and Weinberger, DR and Hariri,
             AR},
   Title = {A Common Polymorphism in SCN2A Predicts General Cognitive
             Ability through Effects on PFC Physiology.},
   Journal = {Journal of Cognitive Neuroscience},
   Volume = {27},
   Number = {9},
   Pages = {1766-1774},
   Year = {2015},
   Month = {September},
   url = {http://dx.doi.org/10.1162/jocn_a_00826},
   Abstract = {Here we provide novel convergent evidence across three
             independent cohorts of healthy adults (n = 531),
             demonstrating that a common polymorphism in the gene
             encoding the α2 subunit of neuronal voltage-gated type II
             sodium channels (SCN2A) predicts human general cognitive
             ability or "g." Using meta-analysis, we demonstrate that the
             minor T allele of a common polymorphism (rs10174400) in
             SCN2A is associated with significantly higher "g"
             independent of gender and age. We further demonstrate using
             resting-state fMRI data from our discovery cohort (n = 236)
             that this genetic advantage may be mediated by increased
             capacity for information processing between the dorsolateral
             PFC and dorsal ACC, which support higher cognitive
             functions. Collectively, these findings fill a gap in our
             understanding of the genetics of general cognitive ability
             and highlight a specific neural mechanism through which a
             common polymorphism shapes interindividual variation in
             "g."},
   Doi = {10.1162/jocn_a_00826},
   Key = {fds325911}
}

@article{fds325912,
   Author = {Trampush, JW and Lencz, T and Knowles, E and Davies, G and Guha, S and Pe'er, I and Liewald, DC and Starr, JM and Djurovic, S and Melle, I and Sundet, K and Christoforou, A and Reinvang, I and Mukherjee, S and DeRosse, P and Lundervold, A and Steen, VM and John, M and Espeseth, T and Räikkönen, K and Widen, E and Palotie, A and Eriksson, JG and Giegling, I and Konte, B and Ikeda, M and Roussos, P and Giakoumaki, S and Burdick, KE and Payton, A and Ollier, W and Horan, M and Scult, M and Dickinson, D and Straub, RE and Donohoe, G and Morris, D and Corvin, A and Gill, M and Hariri, A and Weinberger, DR and Pendleton, N and Iwata, N and Darvasi, A and Bitsios, P and Rujescu, D and Lahti, J and Le Hellard and S and Keller, MC and Andreassen, OA and Deary, IJ and Glahn, DC and Malhotra,
             AK},
   Title = {Independent evidence for an association between general
             cognitive ability and a genetic locus for educational
             attainment.},
   Journal = {American Journal of Medical Genetics. Part B,
             Neuropsychiatric Genetics : the Official Publication of the
             International Society of Psychiatric Genetics},
   Volume = {168B},
   Number = {5},
   Pages = {363-373},
   Year = {2015},
   Month = {July},
   url = {http://dx.doi.org/10.1002/ajmg.b.32319},
   Abstract = {Cognitive deficits and reduced educational achievement are
             common in psychiatric illness; understanding the genetic
             basis of cognitive and educational deficits may be
             informative about the etiology of psychiatric disorders. A
             recent, large genome-wide association study (GWAS) reported
             a genome-wide significant locus for years of education,
             which subsequently demonstrated association to general
             cognitive ability ("g") in overlapping cohorts. The current
             study was designed to test whether GWAS hits for educational
             attainment are involved in general cognitive ability in an
             independent, large-scale collection of cohorts. Using
             cohorts in the Cognitive Genomics Consortium (COGENT; up to
             20,495 healthy individuals), we examined the relationship
             between g and variants associated with educational
             attainment. We next conducted meta-analyses with 24,189
             individuals with neurocognitive data from the educational
             attainment studies, and then with 53,188 largely independent
             individuals from a recent GWAS of cognition. A SNP
             (rs1906252) located at chromosome 6q16.1, previously
             associated with years of schooling, was significantly
             associated with g (P = 1.47 × 10(-4) ) in COGENT.
             The first joint analysis of 43,381 non-overlapping
             individuals for this a priori-designated locus was strongly
             significant (P = 4.94 × 10(-7) ), and the second
             joint analysis of 68,159 non-overlapping individuals was
             even more robust (P = 1.65 × 10(-9) ). These
             results provide independent replication, in a large-scale
             dataset, of a genetic locus associated with cognitive
             function and education. As sample sizes grow, cognitive GWAS
             will identify increasing numbers of associated loci, as has
             been accomplished in other polygenic quantitative traits,
             which may be relevant to psychiatric illness.},
   Doi = {10.1002/ajmg.b.32319},
   Key = {fds325912}
}

@article{fds325913,
   Author = {Wilson, HK and Scult, M and Wilcher, M and Chudnofsky, R and Malloy, L and Drewel, E and Riklin, E and Saul, S and Fricchione, GL and Benson, H and Denninger, JW},
   Title = {Teacher-led relaxation response curriculum in an urban high
             school: impact on student behavioral health and classroom
             environment.},
   Journal = {Advances in Mind Body Medicine},
   Volume = {29},
   Number = {2},
   Pages = {6-14},
   Year = {2015},
   Month = {March},
   Abstract = {Recent data suggest that severe stress during the adolescent
             period is becoming a problem of epidemic proportions.
             Elicitation of the relaxation response (RR) has been shown
             to be effective in treating anxiety, reducing stress, and
             increasing positive health behaviors.The research team's
             objective was to assess the impact of an RR-based
             curriculum, led by teachers, on the psychological status and
             health management behaviors of high-school students and to
             determine whether a train-the-trainer model would be
             feasible in a high-school setting.The research team designed
             a pilot study.The setting was a Horace Mann charter school
             within Boston's public school system.Participants were
             teachers and students at the charter school.The team taught
             teachers a curriculum that included (1) relaxation
             strategies, such as breathing and imagery; (2)
             psychoeducation regarding mind-body pathways; and (3)
             positive psychology. Teachers implemented this curriculum
             with students.The research team assessed changes in student
             outcomes (eg, stress, anxiety, and stress management
             behaviors) using preintervention/postintervention surveys,
             including the Perceived Stress Scale (PSS), the State-Trait
             Anxiety Inventory-Form Y (STAI-Y), the stress management
             subscale of the Health-promoting Lifestyle Profile II
             (HPLP-II), the Rosenberg Self-Esteem Scale (RSES), the Locus
             of Control (LOC) questionnaire, and the Life Orientation
             Test-Revised (LOTR). Classroom observations using the
             Classroom Assessment Scoring System (CLASS)-Secondary were
             also completed to assess changes in classroom
             environment.Using a Bonferroni correction (P < .007), the
             study found that students experienced a significant
             reduction (P < .001) in measures of state-level anxiety on
             the STAI from pre- to postintervention. The study also found
             an increase in the use of stress management behaviors at
             that point. Using a Bonferroni correction (P < .007), the
             study found that students had significantly less perceived
             stress (P < .001), less state anxiety (P < .001) and trait
             anxiety (P < . 001), and increased use of positive stress
             management behaviors (P < .004) at the follow-up assessment
             in the fall of the following year. Using a Bonferroni
             correction (P < .002), the study found a significant
             increase in overall classroom productivity (eg, increased
             time spent on activities and instruction from pre- to
             postintervention).This study showed that teachers can lead
             an RR curriculum with fidelity and suggests that such a
             curriculum has positive benefits on student emotional and
             behavioral health and on classroom functioning.},
   Key = {fds325913}
}

@article{fds325914,
   Author = {Kuo, B and Bhasin, M and Jacquart, J and Scult, MA and Slipp, L and Riklin,
             EIK and Lepoutre, V and Comosa, N and Norton, B-A and Dassatti, A and Rosenblum, J and Thurler, AH and Surjanhata, BC and Hasheminejad, NN and Kagan, L and Slawsby, E and Rao, SR and Macklin, EA and Fricchione, GL and Benson, H and Libermann, TA and Korzenik, J and Denninger,
             JW},
   Title = {Genomic and clinical effects associated with a relaxation
             response mind-body intervention in patients with irritable
             bowel syndrome and inflammatory bowel disease.},
   Journal = {Plos One},
   Volume = {10},
   Number = {4},
   Pages = {e0123861},
   Year = {2015},
   Month = {January},
   url = {http://dx.doi.org/10.1371/journal.pone.0123861},
   Abstract = {Irritable Bowel Syndrome (IBS) and Inflammatory Bowel
             Disease (IBD) can profoundly affect quality of life and are
             influenced by stress and resiliency. The impact of mind-body
             interventions (MBIs) on IBS and IBD patients has not
             previously been examined.Nineteen IBS and 29 IBD patients
             were enrolled in a 9-week relaxation response based
             mind-body group intervention (RR-MBI), focusing on
             elicitation of the RR and cognitive skill building. Symptom
             questionnaires and inflammatory markers were assessed pre-
             and post-intervention, and at short-term follow-up.
             Peripheral blood transcriptome analysis was performed to
             identify genomic correlates of the RR-MBI.Pain
             Catastrophizing Scale scores improved significantly
             post-intervention for IBD and at short-term follow-up for
             IBS and IBD. Trait Anxiety scores, IBS Quality of Life, IBS
             Symptom Severity Index, and IBD Questionnaire scores
             improved significantly post-intervention and at short-term
             follow-up for IBS and IBD, respectively. RR-MBI altered
             expression of more genes in IBD (1059 genes) than in IBS
             (119 genes). In IBD, reduced expression of RR-MBI response
             genes was most significantly linked to inflammatory
             response, cell growth, proliferation, and oxidative
             stress-related pathways. In IBS, cell cycle regulation and
             DNA damage related gene sets were significantly upregulated
             after RR-MBI. Interactive network analysis of RR-affected
             pathways identified TNF, AKT and NF-κB as top focus
             molecules in IBS, while in IBD kinases (e.g. MAPK, P38
             MAPK), inflammation (e.g. VEGF-C, NF-κB) and cell cycle and
             proliferation (e.g. UBC, APP) related genes emerged as top
             focus molecules.In this uncontrolled pilot study,
             participation in an RR-MBI was associated with improvements
             in disease-specific measures, trait anxiety, and pain
             catastrophizing in IBS and IBD patients. Moreover, observed
             gene expression changes suggest that NF-κB is a target
             focus molecule in both IBS and IBD-and that its regulation
             may contribute to counteracting the harmful effects of
             stress in both diseases. Larger, controlled studies are
             needed to confirm this preliminary finding.ClinicalTrials.Gov
             NCT02136745.},
   Doi = {10.1371/journal.pone.0123861},
   Key = {fds325914}
}

@article{fds325915,
   Author = {Park, ER and Traeger, L and Vranceanu, A-M and Scult, M and Lerner, JA and Benson, H and Denninger, J and Fricchione, GL},
   Title = {The development of a patient-centered program based on the
             relaxation response: the Relaxation Response Resiliency
             Program (3RP).},
   Journal = {Psychosomatics},
   Volume = {54},
   Number = {2},
   Pages = {165-174},
   Year = {2013},
   Month = {March},
   url = {http://dx.doi.org/10.1016/j.psym.2012.09.001},
   Abstract = {BACKGROUND: Chronic daily stress has significant physical,
             emotional, and financial implications; levels of stress are
             increasing in the US. Dr. Benson highlighted how the mind
             and body function together in one's experience of the stress
             response and proposed the existence of the relaxation
             response (RR). OBJECTIVE: The current paper describes the
             foundation and development of an 8-session multimodal
             treatment program for coping with chronic stress: the
             Relaxation Response Resiliency Program (3RP). METHODS: We
             review the past decades of RR research, outline the
             development of the 3RP treatment, and provide an overview of
             the program's theory and content. RESULTS: Extensive
             research and clinical work have examined how eliciting the
             RR may combat stress through down-regulation of the
             sympathetic nervous system. Related to this work are the
             multidimensional constructs of resiliency and allostatic
             load. The 3RP is based on principles from the fields of
             stress management, cognitive-behavioral therapy, and
             positive psychology, and has three core target areas: (1)
             elicitation of the RR; (2) stress appraisal and coping; and
             (3) growth enhancement. An 8-week patient-centered treatment
             program has been developed, with the purpose of assisting
             patients with a variety of psychological and medical issues
             to better cope with chronic stress. CONCLUSIONS: Mastery of
             the RR is theorized to maximize one's ability to benefit
             from multimodal mind body strategies. The goal of the 3RP is
             to enhance individuals' adaptive responses to chronic stress
             through increasing awareness and decreasing the
             physiological, emotional, cognitive, and behavioral effects
             of the stress response, while simultaneously promoting the
             effects of being in the RR.},
   Doi = {10.1016/j.psym.2012.09.001},
   Key = {fds325915}
}

@article{fds325916,
   Author = {Vranceanu, A-M and Shaefer, JR and Saadi, AF and Slawsby, E and Sarin,
             J and Scult, M and Benson, H and Denninger, JW},
   Title = {The Relaxation Response Resiliency Enhancement Program in
             the Management of Chronic Refractory Temporomandibular Joint
             Disorder: Results from a Pilot Study.},
   Journal = {Journal of Musculoskeletal Pain},
   Volume = {21},
   Number = {3},
   Pages = {224-230},
   Year = {2013},
   Month = {January},
   url = {http://dx.doi.org/10.3109/10582452.2013.827289},
   Abstract = {This is an open-pilot study to evaluate the feasibility,
             acceptability and efficacy of a pain-specific version of an
             established mind-body medicine program, the Relaxation
             Response [RR] Resiliency Program [R3P], in patients with
             chronic temporomandibular disorder [TMD].Male and female
             with at least a six-month history of pain involving the
             masticatory muscles were sought in the Orofacial Pain
             Centers of the Massachusetts General Hospital [MGH] or
             through an advertisement sent to MGH employees from 2008 to
             2010. Eligible participants underwent the R3P intervention
             [eight group sessions] after standard medical management.
             Pre- and post-group patients underwent objective measures of
             impairment [vertical and lateral range of motion with and
             without pain, temporomandibular joint and muscle pain
             palpation, and algometer measures] and completed
             psychosocial measures [Symptom Severity Index, Perceived
             Stress Scale, the Symptom Checklist-90-Revised and Short
             Form 36 Health Survey].Twenty-four subjects [16 females, 90%
             from MGH Orofacial Pain Centers,10% from among MGH
             employees], mean age 38 years, met eligibility criteria and
             participated in the study. The intervention was highly
             feasible and accepted by patients, as evidenced by a 92%
             rate of completion. Paired t-test analyses revealed
             improvement on self-reported pain measures: pain intensity
             [p<0.02], pain frequency [p<0.002], pain duration [p<0.027],
             pain tolerability [p<0.009] and on several objective
             tests.The pain specific R3P is efficacious in reducing
             objective and subjective symptoms in patients with chronic
             refractory TMD. The comprehensive intervention, which
             combines educational information about pain with RR,
             cognitive behavioral and resiliency-enhancement skills, is
             accepted by patients and may be more efficacious than other
             treatments with fewer elements.},
   Doi = {10.3109/10582452.2013.827289},
   Key = {fds325916}
}

@article{fds325917,
   Author = {Foret, MM and Scult, M and Wilcher, M and Chudnofsky, R and Malloy, L and Hasheminejad, N and Park, ER},
   Title = {Integrating a relaxation response-based curriculum into a
             public high school in Massachusetts.},
   Journal = {Journal of Adolescence},
   Volume = {35},
   Number = {2},
   Pages = {325-332},
   Year = {2012},
   Month = {April},
   url = {http://dx.doi.org/10.1016/j.adolescence.2011.08.008},
   Abstract = {Academic and societal pressures result in U.S. high school
             students feeling stressed. Stress management and relaxation
             interventions may help students increase resiliency to
             stress and overall well-being. The objectives of this study
             were to examine the feasibility (enrollment, participation
             and acceptability) and potential effectiveness (changes in
             perceived stress, anxiety, self-esteem, health-promoting
             behaviors, and locus of control) of a relaxation response
             (RR)-based curriculum integrated into the school day for
             high school students. The curriculum included didactic
             instruction, relaxation exercises, positive psychology, and
             cognitive restructuring. The intervention group showed
             significantly greater improvements in levels of perceived
             stress, state anxiety, and health-promoting behaviors when
             compared to the wait list control group. The intervention
             appeared most useful for girls in the intervention group.
             The results suggest that several modifications may increase
             the feasibility of using this potentially effective
             intervention in high schools.},
   Doi = {10.1016/j.adolescence.2011.08.008},
   Key = {fds325917}
}