Publications of Yu Sun Chung    :chronological  alphabetical  combined listing:

%% Journal Articles   
@article{fds345726,
   Author = {Chung, YS and Calhoun, V and Stevens, MC},
   Title = {Adolescent sex differences in cortico-subcortical functional
             connectivity during response inhibition.},
   Journal = {Cognitive, Affective & Behavioral Neuroscience},
   Volume = {20},
   Number = {1},
   Pages = {1-18},
   Year = {2020},
   Month = {February},
   url = {http://dx.doi.org/10.3758/s13415-019-00718-y},
   Abstract = {Numerous lines of evidence have shown that cognitive
             processes engaged during response inhibition tasks are
             associated with structure and functional integration of
             regions within fronto-parietal networks. However, while
             prior studies have started to characterize how intrinsic
             connectivity during resting state differs between boys and
             girls, comparatively less is known about how functional
             connectivity differs between males and females when brain
             function is exogenously driven by the processing demands of
             typical Go/No-Go tasks that assess both response inhibition
             and error processing. The purpose of this study was to
             characterize adolescent sex differences and possible changes
             in sexually dimorphic regional functional connectivity
             across adolescent development in both cortical and
             subcortical brain connectivity elicited during a visual
             Go/No-Go task. A total of 130 healthy adolescents (ages
             12-25 years) performed a Go/No-Go task during functional
             magnetic resonance imaging. High model-order group
             independent component analysis was used to characterize
             whole-brain network functional connectivity during response
             inhibition and then a univariate technique used to evaluate
             differences related to sex and age. As predicted and similar
             to previously described findings from non-task-driven
             resting state connectivity studies, functional connectivity
             sex differences were observed in several subcortical
             regions, including the amygdala, caudate, thalamus, and
             cortical regions, including inferior frontal gyrus engaged
             most strongly during successful response inhibition and/or
             error processing. Importantly, adolescent boys and girls
             exhibited different normative profiles of age-related
             changes in several default mode networks of regions and
             anterior cingulate cortex. These results suggest that
             cortical-subcortical functional networks supporting response
             inhibition operate differently between sexes during
             adolescence.},
   Doi = {10.3758/s13415-019-00718-y},
   Key = {fds345726}
}

@article{fds345725,
   Author = {Chung, YS and Poppe, A and Novotny, S and Epperson, CN and Kober, H and Granger, DA and Blumberg, HP and Ochsner, K and Gross, JJ and Pearlson,
             G and Stevens, MC},
   Title = {A preliminary study of association between adolescent
             estradiol level and dorsolateral prefrontal cortex activity
             during emotion regulation.},
   Journal = {Psychoneuroendocrinology},
   Volume = {109},
   Pages = {104398},
   Year = {2019},
   Month = {November},
   url = {http://dx.doi.org/10.1016/j.psyneuen.2019.104398},
   Abstract = {Non-human primate models have been useful in clarifying
             estradiol's role in cognitive processing. These animal
             studies indicate estradiol impacts cognitive processes
             supported by regions within dorsolateral prefrontal cortex
             (DLPFC). Although human functional neuroimaging studies have
             begun to find similar relationships between estradiol in
             women for some forms of 'cold' cognitive control, to date no
             studies have examined the relationship between estradiol and
             DLPFC function in the context of active attempts to regulate
             one's emotions. Here, we asked whether peripheral 17-beta
             estradiol levels in adolescent girls in different pubertal
             developmental stages (age = 14.9 years ± 1.74) were
             related to engagement of DLPFC regions during the use of a
             cognitive strategy for regulating emotion known as
             reappraisal using functional Magnetic Resonance Imaging.
             Findings indicated that higher estradiol levels predicted
             greater DLPFC activity during the down-regulation of
             negative emotion using reappraisal. This is the first report
             of an association between estradiol level and DLPFC activity
             during cognitive reappraisal of negative emotion. The study
             suggests a possibility that estradiol might positively
             contribute to regulatory function of a cortical system
             important for emotional experiences.},
   Doi = {10.1016/j.psyneuen.2019.104398},
   Key = {fds345725}
}

@article{fds345727,
   Author = {Chung, YS and Hyatt, CJ and Stevens, MC},
   Title = {Adolescent maturation of the relationship between cortical
             gyrification and cognitive ability.},
   Journal = {Neuroimage},
   Volume = {158},
   Pages = {319-331},
   Year = {2017},
   Month = {September},
   url = {http://dx.doi.org/10.1016/j.neuroimage.2017.06.082},
   Abstract = {There are changes to the degree of cortical folding from
             gestation through adolescence into young adulthood. Recent
             evidence suggests that degree of cortical folding is linked
             to individual differences in general cognitive ability in
             healthy adults. However, it is not yet known whether
             age-related cortical folding changes are related to
             maturation of specific cognitive abilities in adolescence.
             To address this, we examined the relationship between
             frontoparietal cortical folding as measured by a
             Freesurfer-derived local gyrification index (lGI) and
             performance on subtests from the Wechsler Abbreviated Scale
             of Intelligence and scores from Conner's Continuous
             Performance Test-II in 241 healthy adolescents (ages 12-25
             years). We hypothesized that age-related lGI changes in the
             frontoparietal cortex would contribute to cognitive
             development. A secondary goal was to explore if any
             gyrification-cognition relationships were either
             test-specific or sex-specific. Consistent with previous
             studies, our results showed a reduction of frontoparietal
             local gyrification with age. Also, as predicted, all
             cognitive test scores (i.e., Vocabulary, Matrix Reasoning,
             the CPT-II Commission, Omission, Variabiltiy, d') showed
             age × cognitive ability interaction effects in
             frontoparietal and temporoparietal brain regions. Mediation
             analyses confirmed a causal role of age-related cortical
             folding changes only for CPT-II Commission errors. Taken
             together, the results support the functional significance of
             cortical folding, as well as provide the first evidence that
             cortical folding maturational changes play a role in
             cognitive development.},
   Doi = {10.1016/j.neuroimage.2017.06.082},
   Key = {fds345727}
}

@article{fds345728,
   Author = {Chung, YS and Barch, DM},
   Title = {Frontal-striatum dysfunction during reward processing:
             Relationships to amotivation in schizophrenia.},
   Journal = {Journal of Abnormal Psychology},
   Volume = {125},
   Number = {3},
   Pages = {453-469},
   Year = {2016},
   Month = {April},
   url = {http://dx.doi.org/10.1037/abn0000137},
   Abstract = {Schizophrenia is characterized by deficits of context
             processing, thought to be related to dorsolateral prefrontal
             cortex (DLPFC) impairment. Despite emerging evidence
             suggesting a crucial role of the DLPFC in integrating reward
             and goal information, we do not know whether individuals
             with schizophrenia can represent and integrate
             reward-related context information to modulate cognitive
             control. To address this question, 36 individuals with
             schizophrenia (n = 29) or schizoaffective disorder (n = 7)
             and 27 healthy controls performed a variant of a response
             conflict task (Padmala & Pessoa, 2011) during fMRI scanning,
             in both baseline and reward conditions, with monetary
             incentives on some reward trials. We used a mixed state-item
             design that allowed us to examine both sustained and
             transient reward effects on cognitive control. Different
             from predictions about impaired DLPFC function in
             schizophrenia, we found an intact pattern of increased
             sustained DLPFC activity during reward versus baseline
             blocks in individuals with schizophrenia at a group level
             but blunted sustained activations in the putamen. Contrary
             to our predictions, individuals with schizophrenia showed
             blunted cue-related activations in several regions of the
             basal ganglia responding to reward-predicting cues.
             Importantly, as predicted, individual differences in
             anhedonia/amotivation symptoms severity were significantly
             associated with reduced sustained DLPFC activation in the
             same region that showed overall increased activity as a
             function of reward. These results suggest that individual
             differences in motivational impairments in schizophrenia may
             be related to dysfunction of the DLPFC and striatum in
             motivationally salient situations.},
   Doi = {10.1037/abn0000137},
   Key = {fds345728}
}

@article{fds345729,
   Author = {Chung, YS and Barch, D},
   Title = {Anhedonia is associated with reduced incentive cue related
             activation in the basal ganglia.},
   Journal = {Cognitive, Affective & Behavioral Neuroscience},
   Volume = {15},
   Number = {4},
   Pages = {749-767},
   Year = {2015},
   Month = {December},
   url = {http://dx.doi.org/10.3758/s13415-015-0366-3},
   Abstract = {Research has shown that reward incentives improve cognitive
             control in motivationally salient situations. Much previous
             work in this domain has focused on incentive cue-related
             activity in a number of brain regions, including the
             dorsolateral prefrontal cortex (DLPFC) and striatum.
             However, the more sustained changes in functional brain
             activity during task contexts with incentives have been
             relatively less explored. Here, we examined both the
             cue-related and sustained effects of rewards (i.e., monetary
             incentives) on cognitive control, with a particular focus on
             the roles of the DLPFC and striatum, using a mixed
             state-item design. We investigated whether variability in a
             reward-related trait (i.e., anhedonia) would modulate the
             sustained and/or the cue-related transient aspects of
             motivated cognitive control. Twenty-seven healthy
             individuals performed a modified response conflict task
             (Padmala & Pessoa, Journal of Cognitive Neuroscience, 23,
             3419-3432, 2011) during scanning, in which participants were
             asked to categorize images as either houses or buildings
             with either congruent or incongruent overlaid words.
             Participants performed a baseline condition without
             knowledge of monetary incentives, followed by reward blocks
             with monetary incentives on some cued trials (reward cues)
             for fast and correct responses. We replicated previous work
             by showing increases in both sustained activity during
             reward versus baseline blocks and transient. cue-related
             activity in bilateral DLPFC and the basal ganglia.
             Importantly, healthy individuals with higher anhedonia
             showed less of an increase in trial-by-trial activity as a
             function of reward in the lateral globus pallidus. Together,
             our results suggest that reduced hedonic experience may be
             related to abnormality of reward cue-related activity in the
             basal ganglia.},
   Doi = {10.3758/s13415-015-0366-3},
   Key = {fds345729}
}

@article{fds345730,
   Author = {Chung, YS and Barch, D and Strube, M},
   Title = {A meta-analysis of mentalizing impairments in adults with
             schizophrenia and autism spectrum disorder.},
   Journal = {Schizophrenia Bulletin},
   Volume = {40},
   Number = {3},
   Pages = {602-616},
   Year = {2014},
   Month = {May},
   url = {http://dx.doi.org/10.1093/schbul/sbt048},
   Abstract = {Mentalizing has been examined both in autism spectrum
             disorder (ASD) and schizophrenia (SCZ) primarily by either
             cognitive-linguistic (referred to as verbal) or emotion
             recognition from eyes (referred to as visual) mentalizing
             tasks. Each type of task is thought to measure different
             aspects of mentalizing. Differences in clinical features and
             developmental courses of each disorder may predict distinct
             patterns of mentalizing performance across dis orders on
             each type of task. To test this, a meta-analysis was
             conducted using 37 studies that assessed mentalizing either
             verbally or visually in adults with SCZ or ASD. We found
             that the estimated effect sizes of impairments in verbal and
             visual mentalizing tasks for both clinical groups were
             statistically large and at a similar level (overall Hedges'
             g = 0.73-1.05). For each disorder, adults with SCZ showed a
             trend towards larger impairments on verbal (overall Hedges'
             g = 0.99) than on visual mentalizing task (overall Hedges' g
             = 0.73; Qbet = 3.45, p =.06, df =1). Adults with ASD did not
             show different levels of impairment on the verbal versus
             visual tasks (Qbet = 0.08, p =.78, df =1). These results
             suggest that both clinical groups share, at least in part,
             some common cognitive processing deficits associated with
             mentalizing impairments.},
   Doi = {10.1093/schbul/sbt048},
   Key = {fds345730}
}

@article{fds345731,
   Author = {Mann, CL and Footer, O and Chung, YS and Driscoll, LL and Barch,
             DM},
   Title = {Spared and impaired aspects of motivated cognitive control
             in schizophrenia.},
   Journal = {Journal of Abnormal Psychology},
   Volume = {122},
   Number = {3},
   Pages = {745-755},
   Year = {2013},
   Month = {August},
   url = {http://dx.doi.org/10.1037/a0033069},
   Abstract = {The ability to upregulate cognitive control in
             motivationally salient situations was examined in
             individuals with schizophrenia (patients) and healthy
             controls. Fifty-four patients and 39 healthy controls were
             recruited. A computerized monetary response conflict task
             required participants to identity a picture, over which was
             printed a matching (congruent), neutral, or incongruent
             word. This baseline condition was followed by an incentive
             condition, in which participants were given the opportunity
             to win money on reward-cued trials. These reward-cued trials
             were interleaved with nonreward cued trials. Reaction times
             (RT) were examined for both incentive context effects
             (difference in RT between baseline and nonreward cue trials
             in the incentive condition) and incentive cue effects
             (difference in RT between nonreward and reward cue trials in
             the incentive condition). Compared with baseline, controls
             showed a speeding of responses during both the nonreward
             (incentive context effect) and reward cued (incentive cue
             effect) trials during the incentive condition, but with a
             larger incentive context than incentive cue effect,
             suggesting a reliance on proactive control strategies.
             Although patients also showed a speeding of responses to
             both nonreward and reward cued trials, they showed a
             significantly smaller incentive context effect than
             controls, suggesting a reduction in the use of proactive
             control and a greater reliance on the use of "just-in-time,"
             reactive control strategies. These results are discussed in
             light of the relationship between motivation and cognitive
             impairments in schizophrenia, and the potential role of
             impairments in prefrontally mediated active maintenance
             mechanisms.},
   Doi = {10.1037/a0033069},
   Key = {fds345731}
}

@article{fds345732,
   Author = {Chung, YS and Barch, DM},
   Title = {The effect of emotional context on facial emotion ratings in
             schizophrenia.},
   Journal = {Schizophrenia Research},
   Volume = {131},
   Number = {1-3},
   Pages = {235-241},
   Year = {2011},
   Month = {September},
   url = {http://dx.doi.org/10.1016/j.schres.2011.05.028},
   Abstract = {Individuals with schizophrenia show deficits both in facial
             emotion recognition and context processing (Kohler, C.G.,
             Walker, J.B., Martin, E.A., Healey, K.M., Moberg, P.J.,
             2010. Facial emotion perception in schizophrenia: a
             meta-analytic review. Schizophr. Bull. 36, 1009-1019).
             Recent evidence suggests context information can affect
             facial emotion recognition (Aviezer, H., Bentin, S., Hassin,
             R.R., Meschino, W.S., Kennedy, J., Grewal, S., Esmail, S.,
             Cohen, S., Moscovitch, M., 2009. Not on the face alone:
             perception of contextualized face expressions in
             Huntington's disease. Brain 132, 1633-1644). Thus,
             individuals with schizophrenia may have deficits in facial
             emotion processing, at least in part, due to impairments in
             processing context information (Green, M.J., Waldron, J.H.,
             Coltheart, M., 2007. Emotional context processing is
             impaired in schizophrenia. Cogn. Neuropsychiatry 12,
             259-280.). We used a novel experimental task, the Emotion
             Context Processing Task (ECPT) to examine the influences of
             emotional context (IAPS pictures) on the processing of
             subtle surprised faces in schizophrenia. One of the task
             conditions included a manipulation designed to determine
             whether enhancing attention to the context (by requiring a
             categorization judgment on the context pictures) would
             facilitate the influence of context on facial emotion
             processing in schizophrenia. In addition, we tested whether
             deficits on a non-social context processing would predict
             deficits in the influence of context on facial emotion
             processing in schizophrenia. We administered the Dot Probe
             Expectancy Task (a non-social context processing task) and
             the ECPT to individuals with schizophrenia (n=35) and
             healthy controls (n=32). Individuals with schizophrenia
             showed an intact influence of context information on facial
             emotion recognition. The manipulation designed to enhance
             attention to emotional context reduced the effect of context
             for both groups. In schizophrenia, better processing of
             non-social context was associated with a stronger influence
             of context on valence ratings of facial expressions in the
             negative context condition. These results suggest in
             schizophrenia, similar mechanisms may influence the
             processing of context for both social and non-social
             information.},
   Doi = {10.1016/j.schres.2011.05.028},
   Key = {fds345732}
}

@article{fds345733,
   Author = {Chung, YS and Mathews, JR and Barch, DM},
   Title = {The effect of context processing on different aspects of
             social cognition in schizophrenia.},
   Journal = {Schizophrenia Bulletin},
   Volume = {37},
   Number = {5},
   Pages = {1048-1056},
   Year = {2011},
   Month = {September},
   url = {http://dx.doi.org/10.1093/schbul/sbq012},
   Abstract = {<h4>Background</h4>It is well known that individuals with
             schizophrenia have impaired social cognition. The construct
             of social cognition involves several components, including
             perception, interpretation, and the ability to integrate
             context (Adolphs R. The neurobiology of social cognition.
             Curr Opin Neurobiol. 2001;11:231-239; Brothers L. The social
             brain: a project for integrating primate behavior and
             neurophysiology in a new domain. Concepts Neurosci.
             1990;1:27-61). Importantly, a number of studies have
             suggested that deficits in context processing underlie
             cognitive dysfunction in schizophrenia (Penn DL, Corrigan
             PW, Bentall RP, Racenstein JM, Newman L. Social cognition in
             schizophrenia. Psychol Bull. 1997;121(1):114-132; Green MF,
             Nuechterlein KH. Should schizophrenia be treated as a
             neurocognitive disorder? Schizophr Bull. 1999;25:309-319).
             Thus, the purpose of the current study was to investigate
             the relationship between context processing and different
             aspects of social cognition in schizophrenia.<h4>Method</h4>Individuals
             with schizophrenia (n = 41) and the healthy controls (n =
             32) participated in this study. The participants completed 2
             sections of The Awareness of Social Inference Test: (1)
             social inference minimal (SI-M) and (2) social inference
             enriched (SI-E). They also completed face and voice emotion
             discrimination tasks. In addition, we used the AX-Continuous
             Performance Test (AX-CPT) to measure context processing and
             the n-back task to measure working memory more
             generally.<h4>Results</h4>AX-CPT performance in
             schizophrenia was positively correlated with both SI-M and
             SI-E performance but not with either the face or the voice
             discrimination. Furthermore, the correlation between AX-CPT
             performance and SI-M/SI-E performance was significantly
             stronger in individuals with schizophrenia than in
             controls.<h4>Conclusion</h4>These results suggest that
             impairments in context processing are related to inferential
             components of social cognition in schizophrenia but not to
             the ability to recognition facial or vocal emotion. As such,
             deficits in context processing may contribute to deficits in
             both "hot" and "cold" aspects of cognition in
             schizophrenia.},
   Doi = {10.1093/schbul/sbq012},
   Key = {fds345733}
}

@article{fds345734,
   Author = {Shim, G and Kang, D-H and Sun Chung and Y and Young Yoo and S and Young Shin,
             N and Soo Kwon and J},
   Title = {Social Functioning Deficits in Young People at Risk for
             Schizophrenia},
   Journal = {The Australian and New Zealand Journal of
             Psychiatry},
   Volume = {42},
   Number = {8},
   Pages = {678-685},
   Publisher = {SAGE Publications},
   Year = {2008},
   Month = {August},
   url = {http://dx.doi.org/10.1080/00048670802203459},
   Abstract = {<jats:p> Objective: Impairment in social functioning is a
             central feature of schizophrenia and is known to be evident
             before the onset of psychosis, acting as a potential
             vulnerability marker. The aim of the present study was to
             test the hypothesis that social impairment is simultaneously
             a state and trait marker of risk for schizophrenia and
             schizophrenia-related disorder. </jats:p><jats:p> Method:
             Social functioning was examined in three groups:
             ultra-high-risk subjects (UHR, n =32), genetic high-risk
             subjects (GHR, n =32), and age- and IQ-matched healthy
             controls (HC, n =30). Social functioning was assessed using
             the Social Functioning Scale (SFS), and prodromal symptoms
             were assessed in high-risk subjects using the Comprehensive
             Assessment of At-Risk Mental States (CAARMS).
             </jats:p><jats:p> Results: Both the UHR and GHR groups
             exhibited significantly impaired social functioning compared
             with the HC group, and the UHR group was more impaired than
             the GHR group. In the UHR group, duration of prodromal
             symptoms was related to impaired ‘interpersonal
             behaviour’. Positive and negative symptoms were not
             significantly associated with social functioning, whereas
             disorganized and general symptoms were significantly
             correlated with poor ‘independence–competence’ in UHR
             individuals. </jats:p><jats:p> Conclusion: The findings
             support the hypothesis that impairment in social functioning
             is both a trait and state marker of risk for schizophrenia
             and other psychotic disorders, implying that social
             impairment constitutes a mediating vulnerability indicator
             of psychotic disorders including schizophrenia.
             </jats:p>},
   Doi = {10.1080/00048670802203459},
   Key = {fds345734}
}

@article{fds345735,
   Author = {Yu Sun Chung, and Kang, D-H and Na Young Shin, and So Young Yoo, and Jun Soo Kwon},
   Title = {Deficit of theory of mind in individuals at ultra-high-risk
             for schizophrenia},
   Journal = {Schizophrenia Research},
   Volume = {99},
   Number = {1-3},
   Pages = {111-118},
   Publisher = {Elsevier BV},
   Year = {2008},
   Month = {February},
   url = {http://dx.doi.org/10.1016/j.schres.2007.11.012},
   Doi = {10.1016/j.schres.2007.11.012},
   Key = {fds345735}
}