Publications of Madeline Farber    :chronological  alphabetical  combined listing:

%% Journal Articles   
@article{fds346927,
   Author = {Farber, MJ and Kim, MJ and Knodt, AR and Hariri, AR},
   Title = {Maternal overprotection in childhood is associated with
             amygdala reactivity and structural connectivity in
             adulthood.},
   Journal = {Developmental Cognitive Neuroscience},
   Volume = {40},
   Pages = {100711},
   Year = {2019},
   Month = {December},
   url = {http://dx.doi.org/10.1016/j.dcn.2019.100711},
   Abstract = {Recently, we reported that variability in early-life
             caregiving experiences maps onto individual differences in
             threat-related brain function. Here, we extend this work to
             provide further evidence that subtle variability in specific
             features of early caregiving shapes structural and
             functional connectivity between the amygdala and medial
             prefrontal cortex (mPFC) in a cohort of 312 young adult
             volunteers. Multiple regression analyses revealed that
             participants who reported higher maternal overprotection
             exhibited increased amygdala reactivity to explicit signals
             of interpersonal threat but not implicit signals of broad
             environmental threat. While amygdala functional connectivity
             with regulatory regions of the mPFC was not significantly
             associated with maternal overprotection, participants who
             reported higher maternal overprotection exhibited relatively
             decreased structural integrity of the uncinate fasciculus
             (UF), a white matter tract connecting these same brain
             regions. There were no significant associations between
             structural or functional brain measures and either maternal
             or paternal care ratings. These findings suggest that an
             overprotective maternal parenting style during childhood is
             associated with later functional and structural alterations
             of brain regions involved in generating and regulating
             responses to threat.},
   Doi = {10.1016/j.dcn.2019.100711},
   Key = {fds346927}
}

@article{fds348612,
   Author = {Farber, MJ and Romer, AL and Kim, MJ and Knodt, AR and Elsayed, NM and Williamson, DE and Hariri, AR},
   Title = {Paradoxical associations between familial affective
             responsiveness, stress, and amygdala reactivity.},
   Journal = {Emotion},
   Volume = {19},
   Number = {4},
   Pages = {645-654},
   Year = {2019},
   Month = {June},
   url = {http://dx.doi.org/10.1037/emo0000467},
   Abstract = {Studies of early life extremes such as trauma, abuse, and
             neglect highlight the critical importance of quality
             caregiving in the development of brain circuits supporting
             emotional behavior and mental health. The impact of
             normative variability in caregiving on such biobehavioral
             processes, however, is poorly understood. Here, we provide
             initial evidence that even subtle variability in normative
             caregiving maps onto individual differences in
             threat-related brain function and, potentially, associated
             psychopathology in adolescence. Specifically, we report that
             greater familial affective responsiveness is associated with
             heightened amygdala reactivity to interpersonal threat,
             particularly in adolescents having experienced relatively
             low recent stress. These findings extend the literature on
             the effects of caregiving extremes on brain function to
             subtle, normative variability but suggest that presumably
             protective factors may be associated with increased
             risk-related amygdala reactivity. We consider these
             paradoxical associations with regard to studies of basic
             associative threat learning and further consider their
             relevance for understanding potential effects of caregiving
             on psychological development. (PsycINFO Database Record (c)
             2019 APA, all rights reserved).},
   Doi = {10.1037/emo0000467},
   Key = {fds348612}
}

@article{fds348613,
   Author = {Kim, MJ and Farber, MJ and Knodt, AR and Hariri, AR},
   Title = {Corticolimbic circuit structure moderates an association
             between early life stress and later trait
             anxiety.},
   Journal = {Neuroimage. Clinical},
   Volume = {24},
   Pages = {102050},
   Year = {2019},
   Month = {January},
   url = {http://dx.doi.org/10.1016/j.nicl.2019.102050},
   Abstract = {Childhood adversity is associated with a wide range of
             negative behavioral and neurodevelopmental consequences.
             However, individuals vary substantially in their sensitivity
             to such adversity. Here, we examined how individual
             variability in structural features of the corticolimbic
             circuit, which plays a key role in emotional reactivity,
             moderates the association between childhood adversity and
             later trait anxiety in 798 young adult university students.
             Consistent with prior research, higher self-reported
             childhood adversity was significantly associated with higher
             self-reported trait anxiety. However, this association was
             attenuated in participants with higher microstructural
             integrity of the uncinate fasciculus and greater thickness
             of the orbitofrontal cortex. These structural properties of
             the corticolimbic circuit may capture a neural profile of
             relative resiliency to early life stress, especially against
             the negative effects of childhood adversity on later trait
             anxiety.},
   Doi = {10.1016/j.nicl.2019.102050},
   Key = {fds348613}
}