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Publications of Glenn Watson    :chronological  alphabetical  combined listing:

%% Journal Articles   
@article{fds346539,
   Author = {Hughes, RN and Watson, GDR and Petter, EA and Kim, N and Bakhurin, KI and Yin, HH},
   Title = {Precise Coordination of Three-Dimensional Rotational
             Kinematics by Ventral Tegmental Area GABAergic
             Neurons.},
   Journal = {Current Biology : Cb},
   Volume = {29},
   Number = {19},
   Pages = {3244-3255.e4},
   Publisher = {Elsevier BV},
   Year = {2019},
   Month = {October},
   url = {http://dx.doi.org/10.1016/j.cub.2019.08.022},
   Abstract = {The ventral tegmental area (VTA) is a midbrain region
             implicated in a variety of motivated behaviors. However, the
             function of VTA GABAergic (Vgat+) neurons remains poorly
             understood. Here, using three-dimensional motion capture,
             in vivo electrophysiology, calcium imaging, and
             optogenetics, we demonstrate a novel function of VTAVgat+
             neurons. We found three distinct populations of neurons,
             each representing head angle about a principal axis of
             rotation: yaw, roll, and pitch. For each axis, opponent cell
             groups were found that increase firing when the head moves
             in one direction and decrease firing in the opposite
             direction. Selective excitation and inhibition of VTAVgat+
             neurons generate opposite rotational movements. Thus,
             VTAVgat+ neurons serve a critical role in the control of
             rotational kinematics while pursuing a moving target. This
             general-purpose steering function can guide animals toward
             desired spatial targets in any motivated
             behavior.},
   Doi = {10.1016/j.cub.2019.08.022},
   Key = {fds346539}
}

@article{fds343662,
   Author = {Kim, N and Li, HE and Hughes, RN and Watson, GDR and Gallegos, D and West,
             AE and Kim, IH and Yin, HH},
   Title = {A striatal interneuron circuit for continuous target
             pursuit.},
   Journal = {Nature Communications},
   Volume = {10},
   Number = {1},
   Pages = {2715},
   Publisher = {Springer Science and Business Media LLC},
   Year = {2019},
   Month = {June},
   url = {http://dx.doi.org/10.1038/s41467-019-10716-w},
   Abstract = {Most adaptive behaviors require precise tracking of targets
             in space. In pursuit behavior with a moving target, mice use
             distance to target to guide their own movement continuously.
             Here, we show that in the sensorimotor striatum,
             parvalbumin-positive fast-spiking interneurons (FSIs) can
             represent the distance between self and target during
             pursuit behavior, while striatal projection neurons (SPNs),
             which receive FSI projections, can represent self-velocity.
             FSIs are shown to regulate velocity-related SPN activity
             during pursuit, so that movement velocity is continuously
             modulated by distance to target. Moreover, bidirectional
             manipulation of FSI activity can selectively disrupt
             performance by increasing or decreasing the self-target
             distance. Our results reveal a key role of the FSI-SPN
             interneuron circuit in pursuit behavior and elucidate how
             this circuit implements distance to velocity transformation
             required for the critical underlying computation.},
   Doi = {10.1038/s41467-019-10716-w},
   Key = {fds343662}
}

@article{fds340828,
   Author = {Smith, JB and Alloway, KD and Hof, PR and Orman, R and Reser, DH and Watakabe, A and Watson, GDR},
   Title = {The relationship between the claustrum and endopiriform
             nucleus: A perspective towards consensus on cross-species
             homology.},
   Journal = {The Journal of Comparative Neurology},
   Volume = {527},
   Number = {2},
   Pages = {476-499},
   Publisher = {WILEY},
   Year = {2019},
   Month = {February},
   url = {http://dx.doi.org/10.1002/cne.24537},
   Abstract = {With the emergence of interest in studying the claustrum, a
             recent special issue of the Journal of Comparative Neurology
             dedicated to the claustrum (Volume 525, Issue 6, pp.
             1313-1513) brought to light questions concerning the
             relationship between the claustrum (CLA) and a region
             immediately ventral known as the endopiriform nucleus (En).
             These structures have been identified as separate entities
             in rodents but appear as a single continuous structure in
             primates. During the recent Society for Claustrum Research
             meeting, a panel of experts presented data pertaining to the
             relationship of these regions and held a discussion on
             whether the CLA and En should be considered (a) separate
             unrelated structures, (b) separate nuclei within the same
             formation, or (c) subregions of a continuous structure. This
             review article summarizes that discussion, presenting
             comparisons of the cytoarchitecture, neurochemical profiles,
             genetic markers, and anatomical connectivity of the CLA and
             En across several mammalian species. In rodents, we conclude
             that the CLA and the dorsal endopiriform nucleus (DEn) are
             subregions of a larger complex, which likely performs
             analogous computations and exert similar effects on their
             respective cortical targets (e.g., sensorimotor versus
             limbic). Moving forward, we recommend that the field retain
             the nomenclature currently employed for this region but
             should continue to examine the delineation of these
             structures across different species. Using thorough
             descriptions of a variety of anatomical features, this
             review offers a clear definition of the CLA and En in
             rodents, which provides a framework for identifying
             homologous structures in primates.},
   Doi = {10.1002/cne.24537},
   Key = {fds340828}
}

@article{fds344742,
   Author = {Smith, JB and Watson, GDR and Liang, Z and Liu, Y and Zhang, N and Alloway,
             KD},
   Title = {A Role for the Claustrum in Salience Processing?},
   Journal = {Frontiers in Neuroanatomy},
   Volume = {13},
   Pages = {64},
   Year = {2019},
   Month = {January},
   url = {http://dx.doi.org/10.3389/fnana.2019.00064},
   Abstract = {The claustrum (CLA) is a subcortical structure, present only
             in mammals, whose function remains uncertain. Previously,
             using resting-state functional magnetic resonance imaging
             (rs-fMRI) in awake head-fixed rats, we found evidence that
             the CLA is part of the rodent homolog of the default mode
             network (DMN; Smith et al., 2017). This network emerged as
             strong functional connections between the medial prefrontal
             cortex (mPFC), mediodorsal (MD) thalamus, and CLA in the
             awake state, which was not present following administration
             of isoflurane anesthesia. In the present report, we review
             evidence indicating that the rodent CLA also has connections
             with structures identified in the rodent homolog of the
             salience network (SN), a circuit that directs attention
             towards the most relevant stimuli among a multitude of
             sensory inputs (Seeley et al., 2007; Menon and Uddin, 2010).
             In humans, this circuit consists of functional connections
             between the anterior cingulate cortex (ACC) and a region
             that encompasses both the CLA and insular cortex. We further
             go on to review the similarities and differences between the
             functional and anatomical connections of the CLA and insula
             in rodents using both rs-fMRI and neuroanatomical tracing,
             respectively. We analyze in detail the connectivity of the
             CLA with the cingulate cortex, which is a major node in the
             SN and has been shown to modulate attention. When considered
             with other recent behavior and physiology studies, the data
             reveal a role for the CLA in salience-guided orienting. More
             specifically, we hypothesize that limbic information from
             mPFC, MD thalamus, and the basolateral amygdala (BLA) are
             integrated by the CLA to guide modality-related regions of
             motor and sensory cortex in directing attention towards
             relevant (i.e., salient) sensory events.},
   Doi = {10.3389/fnana.2019.00064},
   Key = {fds344742}
}

@article{fds338617,
   Author = {Watson, GDR and Alloway, KD},
   Title = {Opposing collicular influences on the parafascicular (Pf)
             and posteromedial (POm) thalamic nuclei: relationship to
             POm-induced inhibition in the substantia nigra pars
             reticulata (SNR)},
   Journal = {Brain Structure & Function},
   Volume = {223},
   Number = {1},
   Pages = {535-543},
   Publisher = {Springer Nature},
   Year = {2018},
   Month = {January},
   url = {http://dx.doi.org/10.1007/s00429-017-1534-8},
   Doi = {10.1007/s00429-017-1534-8},
   Key = {fds338617}
}

@article{fds330545,
   Author = {Toda, K and Lusk, NA and Watson, GDR and Kim, N and Lu, D and Li, HE and Meck,
             WH and Yin, HH},
   Title = {Nigrotectal Stimulation Stops Interval Timing in
             Mice.},
   Journal = {Current Biology : Cb},
   Volume = {27},
   Number = {24},
   Pages = {3763-3770.e3},
   Year = {2017},
   Month = {December},
   url = {http://dx.doi.org/10.1016/j.cub.2017.11.003},
   Abstract = {Considerable evidence implicates the basal ganglia in
             interval timing, yet the underlying mechanisms remain poorly
             understood. Using a novel behavioral task, we demonstrate
             that head-fixed mice can be trained to show the key features
             of timing behavior within a few sessions. Single-trial
             analysis of licking behavior reveals stepping dynamics with
             variable onset times, which is responsible for the canonical
             Gaussian distribution of timing behavior. Moreover, the
             duration of licking bouts decreased as mice became sated,
             showing a strong motivational modulation of licking bout
             initiation and termination. Using optogenetics, we examined
             the role of the basal ganglia output in interval timing. We
             stimulated a pathway important for licking behavior, the
             GABAergic output projections from the substantia nigra pars
             reticulata to the deep layers of the superior colliculus. We
             found that stimulation of this pathway not only cancelled
             licking but also delayed the initiation of anticipatory
             licking for the next interval in a frequency-dependent
             manner. By combining quantitative behavioral analysis with
             optogenetics in the head-fixed setup, we established a new
             approach for studying the neural basis of interval
             timing.},
   Doi = {10.1016/j.cub.2017.11.003},
   Key = {fds330545}
}

@article{fds327275,
   Author = {Liang, Z and Ma, Y and Watson, GDR and Zhang, N},
   Title = {Simultaneous GCaMP6-based fiber photometry and fMRI in
             rats.},
   Journal = {Journal of Neuroscience Methods},
   Volume = {289},
   Pages = {31-38},
   Year = {2017},
   Month = {September},
   url = {http://dx.doi.org/10.1016/j.jneumeth.2017.07.002},
   Abstract = {Understanding the relationship between neural and vascular
             signals is essential for interpretation of functional MRI
             (fMRI) results with respect to underlying neuronal activity.
             Simultaneously measuring neural activity using
             electrophysiology with fMRI has been highly valuable in
             elucidating the neural basis of the blood oxygenation-level
             dependent (BOLD) signal. However, this approach is also
             technically challenging due to the electromagnetic
             interference that is observed in electrophysiological
             recordings during MRI scanning.Recording optical correlates
             of neural activity, such as calcium signals, avoids this
             issue, and has opened a new avenue to simultaneously acquire
             neural and BOLD signals.The present study is the first to
             demonstrate the feasibility of simultaneously and repeatedly
             acquiring calcium and BOLD signals in animals using a
             genetically encoded calcium indicator, GCaMP6. This approach
             was validated with a visual stimulation experiment, during
             which robust increases of both calcium and BOLD signals in
             the superior colliculus were observed. In addition, repeated
             measurement in the same animal demonstrated reproducible
             calcium and BOLD responses to the same stimuli.Taken
             together, simultaneous GCaMP6-based fiber photometry and
             fMRI recording presents a novel, artifact-free approach to
             simultaneously measuring neural and fMRI signals.
             Furthermore, given the cell-type specificity of GCaMP6, this
             approach has the potential to mechanistically dissect the
             contributions of individual neuron populations to BOLD
             signal, and ultimately reveal its underlying neural
             mechanisms.The current study established the method for
             simultaneous GCaMP6-based fiber photometry and fMRI in
             rats.},
   Doi = {10.1016/j.jneumeth.2017.07.002},
   Key = {fds327275}
}

@article{fds328753,
   Author = {Alloway, KD and Smith, JB and Mowery, TM and Watson,
             GDR},
   Title = {Sensory processing in the dorsolateral striatum: The
             contribution of thalamostriatal pathways},
   Journal = {Frontiers in Systems Neuroscience},
   Volume = {11},
   Publisher = {FRONTIERS MEDIA SA},
   Year = {2017},
   Month = {July},
   url = {http://dx.doi.org/10.3389/fnsys.2017.00053},
   Abstract = {© 2017 Alloway, Smith, Mowery and Watson. The dorsal
             striatum has two functionally-defined subdivisions: a
             dorsomedial striatum (DMS) region involved in mediating
             goal-directed behaviors that require conscious effort, and a
             dorsolateral striatum (DLS) region involved in the execution
             of habitual behaviors in a familiar sensory context.
             Consistent with its presumed role in forming
             stimulus-response (S-R) associations, neurons in DLS receive
             massive inputs from sensorimotor cortex and are responsive
             to both active and passive sensory stimulation. While
             several studies have established that corticostriatal inputs
             contribute to the stimulus-induced responses observed in the
             DLS, there is growing awareness that the thalamus has a
             significant role in conveying sensory-related information to
             DLS and other parts of the striatum. The thalamostriatal
             projections to DLS originate mainly from the caudal
             intralaminar region, which contains the parafascicular (Pf)
             nucleus, and from higher-order thalamic nuclei such as the
             medial part of the posterior (POm) nucleus. Based on recent
             findings, we hypothesize that the thalamostriatal
             projections from these two regions exert opposing influences
             on the expression of behavioral habits. This article reviews
             the subcortical circuits that regulate the transmission of
             sensory information through these thalamostriatal projection
             systems, and describes the evidence that indicates these
             circuits could be manipulated to ameliorate the symptoms of
             Parkinson’s disease (PD) and related neurological
             disorders.},
   Doi = {10.3389/fnsys.2017.00053},
   Key = {fds328753}
}

@article{fds327276,
   Author = {Smith, JB and Liang, Z and Watson, GDR and Alloway, KD and Zhang,
             N},
   Title = {Interhemispheric resting-state functional connectivity of
             the claustrum in the awake and anesthetized
             states},
   Journal = {Brain Structure & Function},
   Volume = {222},
   Number = {5},
   Pages = {2041-2058},
   Publisher = {Springer Science and Business Media LLC},
   Year = {2017},
   Month = {July},
   url = {http://dx.doi.org/10.1007/s00429-016-1323-9},
   Doi = {10.1007/s00429-016-1323-9},
   Key = {fds327276}
}

@article{fds326776,
   Author = {Watson, GDR and Smith, JB and Alloway, KD},
   Title = {Interhemispheric connections between the infralimbic and
             entorhinal cortices: The endopiriform nucleus has limbic
             connections that parallel the sensory and motor connections
             of the claustrum},
   Journal = {The Journal of Comparative Neurology},
   Volume = {525},
   Number = {6},
   Pages = {1363-1380},
   Publisher = {WILEY},
   Year = {2017},
   Month = {April},
   url = {http://dx.doi.org/10.1002/cne.23981},
   Doi = {10.1002/cne.23981},
   Key = {fds326776}
}

@article{fds326777,
   Author = {Smith, JB and Watson, GDR and Alloway, KD and Schwarz, C and Chakrabarti, S},
   Title = {Corticofugal projection patterns of whisker sensorimotor
             cortex to the sensory trigeminal nuclei},
   Journal = {Frontiers in Neural Circuits},
   Volume = {9},
   Publisher = {FRONTIERS MEDIA SA},
   Year = {2015},
   Month = {September},
   url = {http://dx.doi.org/10.3389/fncir.2015.00053},
   Doi = {10.3389/fncir.2015.00053},
   Key = {fds326777}
}

@article{fds326778,
   Author = {Liang, Z and Watson, GDR and Alloway, KD and Lee, G and Neuberger, T and Zhang, N},
   Title = {Mapping the functional network of medial prefrontal cortex
             by combining optogenetics and fMRI in awake
             rats},
   Journal = {Neuroimage},
   Volume = {117},
   Pages = {114-123},
   Publisher = {Elsevier BV},
   Year = {2015},
   Month = {August},
   url = {http://dx.doi.org/10.1016/j.neuroimage.2015.05.036},
   Doi = {10.1016/j.neuroimage.2015.05.036},
   Key = {fds326778}
}

@article{fds326779,
   Author = {Watson, GDR and Smith, JB and Alloway, KD},
   Title = {The Zona Incerta Regulates Communication between the
             Superior Colliculus and the Posteromedial Thalamus:
             Implications for Thalamic Interactions with the Dorsolateral
             Striatum},
   Journal = {The Journal of Neuroscience : the Official Journal of the
             Society for Neuroscience},
   Volume = {35},
   Number = {25},
   Pages = {9463-9476},
   Publisher = {Society for Neuroscience},
   Year = {2015},
   Month = {June},
   url = {http://dx.doi.org/10.1523/jneurosci.1606-15.2015},
   Doi = {10.1523/jneurosci.1606-15.2015},
   Key = {fds326779}
}

@article{fds326780,
   Author = {Alloway, KD and Smith, JB and Watson, GDR},
   Title = {Thalamostriatal projections from the medial posterior and
             parafascicular nuclei have distinct topographic and
             physiologic properties},
   Journal = {Journal of Neurophysiology},
   Volume = {111},
   Number = {1},
   Pages = {36-50},
   Publisher = {American Physiological Society},
   Year = {2014},
   Month = {January},
   url = {http://dx.doi.org/10.1152/jn.00399.2013},
   Abstract = {<jats:p> The dorsolateral striatum (DLS) is critical for
             executing sensorimotor behaviors that depend on
             stimulus-response (S-R) associations. In rats, the DLS
             receives it densest inputs from primary somatosensory (SI)
             cortex, but it also receives substantial input from the
             thalamus. Much of rat DLS is devoted to processing
             whisker-related information, and thalamic projections to
             these whisker-responsive DLS regions originate from the
             parafascicular (Pf) and medial posterior (POm) nuclei. To
             determine which thalamic nucleus is better suited for
             mediating S-R associations in the DLS, we compared their
             input-output connections and neuronal responses to
             repetitive whisker stimulation. Tracing experiments
             demonstrate that POm projects specifically to the DLS, but
             the Pf innervates both dorsolateral and dorsomedial parts of
             the striatum. The Pf nucleus is innervated by
             whisker-sensitive sites in the superior colliculus, and
             these sites also send dense projections to the zona incerta,
             a thalamic region that sends inhibitory projections to the
             POm. These data suggest that projections from POm to the DLS
             are suppressed by incertal inputs when the superior
             colliculus is activated by unexpected sensory stimuli.
             Simultaneous recordings with two electrodes indicate that
             POm neurons are more responsive and habituate significantly
             less than Pf neurons during repetitive whisker stimulation.
             Response latencies are also shorter in POm than in Pf, which
             is consistent with the fact that Pf receives its whisker
             information via synaptic relays in the superior colliculus.
             These findings indicate that, compared with the Pf nucleus,
             POm transmits somatosensory information to the DLS with a
             higher degree of sensory fidelity. </jats:p>},
   Doi = {10.1152/jn.00399.2013},
   Key = {fds326780}
}

@article{fds326781,
   Author = {Shaw, CL and Watson, GDR and Hallock, HL and Cline, KM and Griffin,
             AL},
   Title = {The role of the medial prefrontal cortex in the acquisition,
             retention, and reversal of a tactile visuospatial
             conditional discrimination task},
   Journal = {Behavioural Brain Research},
   Volume = {236},
   Pages = {94-101},
   Publisher = {Elsevier BV},
   Year = {2013},
   Month = {January},
   url = {http://dx.doi.org/10.1016/j.bbr.2012.08.024},
   Doi = {10.1016/j.bbr.2012.08.024},
   Key = {fds326781}
}


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