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| Publications of Glenn Watson :chronological alphabetical combined listing:%% Journal Articles @article{fds346539, Author = {Hughes, RN and Watson, GDR and Petter, EA and Kim, N and Bakhurin, KI and Yin, HH}, Title = {Precise Coordination of Three-Dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons.}, Journal = {Current Biology : Cb}, Volume = {29}, Number = {19}, Pages = {3244-3255.e4}, Publisher = {Elsevier BV}, Year = {2019}, Month = {October}, url = {http://dx.doi.org/10.1016/j.cub.2019.08.022}, Abstract = {The ventral tegmental area (VTA) is a midbrain region implicated in a variety of motivated behaviors. However, the function of VTA GABAergic (Vgat+) neurons remains poorly understood. Here, using three-dimensional motion capture, in vivo electrophysiology, calcium imaging, and optogenetics, we demonstrate a novel function of VTAVgat+ neurons. We found three distinct populations of neurons, each representing head angle about a principal axis of rotation: yaw, roll, and pitch. For each axis, opponent cell groups were found that increase firing when the head moves in one direction and decrease firing in the opposite direction. Selective excitation and inhibition of VTAVgat+ neurons generate opposite rotational movements. Thus, VTAVgat+ neurons serve a critical role in the control of rotational kinematics while pursuing a moving target. This general-purpose steering function can guide animals toward desired spatial targets in any motivated behavior.}, Doi = {10.1016/j.cub.2019.08.022}, Key = {fds346539} } @article{fds343662, Author = {Kim, N and Li, HE and Hughes, RN and Watson, GDR and Gallegos, D and West, AE and Kim, IH and Yin, HH}, Title = {A striatal interneuron circuit for continuous target pursuit.}, Journal = {Nature Communications}, Volume = {10}, Number = {1}, Pages = {2715}, Publisher = {Springer Science and Business Media LLC}, Year = {2019}, Month = {June}, url = {http://dx.doi.org/10.1038/s41467-019-10716-w}, Abstract = {Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target to guide their own movement continuously. Here, we show that in the sensorimotor striatum, parvalbumin-positive fast-spiking interneurons (FSIs) can represent the distance between self and target during pursuit behavior, while striatal projection neurons (SPNs), which receive FSI projections, can represent self-velocity. FSIs are shown to regulate velocity-related SPN activity during pursuit, so that movement velocity is continuously modulated by distance to target. Moreover, bidirectional manipulation of FSI activity can selectively disrupt performance by increasing or decreasing the self-target distance. Our results reveal a key role of the FSI-SPN interneuron circuit in pursuit behavior and elucidate how this circuit implements distance to velocity transformation required for the critical underlying computation.}, Doi = {10.1038/s41467-019-10716-w}, Key = {fds343662} } @article{fds340828, Author = {Smith, JB and Alloway, KD and Hof, PR and Orman, R and Reser, DH and Watakabe, A and Watson, GDR}, Title = {The relationship between the claustrum and endopiriform nucleus: A perspective towards consensus on cross-species homology.}, Journal = {The Journal of Comparative Neurology}, Volume = {527}, Number = {2}, Pages = {476-499}, Publisher = {WILEY}, Year = {2019}, Month = {February}, url = {http://dx.doi.org/10.1002/cne.24537}, Abstract = {With the emergence of interest in studying the claustrum, a recent special issue of the Journal of Comparative Neurology dedicated to the claustrum (Volume 525, Issue 6, pp. 1313-1513) brought to light questions concerning the relationship between the claustrum (CLA) and a region immediately ventral known as the endopiriform nucleus (En). These structures have been identified as separate entities in rodents but appear as a single continuous structure in primates. During the recent Society for Claustrum Research meeting, a panel of experts presented data pertaining to the relationship of these regions and held a discussion on whether the CLA and En should be considered (a) separate unrelated structures, (b) separate nuclei within the same formation, or (c) subregions of a continuous structure. This review article summarizes that discussion, presenting comparisons of the cytoarchitecture, neurochemical profiles, genetic markers, and anatomical connectivity of the CLA and En across several mammalian species. In rodents, we conclude that the CLA and the dorsal endopiriform nucleus (DEn) are subregions of a larger complex, which likely performs analogous computations and exert similar effects on their respective cortical targets (e.g., sensorimotor versus limbic). Moving forward, we recommend that the field retain the nomenclature currently employed for this region but should continue to examine the delineation of these structures across different species. Using thorough descriptions of a variety of anatomical features, this review offers a clear definition of the CLA and En in rodents, which provides a framework for identifying homologous structures in primates.}, Doi = {10.1002/cne.24537}, Key = {fds340828} } @article{fds344742, Author = {Smith, JB and Watson, GDR and Liang, Z and Liu, Y and Zhang, N and Alloway, KD}, Title = {A Role for the Claustrum in Salience Processing?}, Journal = {Frontiers in Neuroanatomy}, Volume = {13}, Pages = {64}, Year = {2019}, Month = {January}, url = {http://dx.doi.org/10.3389/fnana.2019.00064}, Abstract = {The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) in awake head-fixed rats, we found evidence that the CLA is part of the rodent homolog of the default mode network (DMN; Smith et al., 2017). This network emerged as strong functional connections between the medial prefrontal cortex (mPFC), mediodorsal (MD) thalamus, and CLA in the awake state, which was not present following administration of isoflurane anesthesia. In the present report, we review evidence indicating that the rodent CLA also has connections with structures identified in the rodent homolog of the salience network (SN), a circuit that directs attention towards the most relevant stimuli among a multitude of sensory inputs (Seeley et al., 2007; Menon and Uddin, 2010). In humans, this circuit consists of functional connections between the anterior cingulate cortex (ACC) and a region that encompasses both the CLA and insular cortex. We further go on to review the similarities and differences between the functional and anatomical connections of the CLA and insula in rodents using both rs-fMRI and neuroanatomical tracing, respectively. We analyze in detail the connectivity of the CLA with the cingulate cortex, which is a major node in the SN and has been shown to modulate attention. When considered with other recent behavior and physiology studies, the data reveal a role for the CLA in salience-guided orienting. More specifically, we hypothesize that limbic information from mPFC, MD thalamus, and the basolateral amygdala (BLA) are integrated by the CLA to guide modality-related regions of motor and sensory cortex in directing attention towards relevant (i.e., salient) sensory events.}, Doi = {10.3389/fnana.2019.00064}, Key = {fds344742} } @article{fds338617, Author = {Watson, GDR and Alloway, KD}, Title = {Opposing collicular influences on the parafascicular (Pf) and posteromedial (POm) thalamic nuclei: relationship to POm-induced inhibition in the substantia nigra pars reticulata (SNR)}, Journal = {Brain Structure & Function}, Volume = {223}, Number = {1}, Pages = {535-543}, Publisher = {Springer Nature}, Year = {2018}, Month = {January}, url = {http://dx.doi.org/10.1007/s00429-017-1534-8}, Doi = {10.1007/s00429-017-1534-8}, Key = {fds338617} } @article{fds330545, Author = {Toda, K and Lusk, NA and Watson, GDR and Kim, N and Lu, D and Li, HE and Meck, WH and Yin, HH}, Title = {Nigrotectal Stimulation Stops Interval Timing in Mice.}, Journal = {Current Biology : Cb}, Volume = {27}, Number = {24}, Pages = {3763-3770.e3}, Year = {2017}, Month = {December}, url = {http://dx.doi.org/10.1016/j.cub.2017.11.003}, Abstract = {Considerable evidence implicates the basal ganglia in interval timing, yet the underlying mechanisms remain poorly understood. Using a novel behavioral task, we demonstrate that head-fixed mice can be trained to show the key features of timing behavior within a few sessions. Single-trial analysis of licking behavior reveals stepping dynamics with variable onset times, which is responsible for the canonical Gaussian distribution of timing behavior. Moreover, the duration of licking bouts decreased as mice became sated, showing a strong motivational modulation of licking bout initiation and termination. Using optogenetics, we examined the role of the basal ganglia output in interval timing. We stimulated a pathway important for licking behavior, the GABAergic output projections from the substantia nigra pars reticulata to the deep layers of the superior colliculus. We found that stimulation of this pathway not only cancelled licking but also delayed the initiation of anticipatory licking for the next interval in a frequency-dependent manner. By combining quantitative behavioral analysis with optogenetics in the head-fixed setup, we established a new approach for studying the neural basis of interval timing.}, Doi = {10.1016/j.cub.2017.11.003}, Key = {fds330545} } @article{fds327275, Author = {Liang, Z and Ma, Y and Watson, GDR and Zhang, N}, Title = {Simultaneous GCaMP6-based fiber photometry and fMRI in rats.}, Journal = {Journal of Neuroscience Methods}, Volume = {289}, Pages = {31-38}, Year = {2017}, Month = {September}, url = {http://dx.doi.org/10.1016/j.jneumeth.2017.07.002}, Abstract = {Understanding the relationship between neural and vascular signals is essential for interpretation of functional MRI (fMRI) results with respect to underlying neuronal activity. Simultaneously measuring neural activity using electrophysiology with fMRI has been highly valuable in elucidating the neural basis of the blood oxygenation-level dependent (BOLD) signal. However, this approach is also technically challenging due to the electromagnetic interference that is observed in electrophysiological recordings during MRI scanning.Recording optical correlates of neural activity, such as calcium signals, avoids this issue, and has opened a new avenue to simultaneously acquire neural and BOLD signals.The present study is the first to demonstrate the feasibility of simultaneously and repeatedly acquiring calcium and BOLD signals in animals using a genetically encoded calcium indicator, GCaMP6. This approach was validated with a visual stimulation experiment, during which robust increases of both calcium and BOLD signals in the superior colliculus were observed. In addition, repeated measurement in the same animal demonstrated reproducible calcium and BOLD responses to the same stimuli.Taken together, simultaneous GCaMP6-based fiber photometry and fMRI recording presents a novel, artifact-free approach to simultaneously measuring neural and fMRI signals. Furthermore, given the cell-type specificity of GCaMP6, this approach has the potential to mechanistically dissect the contributions of individual neuron populations to BOLD signal, and ultimately reveal its underlying neural mechanisms.The current study established the method for simultaneous GCaMP6-based fiber photometry and fMRI in rats.}, Doi = {10.1016/j.jneumeth.2017.07.002}, Key = {fds327275} } @article{fds328753, Author = {Alloway, KD and Smith, JB and Mowery, TM and Watson, GDR}, Title = {Sensory processing in the dorsolateral striatum: The contribution of thalamostriatal pathways}, Journal = {Frontiers in Systems Neuroscience}, Volume = {11}, Publisher = {FRONTIERS MEDIA SA}, Year = {2017}, Month = {July}, url = {http://dx.doi.org/10.3389/fnsys.2017.00053}, Abstract = {© 2017 Alloway, Smith, Mowery and Watson. The dorsal striatum has two functionally-defined subdivisions: a dorsomedial striatum (DMS) region involved in mediating goal-directed behaviors that require conscious effort, and a dorsolateral striatum (DLS) region involved in the execution of habitual behaviors in a familiar sensory context. Consistent with its presumed role in forming stimulus-response (S-R) associations, neurons in DLS receive massive inputs from sensorimotor cortex and are responsive to both active and passive sensory stimulation. While several studies have established that corticostriatal inputs contribute to the stimulus-induced responses observed in the DLS, there is growing awareness that the thalamus has a significant role in conveying sensory-related information to DLS and other parts of the striatum. The thalamostriatal projections to DLS originate mainly from the caudal intralaminar region, which contains the parafascicular (Pf) nucleus, and from higher-order thalamic nuclei such as the medial part of the posterior (POm) nucleus. Based on recent findings, we hypothesize that the thalamostriatal projections from these two regions exert opposing influences on the expression of behavioral habits. This article reviews the subcortical circuits that regulate the transmission of sensory information through these thalamostriatal projection systems, and describes the evidence that indicates these circuits could be manipulated to ameliorate the symptoms of Parkinson’s disease (PD) and related neurological disorders.}, Doi = {10.3389/fnsys.2017.00053}, Key = {fds328753} } @article{fds327276, Author = {Smith, JB and Liang, Z and Watson, GDR and Alloway, KD and Zhang, N}, Title = {Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states}, Journal = {Brain Structure & Function}, Volume = {222}, Number = {5}, Pages = {2041-2058}, Publisher = {Springer Science and Business Media LLC}, Year = {2017}, Month = {July}, url = {http://dx.doi.org/10.1007/s00429-016-1323-9}, Doi = {10.1007/s00429-016-1323-9}, Key = {fds327276} } @article{fds326776, Author = {Watson, GDR and Smith, JB and Alloway, KD}, Title = {Interhemispheric connections between the infralimbic and entorhinal cortices: The endopiriform nucleus has limbic connections that parallel the sensory and motor connections of the claustrum}, Journal = {The Journal of Comparative Neurology}, Volume = {525}, Number = {6}, Pages = {1363-1380}, Publisher = {WILEY}, Year = {2017}, Month = {April}, url = {http://dx.doi.org/10.1002/cne.23981}, Doi = {10.1002/cne.23981}, Key = {fds326776} } @article{fds326777, Author = {Smith, JB and Watson, GDR and Alloway, KD and Schwarz, C and Chakrabarti, S}, Title = {Corticofugal projection patterns of whisker sensorimotor cortex to the sensory trigeminal nuclei}, Journal = {Frontiers in Neural Circuits}, Volume = {9}, Publisher = {FRONTIERS MEDIA SA}, Year = {2015}, Month = {September}, url = {http://dx.doi.org/10.3389/fncir.2015.00053}, Doi = {10.3389/fncir.2015.00053}, Key = {fds326777} } @article{fds326778, Author = {Liang, Z and Watson, GDR and Alloway, KD and Lee, G and Neuberger, T and Zhang, N}, Title = {Mapping the functional network of medial prefrontal cortex by combining optogenetics and fMRI in awake rats}, Journal = {Neuroimage}, Volume = {117}, Pages = {114-123}, Publisher = {Elsevier BV}, Year = {2015}, Month = {August}, url = {http://dx.doi.org/10.1016/j.neuroimage.2015.05.036}, Doi = {10.1016/j.neuroimage.2015.05.036}, Key = {fds326778} } @article{fds326779, Author = {Watson, GDR and Smith, JB and Alloway, KD}, Title = {The Zona Incerta Regulates Communication between the Superior Colliculus and the Posteromedial Thalamus: Implications for Thalamic Interactions with the Dorsolateral Striatum}, Journal = {The Journal of Neuroscience : the Official Journal of the Society for Neuroscience}, Volume = {35}, Number = {25}, Pages = {9463-9476}, Publisher = {Society for Neuroscience}, Year = {2015}, Month = {June}, url = {http://dx.doi.org/10.1523/jneurosci.1606-15.2015}, Doi = {10.1523/jneurosci.1606-15.2015}, Key = {fds326779} } @article{fds326780, Author = {Alloway, KD and Smith, JB and Watson, GDR}, Title = {Thalamostriatal projections from the medial posterior and parafascicular nuclei have distinct topographic and physiologic properties}, Journal = {Journal of Neurophysiology}, Volume = {111}, Number = {1}, Pages = {36-50}, Publisher = {American Physiological Society}, Year = {2014}, Month = {January}, url = {http://dx.doi.org/10.1152/jn.00399.2013}, Abstract = {<jats:p> The dorsolateral striatum (DLS) is critical for executing sensorimotor behaviors that depend on stimulus-response (S-R) associations. In rats, the DLS receives it densest inputs from primary somatosensory (SI) cortex, but it also receives substantial input from the thalamus. Much of rat DLS is devoted to processing whisker-related information, and thalamic projections to these whisker-responsive DLS regions originate from the parafascicular (Pf) and medial posterior (POm) nuclei. To determine which thalamic nucleus is better suited for mediating S-R associations in the DLS, we compared their input-output connections and neuronal responses to repetitive whisker stimulation. Tracing experiments demonstrate that POm projects specifically to the DLS, but the Pf innervates both dorsolateral and dorsomedial parts of the striatum. The Pf nucleus is innervated by whisker-sensitive sites in the superior colliculus, and these sites also send dense projections to the zona incerta, a thalamic region that sends inhibitory projections to the POm. These data suggest that projections from POm to the DLS are suppressed by incertal inputs when the superior colliculus is activated by unexpected sensory stimuli. Simultaneous recordings with two electrodes indicate that POm neurons are more responsive and habituate significantly less than Pf neurons during repetitive whisker stimulation. Response latencies are also shorter in POm than in Pf, which is consistent with the fact that Pf receives its whisker information via synaptic relays in the superior colliculus. These findings indicate that, compared with the Pf nucleus, POm transmits somatosensory information to the DLS with a higher degree of sensory fidelity. </jats:p>}, Doi = {10.1152/jn.00399.2013}, Key = {fds326780} } @article{fds326781, Author = {Shaw, CL and Watson, GDR and Hallock, HL and Cline, KM and Griffin, AL}, Title = {The role of the medial prefrontal cortex in the acquisition, retention, and reversal of a tactile visuospatial conditional discrimination task}, Journal = {Behavioural Brain Research}, Volume = {236}, Pages = {94-101}, Publisher = {Elsevier BV}, Year = {2013}, Month = {January}, url = {http://dx.doi.org/10.1016/j.bbr.2012.08.024}, Doi = {10.1016/j.bbr.2012.08.024}, Key = {fds326781} } | |
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