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| Publications of Scott Huettel :recent first alphabetical combined listing:
%% Journal Articles
@article{fds330851,
Author = {Huettel, SA and Lockhead, GR},
Title = {A framework for structural constraints on feature
creation},
Journal = {Behavioral and Brain Sciences},
Volume = {21},
Number = {1},
Pages = {29-29},
Publisher = {Cambridge University Press (CUP)},
Year = {1998},
Month = {February},
url = {http://dx.doi.org/10.1017/s0140525x98380103},
Abstract = {<jats:p>We address two major limitations of Schyns et al.
First, we clarify their concept of “features” by
postulating several levels for processing. The composition
of the feature set at each level determines the set at the
next higher level, following simple structural guidelines.
Second, we show that our proposed framework reconciles
feature-creation and fixed-feature approaches.</jats:p>},
Doi = {10.1017/s0140525x98380103},
Key = {fds330851}
}
@article{fds252342,
Author = {Sandstrom, NJ and Kaufman, J and Huettel, SA},
Title = {Males and females use different distal cues in a virtual
environment navigation task.},
Journal = {Brain Research. Cognitive Brain Research},
Volume = {6},
Number = {4},
Pages = {351-360},
Year = {1998},
Month = {April},
ISSN = {0926-6410},
url = {http://dx.doi.org/10.1016/s0926-6410(98)00002-0},
Keywords = {Adult • Analysis of Variance • Cues* • Female
• Humans • Male • Maze Learning •
Reaction Time • Sex Characteristics* •
User-Computer Interface* • physiology •
physiology*},
Abstract = {The study of navigational ability in humans is often limited
by the restricted availability and inconvenience of using
large novel environments. In the present study we use a
computer-generated virtual environment to study sex
differences in human spatial navigation. Adult male and
female participants navigated through a virtual water maze
where both landmarks and room geometry were available as
distal cues. Manipulation of environmental characteristics
revealed that females rely predominantly on landmark
information, while males more readily use both landmark and
geometric information. We discuss these results as a
possible link between recent human research reporting
hippocampal activation in spatial tasks and animal work
showing sex differences in both spatial ability and
hippocampal development.},
Doi = {10.1016/s0926-6410(98)00002-0},
Key = {fds252342}
}
@article{fds252258,
Author = {Lockhead, GR and Huettel, SA},
Title = {Isomorphisms and subjective colors},
Journal = {Behavioral and Brain Sciences},
Volume = {22},
Number = {6},
Pages = {959-960},
Publisher = {Cambridge University Press (CUP)},
Year = {1999},
Month = {January},
ISSN = {0140-525X},
url = {http://dx.doi.org/10.1017/S0140525X99392219},
Abstract = {Palmer describes a 'subjective barrier' that limits
knowledge of others' experience. We discuss how this barrier
extends to all knowledge, becoming less distinct as
theoretical constructs are strengthened. We provide evidence
for isomorphic experience, among individuals with similar
physiologies, by showing that perceived relations between
colors are as similar when viewing pigments as when viewing
subjective colors caused by flickering bars.},
Doi = {10.1017/S0140525X99392219},
Key = {fds252258}
}
@article{fds252334,
Author = {Huettel, SA and Lockhead, GR},
Title = {Range effects of an irrelevant dimension on
classification.},
Journal = {Perception & Psychophysics},
Volume = {61},
Number = {8},
Pages = {1624-1645},
Year = {1999},
Month = {November},
ISSN = {0031-5117},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10598475},
Keywords = {Adult • Attention* • Female • Humans •
Loudness Perception* • Male • Pitch
Discrimination* • Psychoacoustics • Reaction
Time},
Abstract = {In univariate classification tasks, subjects sort stimuli on
the basis of the only attribute that varies. In orthogonal
classification tasks, often called filtering tasks, there
additionally are trial-to-trial variations in irrelevant
attributes that the subjects are instructed to ignore.
Performance is generally slower in filtering tasks than in
univariate control tasks. We investigated this slowing in
experiments of how the range of irrelevant trial-to-trial
variation affects responses in pitch/loudness classification
tasks. Using two levels of pitch and of loudness as stimuli,
Experiment 1 replicated prior work showing that responses
are slowed more when the range of the irrelevant dimension
is made larger. Also in Experiment 1, sequential analyses
showed that response time depends both on sequence and on
the stimulus set independent of sequence. Experiments 2 and
3 used several levels on the irrelevant dimension and showed
that responses to categorize loudness are slowed more by
larger trial-to-trial pitch differences, but only on trials
when the response repeats. When the response changes,
performance is essentially unaffected by trial-to-trial
irrelevant variation. This interaction supports the
conclusion that slowed average performance in orthogonal
classification tasks, which is known as Garner interference,
is not due to difficulties that subjects have in filtering
stimulus attributes. It is due to how subjects process
successive stimulus differences. We call for more frequent
reports of sequential analyses, because these can reveal
information that is not available from data
averages.},
Doi = {10.3758/bf03213123},
Key = {fds252334}
}
@article{fds252259,
Author = {Huettel, S and Singerman, J and McCarthy, G},
Title = {Effects of aging on the refractory period of the fMRI
hemodynamic response},
Journal = {Neuroimage},
Volume = {11},
Number = {5},
Pages = {S644},
Publisher = {Elsevier BV},
Year = {2000},
Month = {January},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/S1053-8119(00)91574-X},
Doi = {10.1016/S1053-8119(00)91574-X},
Key = {fds252259}
}
@article{fds252260,
Author = {Huettel, SA and Lockhead, G},
Title = {Psychologically rational choice: Selection between
alternatives in a multiple-equilibrium game},
Journal = {Cognitive Systems Research},
Volume = {1},
Number = {3},
Pages = {143-160},
Publisher = {Elsevier BV},
Year = {2000},
Month = {January},
url = {http://dx.doi.org/10.1016/S1389-0417(00)00006-1},
Abstract = {Choice is modeled by game theory through analyses of the
structure of a game situation. However, at least some
choices, such as those in games that have more than one
rational solution, are difficult to address under standard
game theory. We investigated choice in a simple
multiple-equilibrium game, Wolf's Dilemma, and found that
choice depends on both structural components of the game,
such as the number of opponents, and non-structural
components, such as judgments about opponents' likely
choices. Significant effects of trial-to-trial sequence were
identified. We conclude that game theoretic methods cannot
deal with multiple and equilibrium games in the absence of a
psychological understanding of choice, and that
psychological measures are required to predict performance
in such games. © 2000 Elsevier Science B.V. All rights
reserved.},
Doi = {10.1016/S1389-0417(00)00006-1},
Key = {fds252260}
}
@article{fds252261,
Author = {Huettel, SA and Needham, A},
Title = {Effects of balance relations between objects on infants'
object segregation},
Journal = {Developmental Science},
Volume = {3},
Number = {4},
Pages = {415-427},
Publisher = {WILEY},
Year = {2000},
Month = {January},
url = {http://dx.doi.org/10.1111/1467-7687.00136},
Abstract = {Young infants are sensitive to support relations between
objects. However, the types of contact perceived to be
sufficient for object support change over development. At
4.5 months of age, infants expect an object to be adequately
supported when in contact with another object. By 6.5
months, this simple contact/no-contact distinction is
refined to account for proportion of contact: an object is
perceived to be supported when 70% of its bottom surface is
in contact with another object, but it is not perceived to
be supported when 15% is contacted. Here, we employ an
object segregation paradigm to investigate whether
8-month-old infants' judgments of support relations are
mediated by assessments both of the proportion of contact
and of the position of contact. Infants in the current
experiments viewed test displays consisting of two objects,
a long thin object (a box) and a smaller roughly cubic
object (a box in Experiment 1, a cylinder in Experiments 2
and 3). Two basic positions of contact were used, such that
either the centers or the lateral edges of the two objects
were aligned. The proportion of contact was manipulated
across experiments by having the smaller object support the
larger or the larger object support the smaller. There was a
significant effect of position of contact when only a small
proportion of the upper object was contacted by the lower
object. However, position of contact was found not to matter
when all of the upper object was in contact with the lower
object. We conclude that 8-month-old infants' judgments of
support relations are influenced by both proportion and
position of supporting contact. We integrate the findings
from the current experiments into the general developmental
framework proposed by Baillargeon and colleagues.},
Doi = {10.1111/1467-7687.00136},
Key = {fds252261}
}
@article{fds252335,
Author = {Huettel, SA and McCarthy, G},
Title = {Evidence for a refractory period in the hemodynamic response
to visual stimuli as measured by MRI.},
Journal = {Neuroimage},
Volume = {11},
Number = {5 Pt 1},
Pages = {547-553},
Year = {2000},
Month = {May},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1006/nimg.2000.0553},
Keywords = {Adult • Analysis of Variance • Hemodynamic
Processes • Humans • Magnetic Resonance Imaging
• Male • Photic Stimulation • Reaction Time
• Refractory Period, Electrophysiological •
Regression Analysis • Visual Cortex • blood
supply* • methods • physiology •
physiology*},
Abstract = {We investigated the effects of paired presentations of
visual stimuli upon the evoked hemodynamic response of
visual cortex measured by magnetic resonance imaging (MRI).
Stimuli were identical 500-ms high-contrast checkerboard
patterns, presented singly or with an interpair interval
(IPI) of 1, 2, 4, or 6 s (onset-to-onset), followed by an
intertrial interval of 16-20 s. Images were acquired at 1.5
Tesla using a gradient-echo echoplanar imaging sequence
sensitive to blood-oxygenation-level dependent (BOLD)
contrast. Single checkerboards evoked a hemodynamic response
from visual cortex characterized by a rise at 3 s, peak
activation at 5 s, and return to baseline by 10 s. We
subtracted subjects' single-stimulus hemodynamic response
from their paired-stimulus responses to isolate the
contribution of the second stimulus. If the hemodynamic
responses were fully additive, the residual should be a
time-shifted replica of the single stimulus response.
However, the amplitude of the hemodynamic response to the
second checkerboard was smaller, and the peak latency was
longer, than for the first. Furthermore, the amplitude
decrement was dependent upon IPI, such that the response to
the second stimulus at 1 s IPI was only 55% of that to a
single stimulus, with recovery to 90% at a 6 s IPI. Peak
latency was similarly dependent upon IPI with longer
latencies observed for shorter IPIs. These results
demonstrate an extended refractory period in the hemodynamic
response to visual stimuli consistent with that shown
previously for neuronal activity measured
electrophysiologically.},
Doi = {10.1006/nimg.2000.0553},
Key = {fds252335}
}
@article{fds252262,
Author = {Huettel, SA and Lockhead, G},
Title = {Variability is not uniformily bad: The practices of
psychologists generate research questions},
Journal = {Behavioral and Brain Sciences},
Volume = {24},
Number = {3},
Pages = {418-419},
Year = {2001},
Month = {January},
ISSN = {0140-525X},
url = {http://dx.doi.org/10.1017/s0140525x01394141},
Abstract = {The practices of economists increase experimental
reproducibility relative to those of selected psychologists
but should not be universally adopted. Procedures criticized
by Hertwig and Ortmann as producing variable data are
valuable, instead, for generating questions. The procedure
of choice should depend on the theoretical goal: measure a
known factor or learn what factors are important and need to
be measured.},
Doi = {10.1017/s0140525x01394141},
Key = {fds252262}
}
@article{fds252344,
Author = {Huettel, SA and Singerman, JD and McCarthy, G},
Title = {The effects of aging upon the hemodynamic response measured
by functional MRI.},
Journal = {Neuroimage},
Volume = {13},
Number = {1},
Pages = {161-175},
Year = {2001},
Month = {January},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1006/nimg.2000.0675},
Keywords = {Adolescent • Adult • Aged • Aging •
Cerebrovascular Circulation • Evoked Potentials, Visual
• Female • Head Movements • Humans •
Image Processing, Computer-Assisted • Magnetic
Resonance Imaging • Male • Middle Aged •
Pattern Recognition, Visual • Photic Stimulation •
physiology • physiology*},
Abstract = {We comparedthe characteristics of the visually evoked
hemodynamic response (HDR) in groups of young and elderly
adults. Checkerboard stimuli were presented for 500 ms
either singly or in pairs separated by a 2-s intrapair
interval while gradient-echo echoplanar fMRI images were
acquired concurrently every 1 s. Activated voxels,
identified by correlation with an empirically derived
reference waveform, were found for both groups in cortex
along the calcarine sulcus and in the fusiform gyrus, with
the mean HDR latency in calcarine cortex peaking
approximately 300 ms earlier than the HDR evoked in the
fusiform gyrus. On average, younger subjects had twice as
many activated voxels as older subjects. The mean HDR had a
similar onset time, rate of rise, and peak amplitude in both
groups. However, the HDRs of older subjects reached their
peak earlier and were more variable across subjects. Despite
having average HDR amplitudes similar to those of younger
subjects, older subjects had higher noise levels in
activated voxels, resulting in lower signal-to-noise ratios.
Distribution analyses of voxel statistics (t value, peak
amplitude, peak latency) revealed that older subjects had
proportionally fewer small-effect-size voxels, due to their
increased voxelwise noise. This finding was consistent with
the smaller spatial extent of activation in older subjects.
To investigate age differences in the refractory period of
the visual HDR, the HDR evoked by the second stimulus of
each pair was isolated by subtracting the HDR evoked by a
single stimulus from the composite HDR evoked by a pair.
Recovery measures were similar across the age
groups.},
Doi = {10.1006/nimg.2000.0675},
Key = {fds252344}
}
@article{fds252333,
Author = {Huettel, SA and McCarthy, G},
Title = {The effects of single-trial averaging upon the spatial
extent of fMRI activation.},
Journal = {Neuroreport},
Volume = {12},
Number = {11},
Pages = {2411-2416},
Year = {2001},
Month = {August},
ISSN = {0959-4965},
url = {http://dx.doi.org/10.1097/00001756-200108080-00025},
Keywords = {Adult • Artifacts • Evoked Potentials, Visual
• Humans • Magnetic Resonance Imaging • Male
• Middle Aged • Photic Stimulation • Visual
Cortex • methods* • physiology*},
Abstract = {We examined effects of trial averaging upon spatial extent,
spatial topography, and temporal properties of fMRI
activation. Two subjects participated in an event-related
visual stimulation design. There was an exponential relation
between number of trials and spatial extent, such that
additional trials identified, on average, a constant
proportion of the remaining voxels. At values typical of
fMRI experimentation (e.g. 50 trials) only about 50% of
eventually active voxels were significant; asymptotic values
were approached by 150 trials. The variability of the
estimated hemodynamic response decreased with signal
averaging, becoming stable across samples of > or = 25
trials. Therefore, group or condition differences may result
from differences in voxelwise noise exacerbated by averaging
small numbers of trials.},
Doi = {10.1097/00001756-200108080-00025},
Key = {fds252333}
}
@article{fds252337,
Author = {Huettel, SA and Güzeldere, G and McCarthy, G},
Title = {Dissociating the neural mechanisms of visual attention in
change detection using functional MRI.},
Journal = {Journal of Cognitive Neuroscience},
Volume = {13},
Number = {7},
Pages = {1006-1018},
Year = {2001},
Month = {October},
ISSN = {0898-929X},
url = {http://dx.doi.org/10.1162/089892901753165908},
Keywords = {Adult • Attention • Brain • Humans •
Image Processing, Computer-Assisted • Magnetic
Resonance Imaging • Visual Cortex • Visual
Perception • physiology • physiology*},
Abstract = {We investigated using functional magnetic resonance imaging
(fMRI) the neural processes associated with performance of a
change-detection task. In this task, two versions of the
same picture are presented in alternation, separated by a
brief mask interval. Even when the two pictures greatly
differ (e.g., as when a building is in different locations),
subjects report that identification of the change is
difficult and often take 30 or more seconds to identify the
change. This phenomenon of "change blindness" provides a
powerful and novel paradigm for segregating components of
visual attention using fMRI that can otherwise be confounded
in short-duration tasks. By using a response-contingent
event-related analysis technique, we successfully
dissociated brain regions associated with different
processing components of a visual change-detection task.
Activation in the calcarine cortex was associated with task
onset, but did not vary with the duration of visual search.
In contrast, the pattern of activation in dorsal and ventral
visual areas was temporally associated with the duration of
visual search. As such, our results support a distinction
between brain regions whose activation is modulated by
attentional demands of the visual task (extrastriate cortex)
and those that are not affected by it (primary visual
cortex). A second network of areas including central sulcus,
insular, and inferior frontal cortical areas, along with the
thalamus and basal ganglia, showed phasic activation tied to
the execution of responses. Finally, parietal and frontal
regions showed systematic deactivations during task
performance, consistent with previous reports that these
regions may be associated with nontask semantic processing.
We conclude that detection of change, when transient visual
cues are not present, requires activation of extrastriate
visual regions and frontal regions responsible for eye
movements. These results suggest that studies of change
blindness can inform understanding of more general
attentional processing.},
Doi = {10.1162/089892901753165908},
Key = {fds252337}
}
@article{fds252336,
Author = {Huettel, SA and McCarthy, G},
Title = {Regional differences in the refractory period of the
hemodynamic response: an event-related fMRI
study.},
Journal = {Neuroimage},
Volume = {14},
Number = {5},
Pages = {967-976},
Year = {2001},
Month = {November},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1006/nimg.2001.0900},
Keywords = {Adult • Arousal • Attention • Brain Mapping
• Echo-Planar Imaging • Evoked Potentials, Visual
• Face • Female • Hemodynamic Processes
• Humans • Image Enhancement • Magnetic
Resonance Imaging* • Male • Oxygen Consumption
• Pattern Recognition, Visual • Reaction Time
• Refractory Period, Electrophysiological •
Regional Blood Flow • Visual Cortex • blood
supply* • physiology • physiology*},
Abstract = {We investigated the characteristics of the hemodynamic
response (HDR) to paired presentations of visual face
stimuli using functional magnetic resonance imaging (fMRI).
Photographs of faces were presented singly or in pairs with
either a 1-s or 6-s intrapair interval (IPI). Each trial
(single face or face pairs) was followed by an intertrial
interval of 16-20 s. Faces were presented at fixation and
passively viewed by the 10 subjects. Images were acquired at
1.5 Tesla using a gradient-echo echo-planar imaging sequence
sensitive to blood-oxygenation-level-dependent (BOLD)
contrast. To examine the refractory properties of the HDR,
we subtracted the single-stimulus hemodynamic response from
the composite response evoked by face pairs for all voxels
significantly active on single face trials. The residual
represents the contribution of the second stimulus to the
fMRI signal. Event-related presentation of faces evoked
activity in medial calcarine cortex and the fusiform gyrus
bilaterally. In both calcarine and fusiform regions, the
hemodynamic response to the second face in a pair was of
lower amplitude and of increased latency at 1 s IPI, with
significant recovery of both amplitude and latency toward
single-stimulus values at 6 s IPI. At 1 s IPI, significantly
greater recovery was found in posterior fusiform regions
(50-60%) than in midfusiform regions (10-40%). These
regional differences were not apparent at 6 s IPI. No
differences were found across slices in calcarine cortex.
There was a significant difference in mean latency to HDR
peak between calcarine and fusiform cortex, with the HDR
peaking about 400 ms earlier in calcarine cortex. We
conclude that characteristics of the HDR, notably its
amplitude, latency, and refractory properties, differ across
visual cortical areas.},
Doi = {10.1006/nimg.2001.0900},
Key = {fds252336}
}
@article{fds327385,
Author = {McCarthy, G and Huettel, S},
Title = {A functional brain system for face processing revealed by
event-related potentials and functional MRI},
Journal = {International Congress Series},
Volume = {1226},
Number = {C},
Pages = {3-16},
Publisher = {Elsevier BV},
Year = {2002},
Month = {January},
url = {http://dx.doi.org/10.1016/S0531-5131(01)00492-7},
Doi = {10.1016/S0531-5131(01)00492-7},
Key = {fds327385}
}
@article{fds252251,
Author = {Madden, D and Huettel, S and Langley, L and Harlan, N and Whiting, W and Provenzale, J and McCarthy, G},
Title = {Adult age differences in the hemodynamic response during
visual target detection measured by functional
MRI},
Journal = {Journal of Cognitive Neuroscience},
Pages = {19-20},
Publisher = {M I T PRESS},
Year = {2002},
Month = {April},
ISSN = {0898-929X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174072000021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252251}
}
@article{fds252253,
Author = {Huettel, S and McKeown, M and Hart, S and Allison, T and Song, A and McCarthy, G},
Title = {The effects of stimulus duration upon visual cortical
activation: Evidence from functional MRI and intracranial
ERPS},
Journal = {Journal of Cognitive Neuroscience},
Pages = {89-89},
Publisher = {M I T PRESS},
Year = {2002},
Month = {April},
ISSN = {0898-929X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174072000339&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252253}
}
@article{fds252338,
Author = {Huettel, SA and Mack, PB and McCarthy, G},
Title = {Perceiving patterns in random series: dynamic processing of
sequence in prefrontal cortex.},
Journal = {Nature Neuroscience},
Volume = {5},
Number = {5},
Pages = {485-490},
Year = {2002},
Month = {May},
ISSN = {1097-6256},
url = {http://dx.doi.org/10.1038/nn841},
Keywords = {Adolescent • Adult • Basal Ganglia • Behavior
• Brain Mapping • Female • Humans •
Magnetic Resonance Imaging • Male • Pattern
Recognition, Visual • Photic Stimulation •
Prefrontal Cortex • Reaction Time • anatomy &
histology • methods • physiology •
physiology*},
Abstract = {We demonstrate that regions within human prefrontal cortex
develop moment-to-moment models for patterns of events
occurring in the sensory environment. Subjects viewed a
random binary sequence of images, each presented singly and
each requiring a different button press response. Patterns
occurred by chance within the presented series of images.
Using functional magnetic resonance imaging (fMRI), we
identified activity evoked by viewing a stimulus that
interrupted a pattern. Prefrontal activation was evoked by
violations of both repeating and alternating patterns, and
the amplitude of this activation increased with increasing
pattern length. Violations of repeating patterns, but not of
alternating patterns, activated the basal
ganglia.},
Doi = {10.1038/nn841},
Key = {fds252338}
}
@article{fds252343,
Author = {Due, DL and Huettel, SA and Hall, WG and Rubin, DC},
Title = {Activation in mesolimbic and visuospatial neural circuits
elicited by smoking cues: evidence from functional magnetic
resonance imaging.},
Journal = {The American Journal of Psychiatry},
Volume = {159},
Number = {6},
Pages = {954-960},
Year = {2002},
Month = {June},
ISSN = {0002-953X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12042183},
Keywords = {Adult • Attention • Behavior, Addictive •
Brain • Cerebral Cortex • Cues • Dopamine
• Female • Humans • Limbic System •
Magnetic Resonance Imaging • Male • Neural
Pathways • Reward • Smoking • Space
Perception • Tobacco Use Disorder • Visual
Perception • diagnosis* • physiology •
physiology* • psychology • psychology* •
statistics & numerical data*},
Abstract = {OBJECTIVE: The authors sought to increase understanding of
the brain mechanisms involved in cigarette addiction by
identifying neural substrates modulated by visual smoking
cues in nicotine-deprived smokers. METHOD: Event-related
functional magnetic resonance imaging (fMRI) was used to
detect brain activation after exposure to smoking-related
images in a group of nicotine-deprived smokers and a
nonsmoking comparison group. Subjects viewed a pseudo-random
sequence of smoking images, neutral nonsmoking images, and
rare targets (photographs of animals). Subjects pressed a
button whenever a rare target appeared. RESULTS: In smokers,
the fMRI signal was greater after exposure to
smoking-related images than after exposure to neutral images
in mesolimbic dopamine reward circuits known to be activated
by addictive drugs (right posterior amygdala, posterior
hippocampus, ventral tegmental area, and medial thalamus) as
well as in areas related to visuospatial attention
(bilateral prefrontal and parietal cortex and right fusiform
gyrus). In nonsmokers, no significant differences in fMRI
signal following exposure to smoking-related and neutral
images were detected. In most regions studied, both subject
groups showed greater activation following presentation of
rare target images than after exposure to neutral images.
CONCLUSIONS: In nicotine-deprived smokers, both reward and
attention circuits were activated by exposure to
smoking-related images. Smoking cues are processed like rare
targets in that they activate attentional regions. These
cues are also processed like addictive drugs in that they
activate mesolimbic reward regions.},
Doi = {10.1176/appi.ajp.159.6.954},
Key = {fds252343}
}
@article{fds252263,
Author = {McKeown, MJ and Varadarajan, V and Huettel, S and McCarthy,
G},
Title = {Deterministic and stochastic features of fMRI data:
implications for analysis of event-related
experiments.},
Journal = {Journal of Neuroscience Methods},
Volume = {118},
Number = {2},
Pages = {103-113},
Year = {2002},
Month = {August},
ISSN = {0165-0270},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12204302},
Abstract = {As the limits of stimuli presentation rates are explored in
event-related fMRI design, there is a greater need to assess
the implications of averaging raw fMRI data. Selective
averaging assumes that the fMRI signal consists of
task-dependent signal, random noise, and non-task dependent
brain signal that can be modeled as random noise so that it
tends to zero when averaged over a practical number of
trials. We recorded a total of four fMRI data series from
two normal subjects (subject 1, axially acquired; subject 2,
coronally acquired) performing a simple visual event-related
task and a water phantom with the same fMRI scanner imaging
parameters. To determine which fraction of the fMRI data was
deterministic as opposed to random, we created different
data subsets by taking the odd or even time points of the
full data sets. All data sets were first dimension-reduced
with principal component analysis (PCA) and separated into
100 spatially independent components with independent
component analysis (ICA). The mutual information between
best-matching pairs of components selected from full data
set-subset comparisons was plotted for each data set. Visual
inspection suggested that 45-85 components were
reproducible, and hence deterministic, accounting for 79-97%
of the variance, respectively, in the raw data. The
reproducible components exhibited much less trial-to-trial
variability than the raw data from even the most activated
voxel. Many (22-47) of reproducible components were
significantly affected by stimulus presentation (P < 0.001).
The most significantly-stimulus-correlated component was
strongly time-locked to stimulus presentation and was
directly stimulus correlated, corresponding to occipital
brain regions. However, other spatially distinct
task-related components demonstrated variable temporal
relationships with the most significantly-stimulus-correlated
component. Our results suggest that the majority of the
variance in fMRI data is in fact deterministic, and support
the notion that the data consist of differing components
with differing temporal relationships to visual stimulation.
They further suggest roles for restricting interpretations
of the spatial extent of activation from event-related
designs to a specific region of interest (ROI) and/or first
separating the data into spatially independent components.
Averaging the time courses of spatially independent
components time-locked to stimulus presentation may prevent
possible biases in the estimates of the spatial and temporal
extent of stimulus-correlated activation and of
trial-to-trial variability.},
Doi = {10.1016/s0165-0270(02)00120-6},
Key = {fds252263}
}
@article{fds252264,
Author = {Huettel, S and Polger, T and Riley, M},
Title = {In favor of an ecological account of color},
Journal = {Behavioral and Brain Sciences},
Volume = {26},
Number = {1},
Pages = {33},
Publisher = {Cambridge University Press (CUP)},
Year = {2003},
Month = {February},
url = {http://dx.doi.org/10.1017/S0140525X03340014},
Abstract = {Byrne & Hilbert understate the difficulties facing their
version of color realism. We doubt that they can fix
reflectance types and magnitudes in a way that does not
invoke relations to perceivers. B&H's account, therefore,
resembles the dispositional or ecological accounts that they
dismiss. This is a good thing, for a dispositional account
is promising if understood in an ecological
framework.},
Doi = {10.1017/S0140525X03340014},
Key = {fds252264}
}
@article{fds252265,
Author = {Huettel, SA},
Title = {Non-linearities in the blood-oxygenation-level dependent
(BOLD) response measured by functional magnetic resonance
imaging (fMRI).},
Journal = {Conference Proceedings : ... Annual International Conference
of the Ieee Engineering in Medicine and Biology Society.
Ieee Engineering in Medicine and Biology Society. Annual
Conference},
Volume = {2004},
Pages = {4413-4416},
Year = {2004},
Month = {January},
ISSN = {0589-1019},
url = {http://dx.doi.org/10.1109/iembs.2004.1404227},
Abstract = {A central question in the analysis of functional magnetic
resonance imaging (IMRI) data is whether the measured fMRI
signal summates in a linear fashion over repeated inputs.
Most fMRI studies collect images sensitive to
blood-oxygenation-level dependent (BOLD) contrast, which
measures the local amount of deoxygenated hemoglobin (dHb).
When neurons are active, more oxygenated hemoglobin is
supplied than is needed for their metabolic demands,
resulting in a decrease in dHb and an increase in MR signal.
For analysis of fMRI data, researchers must therefore create
experimental hypotheses of the measurable BOLD response
based upon the predicted neuronal activity. An influential
early model of the fMRI BOLD response assumes that BOLD
activity is a linear transformation of neuronal input,
representing the filtering effects of the vascular system.
Recent studies have called this interpretation into
question, due to observed differences in the pattern of
linearity across brain regions that serve distinct
functions.},
Doi = {10.1109/iembs.2004.1404227},
Key = {fds252265}
}
@article{fds252327,
Author = {Huettel, SA and McCarthy, G},
Title = {What is odd in the oddball task? Prefrontal cortex is
activated by dynamic changes in response
strategy.},
Journal = {Neuropsychologia},
Volume = {42},
Number = {3},
Pages = {379-386},
Year = {2004},
Month = {January},
ISSN = {0028-3932},
url = {http://dx.doi.org/10.1016/j.neuropsychologia.2003.07.009},
Keywords = {Adolescent • Adult • Attention* • Brain
Mapping* • Discrimination Learning • Evoked
Potentials, Visual • Female • Field
Dependence-Independence* • Humans • Male •
Photic Stimulation • Prefrontal Cortex • Reaction
Time • Reference Values • Visual Fields •
physiology • physiology*},
Abstract = {In the "oddball" target detection task, subjects respond to
target stimuli that occur infrequently and irregularly
within a series of standard stimuli. Although detection of
these targets reliably evokes transient activity in
prefrontal cortical regions, it has not been established
whether this activity is due to selection of an infrequent
response or to changes in response strategy. We investigated
this issue using a novel variant of the oddball task that
incorporated the Simon effect, while measuring hemodynamic
brain activity in prefrontal cortex using functional
magnetic resonance imaging (fMRI). Subjects viewed a series
of circles and squares that required left and right button
presses, respectively. On 90% of trials ("standard" trials),
the stimuli were presented in the same visual hemifield as
the hand of response, but on 10% of trials
("strategy-change" trials) they were presented in the
opposite visual hemifield. Significant activation to the
infrequent strategy-change trials was found in the anterior
middle frontal gyrus (MFG), the posterior inferior frontal
gyrus (IFG) and adjacent insular cortex, and in the anterior
cingulate gyrus (ACG). These regions, which correspond to
previous reports of oddball-related activation, were
consistent across subjects. Behavioral results supported our
interpretation that subjects potentiated a position-based
response strategy, which was inhibited on the
strategy-change trials. Activity within the MFG and ACG was
much greater on error trials than on correct trials, while
IFG activity was similar between error and correct trials.
We conclude that the dorsolateral prefrontal cortex (dlPFC)
is associated with dynamic changes in the mapping of stimuli
to responses (e.g. response strategies), independently of
any changes in behavior.},
Doi = {10.1016/j.neuropsychologia.2003.07.009},
Key = {fds252327}
}
@article{fds252329,
Author = {Huettel, SA and McKeown, MJ and Song, AW and Hart, S and Spencer, DD and Allison, T and McCarthy, G},
Title = {Linking hemodynamic and electrophysiological measures of
brain activity: evidence from functional MRI and
intracranial field potentials.},
Journal = {Cerebral Cortex (New York, N.Y. : 1991)},
Volume = {14},
Number = {2},
Pages = {165-173},
Year = {2004},
Month = {February},
ISSN = {1047-3211},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14704213},
Keywords = {Adult • Brain • Electrophysiology • Epilepsy
• Evoked Potentials, Visual • Female •
Hemodynamic Processes • Humans • Magnetic
Resonance Imaging • Male • Photic Stimulation
• methods • methods* • physiology* •
physiopathology},
Abstract = {We investigated the relation between electrophysiological
and hemodynamic measures of brain activity through
comparison of intracranially recorded event-related local
field potentials (ERPs) and blood-oxygenation level
dependent functional magnetic resonance imaging (BOLD fMRI).
We manipulated the duration of visual checkerboard stimuli
across trials and measured stimulus-duration-related changes
in ERP and BOLD activity in three brain regions:
peri-calcarine cortex, the fusiform gyrus and lateral
temporal-occipital (LTO) cortex. ERPs were recorded from
patients who had indwelling subdural electrodes as part of
presurgical testing, while BOLD responses were measured in
similar brain regions in a second set of subjects. Similar
BOLD responses were measured in peri-calcarine and fusiform
regions, with both showing monotonic but non-linear
increases in hemodynamic amplitude with stimulus duration.
In sharp contrast, very different ERP responses were
observed in these same regions, such that calcarine
electrodes exhibited onset potentials, sustained activity
over the course of stimulus duration and prominent offset
potentials, while fusiform electrodes only exhibited onset
potentials that did not vary with stimulus duration. No
duration-related ERP or BOLD changes were observed in LTO.
Additional analyses revealed no consistent changes in the
EEG spectrum across different brain sites that correlated
with duration-related changes in the BOLD response. We
conclude that the relation between ERPs and fMRI differs
across brain regions.},
Doi = {10.1093/cercor/bhg115},
Key = {fds252329}
}
@article{fds252330,
Author = {Madden, DJ and Whiting, WL and Provenzale, JM and Huettel,
SA},
Title = {Age-related changes in neural activity during visual target
detection measured by fMRI.},
Journal = {Cerebral Cortex (New York, N.Y. : 1991)},
Volume = {14},
Number = {2},
Pages = {143-155},
Year = {2004},
Month = {February},
ISSN = {1047-3211},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14704211},
Keywords = {Adult • Aged • Aging • Analysis of Variance
• Female • Humans • Magnetic Resonance
Imaging • Male • Middle Aged • Neurons •
Photic Stimulation • Prefrontal Cortex • Reaction
Time • Regression Analysis • Visual Perception
• methods* • physiology •
physiology*},
Abstract = {We used functional magnetic resonance imaging (fMRI) of a
visual target detection (oddball) task to investigate age
differences in neural activation for the detection of two
types of infrequent events: visually simple items requiring
a response shift (targets) and visually complex items that
did not entail a response shift (novels). Targets activated
several prefrontal regions (e.g. middle frontal gyrus), as
well as deep gray matter regions (caudate, putamen, thalamus
and insula). Prefrontal activation was similar for younger
and older adults, whereas deep gray matter activation was
relatively greater for the older adults. Novels activated
occipital regions (fusiform and lateral occipital gyri), and
this activation was relatively reduced for older adults. The
changes in behavioral performance across the task conditions
were similar for the two age groups, although the older
adults' responses were slower overall. Regression analyses
of the relation between neural activation and task
performance (response time) indicated that whereas
performance was mediated most directly by prefrontal cortex
for younger adults, older adults' performance was influenced
to a greater extent by deep gray matter structures. Older
adults may place relatively greater emphasis on the
attentional control of response regulation, in compensation
for the age-related decline in visual processing
efficiency.},
Doi = {10.1093/cercor/bhg113},
Key = {fds252330}
}
@article{fds252326,
Author = {Huettel, SA and Misiurek, J and Jurkowski, AJ and McCarthy,
G},
Title = {Dynamic and strategic aspects of executive
processing.},
Journal = {Brain Research},
Volume = {1000},
Number = {1-2},
Pages = {78-84},
Year = {2004},
Month = {March},
ISSN = {0006-8993},
url = {http://dx.doi.org/10.1016/j.brainres.2003.11.041},
Keywords = {Adolescent • Adult • Brain • Female •
Humans • Linear Models • Magnetic Resonance
Imaging • Male • Photic Stimulation •
Psychomotor Performance • methods* •
physiology*},
Abstract = {Executive cognitive functions have been postulated to
include both dynamic behavioral selection and strategic
goal-setting or response preparation. To investigate the
relation between these aspects of executive processing, we
embedded an event-related oddball paradigm within a blocked
design. Subjects responded to infrequent targets presented
within a series of standard stimuli that required no
response; this task alternated with a visually similar
nontask condition. Using functional magnetic resonance
imaging (fMRI), we found that a set of brain regions
including dorsolateral prefrontal cortex (dlPFC), insular
cortex, cingular cortex, and the basal ganglia demonstrated
transient activation both to target stimuli and to the onset
of task blocks. Within the parietal cortex, there was a
dissociation such that the supramarginal gyrus exhibited
greater activity to the target stimuli than to block onsets,
while the converse pattern was observed in the intraparietal
sulcus. Sustained positive activity during task blocks was
present in the caudate and supplementary motor area, while
sustained negative activity was present in the precuneus and
medial parietal cortex. We conclude that dlPFC and related
brain regions mediate both dynamic and strategic processing,
through the preparation and selection of rules for
behavior.},
Doi = {10.1016/j.brainres.2003.11.041},
Key = {fds252326}
}
@article{fds252328,
Author = {Madden, DJ and Whiting, WL and Huettel, SA and White, LE and MacFall,
JR and Provenzale, JM},
Title = {Diffusion tensor imaging of adult age differences in
cerebral white matter: relation to response
time.},
Journal = {Neuroimage},
Volume = {21},
Number = {3},
Pages = {1174-1181},
Year = {2004},
Month = {March},
ISSN = {1053-8119},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15006684},
Keywords = {Adult • Aging • Algorithms • Anisotropy
• Brain • Diffusion Magnetic Resonance Imaging
• Female • Humans • Image Interpretation,
Computer-Assisted • Male • Neural Pathways •
Prefrontal Cortex • Psychomotor Performance •
Reaction Time • anatomy & histology • anatomy &
histology* • growth & development* • methods*
• physiology • physiology*},
Abstract = {Diffusion tensor imaging (DTI) measures the displacement of
water molecules across tissue components, thus providing
information regarding the microstructure of cerebral white
matter. Fractional anisotropy (FA), the degree to which
diffusion is directionally dependent, is typically higher
for compact, homogeneous fiber bundles such as the corpus
callosum. Previous DTI studies in adults have demonstrated
an age-related decline in white matter FA, but whether the
relation between FA and behavioral performance varies as a
function of age has not been determined. We investigated
adult age differences in FA, and age-related changes in the
relation between FA and response time (RT), in a visual
target-detection task. The results confirmed that,
independently of age, FA is higher in the corpus callosum
than in other brain regions. We also observed an age-related
decline in FA that did not vary significantly across the
brain regions. For both age groups, a lower level of
integrity of the cerebral white matter (as indexed by FA),
in specific brain regions, was associated with slower
responses in the visual task. An age-related change in this
relation was evident, however, in that the best predictor of
RT for younger adults was FA in the splenium of the corpus
callosum, whereas for older adults the best predictor was FA
in the anterior limb of the internal capsule. This pattern
is consistent with measures of the task-related cortical
activation obtained from these same individuals and suggests
an age-related increase in the attentional control of
responses mediated by corticostriatal or corticothalamic
circuits.},
Doi = {10.1016/j.neuroimage.2003.11.004},
Key = {fds252328}
}
@article{fds252340,
Author = {Madden, DJ and Whiting, WL and Cabeza, R and Huettel,
SA},
Title = {Age-related preservation of top-down attentional guidance
during visual search.},
Journal = {Psychology and Aging},
Volume = {19},
Number = {2},
Pages = {304-309},
Year = {2004},
Month = {June},
ISSN = {0882-7974},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15222823},
Keywords = {Adolescent • Adult • Age Factors • Aged
• Aged, 80 and over • Aging • Attention*
• Cues* • Exploratory Behavior* • Female
• Humans • Male • Middle Aged •
Questionnaires • Random Allocation • Reaction
Time* • Visual Perception* • physiology*},
Abstract = {Younger (19-27 years of age) and older (60-82 years of age)
adults performed a letter search task in which a color
singleton was either noninformative (baseline condition) or
highly informative (guided condition) regarding target
location. In the guided condition, both age groups exhibited
a substantial decrease in response time (RT) to singleton
targets, relative to the baseline condition, as well as an
increase in RT to nonsingleton targets. The authors conclude
that under conditions that equate the physical structure of
individual displays, top-down attentional guidance can be at
least as effective for older adults as for younger
adults.},
Doi = {10.1037/0882-7974.19.2.304},
Key = {fds252340}
}
@article{fds252331,
Author = {Huettel, SA and Misiurek, J},
Title = {Modulation of prefrontal cortex activity by information
toward a decision rule.},
Journal = {Neuroreport},
Volume = {15},
Number = {12},
Pages = {1883-1886},
Year = {2004},
Month = {August},
ISSN = {0959-4965},
url = {http://dx.doi.org/10.1097/00001756-200408260-00009},
Keywords = {Adult • Brain Mapping • Decision Making •
Discrimination Learning • Female • Functional
Laterality • Humans • Image Processing,
Computer-Assisted • Magnetic Resonance Imaging •
Male • Mental Processes • Oxygen • Photic
Stimulation • Prefrontal Cortex • Reaction Time
• blood • blood supply • methods •
physiology • physiology*},
Abstract = {We used fMRI to investigate how the information content of a
stimulus influences activity in brain systems that support
decision making. Subjects learned decision rules that were
based upon the color, shape, or fill pattern of a series of
stimuli. Each stimulus was classified by its information
content, defined formally by the decision rules it excluded.
While activity in dorsolateral prefrontal cortex (dlPFC)
increased with increasing stimulus information, activity in
the striatum did not. In contrast, within both the striatum
and dlPFC, stimuli consistent with the rule evoked greater
activity than stimuli inconsistent with the rule. This
dissociation indicates that dlPFC supports modification of
sets of stimulus-response contingencies while the striatum
supports stimulus-specific learning.},
Doi = {10.1097/00001756-200408260-00009},
Key = {fds252331}
}
@article{fds252332,
Author = {Huettel, SA and Obembe, OO and Song, AW and Woldorff,
MG},
Title = {The BOLD fMRI refractory effect is specific to stimulus
attributes: evidence from a visual motion
paradigm.},
Journal = {Neuroimage},
Volume = {23},
Number = {1},
Pages = {402-408},
Year = {2004},
Month = {September},
ISSN = {1053-8119},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15325388},
Keywords = {Adult • Female • Humans • Magnetic Resonance
Imaging* • Male • Motion Perception •
Occipital Lobe • Orientation • Oxygen •
Pattern Recognition, Visual • Reference Values •
Refractory Period, Electrophysiological • Regional
Blood Flow • Temporal Lobe • blood supply •
blood* • physiology • physiology*},
Abstract = {Functional magnetic resonance imaging (fMRI) studies have
demonstrated that the blood oxygenation level-dependent
(BOLD) hemodynamic response (HDR) to a stimulus is reduced
by the previous presentation of a similar stimulus. We
investigated the dependence of this refractory effect upon
stimulus characteristics using a novel adaptation paradigm
while scanning subjects using fMRI at 4 T. The stimuli were
composed of horizontal stripes that scrolled up, scrolled
down, or remained static, randomly presented for 1-s
duration with stimulus-onset asynchronies (SOAs) of 2-7 s.
We identified regions of interest (ROI) in lateral
temporal--occipital cortex that were activated by motion
stimuli, regardless of direction or SOA. We found strong
evidence for direction specificity in motion-sensitive
lateral temporal-occipital (LTO) cortex. For stimuli whose
direction of motion reprised that of the previous stimulus
(e.g., up preceded by up), the fMRI response was attenuated
at short SOAs (2-4 s) compared to long SOAs (5-7 s).
However, for stimuli whose direction of motion was opposite
that of the previous stimulus (e.g., up preceded by down),
little or no refractory effect was observed. Additionally,
examination of activity in pericalcarine cortex indicated a
similar pattern. We conclude that the fMRI refractory effect
predominantly reflects local stimulus-specific neuronal or
neurovascular adaptation and is unlikely to be a nonspecific
response of large vessels that support broad functional
regions.},
Doi = {10.1016/j.neuroimage.2004.04.031},
Key = {fds252332}
}
@article{fds252252,
Author = {Huettel, S and Stowe, C and Platt, M and Gordon, E and Warner,
B},
Title = {Choices between gambles: Effects of certainty, risk, and
ambiguity upon brain systems for decision making and reward
evaluation},
Journal = {Journal of Cognitive Neuroscience},
Pages = {221-221},
Publisher = {M I T PRESS},
Year = {2005},
Month = {January},
ISSN = {0898-929X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000227878701340&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252252}
}
@article{fds252255,
Author = {Madden, D and Spaniol, J and Whiting, W and Bucur, B and Provenzale, J and Cabeza, R and Huettel, S},
Title = {Adult age differences and similarities in the functional
neuroanatomy of visual attention: Evidence from
FMRI},
Journal = {Journal of Cognitive Neuroscience},
Pages = {154-154},
Publisher = {M I T PRESS},
Year = {2005},
Month = {January},
ISSN = {0898-929X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000227878701039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252255}
}
@article{fds330182,
Author = {Bucur, B and Madden, DJ and Spaniol, J and Provenzale, JM and White, LE and Cabeza, R and Huettel, SA},
Title = {Age-related decreases in cerebral white matter integrity:
Implications for episodic and semantic retrieval
processes},
Journal = {Journal of Cognitive Neuroscience},
Pages = {234-234},
Publisher = {M I T PRESS},
Year = {2005},
Month = {January},
Key = {fds330182}
}
@article{fds252324,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Decisions under uncertainty: probabilistic context
influences activation of prefrontal and parietal
cortices.},
Journal = {Journal of Neuroscience},
Volume = {25},
Number = {13},
Pages = {3304-3311},
Year = {2005},
Month = {March},
ISSN = {1529-2401},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15800185},
Keywords = {Adult • Brain Mapping • Decision Making •
Female • Humans • Image Processing,
Computer-Assisted • Magnetic Resonance Imaging •
Male • Oxygen • Parietal Lobe • Pattern
Recognition, Visual • Photic Stimulation •
Prefrontal Cortex • Probability* • Reaction Time
• Time Factors • blood • blood supply •
methods • physiology • physiology*},
Abstract = {Many decisions are made under uncertainty; that is, with
limited information about their potential consequences.
Previous neuroimaging studies of decision making have
implicated regions of the medial frontal lobe in processes
related to the resolution of uncertainty. However, a
different set of regions in dorsal prefrontal and posterior
parietal cortices has been reported to be critical for
selection of actions to unexpected or unpredicted stimuli
within a sequence. In the current study, we induced
uncertainty using a novel task that required subjects to
base their decisions on a binary sequence of eight stimuli
so that uncertainty changed dynamically over time (from 20
to 50%), depending on which stimuli were presented.
Activation within prefrontal, parietal, and insular cortices
increased with increasing uncertainty. In contrast, within
medial frontal regions, as well as motor and visual
cortices, activation did not increase with increasing
uncertainty. We conclude that the brain response to
uncertainty depends on the demands of the experimental task.
When uncertainty depends on learned associations between
stimuli and responses, as in previous studies, it modulates
activation in the medial frontal lobes. However, when
uncertainty develops over short time scales as information
is accumulated toward a decision, dorsal prefrontal and
posterior parietal contributions are critical for its
resolution. The distinction between neural mechanisms
subserving different forms of uncertainty resolution
provides an important constraint for neuroeconomic models of
decision making.},
Doi = {10.1523/JNEUROSCI.5070-04.2005},
Key = {fds252324}
}
@article{fds252339,
Author = {McClernon, FJ and Hiott, FB and Huettel, SA and Rose,
JE},
Title = {Abstinence-induced changes in self-report craving correlate
with event-related FMRI responses to smoking
cues.},
Journal = {Neuropsychopharmacology},
Volume = {30},
Number = {10},
Pages = {1940-1947},
Year = {2005},
Month = {October},
ISSN = {0893-133X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15920499},
Keywords = {Adult • Analysis of Variance • Behavior,
Addictive* • Brain Mapping • Cues* •
Functional Laterality • Gyrus Cinguli • Humans
• Magnetic Resonance Imaging • Oxygen •
Photic Stimulation • Questionnaires • Smoking
• Smoking Cessation* • blood • blood supply*
• methods • physiopathology •
physiopathology* • psychology},
Abstract = {Drug cues have been shown to activate brain regions involved
in attention, motivation, and reward in addicted users.
However, as studies have typically measured responses in
only one state (ie drug abstinence), it is unclear whether
observed activations represent amplification by abstinence
or stable responses. Thus, the present study was designed to
evaluate the stability of event-related responses to visual
drug cues in dependent smokers (n=13) using event-related
functional magnetic resonance imaging measures. Imaging was
conducted following smoking as usual and following overnight
abstinence, and self-reported craving measures were obtained
before, during, and after scanning. Analysis of hemodynamic
response (HDR) amplitudes in each of 13 regions of interest
revealed larger responses to smoking compared to control
cues in ventral anterior cingulate gyrus (vACG) and superior
frontal gyrus. Responses to smoking cues in these and all
other regions revealed no effects of abstinence/satiety,
thus supporting the notion that cue-elicited brain responses
are relatively stable. However, while the abstinence
manipulation did not alter group-level responses to smoking
cues, at the individual level, abstinence-induced changes in
craving (abstinence minus satiety) were positively
correlated with changes in HDR amplitude to smoking cues in
frontal regions including left inferior frontal gyrus, left
vACG, and bilateral middle frontal gyrus. These results
suggest that brain responses to smoking cues, while
relatively stable at the group level following short-term
abstinence, may be modulated by individual differences in
craving in response to abstinence-particularly in regions
subserving attention and motivation.},
Doi = {10.1038/sj.npp.1300780},
Key = {fds252339}
}
@article{fds252322,
Author = {Huettel, SA and Stowe, CJ and Gordon, EM and Warner, BT and Platt,
ML},
Title = {Neural signatures of economic preferences for risk and
ambiguity.},
Journal = {Neuron},
Volume = {49},
Number = {5},
Pages = {765-775},
Year = {2006},
Month = {March},
ISSN = {0896-6273},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16504951},
Keywords = {Adolescent • Adult • Brain • Brain Mapping*
• Decision Theory • Female • Humans •
Image Processing, Computer-Assisted • Magnetic
Resonance Imaging • Male • Mental Processes •
Oxygen • Photic Stimulation • Reaction Time •
Reward* • Risk-Taking* • Statistics •
Uncertainty* • Visual Perception • blood •
blood supply • methods • physiology •
physiology*},
Abstract = {People often prefer the known over the unknown, sometimes
sacrificing potential rewards for the sake of surety.
Overcoming impulsive preferences for certainty in order to
exploit uncertain but potentially lucrative options may
require specialized neural mechanisms. Here, we demonstrate
by functional magnetic resonance imaging (fMRI) that
individuals' preferences for risk (uncertainty with known
probabilities) and ambiguity (uncertainty with unknown
probabilities) predict brain activation associated with
decision making. Activation within the lateral prefrontal
cortex was predicted by ambiguity preference and was also
negatively correlated with an independent clinical measure
of behavioral impulsiveness, suggesting that this region
implements contextual analysis and inhibits impulsive
responses. In contrast, activation of the posterior parietal
cortex was predicted by risk preference. Together, this
novel double dissociation indicates that decision making
under ambiguity does not represent a special, more complex
case of risky decision making; instead, these two forms of
uncertainty are supported by distinct mechanisms.},
Doi = {10.1016/j.neuron.2006.01.024},
Key = {fds252322}
}
@article{fds252323,
Author = {Huettel, SA},
Title = {Behavioral, but not reward, risk modulates activation of
prefrontal, parietal, and insular cortices.},
Journal = {Cognitive, Affective & Behavioral Neuroscience},
Volume = {6},
Number = {2},
Pages = {141-151},
Year = {2006},
Month = {June},
ISSN = {1530-7026},
url = {http://dx.doi.org/10.3758/cabn.6.2.141},
Keywords = {Adolescent • Adult • Cerebral Cortex • Cues
• Decision Making • Female • Functional
Laterality • Humans • Magnetic Resonance Imaging*
• Male • Nucleus Accumbens • Parietal Lobe
• Prefrontal Cortex • Reward* • physiology
• physiology*},
Abstract = {Risky decisions may involve uncertainty about possible
outcomes (i.e., reward risk) or uncertainty about which
action should be taken (i.e., behavioral risk). Determining
whether different forms of risk have distinct neural
correlates is a central goal of neuroeconomic research. In
two functional magnetic resonance imaging experiments,
subjects viewed shapes that had well-learned response-reward
contingencies. Magnitude of a monetary reward was held
constant within one experiment, whereas expected value was
held constant within the other. Response selection, in the
absence of behavioral risk, evoked activation within a broad
set of brain regions, as had been found in prior studies.
However, behavioral risk additionally modulated activation
in prefrontal, parietal, and insular regions,within which no
effect of reward risk was observed. Reward delivery, in
comparison with omission, evoked increased activity in the
ventromedial prefrontal cortex and the nucleus accumbens. We
conclude that distinct brain systems are recruited for the
resolution of different forms of risk.},
Doi = {10.3758/cabn.6.2.141},
Key = {fds252323}
}
@article{fds252316,
Author = {Marks, BL and Madden, DJ and Bucur, B and Provenzale, JM and White, LE and Cabeza, R and Huettel, SA},
Title = {Role of aerobic fitness and aging on cerebral white matter
integrity.},
Journal = {Annals of the New York Academy of Sciences},
Volume = {1097},
Pages = {171-174},
Year = {2007},
Month = {February},
ISSN = {0077-8923},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17413020},
Keywords = {Adult • Aerobiosis • Aged • Aging •
Anaerobic Threshold • Anisotropy • Body Mass Index
• Brain • Diffusion Magnetic Resonance Imaging
• Female • Humans • Male • Motor
Activity • Oxygen Consumption • Physical Fitness
• Sex Characteristics • growth & development*
• physiology • physiology*},
Abstract = {Neuroimaging research suggests that cerebral white matter
(WM) integrity, as reflected in fractional anisotropy (FA)
via diffusion tensor imaging (DTI), is decreased in older
adults, especially in the prefrontal regions of the brain.
Behavioral investigations of cognitive functioning suggest
that some aspects of cognition may be better preserved in
older adults who possess higher levels of aerobic fitness.
There are only a few studies, however, investigating
potential mechanisms for the improvements in aerobic
fitness. Our study suggests that greater aerobic fitness may
be related to greater WM integrity in select brain
regions.},
Doi = {10.1196/annals.1379.022},
Key = {fds252316}
}
@article{fds252325,
Author = {Tankersley, D and Stowe, CJ and Huettel, SA},
Title = {Altruism is associated with an increased neural response to
agency.},
Journal = {Nature Neuroscience},
Volume = {10},
Number = {2},
Pages = {150-151},
Year = {2007},
Month = {February},
ISSN = {1097-6256},
url = {http://dx.doi.org/10.1038/nn1833},
Keywords = {Altruism* • Brain • Brain Mapping • Cognition
• Empathy* • Functional Laterality • Humans
• Magnetic Resonance Imaging • Neuropsychological
Tests • Personality • Social Behavior* •
Temporal Lobe • User-Computer Interface • anatomy
& histology • anatomy & histology* • physiology
• physiology*},
Abstract = {Although the neural mechanisms underlying altruism remain
unknown, empathy and its component abilities, such as the
perception of the actions and intentions of others, have
been proposed as key contributors. Tasks requiring the
perception of agency activate the posterior superior
temporal cortex (pSTC), particularly in the right
hemisphere. Here, we demonstrate that differential
activation of the human pSTC during action perception versus
action performance predicts self-reported
altruism.},
Doi = {10.1038/nn1833},
Key = {fds252325}
}
@article{fds252341,
Author = {Madden, DJ and Spaniol, J and Whiting, WL and Bucur, B and Provenzale,
JM and Cabeza, R and White, LE and Huettel, SA},
Title = {Adult age differences in the functional neuroanatomy of
visual attention: a combined fMRI and DTI
study.},
Journal = {Neurobiol Aging},
Volume = {28},
Number = {3},
Pages = {459-476},
Year = {2007},
Month = {March},
ISSN = {1558-1497},
url = {http://www.ncbi.nlm.nih.gov/pubmed/16500004},
Keywords = {Adult • Aging • Anisotropy • Attention •
Brain Mapping • Choice Behavior • Diffusion
Magnetic Resonance Imaging* • Female • Humans
• Image Processing, Computer-Assisted • Magnetic
Resonance Imaging* • Male • Multivariate Analysis
• Oxygen • Photic Stimulation • Reaction Time
• Statistics • Visual Cortex* • Visual
Perception • anatomy & histology • blood •
blood supply • metabolism • methods •
physiology • physiology*},
Abstract = {We combined measures from event-related functional magnetic
resonance imaging (fMRI), diffusion tensor imaging (DTI),
and cognitive performance (visual search response time) to
test the hypotheses that differences between younger and
older adults in top-down (goal-directed) attention would be
related to cortical activation, and that white matter
integrity as measured by DTI (fractional anisotropy, FA)
would be a mediator of this age-related effect. Activation
in frontal and parietal cortical regions was overall greater
for older adults than for younger adults. The relation
between activation and search performance supported the
hypothesis of age differences in top-down attention. When
the task involved top-down control (increased target
predictability), performance was associated with
frontoparietal activation for older adults, but with
occipital (fusiform) activation for younger adults. White
matter integrity (FA) exhibited an age-related decline that
was more pronounced for anterior brain regions than for
posterior regions, but white matter integrity did not
specifically mediate the age-related increase in activation
of the frontoparietal attentional network.},
Doi = {10.1016/j.neurobiolaging.2006.01.005},
Key = {fds252341}
}
@article{fds252318,
Author = {Venkatraman, V and Chuah, YML and Huettel, SA and Chee,
MWL},
Title = {Sleep deprivation elevates expectation of gains and
attenuates response to losses following risky
decisions.},
Journal = {Sleep},
Volume = {30},
Number = {5},
Pages = {603-609},
Year = {2007},
Month = {May},
ISSN = {0161-8105},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17552375},
Keywords = {Adult • Affect* • Brain Mapping • Cerebral
Cortex • Choice Behavior • Decision Making* •
Dominance, Cerebral • Female • Frontal Lobe •
Gambling • Humans • Magnetic Resonance Imaging
• Male • Nucleus Accumbens • Reaction Time
• Reward* • Set (Psychology)* • Sleep
Deprivation • physiology • physiopathology •
psychology*},
Abstract = {<h4>Study objectives</h4>Using a gambling task, we
investigated how 24 hours of sleep deprivation modulates the
neural response to the making of risky decisions with
potentially loss-bearing outcomes.<h4>Design</h4>Two
experiments involving sleep-deprived subjects were
performed. In the first, neural responses to decision making
and reward outcome were evaluated. A second control
experiment evaluated responses to reward outcome
only.<h4>Participants</h4>Healthy right-handed adults
participated in these experiments (26 [mean age 21.3 years]
in Experiment 1 and 13 [mean age 21.7 years] in Experiment
2.)<h4>Measurements and results</h4>Following sleep
deprivation, choices involving higher relative risk elicited
greater activation in the right nucleus accumbens,
signifying an elevated expectation of the higher reward once
the riskier choice was made. Concurrently, activation for
losses in the insular and orbitofrontal cortices was
reduced, denoting a diminished response to losses. This
latter finding of reduced insular activation to losses was
also true when volunteers were merely shown the results of
the computer's decision, that is, without having to make
their own choice.<h4>Conclusions</h4>These results suggest
that sleep deprivation poses a dual threat to competent
decision making by modulating activation in nucleus
accumbens and insula, brain regions associated with risky
decision making and emotional processing.},
Doi = {10.1093/sleep/30.5.603},
Key = {fds252318}
}
@article{fds252270,
Author = {Wang, L and Huettel, S and De Bellis, MD},
Title = {Neural substrates for processing task-irrelevant sad images
in adolescents.},
Journal = {Dev Sci},
Volume = {11},
Number = {1},
Pages = {23-32},
Year = {2008},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18171363},
Abstract = {Neural systems related to cognitive and emotional processing
were examined in adolescents using event-related functional
magnetic resonance imaging (fMRI). Ten healthy adolescents
performed an emotional oddball task. Subjects detected
infrequent circles (targets) within a continual stream of
phase-scrambled images (standards). Sad and neutral images
were intermittently presented as task-irrelevant distracters
(novels). As previously shown for adults, when the
adolescents responded to the task-relevant targets,
activation increased in the dorsal attention-executive
system including the anterior middle frontal gyrus (aMFG),
dorsal anterior cingulate (ACG), posterior cingulate (PCG),
insula, and supramarginal gyrus (SMG). Unlike adults,
however, the adolescents exhibited strong activation to the
emotional distracter images not only in the ventromedial
prefrontal cortex (VmPFC), but also in the posterior middle
frontal gyrus (pMFG) and in the parietal cortex. Those
subjects who had stronger VmPFC activation to emotional
distraction also had reduced activation in the aMFG during
target detection, suggesting that emotional information may
interfere with executive processing in these adolescents. In
contrast, pMFG and PCG activation to emotional distracters
was positively correlated with aMFG activation to targets,
indicating a different role of these regions from the VmPFC.
The pattern of activation to task-irrelevant emotional
distraction suggests a possible immaturity of brain function
in cognitive control over emotional distraction in
adolescents.},
Doi = {10.1111/j.1467-7687.2007.00661.x},
Key = {fds252270}
}
@article{fds252296,
Author = {Dubé, L and Bechara, A and Böckenholt, U and Ansari, A and Dagher, A and Daniel, M and Desarbo, WS and Fellows, LK and Hammond, RA and Huang,
TTK and Huettel, S and Kestens, Y and Knäuper, B and Kooreman, P and Moore, DS and Smidts, A},
Title = {Towards a brain-to-society systems model of individual
choice},
Journal = {Marketing Letters},
Volume = {19},
Number = {3-4},
Pages = {323-336},
Publisher = {Springer Nature},
Year = {2008},
Month = {January},
ISSN = {0923-0645},
url = {http://dx.doi.org/10.1007/s11002-008-9057-y},
Abstract = {Canonical models of rational choice fail to account for many
forms of motivated adaptive behaviors, specifically in
domains such as food selections. To describe behavior in
such emotion- and reward-laden scenarios, researchers have
proposed dual-process models that posit competition between
a slower, analytic faculty and a fast, impulsive, emotional
faculty. In this paper, we examine the assumptions and
limitations of these approaches to modeling motivated
choice. We argue that models of this form, though
intuitively attractive, are biologically implausible. We
describe an approach to motivated choice based on sequential
sampling process models that can form a solid theoretical
bridge between what is known about brain function and
environmental influences upon choice. We further suggest
that the complex and dynamic relationships between biology,
behavior, and environment affecting choice at the individual
level must inform aggregate models of consumer choice.
Models using agent-based complex systems may further provide
a principled way to relate individual and aggregate consumer
choices to the aggregate choices made by businesses and
social institutions. We coin the term "brain-to-society
systems" choice model for this broad integrative approach.
© 2008 Springer Science+Business Media,
LLC.},
Doi = {10.1007/s11002-008-9057-y},
Key = {fds252296}
}
@article{fds330181,
Author = {Yaxley, RH and Van Voorhees and EE and Huettel, SA and De Bellis,
MD},
Title = {Brain activation during decisions involving behavioral risk:
Adolescents v. adults},
Journal = {Biological Psychiatry},
Volume = {63},
Number = {7},
Pages = {79S-79S},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2008},
Month = {April},
Key = {fds330181}
}
@article{fds252320,
Author = {Platt, ML and Huettel, SA},
Title = {Risky business: the neuroeconomics of decision making under
uncertainty.},
Journal = {Nature Neuroscience},
Volume = {11},
Number = {4},
Pages = {398-403},
Year = {2008},
Month = {April},
ISSN = {1097-6256},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18368046},
Keywords = {Animals • Brain • Choice Behavior* • Decision
Making* • Female • Humans • Male •
Probability Learning • Reinforcement (Psychology)
• Risk-Taking* • Sex Factors • Uncertainty*
• physiology*},
Abstract = {Many decisions involve uncertainty, or imperfect knowledge
about how choices lead to outcomes. Colloquial notions of
uncertainty, particularly when describing a decision as
'risky', often carry connotations of potential danger as
well. Gambling on a long shot, whether a horse at the
racetrack or a foreign oil company in a hedge fund, can have
negative consequences, but the impact of uncertainty on
decision making extends beyond gambling. Indeed, uncertainty
in some form pervades nearly all our choices in daily life.
Stepping into traffic to hail a cab, braving an ice storm to
be the first at work, or dating the boss's son or daughter
also offer potentially great windfalls, at the expense of
surety. We continually face trade-offs between options that
promise safety and others that offer an uncertain potential
for jackpot or bust. When mechanisms for dealing with
uncertain outcomes fail, as in mental disorders such as
problem gambling or addiction, the results can be
disastrous. Thus, understanding decision making-indeed,
understanding behavior itself-requires knowing how the brain
responds to and uses information about uncertainty.},
Doi = {10.1038/nn2062},
Key = {fds252320}
}
@article{fds252314,
Author = {Dennis, NA and Hayes, SM and Prince, SE and Madden, DJ and Huettel, SA and Cabeza, R},
Title = {Effects of aging on the neural correlates of successful item
and source memory encoding.},
Journal = {Journal of Experimental Psychology. Learning, Memory, and
Cognition},
Volume = {34},
Number = {4},
Pages = {791-808},
Year = {2008},
Month = {July},
ISSN = {0278-7393},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18605869},
Abstract = {To investigate the neural basis of age-related source memory
(SM) deficits, young and older adults were scanned with fMRI
while encoding faces, scenes, and face-scene pairs.
Successful encoding activity was identified by comparing
encoding activity for subsequently remembered versus
forgotten items or pairs. Age deficits in successful
encoding activity in hippocampal and prefrontal regions were
more pronounced for SM (pairs) as compared with item memory
(faces and scenes). Age-related reductions were also found
in regions specialized in processing faces (fusiform face
area) and scenes (parahippocampal place area), but these
reductions were similar for item and SM. Functional
connectivity between the hippocampus and the rest of the
brain was also affected by aging; whereas connections with
posterior cortices were weaker in older adults, connections
with anterior cortices, including prefrontal regions, were
stronger in older adults. Taken together, the results
provide a link between SM deficits in older adults and
reduced recruitment of hippocampal and prefrontal regions
during encoding. The functional connectivity findings are
consistent with a posterior-anterior shift with aging
previously reported in several cognitive domains and linked
to functional compensation.},
Doi = {10.1037/0278-7393.34.4.791},
Key = {fds252314}
}
@article{fds252321,
Author = {Bucur, B and Madden, DJ and Spaniol, J and Provenzale, JM and Cabeza, R and White, LE and Huettel, SA},
Title = {Age-related slowing of memory retrieval: contributions of
perceptual speed and cerebral white matter
integrity.},
Journal = {Neurobiol Aging},
Volume = {29},
Number = {7},
Pages = {1070-1079},
Year = {2008},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17383774},
Abstract = {Previous research suggests that, in reaction time (RT)
measures of episodic memory retrieval, the unique effects of
adult age are relatively small compared to the effects aging
shares with more elementary abilities such as perceptual
speed. Little is known, however, regarding the mechanisms of
perceptual speed. We used diffusion tensor imaging (DTI) to
test the hypothesis that white matter integrity, as indexed
by fractional anisotropy (FA), serves as one mechanism of
perceptual slowing in episodic memory retrieval. Results
indicated that declines in FA in the pericallosal frontal
region and in the genu of the corpus callosum, but not in
other regions, mediated the relationship between perceptual
speed and episodic retrieval RT. This relation held, though
to a different degree, for both hits and correct rejections.
These findings suggest that white matter integrity in
prefrontal regions is one mechanism underlying the relation
between individual differences in perceptual speed and
episodic retrieval.},
Doi = {10.1016/j.neurobiolaging.2007.02.008},
Key = {fds252321}
}
@article{fds252317,
Author = {Weber, BJ and Huettel, SA},
Title = {The neural substrates of probabilistic and intertemporal
decision making.},
Journal = {Brain Research},
Volume = {1234},
Pages = {104-115},
Year = {2008},
Month = {October},
ISSN = {0006-8993},
url = {http://dx.doi.org/10.1016/j.brainres.2008.07.105},
Abstract = {Many important decisions involve outcomes that are either
probabilistic or delayed. Based on similarities in decision
preferences, models of decision making have postulated that
the same psychological processes may underlie decisions
involving probabilities (i.e., risky choice) and decisions
involving delay (i.e., intertemporal choice). Equivocal
behavioral evidence has made this hypothesis difficult to
evaluate. However, a combination of functional neuroimaging
and behavioral data may allow identification of differences
between these forms of decision making. Here, we used
functional magnetic resonance imaging (fMRI) to examine
brain activation in subjects making a series of choices
between pairs of real monetary rewards that differed either
in their relative risk or their relative delay. While both
sorts of choices evoked activation in brain systems
previously implicated in executive control, we observed
clear distinctions between these forms of decision making.
Notably, choices involving risk evoked greater activation in
posterior parietal and lateral prefrontal cortices, whereas
choices involving delay evoked greater activation in the
posterior cingulate cortex and the striatum. Moreover,
activation of regions associated with reward evaluation
predicted choices of a more-risky option, whereas activation
of control regions predicted choices of more-delayed or
less-risky options. These results indicate that there are
differences in the patterns of brain activation evoked by
risky and intertemporal choices, suggesting that the two
domains utilize at least partially distinct sets of
cognitive processes.},
Doi = {10.1016/j.brainres.2008.07.105},
Key = {fds252317}
}
@article{fds252312,
Author = {Clithero, JA and Tankersley, D and Huettel, SA},
Title = {Foundations of neuroeconomics: from philosophy to
practice.},
Journal = {Plos Biology},
Volume = {6},
Number = {11},
Pages = {e298},
Year = {2008},
Month = {November},
ISSN = {1545-7885},
url = {http://dx.doi.org/10.1371/journal.pbio.0060298},
Doi = {10.1371/journal.pbio.0060298},
Key = {fds252312}
}
@article{fds252315,
Author = {Goyer, JP and Woldorff, MG and Huettel, SA},
Title = {Rapid electrophysiological brain responses are influenced by
both valence and magnitude of monetary rewards.},
Journal = {Journal of Cognitive Neuroscience},
Volume = {20},
Number = {11},
Pages = {2058-2069},
Year = {2008},
Month = {November},
ISSN = {0898-929X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18416673},
Abstract = {Abstract Negative outcomes, as identified from external
feedback, cause a short-latency negative deflection in the
event-related potential (ERP) waveform over medial frontal
electrode sites. This brain response, which has been called
an "error related negativity" (ERN) or "medial frontal
negativity" (MFN), may reflect a coarse evaluation of
performance outcomes, such as the valence of a reward within
a monetary gambling task. Yet, for feedback to lead to the
adaptive control of behavior, other information concerning
reward outcomes besides experienced valence may also be
important. Here, we used a gambling task in which subjects
chose between two options that could vary in both outcome
valence (gain or loss) and outcome magnitude (larger or
smaller). We measured changes in brain ERP responses
associated with the presentation of the outcomes. We found,
as shown in prior studies, that valence of the chosen
outcome has an early effect upon frontal ERPs, with maximal
difference observed at approximately 250 msec. However, our
results demonstrated that the early ERP responses to outcome
feedback were driven not just by valence but by the
combination of valence and magnitude for both chosen and
unchosen options. Beginning even earlier, at around 150
msec, responses to high-consequence outcomes resulted in a
greater, more centrally distributed, positive potential than
those involving low-consequence outcomes, independent of
valence. Furthermore, the amplitude of these early effects
was significantly modulated by the sequence of outcomes in
previous trials. These results indicate that early
evaluation of feedback goes beyond simple identification of
valence-it involves the consideration of multiple factors,
including outcome magnitude, context of unchosen options,
and prior history.},
Doi = {10.1162/jocn.2008.20134},
Key = {fds252315}
}
@article{fds252308,
Author = {Mullette Gillman and O and Huettel, SA},
Title = {Neural substrates of contingency learning and executive
control: dissociating physical, valuative, and behavioral
changes},
Journal = {Frontiers in Human Neuroscience},
Volume = {3},
Pages = {23},
Year = {2009},
url = {http://dx.doi.org/10.3389/neuro.09.023.2009},
Abstract = {Contingency learning is fundamental to cognition. Knowledge
about environmental contingencies allows behavioral
flexibility, as executive control processes accommodate the
demands of novel or changing environments. Studies of
experiential learning have focused on the relationship
between actions and the values of associated outcomes.
However, outcome values have often been confounded with the
physical changes in the outcomes themselves. Here, we
dissociated contingency learning into valuative and
non-valuative forms, using a novel version of the
two-alternative choice task, while measuring the neural
effects of contingency changes using functional magnetic
resonance imaging (fMRI). Changes in value-relevant
contingencies evoked activation in the lateral prefrontal
cortex (LPFC), posterior parietal cortex (PPC), and
dorsomedial prefrontal cortex (DMPFC) consistent with prior
results (e.g., reversal-learning paradigms). Changes in
physical contingencies unrelated to value or to action
produced similar activations within the LPFC, indicating
that LPFC may engage in generalized contingency learning
that is not specific to valuation. In contrast, contingency
changes that required behavioral shifts evoked activation
localized to the DMPFC, supplementary motor, and precentral
cortices, suggesting that these regions play more specific
roles within the executive control of behavior.},
Doi = {10.3389/neuro.09.023.2009},
Key = {fds252308}
}
@article{fds252310,
Author = {Carter, RM and Macinnes, JJ and Huettel, SA and Adcock,
RA},
Title = {Activation in the VTA and nucleus accumbens increases in
anticipation of both gains and losses.},
Journal = {Frontiers in Behavioral Neuroscience},
Volume = {3},
Pages = {21},
Year = {2009},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19753142},
Abstract = {To represent value for learning and decision making, the
brain must encode information about both the motivational
relevance and affective valence of anticipated outcomes. The
nucleus accumbens (NAcc) and ventral tegmental area (VTA)
are thought to play key roles in representing these and
other aspects of valuation. Here, we manipulated the valence
(i.e., monetary gain or loss) and personal relevance (i.e.,
self-directed or charity-directed) of anticipated outcomes
within a variant of the monetary incentive delay task. We
scanned young-adult participants using functional magnetic
resonance imaging (fMRI), utilizing imaging parameters
targeted for the NAcc and VTA. For both self-directed and
charity-directed trials, activation in the NAcc and VTA
increased to anticipated gains, as predicted by prior work,
but also increased to anticipated losses. Moreover, the
magnitude of responses in both regions was positively
correlated for gains and losses, across participants, while
an independent reward-sensitivity covariate predicted the
relative difference between and gain- and loss-related
activation on self-directed trials. These results are
inconsistent with the interpretation that these regions
reflect anticipation of only positive-valence events.
Instead, they indicate that anticipatory activation in
reward-related regions largely reflects the motivational
relevance of an upcoming event.},
Doi = {10.3389/neuro.08.021.2009},
Key = {fds252310}
}
@article{fds252241,
Author = {Huettel, SA},
Title = {fMRI: BOLD Contrast},
Pages = {273-281},
Publisher = {Elsevier},
Year = {2009},
Month = {January},
url = {http://dx.doi.org/10.1016/B978-008045046-9.00318-1},
Abstract = {An influential technique for the study of the human brain
has been functional magnetic resonance imaging (fMRI). The
most common form of fMRI uses standard clinical magnetic
resonance imaging scanners to create images based on blood
oxygenation level-dependent (BOLD) contrast. Compared to
other human neuroimaging techniques, BOLD fMRI has good
spatial resolution but only fair temporal resolution.
Nevertheless, because it is noninvasive and well matched to
many experimental paradigms, it has become the dominant
technique in cognitive neuroscience. This article describes
the physical and physiological principles underlying fMRI,
along with the key concepts of designing and analyzing fMRI
experiments. © 2009 Elsevier Ltd All rights
reserved.},
Doi = {10.1016/B978-008045046-9.00318-1},
Key = {fds252241}
}
@article{fds252306,
Author = {Huettel, SA and Payne, JW},
Title = {Integrating neural and decision sciences: Convergence and
constraints},
Journal = {Journal of Marketing Research},
Volume = {46},
Number = {1},
Pages = {14-17},
Publisher = {SAGE Publications},
Year = {2009},
Month = {January},
ISSN = {0022-2437},
url = {http://dx.doi.org/10.1509/jmkr.46.1.14},
Doi = {10.1509/jmkr.46.1.14},
Key = {fds252306}
}
@article{fds252313,
Author = {Madden, DJ and Spaniol, J and Costello, MC and Bucur, B and White, LE and Cabeza, R and Davis, SW and Dennis, NA and Provenzale, JM and Huettel,
SA},
Title = {Cerebral white matter integrity mediates adult age
differences in cognitive performance.},
Journal = {Journal of Cognitive Neuroscience},
Volume = {21},
Number = {2},
Pages = {289-302},
Year = {2009},
Month = {February},
ISSN = {0898-929X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18564054},
Abstract = {Previous research has established that age-related decline
occurs in measures of cerebral white matter integrity, but
the role of this decline in age-related cognitive changes is
not clear. To conclude that white matter integrity has a
mediating (causal) contribution, it is necessary to
demonstrate that statistical control of the white
matter-cognition relation reduces the magnitude of
age-cognition relation. In this research, we tested the
mediating role of white matter integrity, in the context of
a task-switching paradigm involving word categorization.
Participants were 20 healthy, community-dwelling older
adults (60-85 years), and 20 younger adults (18-27 years).
From diffusion tensor imaging tractography, we obtained
fractional anisotropy (FA) as an index of white matter
integrity in the genu and splenium of the corpus callosum
and the superior longitudinal fasciculus (SLF). Mean FA
values exhibited age-related decline consistent with a
decrease in white matter integrity. From a model of reaction
time distributions, we obtained independent estimates of the
decisional and nondecisional (perceptual-motor) components
of task performance. Age-related decline was evident in both
components. Critically, age differences in task performance
were mediated by FA in two regions: the central portion of
the genu, and splenium-parietal fibers in the right
hemisphere. This relation held only for the decisional
component and was not evident in the nondecisional
component. This result is the first demonstration that the
integrity of specific white matter tracts is a mediator of
age-related changes in cognitive performance.},
Doi = {10.1162/jocn.2009.21047},
Key = {fds252313}
}
@article{fds252268,
Author = {Dubé, L and Bechara, A and Böckenholt, U and Ansari, A and Dagher, A and Daniel, M and DeSarbo, W and Fellows, L and Hammond, R and Huang, T and Huettel, S and Kestens, Y and Knäuper, B and Kooreman, P and Moore, D and Smidts, A},
Title = {Towards a brain-to-society systems model of individual
choice},
Journal = {Marketing Letters},
Volume = {20},
Number = {1},
Pages = {105-106},
Publisher = {Springer Nature},
Year = {2009},
Month = {March},
ISSN = {0923-0645},
url = {http://dx.doi.org/10.1007/s11002-008-9067-9},
Doi = {10.1007/s11002-008-9067-9},
Key = {fds252268}
}
@article{fds252309,
Author = {Venkatraman, V and Payne, JW and Bettman, JR and Luce, MF and Huettel,
SA},
Title = {Separate neural mechanisms underlie choices and strategic
preferences in risky decision making.},
Journal = {Neuron},
Volume = {62},
Number = {4},
Pages = {593-602},
Year = {2009},
Month = {May},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19477159},
Abstract = {Adaptive decision making in real-world contexts often relies
on strategic simplifications of decision problems. Yet, the
neural mechanisms that shape these strategies and their
implementation remain largely unknown. Using an economic
decision-making task, we dissociate brain regions that
predict specific choices from those predicting an
individual's preferred strategy. Choices that maximized
gains or minimized losses were predicted by functional
magnetic resonance imaging activation in ventromedial
prefrontal cortex or anterior insula, respectively. However,
choices that followed a simplifying strategy (i.e.,
attending to overall probability of winning) were associated
with activation in parietal and lateral prefrontal cortices.
Dorsomedial prefrontal cortex, through differential
functional connectivity with parietal and insular cortex,
predicted individual variability in strategic preferences.
Finally, we demonstrate that robust decision strategies
follow from neural sensitivity to rewards. We conclude that
decision making reflects more than compensatory interaction
of choice-related regions; in addition, specific brain
systems potentiate choices depending on strategies, traits,
and context.},
Doi = {10.1016/j.neuron.2009.04.007},
Key = {fds252309}
}
@article{fds252311,
Author = {Clithero, JA and Carter, RM and Huettel, SA},
Title = {Local pattern classification differentiates processes of
economic valuation.},
Journal = {Neuroimage},
Volume = {45},
Number = {4},
Pages = {1329-1338},
Year = {2009},
Month = {May},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2008.12.074},
Abstract = {For effective decision making, individuals must be able to
form subjective values from many types of information. Yet,
the neural mechanisms that underlie potential differences in
value computation across different decision scenarios are
incompletely understood. Here, we used functional magnetic
resonance imaging (fMRI), in conjunction with the machine
learning technique of support vector machines (SVM), to
identify brain regions that contain unique local information
associated with different types of valuation. We used a
combinatoric approach that evaluated the unique
contributions of different brain regions to model
generalization strength. Local voxel patterns in left
posterior parietal cortex contained unique information
differentiating probabilistic and intertemporal valuation, a
result that was not accessible using standard fMRI analyses.
We conclude that the early valuation phases for these reward
types differ on a fine spatial scale, suggesting the
existence of computational topographies along the value
construction pathway.},
Doi = {10.1016/j.neuroimage.2008.12.074},
Key = {fds252311}
}
@article{fds252319,
Author = {Han, S and Huettel, SA and Dobbins, IG},
Title = {Rule-dependent prefrontal cortex activity across episodic
and perceptual decisions: an fMRI investigation of the
criterial classification account.},
Journal = {Journal of Cognitive Neuroscience},
Volume = {21},
Number = {5},
Pages = {922-937},
Year = {2009},
Month = {May},
ISSN = {0898-929X},
url = {http://dx.doi.org/10.1162/jocn.2009.21060},
Abstract = {Although lateral prefrontal cortex (LPFC) is clearly
involved in decision-making, competing functional
characterizations exist. One characterization posits that
activation reflects the need to select among competing
representations. In contrast, recent fMRI research suggests
that activation is driven by the criterial classification of
representations, even with minimal competition. To
adjudicate between these hypotheses, we used event-related
fMRI and contrasted tasks that required different numbers of
criterial classifications prior to response in both
perceptual and memory domains. Additionally, we manipulated
the level of interstimulus competition by increasing the
number of probes. Experiment 1 demonstrated that LPFC
activation tracked the number of intermediate
classifications during trials yet was insensitive to the
number of competing probes and the behavioral decline
accompanying competition. Furthermore, Experiment 2
demonstrated equivalent increases in LPFC activation for a
task requiring two overt criterial classifications
(independent classification) and one requiring two covert
criterial classifications prior to the single overt response
(same-different judgment). As found in Experiment 1, both
tasks showed greater activation than a judgment requiring
only one classification act (forced choice). These data
indicate that LPFC responses reflect the number of executed
criterial classifications or judgments, independent of the
number of competing stimuli and the overt response demands
of the decision task.},
Doi = {10.1162/jocn.2009.21060},
Key = {fds252319}
}
@article{fds252307,
Author = {Venkatraman, V and Rosati, AG and Taren, AA and Huettel,
SA},
Title = {Resolving response, decision, and strategic control:
evidence for a functional topography in dorsomedial
prefrontal cortex.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {29},
Number = {42},
Pages = {13158-13164},
Year = {2009},
Month = {October},
ISSN = {0270-6474},
url = {http://hdl.handle.net/10161/6928 Duke open
access},
Abstract = {The dorsomedial prefrontal cortex (DMPFC) plays a central
role in aspects of cognitive control and decision making.
Here, we provide evidence for an anterior-to-posterior
topography within the DMPFC using tasks that evoke three
distinct forms of control demands--response, decision, and
strategic--each of which could be mapped onto independent
behavioral data. Specifically, we identify three spatially
distinct regions within the DMPFC: a posterior region
associated with control demands evoked by multiple
incompatible responses, a middle region associated with
control demands evoked by the relative desirability of
decision options, and an anterior region that predicts
control demands related to deviations from an individual's
preferred decision-making strategy. These results provide
new insight into the functional organization of DMPFC and
suggest how recent controversies about its role in complex
decision making and response mapping can be
reconciled.},
Doi = {10.1523/jneurosci.2708-09.2009},
Key = {fds252307}
}
@article{fds252303,
Author = {Wang, L and Mullette-Gillman, OA and Gadde, KM and Kuhn, CM and McCarthy, G and Huettel, SA},
Title = {The effect of acute tryptophan depletion on emotional
distraction and subsequent memory.},
Journal = {Soc Cogn Affect Neurosci},
Volume = {4},
Number = {4},
Pages = {357-368},
Year = {2009},
Month = {December},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19628700},
Abstract = {Serotonin is a key neurotransmitter involved in emotional
regulation and memory. A number of studies using acute
tryptophan depletion (ATD) in healthy subjects have shown
that a temporary serotonin reduction both induces a negative
emotional bias and impairs long-term memory. However, little
is known about the specific effects of ATD on emotional
memory. Using functional magnetic resonance imaging (fMRI),
we investigated the effect of ATD on negative memory and
executive function in healthy volunteers. Our emotional
oddball task required participants to distinguish
infrequently presented targets from distracting negative and
neutral pictures. Memory for the distracting pictures was
tested 1 h following the fMRI session. ATD selectively
enhanced memory for negative distractors relative to neutral
distractors and increased activation in response to the
negative distractors in the left orbital-inferior frontal,
dorsomedial prefrontal and bilateral angular gyri. ATD also
induced greater activation in the left inferior frontal
gyrus and anterior cingulate across all stimuli. Stronger
frontal activation to distractors was positively correlated
with memory performance on ATD but not control days,
indicating a possible compensatory mechanism for coping with
increased task demand under the ATD challenge. These
findings highlight the importance of serotonin in negative
memory with implications for mood disorders.},
Doi = {10.1093/scan/nsp025},
Key = {fds252303}
}
@misc{fds252302,
Author = {Henninger, DE and Madden, D and Huettel, SA},
Title = {Age-Related Cognitive Decline Predicts Changes in Risk
Preference},
Journal = {Psychology and Aging},
Volume = {25},
Number = {2},
Pages = {262-270},
Year = {2010},
Key = {fds252302}
}
@article{fds252304,
Author = {Huettel, SA},
Title = {Ten challenges for decision neuroscience},
Journal = {Frontiers in Decision Neuroscience},
Volume = {4},
Year = {2010},
url = {http://dx.doi.org/10.3389/fnins.2010.00171},
Abstract = {Decision neuroscience research, as currently practiced,
employs the methods of neuroscience to investigate concepts
drawn from the social sciences. A typical study selects one
or more variables from psychological or economic models,
manipulates or measures choices within a simplified choice
task, and then identifies neural correlates. Using this
"neuroeconomic" approach, researchers have described brain
systems whose functioning shapes key economic variables,
most notably aspects of subjective value. Yet, the standard
approach has fundamental limitations. Important aspects of
the mechanisms of decision making - from the sources of
variability in decision making to the very computations
supported by decision-related regions - remain incompletely
understood. Here, I outline 10 outstanding challenges for
future research in decision neuroscience. While some will be
readily addressed using current methods, others will require
new conceptual frameworks. Accordingly, a new strain of
decision neuroscience will marry methods from economics and
cognitive science to concepts from neurobiology and
cognitive neuroscience.},
Doi = {10.3389/fnins.2010.00171},
Key = {fds252304}
}
@article{fds252300,
Author = {Smith, DV and Hayden, BY and Truong, T-K and Song, AW and Platt, ML and Huettel, SA},
Title = {Distinct value signals in anterior and posterior
ventromedial prefrontal cortex.},
Journal = {Journal of Neuroscience},
Volume = {30},
Number = {7},
Pages = {2490-2495},
Year = {2010},
Month = {February},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20164333},
Abstract = {The core feature of an economic exchange is a decision to
trade one good for another, based on a comparison of
relative value. Economists have long recognized, however,
that the value an individual ascribes to a good during
decision making (i.e., their relative willingness to trade
for that good) does not always map onto the reward they
actually experience. Here, we show that experienced value
and decision value are represented in distinct regions of
ventromedial prefrontal cortex (VMPFC) during the passive
consumption of rewards. Participants viewed two categories
of rewards-images of faces that varied in their
attractiveness and monetary gains and losses-while being
scanned using functional magnetic resonance imaging. An
independent market task, in which participants exchanged
some of the money that they had earned for brief views of
attractive faces, determined the relative decision value
associated with each category. We found that activation of
anterior VMPFC increased with increasing experienced value,
but not decision value, for both reward categories. In
contrast, activation of posterior VMPFC predicted each
individual's relative decision value for face and monetary
stimuli. These results indicate not only that experienced
value and decision value are represented in distinct regions
of VMPFC, but also that decision value signals are evident
even in the absence of an overt choice task. We conclude
that decisions are made by comparing neural representations
of the value of different goods encoded in posterior VMPFC
in a common, relative currency.},
Doi = {10.1523/JNEUROSCI.3319-09.2010},
Key = {fds252300}
}
@article{fds252305,
Author = {Han, S and Huettel, SA and Raposo, A and Adcock, RA and Dobbins,
IG},
Title = {Functional significance of striatal responses during
episodic decisions: recovery or goal attainment?},
Journal = {Journal of Neuroscience},
Volume = {30},
Number = {13},
Pages = {4767-4775},
Year = {2010},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20357127},
Abstract = {Memory retrieval is typically a goal-directed behavior, and
as such, potentially influenced by reinforcement and
motivation processes. Although striatal activation is often
evident during memory retrieval, its functional significance
remains unclear because typical memory paradigms do not
control the motivational significance of memory decisions.
We used event-related functional magnetic resonance imaging
(fMRI) to investigate striatal activation during recognition
with and without performance-linked monetary incentives.
During initial performance in the absence of incentives,
dorsal striatal activation for "Old" memory conclusions
nonetheless exceeded that for "New" conclusions regardless
of the accuracy of these conclusions. In contrast,
subsequent scans paired incentives with either "Old" or
"New" conclusions and demonstrated greater activation for
whichever judgment was potentially rewarded, both with and
without performance feedback. The data demonstrate that
striatal activation during recognition judgments does not
signal monetary reward receipt, cognitive feedback, or
successful episodic retrieval. Instead, it is heavily
dependent upon satisfaction of the subjective goals of the
observer.},
Doi = {10.1523/JNEUROSCI.3077-09.2010},
Key = {fds252305}
}
@article{fds330850,
Author = {Wang, L and Newell, B and Mullette-Gillman, OA and Gadde, KM and Kuhn,
CM and McCarthy, G and Huettel, SA},
Title = {Modulation Effect of Rumination Trait and Low Tryptophan on
Default-Mode Network Connectivity},
Journal = {Biological Psychiatry},
Volume = {67},
Number = {9},
Pages = {224S-224S},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2010},
Month = {May},
Key = {fds330850}
}
@article{fds252298,
Author = {Carter, RMK and Meyer, JR and Huettel, SA},
Title = {Functional Neuroimaging of Intertemporal Choice Models: A
Review},
Journal = {Journal of Neuroscience, Psychology, and
Economics},
Volume = {3},
Number = {1},
Pages = {27-45},
Publisher = {American Psychological Association (APA)},
Year = {2010},
Month = {May},
ISSN = {1937-321X},
url = {http://dx.doi.org/10.1037/a0018046},
Abstract = {People often forsake a larger reward later for a smaller
reward sooner. The process of devaluing the larger, later
prize is called temporal discounting or delay discounting,
which lies at the core of intertemporal choice. Here, we
describe the methodology and findings of research on the
mechanisms of intertemporal choice, with a focus on those
that utilize functional MRI (fMRI). We consider the neural
bases for the most common economic models of intertemporal
choice and examine whether these models require neural
processes that are common or distinct across types of
decision making. Considered as a whole, current research
points to potentially distinct contributions from brain
systems associated with valuation and with prospective
thought, which may be reflected in separable foci in
posterior cingulate cortex. Based on open questions in the
field, we suggest two core goals for future research:
identifying aspects of valuation that are unique to
intertemporal choice and evaluating direct or indirect
interactions between delay and prize magnitude. © 2010
American Psychological Association.},
Doi = {10.1037/a0018046},
Key = {fds252298}
}
@article{fds252269,
Author = {Henninger, DE and Madden, DJ and Huettel, SA},
Title = {Processing speed and memory mediate age-related differences
in decision making.},
Journal = {Psychol Aging},
Volume = {25},
Number = {2},
Pages = {262-270},
Year = {2010},
Month = {June},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20545412},
Abstract = {Decision making under risk changes with age. Increases in
risk aversion with age have been most commonly
characterized, although older adults may be risk seeking in
some decision contexts. An important, and unanswered,
question is whether these changes in decision making reflect
a direct effect of aging or, alternatively, an indirect
effect caused by age-related changes in specific cognitive
processes. In the current study, older adults (M = 71 years)
and younger adults (M = 24 years) completed a battery of
tests of cognitive capacities and decision-making
preferences. The results indicated systematic effects of age
upon decision quality-with both increased risk seeking and
increased risk aversion observed in different
tasks-consistent with prior studies. Path analyses, however,
revealed that age-related effects were mediated by
individual differences in processing speed and memory. When
those variables were included in the model, age was no
longer a significant predictor of decision quality. The
authors conclude that the reduction in decision quality and
associated changes in risk preferences commonly ascribed to
aging are instead mediated by age-related changes in
underlying cognitive capacities.},
Doi = {10.1037/a0019096},
Key = {fds252269}
}
@article{fds252299,
Author = {Morey, RA and Selgrade, ES and Wagner, HR and Huettel, SA and Wang, L and McCarthy, G},
Title = {Scan-rescan reliability of subcortical brain volumes derived
from automated segmentation.},
Journal = {Hum Brain Mapp},
Volume = {31},
Number = {11},
Pages = {1751-1762},
Year = {2010},
Month = {November},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20162602},
Abstract = {Large-scale longitudinal studies of regional brain volume
require reliable quantification using automated segmentation
and labeling. However, repeated MR scanning of the same
subject, even if using the same scanner and acquisition
parameters, does not result in identical images due to small
changes in image orientation, changes in prescan parameters,
and magnetic field instability. These differences may lead
to appreciable changes in estimates of volume for different
structures. This study examined scan-rescan reliability of
automated segmentation algorithms for measuring several
subcortical regions, using both within-day and across-day
comparison sessions in a group of 23 normal participants. We
found that the reliability of volume measures including
percent volume difference, percent volume overlap (Dice's
coefficient), and intraclass correlation coefficient (ICC),
varied substantially across brain regions. Low reliability
was observed in some structures such as the amygdala (ICC =
0.6), with higher reliability (ICC = 0.9) for other
structures such as the thalamus and caudate. Patterns of
reliability across regions were similar for automated
segmentation with FSL/FIRST and FreeSurfer (longitudinal
stream). Reliability was associated with the volume of the
structure, the ratio of volume to surface area for the
structure, the magnitude of the interscan interval, and the
method of segmentation. Sample size estimates for detecting
changes in brain volume for a range of likely effect sizes
also differed by region. Thus, longitudinal research
requires a careful analysis of sample size and choice of
segmentation method combined with a consideration of the
brain structure(s) of interest and the magnitude of the
anticipated effects.},
Doi = {10.1002/hbm.20973},
Key = {fds252299}
}
@article{fds252301,
Author = {Smith, DV and Huettel, SA},
Title = {Decision neuroscience: neuroeconomics.},
Journal = {Wiley Interdisciplinary Reviews. Cognitive
Science},
Volume = {1},
Number = {6},
Pages = {854-871},
Year = {2010},
Month = {November},
ISSN = {1939-5078},
url = {http://dx.doi.org/10.1002/wcs.73},
Abstract = {Few aspects of human cognition are more personal than the
choices we make. Our decisions-from the mundane to the
impossibly complex-continually shape the courses of our
lives. In recent years, researchers have applied the tools
of neuroscience to understand the mechanisms that underlie
decision making, as part of the new discipline of decision
neuroscience. A primary goal of this emerging field has been
to identify the processes that underlie specific decision
variables, including the value of rewards, the uncertainty
associated with particular outcomes, and the consequences of
social interactions. Recent work suggests potential neural
substrates that integrate these variables, potentially
reflecting a common neural currency for value, to facilitate
value comparisons. Despite the successes of decision
neuroscience research for elucidating brain mechanisms,
significant challenges remain. These include building new
conceptual frameworks for decision making, integrating
research findings across disparate techniques and species,
and extending results from neuroscience to shape economic
theory. To overcome these challenges, future research will
likely focus on interpersonal variability in decision
making, with the eventual goal of creating biologically
plausible models for individual choice. WIREs Cogn Sci 2010
1 854-871 This article is categorized under: Psychology >
Reasoning and Decision Making Neuroscience >
Cognition.},
Doi = {10.1002/wcs.73},
Key = {fds252301}
}
@article{fds252240,
Author = {Huettel, SA},
Title = {Functional MRI (fMRI)},
Pages = {741-748},
Booktitle = {Encyclopedia of Spectroscopy and Spectrometry, 2nd
edition},
Publisher = {Elsevier},
Year = {2010},
Month = {December},
url = {http://dx.doi.org/10.1016/B978-0-12-374413-5.00053-1},
Abstract = {Functional magnetic resonance imaging (fMRI) allows
researchers to investigate the mechanisms underlying
information processing in the human brain. Most fMRI studies
use standard MRI scanners to collect images sensitive to
changes in blood oxygenation level-dependent (BOLD)
contrast, which provides an indirect measure of neuronal
activity. The images collected in BOLD fMRI experiments
generally have spatial resolution on the order of several
millimeters and temporal resolution on the order of several
seconds. fMRI provides several advantages over other human
neuroimaging techniques: it is noninvasive, can be adapted
to a wide range of experiments, and allows good localization
of activation. Because of these and other strengths, fMRI
has grown over the past two decades to become the dominant
technique in human cognitive neuroscience. However, fMRI
also has significant limitations, especially regarding the
conclusions that can be drawn from individual studies. This
article introduces the basic physical and physiological
principles of fMRI, followed by a consideration of the core
concepts involved in fMRI experimentation. © 2010 Elsevier
Ltd All rights reserved.},
Doi = {10.1016/B978-0-12-374413-5.00053-1},
Key = {fds252240}
}
@article{fds318720,
Author = {Paulsen, DJ and Carter, RM and Platt, ML and Huettel, SA and Brannon,
EM},
Title = {Neurocognitive development of risk aversion from early
childhood to adulthood.},
Journal = {Frontiers in Human Neuroscience},
Volume = {5},
Pages = {178},
Year = {2011},
url = {http://dx.doi.org/10.3389/fnhum.2011.00178},
Abstract = {Human adults tend to avoid risk. In behavioral economic
studies, risk aversion is manifest as a preference for sure
gains over uncertain gains. However, children tend to be
less averse to risk than adults. Given that many of the
brain regions supporting decision-making under risk do not
reach maturity until late adolescence or beyond it is
possible that mature risk-averse behavior may emerge from
the development of decision-making circuitry. To explore
this hypothesis, we tested 5- to 8-year-old children, 14- to
16-year-old adolescents, and young adults in a
risky-decision task during functional magnetic resonance
imaging (fMRI) data acquisition. To our knowledge, this is
the youngest sample of children in an fMRI decision-making
task. We found a number of decision-related brain regions to
increase in activation with age during decision-making,
including areas associated with contextual memory retrieval
and the incorporation of prior outcomes into the current
decision-making strategy, e.g., insula, hippocampus, and
amygdala. Further, children who were more risk-averse showed
increased activation during decision-making in ventromedial
prefrontal cortex and ventral striatum. Our findings
indicate that the emergence of adult levels of risk aversion
co-occurs with the recruitment of regions supporting
decision-making under risk, including the integration of
prior outcomes into current decision-making behavior. This
pattern of results suggests that individual differences in
the development of risk aversion may reflect differences in
the maturation of these neural processes.},
Doi = {10.3389/fnhum.2011.00178},
Key = {fds318720}
}
@article{fds252286,
Author = {Yaxley, RH and Van Voorhees and EE and Bergman, S and Hooper, SR and Huettel, SA and De Bellis, MD},
Title = {Behavioral risk elicits selective activation of the
executive system in adolescents: clinical
implications.},
Journal = {Frontiers in Psychiatry},
Volume = {2},
Pages = {68},
Year = {2011},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22194728},
Abstract = {We investigated adolescent brain processing of decisions
under conditions of varying risk, reward, and uncertainty.
Adolescents (n = 31) preformed a Decision-Reward
Uncertainty task that separates decision uncertainty into
behavioral and reward risk, while they were scanned using
functional magnetic resonance imaging. Behavioral risk
trials involved uncertainty about which action to perform to
earn a fixed monetary reward. In contrast, during reward
risk the decision that might lead to a reward was known, but
the likelihood of earning a reward was probabilistically
determined. Behavioral risk trials evoked greater activation
than the reward risk and no risk conditions in the anterior
cingulate, medial frontal gyrus, bilateral frontal poles,
bilateral inferior parietal lobe, precuneus, bilateral
superior-middle frontal gyrus, inferior frontal gyrus, and
insula. Our results were similar to those of young adults
using the same task (Huettel, 2006) except that adolescents
did not show significant activation in the posterior
supramarginal gyrus during behavioral risk. During the
behavioral risk condition regardless of reward outcome,
overall mean frontal pole activity showed a positive
correlation with age during the behavioral and reward risk
conditions suggesting a developmental difference of this
region of interest. Additionally, reward response to the
Decision-Reward Uncertainty task in adolescents was similar
to that seen in young adults (Huettel, 2006). Our data did
not show a correlation between age and mean ventral striatum
activity during the three conditions. While our results came
from a healthy high functioning non-maltreated sample of
adolescents, this method can be used to address types of
risks and reward processing in children and adolescents with
predisposing vulnerabilities and add to the paucity of
imaging studies of risk and reward processing during
adolescence.},
Doi = {10.3389/fpsyt.2011.00068},
Key = {fds252286}
}
@article{fds252291,
Author = {Paulsen, DJ and Platt, ML and Huettel, SA and Brannon,
EM},
Title = {Decision-making under risk in children, adolescents, and
young adults.},
Journal = {Frontiers in Psychology},
Volume = {2},
Pages = {72},
Year = {2011},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21687443},
Abstract = {Adolescents often make risky and impulsive decisions. Such
behavior has led to the common assumption that a dysfunction
in risk-related decision-making peaks during this age.
Differences in how risk has been defined across studies,
however, make it difficult to draw conclusions about
developmental changes in risky decision-making. Here, we
developed a non-symbolic economic decision-making task that
can be used across a wide age span and that uses coefficient
of variation (CV) in reward as an index of risk. We found
that young children showed the strongest preference for
risky compared to sure bet options of equal expected value,
adolescents were intermediate in their risk preference, and
young adults showed the strongest risk aversion.
Furthermore, children's preference for the risky option
increased for larger CVs, while adolescents and young adults
showed the opposite pattern, favoring the sure bet more
often as CV increased. Finally, when faced with two gambles
in a risk-return tradeoff, all three age groups exhibited a
greater preference for the option with the lower risk and
return as the disparity in risk between the two options
increased. These findings demonstrate clear age-related
differences in economic risk preferences that vary with
choice set and risk. Importantly, adolescence appears to
represent an intermediate decision-making phenotype along
the transition from childhood to adulthood, rather than an
age of heightened preference for economic
risk.},
Doi = {10.3389/fpsyg.2011.00072},
Key = {fds252291}
}
@article{fds198096,
Author = {Paulsen, D. and Platt, M.L. and Huettel, S.A. and Brannon,
E.M.},
Title = {Decision-making Under Risk in Children, Adolescents, and
Adults},
Journal = {Frontiers in Developmental Psychology},
Year = {2011},
url = {http://dx.doi.org/10.3389/fpsyg.2011.00072},
Doi = {10.3389/fpsyg.2011.00072},
Key = {fds198096}
}
@article{fds252254,
Author = {Libedinsky, C and Smith, D and Huettel, S and Chee,
MW},
Title = {REWARD VALUATION IN SLEEP-DEPRIVED INDIVIDUALS},
Journal = {Sleep},
Volume = {34},
Pages = {A78-A78},
Publisher = {OXFORD UNIV PRESS INC},
Year = {2011},
Month = {January},
ISSN = {0161-8105},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299834400220&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252254}
}
@article{fds252284,
Author = {Clithero, JA and Reeck, C and Carter, RM and Smith, DV and Huettel,
SA},
Title = {Nucleus accumbens mediates relative motivation for rewards
in the absence of choice.},
Journal = {Frontiers in Human Neuroscience},
Volume = {5},
Number = {AUGUST},
Pages = {87},
Year = {2011},
Month = {January},
ISSN = {1662-5161},
url = {http://dx.doi.org/10.3389/fnhum.2011.00087},
Abstract = {To dissociate a choice from its antecedent neural states,
motivation associated with the expected outcome must be
captured in the absence of choice. Yet, the neural
mechanisms that mediate behavioral idiosyncrasies in
motivation, particularly with regard to complex economic
preferences, are rarely examined in situations without overt
decisions. We employed functional magnetic resonance imaging
in a large sample of participants while they anticipated
earning rewards from two different modalities: monetary and
candy rewards. An index for relative motivation toward
different reward types was constructed using reaction times
to the target for earning rewards. Activation in the nucleus
accumbens (NAcc) and anterior insula (aINS) predicted
individual variation in relative motivation between our
reward modalities. NAcc activation, however, mediated the
effects of aINS, indicating the NAcc is the likely source of
this relative weighting. These results demonstrate that
neural idiosyncrasies in reward efficacy exist even in the
absence of explicit choices, and extend the role of NAcc as
a critical brain region for such choice-free
motivation.},
Doi = {10.3389/fnhum.2011.00087},
Key = {fds252284}
}
@article{fds252287,
Author = {Libedinsky, C and Smith, DV and Teng, CS and Namburi, P and Chen, VW and Huettel, SA and Chee, MWL},
Title = {Sleep deprivation alters valuation signals in the
ventromedial prefrontal cortex.},
Journal = {Frontiers in Behavioral Neuroscience},
Volume = {5},
Pages = {70},
Year = {2011},
Month = {January},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22028686},
Abstract = {Even a single night of total sleep deprivation (SD) can have
dramatic effects on economic decision making. Here we tested
the novel hypothesis that SD influences economic decisions
by altering the valuation process. Using functional magnetic
resonance imaging we identified value signals related to the
anticipation and the experience of monetary and social
rewards (attractive female faces). We then derived decision
value signals that were predictive of each participant's
willingness to exchange money for brief views of attractive
faces in an independent market task. Strikingly, SD altered
decision value signals in ventromedial prefrontal cortex
(VMPFC) in proportion to the corresponding change in
economic preferences. These changes in preference were
independent of the effects of SD on attention and vigilance.
Our results provide novel evidence that signals in VMPFC
track the current state of the individual, and thus reflect
not static but constructed preferences.},
Doi = {10.3389/fnbeh.2011.00070},
Key = {fds252287}
}
@article{fds290505,
Author = {Clithero, JA and Reeck, C and Mckell Carter and R and Smith, DV and Huettel, SA},
Title = {Nucleus accumbens mediates relative motivation for rewards
in the absence of choice},
Journal = {Frontiers in Human Neuroscience},
Number = {AUGUST},
Year = {2011},
Month = {January},
ISSN = {1662-5161},
url = {http://hdl.handle.net/10161/10252 Duke open
access},
Abstract = {To dissociate a choice from its antecedent neural states,
motivation associated with the expected outcome must be
captured in the absence of choice. Yet, the neural
mechanisms that mediate behavioral idiosyncrasies in
motivation, particularly with regard to complex economic
preferences, are rarely examined in situations without overt
decisions. We employed functional magnetic resonance imaging
in a large sample of participants while they anticipated
earning rewards from two different modalities: monetary and
candy rewards. An index for relative motivation toward
different reward types was constructed using reaction times
to the target for earning rewards. Activation in the nucleus
accumbens (NAcc) and anterior insula (aINS) predicted
individual variation in relative motivation between our
reward modalities. NAcc activation, however, mediated the
effects of aINS, indicating the NAcc is the likely source of
this relative weighting. These results demonstrate that
neural idiosyncrasies in reward efficacy exist even in the
absence of explicit choices, and extend the role of NAcc as
a critical brain region for such choice-free motivation. ©
2011 Clithero, Reeck, Carter, Smith and Huettel.},
Doi = {10.3389/fnhum.2011.00087},
Key = {fds290505}
}
@article{fds252292,
Author = {Taren, AA and Venkatraman, V and Huettel, SA},
Title = {A parallel functional topography between medial and lateral
prefrontal cortex: evidence and implications for cognitive
control.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {31},
Number = {13},
Pages = {5026-5031},
Year = {2011},
Month = {March},
ISSN = {0270-6474},
url = {http://dx.doi.org/10.1523/jneurosci.5762-10.2011},
Abstract = {The dorsomedial and dorsolateral prefrontal cortices (dmPFC
and dlPFC) together support cognitive control, with dmPFC
responsible for monitoring performance and dlPFC responsible
for adjusting behavior. The dlPFC contains a topographic
organization that reflects complexity of control demands,
with more anterior regions guiding increasingly abstract
processing. Recent evidence for a similar gradient within
dmPFC suggests the possibility of parallel, hierarchical
organization. Here, we measured connectivity between
functional nodes of dmPFC and dlPFC using resting-state
functional magnetic resonance imaging in humans. We found a
posterior-to-anterior connectivity gradient; posterior dmPFC
maximally connected to posterior dlPFC and anterior dmPFC
maximally connected to anterior dlPFC. This parallel
topographic pattern replicated across three independent
datasets collected on different scanners, within individual
participants, and through both point-to-point and voxelwise
analyses. We posit a model of cognitive control
characterized by hierarchical interactions--whose level
depends on current environmental demands--between functional
subdivisions of medial and lateral PFC.},
Doi = {10.1523/jneurosci.5762-10.2011},
Key = {fds252292}
}
@article{fds252293,
Author = {Venkatraman, V and Huettel, SA and Chuah, LYM and Payne, JW and Chee,
MWL},
Title = {Sleep deprivation biases the neural mechanisms underlying
economic preferences.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {31},
Number = {10},
Pages = {3712-3718},
Year = {2011},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21389226},
Abstract = {A single night of sleep deprivation (SD) evoked a strategy
shift during risky decision making such that healthy human
volunteers moved from defending against losses to seeking
increased gains. This change in economic preferences was
correlated with the magnitude of an SD-driven increase in
ventromedial prefrontal activation as well as by an
SD-driven decrease in anterior insula activation during
decision making. Analogous changes were observed during
receipt of reward outcomes: elevated activation to gains in
ventromedial prefrontal cortex and ventral striatum, but
attenuated anterior insula activation following losses.
Finally, the observed shift in economic preferences was not
correlated with change in psychomotor vigilance. These
results suggest that a night of total sleep deprivation
affects the neural mechanisms underlying economic
preferences independent of its effects on vigilant
attention.},
Doi = {10.1523/jneurosci.4407-10.2011},
Key = {fds252293}
}
@article{fds252285,
Author = {Stanton, SJ and Mullette-Gillman, OA and McLaurin, RE and Kuhn, CM and LaBar, KS and Platt, ML and Huettel, SA},
Title = {Low- and high-testosterone individuals exhibit decreased
aversion to economic risk.},
Journal = {Psychol Sci},
Volume = {22},
Number = {4},
Pages = {447-453},
Year = {2011},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21393575},
Abstract = {Testosterone is positively associated with risk-taking
behavior in social domains (e.g., crime, physical
aggression). However, the scant research linking
testosterone to economic risk preferences presents
inconsistent findings. We examined the relationship between
endogenous testosterone and individuals' economic
preferences (i.e., risk preference, ambiguity preference,
and loss aversion) in a large sample (N = 298) of men and
women. We found that endogenous testosterone levels have a
significant U-shaped association with individuals' risk and
ambiguity preferences, but not loss aversion. Specifically,
individuals with low or high levels of testosterone (more
than 1.5 SD from the mean for their gender) were risk and
ambiguity neutral, whereas individuals with intermediate
levels of testosterone were risk and ambiguity averse. This
relationship was highly similar in men and women. In
contrast to received wisdom regarding testosterone and risk,
the present data provide the first robust evidence for a
nonlinear association between economic preferences and
levels of endogenous testosterone.},
Doi = {10.1177/0956797611401752},
Key = {fds252285}
}
@article{fds252297,
Author = {Winecoff, A and Labar, KS and Madden, DJ and Cabeza, R and Huettel,
SA},
Title = {Cognitive and neural contributors to emotion regulation in
aging.},
Journal = {Soc Cogn Affect Neurosci},
Volume = {6},
Number = {2},
Pages = {165-176},
Year = {2011},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20385663},
Abstract = {Older adults, compared to younger adults, focus on emotional
well-being. While the lifespan trajectory of emotional
processing and its regulation has been characterized
behaviorally, few studies have investigated the underlying
neural mechanisms. Here, older adults (range: 59-73 years)
and younger adults (range: 19-33 years) participated in a
cognitive reappraisal task during functional magnetic
resonance imaging (fMRI) scanning. On each trial,
participants viewed positive, negative or neutral pictures
and either naturally experienced the image ('Experience'
condition) or attempted to detach themselves from the image
('Reappraise' condition). Across both age groups, cognitive
reappraisal activated prefrontal regions similar to those
reported in prior studies of emotion regulation, while
emotional experience activated the bilateral amygdala.
Psychophysiological interaction analyses revealed that the
left inferior frontal gyrus (IFG) and amygdala demonstrated
greater inverse connectivity during the 'Reappraise'
condition relative to the 'Experience' condition. The only
regions exhibiting significant age differences were the left
IFG and the left superior temporal gyrus, for which greater
regulation-related activation was observed in younger
adults. Controlling for age, increased performance on
measures of cognition predicted greater regulation-related
decreases in amygdala activation. Thus, while older and
younger adults use similar brain structures for emotion
regulation and experience, the functional efficacy of those
structures depends on underlying cognitive
ability.},
Doi = {10.1093/scan/nsq030},
Key = {fds252297}
}
@article{fds252295,
Author = {Clithero, JA and Smith, DV and Carter, RM and Huettel,
SA},
Title = {Within- and cross-participant classifiers reveal different
neural coding of information.},
Journal = {Neuroimage},
Volume = {56},
Number = {2},
Pages = {699-708},
Year = {2011},
Month = {May},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2010.03.057},
Abstract = {Analyzing distributed patterns of brain activation using
multivariate pattern analysis (MVPA) has become a popular
approach for using functional magnetic resonance imaging
(fMRI) data to predict mental states. While the majority of
studies currently build separate classifiers for each
participant in the sample, in principle a single classifier
can be derived from and tested on data from all
participants. These two approaches, within- and
cross-participant classification, rely on potentially
different sources of variability and thus may provide
distinct information about brain function. Here, we used
both approaches to identify brain regions that contain
information about passively received monetary rewards (i.e.,
images of currency that influenced participant payment) and
social rewards (i.e., images of human faces). Our
within-participant analyses implicated regions in the
ventral visual processing stream-including fusiform gyrus
and primary visual cortex-and ventromedial prefrontal cortex
(VMPFC). Two key results indicate these regions may contain
statistically discriminable patterns that contain different
informational representations. First, cross-participant
analyses implicated additional brain regions, including
striatum and anterior insula. The cross-participant analyses
also revealed systematic changes in predictive power across
brain regions, with the pattern of change consistent with
the functional properties of regions. Second, individual
differences in classifier performance in VMPFC were related
to individual differences in preferences between our two
reward modalities. We interpret these results as reflecting
a distinction between patterns showing participant-specific
functional organization and those indicating aspects of
brain organization that generalize across
individuals.},
Doi = {10.1016/j.neuroimage.2010.03.057},
Key = {fds252295}
}
@article{fds252290,
Author = {Mullette-Gillman, OA and Detwiler, JM and Winecoff, A and Dobbins, I and Huettel, SA},
Title = {Infrequent, task-irrelevant monetary gains and losses engage
dorsolateral and ventrolateral prefrontal
cortex.},
Journal = {Brain Research},
Volume = {1395},
Pages = {53-61},
Year = {2011},
Month = {June},
ISSN = {0006-8993},
url = {http://dx.doi.org/10.1016/j.brainres.2011.04.026},
Abstract = {Decision making is commonly conceived to reflect the
interplay of mutually antagonistic systems: executive
processes must inhibit affective information to make
adaptive choices. Consistent with this interpretation, prior
studies have shown that the dorsolateral prefrontal cortex
(dlPFC) is activated by executive processing and deactivated
during emotional processing, with the reverse pattern found
within the ventrolateral prefrontal cortex (vlPFC). To
evaluate whether this pattern generalizes to other affective
stimuli--here, monetary rewards--we modified the emotional
oddball task to use behaviorally irrelevant reward stimuli,
while matching analysis methods and task parameters to those
of previous research. Contrary to the double-dissociation
model advanced for emotional stimuli, we found that monetary
stimuli produced activations within both the dlPFC and the
vlPFC. This suggests that monetary stimuli are treated like
affective stimuli by vlPFC but like task-relevant target
stimuli by dlPFC. Our results suggest differential
functional roles in affective and executive processing for
these brain regions: the dlPFC supports contingency
processing, while the vlPFC evaluates affective or
conceptual information.},
Doi = {10.1016/j.brainres.2011.04.026},
Key = {fds252290}
}
@article{fds252294,
Author = {Raposo, A and Vicens, L and Clithero, JA and Dobbins, IG and Huettel,
SA},
Title = {Contributions of frontopolar cortex to judgments about self,
others and relations.},
Journal = {Social Cognitive and Affective Neuroscience},
Volume = {6},
Number = {3},
Pages = {260-269},
Year = {2011},
Month = {June},
ISSN = {1749-5016},
url = {http://dx.doi.org/10.1093/scan/nsq033},
Abstract = {Activation in frontopolar cortex (FPC; BA 10) has been
associated both with attending to mental states and with
integrating multiple mental relations. However, few previous
studies have manipulated both of these cognitive processes,
precluding a clear functional distinction among regions
within FPC. To address this issue, we developed an fMRI task
that combined mentalizing and relational integration
processes. Participants saw blocks of single words and
performed one of three judgments: how pleasant or unpleasant
they found each word (Self condition), how a specific friend
would evaluate the pleasantness of the word (Other
condition), or the difference between their own pleasantness
judgment and that of their friend (Relational condition). We
found that medial FPC was modulated by Other relative to
Self judgments, consistent with a role in mentalizing.
Lateral FPC was significantly activated during Relational
compared to Self judgements, suggesting that this region is
particularly involved in relational integration. The results
point to a strong functional dissociation between medial and
lateral FPC. In addition, the data demonstrate a role for
lateral FPC in the social domain, provided that the task
requires the integration of one's preferences with those of
others.},
Doi = {10.1093/scan/nsq033},
Key = {fds252294}
}
@article{fds252289,
Author = {Ballard, IC and Murty, VP and Carter, RM and MacInnes, JJ and Huettel,
SA and Adcock, RA},
Title = {Dorsolateral prefrontal cortex drives mesolimbic
dopaminergic regions to initiate motivated
behavior.},
Journal = {Journal of Neuroscience},
Volume = {31},
Number = {28},
Pages = {10340-10346},
Year = {2011},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21753011},
Abstract = {How does the brain translate information signaling potential
rewards into motivation to get them? Motivation to obtain
reward is thought to depend on the midbrain [particularly
the ventral tegmental area (VTA)], the nucleus accumbens
(NAcc), and the dorsolateral prefrontal cortex (dlPFC), but
it is not clear how the interactions among these regions
relate to reward-motivated behavior. To study the influence
of motivation on these reward-responsive regions and on
their interactions, we used dynamic causal modeling to
analyze functional magnetic resonance imaging (fMRI) data
from humans performing a simple task designed to isolate
reward anticipation. The use of fMRI permitted the
simultaneous measurement of multiple brain regions while
human participants anticipated and prepared for
opportunities to obtain reward, thus allowing
characterization of how information about reward changes
physiology underlying motivational drive. Furthermore, we
modeled the impact of external reward cues on causal
relationships within this network, thus elaborating a link
between physiology, connectivity, and motivation.
Specifically, our results indicated that dlPFC was the
exclusive entry point of information about reward in this
network, and that anticipated reward availability caused VTA
activation only via its effect on the dlPFC. Anticipated
reward thus increased dlPFC activation directly, whereas it
influenced VTA and NAcc only indirectly, by enhancing
intrinsically weak or inactive pathways from the dlPFC. Our
findings of a directional prefrontal influence on
dopaminergic regions during reward anticipation suggest a
model in which the dlPFC integrates and transmits
representations of reward to the mesolimbic and mesocortical
dopamine systems, thereby initiating motivated
behavior.},
Doi = {10.1523/JNEUROSCI.0895-11.2011},
Key = {fds252289}
}
@misc{fds252288,
Author = {Stanton, SJ and Mullette-Gillman, OA and Huettel,
SA},
Title = {Seasonal variation of salivary testosterone in men, normally
cycling women, and women using hormonal contraceptives.},
Journal = {Physiology & Behavior},
Volume = {104},
Number = {5},
Pages = {804-808},
Year = {2011},
Month = {October},
ISSN = {0031-9384},
url = {http://dx.doi.org/10.1016/j.physbeh.2011.07.009},
Abstract = {Humans' endogenous testosterone concentrations vary over a
number of temporal scales, with little known about variation
longer than monthly cycles. Past studies of seasonal or
circannual variation have principally used male participants
and have produced inconsistent results. Thus, little is
known about how testosterone concentrations fluctuate
throughout the year, whether such variation differs between
men and women, and whether there are influences of hormonal
contraceptive use. The present study collected saliva
samples from a large sample (N=718) of men and women, each
collected at one time point within a relatively uniform
distribution over a full calendar year. Both men and
normally-cycling women displayed seasonal variation in
salivary testosterone concentrations, such that testosterone
concentrations are maximal in the fall and minimal in the
summer. Notably, normally-cycling women had testosterone
concentrations that were over 100% greater at their maximum
in fall compared to their minimum in summer. Women using
hormonal contraceptives not only had consistently lower
endogenous testosterone concentrations, but also showed a
flatter seasonal testosterone profile. The implications for
studies of psychology and human behavioral endocrinology are
discussed.},
Doi = {10.1016/j.physbeh.2011.07.009},
Key = {fds252288}
}
@article{fds252274,
Author = {Paulsen, DJ and Platt, ML and Huettel, SA and Brannon,
EM},
Title = {From risk-seeking to risk-averse: the development of
economic risk preference from childhood to
adulthood.},
Journal = {Frontiers in Psychology},
Volume = {3},
Pages = {313},
Year = {2012},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22973247},
Abstract = {Adolescence is often described as a period of heightened
risk-taking. Adolescents are notorious for impulsivity,
emotional volatility, and risky behaviors such as drinking
and driving under the influence of alcohol. By contrast, we
found that risk-taking declines linearly from childhood to
adulthood when individuals make choices over monetary
gambles. Further, with age we found increases in the
sensitivity to economic risk, defined as the degree to which
a preference for assured monetary gains over a risky payoff
depends upon the variability in the risky payoff. These
findings indicate that decisions about economic risk may
follow a different developmental trajectory than other kinds
of risk-taking, and that changes in sensitivity to risk may
be a major factor in the development of mature risk
aversion.},
Doi = {10.3389/fpsyg.2012.00313},
Key = {fds252274}
}
@article{fds252283,
Author = {Venkatraman, V and Clithero, JA and Fitzsimons, G and Huettel,
SA},
Title = {New scanner data for brand marketers: How neuroscience can
help better understand differences in brand
preferences},
Journal = {Journal of Consumer Psychology},
Volume = {22},
Number = {1},
Pages = {143-153},
Publisher = {WILEY},
Year = {2012},
ISSN = {1057-7408},
url = {http://dx.doi.org/10.1016/j.jcps.2011.11.008},
Abstract = {A core goal for marketers is effective segmentation:
partitioning a brand's or product's consumer base into
distinct and meaningful groups with differing needs.
Traditional segmentation data include factors like
geographic location, demographics, and shopping history.
Yet, research into the cognitive and affective processes
underlying consumption decisions shows that these variables
can improve the matching of consumers with products beyond
traditional demographic and benefit approaches. We propose,
using managing a brand as an example, that neuroscience
provides a novel way to establish mappings between cognitive
processes and traditional marketing data. An improved
understanding of the neural mechanisms of decision making
will enhance the ability of marketers to effectively market
their products. Just as neuroscience can model potential
influences on the decision process. -including pricing,
choice strategy, context, experience, and memory. -it can
also provide new insights into individual differences in
consumption behavior and brand preferences. We outline such
a research agenda for incorporating neuroscience data into
future attempts to match consumers to brands. © 2011
Society for Consumer Psychology.},
Doi = {10.1016/j.jcps.2011.11.008},
Key = {fds252283}
}
@article{fds252276,
Author = {Kragel, PA and Carter, RM and Huettel, SA},
Title = {What makes a pattern? Matching decoding methods to data in
multivariate pattern analysis.},
Journal = {Frontiers in Neuroscience},
Volume = {6},
Number = {NOV},
Pages = {162},
Year = {2012},
Month = {January},
ISSN = {1662-4548},
url = {http://dx.doi.org/10.3389/fnins.2012.00162},
Abstract = {Research in neuroscience faces the challenge of integrating
information across different spatial scales of brain
function. A promising technique for harnessing information
at a range of spatial scales is multivariate pattern
analysis (MVPA) of functional magnetic resonance imaging
(fMRI) data. While the prevalence of MVPA has increased
dramatically in recent years, its typical implementations
for classification of mental states utilize only a subset of
the information encoded in local fMRI signals. We review
published studies employing multivariate pattern
classification since the technique's introduction, which
reveal an extensive focus on the improved detection power
that linear classifiers provide over traditional analysis
techniques. We demonstrate using simulations and a
searchlight approach, however, that non-linear classifiers
are capable of extracting distinct information about
interactions within a local region. We conclude that for
spatially localized analyses, such as searchlight and region
of interest, multiple classification approaches should be
compared in order to match fMRI analyses to the properties
of local circuits.},
Doi = {10.3389/fnins.2012.00162},
Key = {fds252276}
}
@article{fds252280,
Author = {Coutlee, CG and Huettel, SA},
Title = {The functional neuroanatomy of decision making: prefrontal
control of thought and action.},
Journal = {Brain Research},
Volume = {1428},
Pages = {3-12},
Year = {2012},
Month = {January},
ISSN = {0006-8993},
url = {http://dx.doi.org/10.1016/j.brainres.2011.05.053},
Abstract = {Humans exhibit a remarkable capacity for flexible thought
and action. Despite changing internal needs and external
context, individuals maintain stable goals and pursue
purposeful action. Functional neuroimaging research
examining the neural underpinnings of such behavioral
flexibility has progressed within several distinct
traditions, as evident in the largely separate literatures
on "cognitive control" and on "decision making." Both topics
investigate the formulation of desires and intentions, the
integration of knowledge and context, and the resolution of
conflict and uncertainty. Additionally, each recognizes the
fundamental role of the prefrontal cortex in supporting
flexible selection of behavior. But despite this notable
overlap, neuroimaging studies in cognitive control and
decision making have exerted only limited influence on each
other, in part due to differences in their theoretical and
experimental groundings. Additionally, the precise
organization of control processing within prefrontal cortex
has remained unclear, fostering an acceptance of vague
descriptions of decision making in terms of canonical
cognitive control functions such as "inhibition" or
"self-control." We suggest a unifying role for models of the
hierarchical organization of action selection within
prefrontal cortex. These models provide an important
conceptual link between decision-making phenomena and
cognitive-control processes, potentially facilitating
cross-fertilization between these topics.},
Doi = {10.1016/j.brainres.2011.05.053},
Key = {fds252280}
}
@article{fds252282,
Author = {Paulsen, DJ and Carter, RMK and Platt, ML and Huettel, SA and Brannon,
EM},
Title = {Neurocognitive development of risk aversion from early
childhood to adulthood},
Journal = {Frontiers in Human Neuroscience},
Volume = {5},
Number = {JANUARY 2012},
Pages = {1-17},
Publisher = {FRONTIERS MEDIA SA},
Year = {2012},
Month = {January},
ISSN = {1662-5161},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000299563000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Abstract = {Human adults tend to avoid risk. In behavioral economic
studies, risk aversion is manifest as a preference for sure
gains over uncertain gains. However, children tend to be
less averse to risk than adults. Given that many of the
brain regions supporting decision-making under risk do not
reach maturity until late adolescence or beyond it is
possible that mature risk-averse behavior may emerge from
the development of decision-making circuitry. To explore
this hypothesis, we tested 5- to 8-year-old children, 14- to
16-year-old adolescents, and young adults in a
risky-decision task during functional magnetic resonance
imaging (fMRI) data acquisition. To our knowledge, this is
the youngest sample of children in an fMRI decision-making
task. We found a number of decision-related brain regions to
increase in activation with age during decision-making,
including areas associated with contextual memory retrieval
and the incorporation of prior outcomes into the current
decision-making strategy, e.g., insula, hippocampus, and
amygdala. Further, children who were more riskaverse showed
increased activation during decision-making in ventromedial
prefrontal cortex and ventral striatum. Our findings
indicate that the emergence of adult levels of risk aversion
co-occurs with the recruitment of regions supporting
decision-making under risk, including the integration of
prior outcomes into current decision-making behavior. This
pattern of results suggests that individual differences in
the development of risk aversion may reflect differences in
the maturation of these neural processes. © 2012 Paulsen,
Carter, Platt, Huettel and Brannon.},
Doi = {10.3389/fnhum.2011.00178},
Key = {fds252282}
}
@article{fds252278,
Author = {Engell, AD and Huettel, S and McCarthy, G},
Title = {The fMRI BOLD signal tracks electrophysiological spectral
perturbations, not event-related potentials.},
Journal = {Neuroimage},
Volume = {59},
Number = {3},
Pages = {2600-2606},
Year = {2012},
Month = {February},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21925278},
Abstract = {Functional magnetic resonance imaging (fMRI) and
electroencephalography (EEG) are primary tools of the
psychological neurosciences. It is therefore important to
understand the relationship between hemodynamic and
electrophysiological responses. An early study by Huettel
and colleagues found that the coupling of fMRI
blood-oxygen-level-dependent signal (BOLD) and
subdurally-recorded signal-averaged event-related potentials
(ERPs) was not consistent across brain regions. Instead, a
growing body of evidence now indicates that hemodynamic
changes measured by fMRI reflect non-phase-locked changes in
high frequency power rather than the phase-locked ERP. Here,
we revisit the data from Huettel and colleagues and measure
event-related spectral perturbations (ERSPs) to examine the
time course of frequency changes. We found that, unlike the
ERP, γ-ERSP power was consistently coupled with the
hemodynamic response across three visual cortical regions.
Stimulus duration modulated the BOLD signal and the γ-ERSP
in the peri-calcarine and fusiform cortices, whereas there
was no such modulation of either physiological signal in the
lateral temporal-occipital cortex. This finding reconciles
the original report with the more recent literature and
demonstrates that the ERP and ERSP reflect dissociable
aspects of neural activity.},
Doi = {10.1016/j.neuroimage.2011.08.079},
Key = {fds252278}
}
@article{fds252279,
Author = {Huettel, SA and Kranton, RE},
Title = {Identity economics and the brain: uncovering the mechanisms
of social conflict.},
Journal = {Philosophical Transactions of the Royal Society of London.
Series B, Biological Sciences},
Volume = {367},
Number = {1589},
Pages = {680-691},
Year = {2012},
Month = {March},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22271784},
Abstract = {Social contexts can have dramatic effects on decisions. When
individuals recognize each other as coming from the same
social group, they can coordinate their actions towards a
common goal. Conversely, information about group differences
can lead to conflicts both economic and physical.
Understanding how social information shapes decision
processes is now a core goal both of behavioural economics
and neuroeconomics. Here, we describe the foundations for
research that combines the theoretical framework from
identity economics with the experimental methods of
neuroscience. Research at this intersection would fill
important gaps in the literature not addressed by current
approaches in either of these disciplines, nor within social
neuroscience, psychology or other fields. We set forth a
simple taxonomy of social contexts based on the information
content they provide. And, we highlight the key questions
that would be addressed by a new 'identity neuroeconomics'.
Such research could serve as an important and novel link
between the social and natural sciences.},
Doi = {10.1098/rstb.2011.0264},
Key = {fds252279}
}
@article{fds252272,
Author = {Venkatraman, V and Huettel, SA},
Title = {Strategic control in decision-making under
uncertainty.},
Journal = {The European Journal of Neuroscience},
Volume = {35},
Number = {7},
Pages = {1075-1082},
Year = {2012},
Month = {April},
ISSN = {0953-816X},
url = {http://dx.doi.org/10.1111/j.1460-9568.2012.08009.x},
Abstract = {Complex economic decisions - whether investing money for
retirement or purchasing some new electronic gadget - often
involve uncertainty about the likely consequences of our
choices. Critical for resolving that uncertainty are
strategic meta-decision processes, which allow people to
simplify complex decision problems, evaluate outcomes
against a variety of contexts, and flexibly match behavior
to changes in the environment. In recent years, substantial
research has implicated the dorsomedial prefrontal cortex
(dmPFC) in the flexible control of behavior. However, nearly
all such evidence comes from paradigms involving executive
function or response selection, not complex decision-making.
Here, we review evidence that demonstrates that the dmPFC
contributes to strategic control in complex decision-making.
This region contains a functional topography such that the
posterior dmPFC supports response-related control, whereas
the anterior dmPFC supports strategic control. Activation in
the anterior dmPFC signals changes in how a decision problem
is represented, which in turn can shape computational
processes elsewhere in the brain. Based on these findings,
we argue for both generalized contributions of the dmPFC to
cognitive control, and specific computational roles for its
subregions depending upon the task demands and context. We
also contend that these strategic considerations are likely
to be critical for decision-making in other domains,
including interpersonal interactions in social
settings.},
Doi = {10.1111/j.1460-9568.2012.08009.x},
Key = {fds252272}
}
@article{fds252273,
Author = {Yoon, C and Gonzalez, R and Bechara, A and Berns, GS and Dagher, AA and Dubé, L and Huettel, SA and Kable, JW and Liberzon, I and Plassmann, H and Smidts, A and Spence, C},
Title = {Decision neuroscience and consumer decision
making},
Journal = {Marketing Letters},
Volume = {23},
Number = {2},
Pages = {473-485},
Publisher = {Springer Nature},
Year = {2012},
Month = {June},
ISSN = {0923-0645},
url = {http://dx.doi.org/10.1007/s11002-012-9188-z},
Abstract = {This article proposes that neuroscience can shape future
theory and models in consumer decision making and suggests
ways that neuroscience methods can be used in
decision-making research. The article argues that
neuroscience facilitates better theory development and
empirical testing by considering the physiological context
and the role of constructs such as hunger, stress, and
social influence on consumer choice and preferences.
Neuroscience can also provide new explanations for different
sources of heterogeneity within and across populations,
suggest novel hypotheses with respect to choices and
underlying mechanisms that accord with an understanding of
biology, and allow for the use of neural data to make better
predictions about consumer behavior. The article suggests
that despite some challenges associated with incorporating
neuroscience into research on consumer decision processes,
the use of neuroscience paradigms will produce a deeper
understanding of decision making that can lead to the
development of more effective decision aids and
interventions. © 2012 Springer Science+Business Media,
LLC.},
Doi = {10.1007/s11002-012-9188-z},
Key = {fds252273}
}
@article{fds252281,
Author = {Carter, RM and Bowling, DL and Reeck, C and Huettel,
SA},
Title = {A distinct role of the temporal-parietal junction in
predicting socially guided decisions.},
Journal = {Science (New York, N.Y.)},
Volume = {337},
Number = {6090},
Pages = {109-111},
Year = {2012},
Month = {July},
ISSN = {0036-8075},
url = {http://dx.doi.org/10.1126/science.1219681},
Abstract = {To make adaptive decisions in a social context, humans must
identify relevant agents in the environment, infer their
underlying strategies and motivations, and predict their
upcoming actions. We used functional magnetic resonance
imaging, in conjunction with combinatorial multivariate
pattern analysis, to predict human participants' subsequent
decisions in an incentive-compatible poker game. We found
that signals from the temporal-parietal junction provided
unique information about the nature of the upcoming
decision, and that information was specific to decisions
against agents who were both social and relevant for future
behavior.},
Doi = {10.1126/science.1219681},
Key = {fds252281}
}
@article{fds252277,
Author = {Huettel, SA},
Title = {Event-related fMRI in cognition.},
Journal = {Neuroimage},
Volume = {62},
Number = {2},
Pages = {1152-1156},
Year = {2012},
Month = {August},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2011.08.113},
Abstract = {A primary advantage of functional magnetic resonance imaging
(fMRI) over other techniques in neuroscience is its
flexibility. Researchers have used fMRI to study a
remarkable diversity of topics, from basic processes of
perception and memory, to the complex mechanisms of economic
decision making and moral cognition. The chief contributor
to this experimental flexibility-indeed, to the growth of
fMRI itself-has been the development of event-related
experimental designs and associated analyses. The core idea
of an event-related design, as first articulated in the late
1990s, is the separation of cognitive processes into
discrete points in time (i.e., "events") allowing
differentiation of their associated fMRI signals. By
modeling brain function as a series of transient changes,
rather than as an ongoing state, event-related fMRI allowed
researchers to create much more complex paradigms and more
dynamic analysis methods. Yet, this flexibility came with a
cost. As the complexity of experimental designs increased,
fMRI analyses became increasingly abstracted from the
original data, which in turn has had consequences both
positive (e.g., greater use of model-based fMRI) and
negative (e.g., fewer articles plot the timing of
activation). And, as event-related methods have become
ubiquitous, they no longer represent a distinct category of
fMRI research. In a real sense, event-related fMRI has now
become, simply, fMRI.},
Doi = {10.1016/j.neuroimage.2011.08.113},
Key = {fds252277}
}
@article{fds252275,
Author = {Levallois, C and Clithero, JA and Wouters, P and Smidts, A and Huettel,
SA},
Title = {Translating upwards: linking the neural and social sciences
via neuroeconomics.},
Journal = {Nature Reviews. Neuroscience},
Volume = {13},
Number = {11},
Pages = {789-797},
Year = {2012},
Month = {November},
ISSN = {1471-003X},
url = {http://dx.doi.org/10.1038/nrn3354},
Abstract = {The social and neural sciences share a common interest in
understanding the mechanisms that underlie human behaviour.
However, interactions between neuroscience and social
science disciplines remain strikingly narrow and tenuous. We
illustrate the scope and challenges for such interactions
using the paradigmatic example of neuroeconomics. Using
quantitative analyses of both its scientific literature and
the social networks in its intellectual community, we show
that neuroeconomics now reflects a true disciplinary
integration, such that research topics and scientific
communities with interdisciplinary span exert greater
influence on the field. However, our analyses also reveal
key structural and intellectual challenges in balancing the
goals of neuroscience with those of the social sciences. To
address these challenges, we offer a set of prescriptive
recommendations for directing future research in
neuroeconomics.},
Doi = {10.1038/nrn3354},
Key = {fds252275}
}
@article{fds220100,
Author = {Stanton, S.J. and Reeck, C. and Huettel, S.A. and LaBar,
K.S.},
Title = {Affective states and cognitive contexts: Induced moods alter
the influence of frames on economic choices},
Journal = {Judgment and Decision Making},
Year = {2013},
Key = {fds220100}
}
@article{fds252250,
Author = {Appelbaum, L and Beam, E and Jack, J and Moody, J and Huettel,
S},
Title = {NEURORHETORIC: MAPPING THE SEMANTIC STRUCTURE OF COGNITIVE
NEUROSCIENCE},
Journal = {Journal of Cognitive Neuroscience},
Pages = {260-261},
Publisher = {M I T PRESS},
Year = {2013},
Month = {January},
ISSN = {0898-929X},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000317030501416&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252250}
}
@article{fds330180,
Author = {Martin, RS and Appelbaum, LG and Huettel, SA and Woldorff,
MG},
Title = {NEURAL SIGNATURES OF VALUE-DRIVEN ATTENTIONAL CAPTURE
PREDICT INDIVIDUAL DIFFERENCES IN ECONOMIC
CHOICE},
Journal = {Journal of Cognitive Neuroscience},
Pages = {208-208},
Publisher = {M I T PRESS},
Year = {2013},
Month = {January},
Key = {fds330180}
}
@article{fds252229,
Author = {Ruff, CC and Huettel, SA},
Title = {Experimental Methods in Cognitive Neuroscience},
Pages = {77-108},
Booktitle = {Neuroeconomics (2nd Edition)},
Publisher = {Elsevier},
Editor = {Glimcher, P. and Fehr, E.},
Year = {2013},
Month = {January},
url = {http://dx.doi.org/10.1016/B978-0-12-416008-8.00006-1},
Abstract = {The growth of neuroeconomics as an academic discipline has
been inextricably tied to the development of research
methods to study brain function and its relationship to
behavior. The aim of this chapter is to give an overview of
these methods at a cursory level, while at the same time
referring the reader to excellent textbooks and primary
research articles for more in-depth information. The chapter
focuses primarily on the conceptual issues involved in
choosing a research technique and evaluating results using
different techniques. As such, it is primarily intended for
those who are new to neuroeconomics and cognitive
neuroscience and who seek guidance on how to evaluate the
strengths and limitations of published work. Accordingly,
each technique is introduced in conjunction with specific
examples drawn from recent neuroeconomic studies. © 2014
Elsevier Inc. All rights reserved.},
Doi = {10.1016/B978-0-12-416008-8.00006-1},
Key = {fds252229}
}
@article{fds252245,
Author = {Carter, RM and Huettel, SA},
Title = {Learning from silver linings.},
Journal = {Frontiers in Neuroscience},
Volume = {7},
Pages = {80},
Year = {2013},
Month = {January},
ISSN = {1662-4548},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23734092},
Doi = {10.3389/fnins.2013.00080},
Key = {fds252245}
}
@article{fds252247,
Author = {Camerer, C and Smith, A and Kuhnen, CM and Wargo, DT and Samanez-Larkin,
G and Montague, R and Levy, DJ and Smith, D and Meshi, D and Kenning, PH and Clithero, J and Weber, B and Hare, T and Huettel, S and Josephson, C and d'Acremont, M and Knoch, D and Krajbich, I and De Martino and B and Mohr,
PNC and Barton, J and Halko, M-L and Chick, CF and Gianotti, L and Heekeren, HR},
Title = {Correspondence Are Cognitive Functions Localizable?},
Journal = {The Journal of Economic Perspectives : a Journal of the
American Economic Association},
Volume = {27},
Number = {2},
Pages = {247-250},
Publisher = {AMER ECONOMIC ASSOC},
Year = {2013},
Month = {March},
ISSN = {0895-3309},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318610700012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92},
Key = {fds252247}
}
@article{fds252248,
Author = {San Martín and R and Appelbaum, LG and Pearson, JM and Huettel, SA and Woldorff, MG},
Title = {Rapid brain responses independently predict gain
maximization and loss minimization during economic decision
making.},
Journal = {Journal of Neuroscience},
Volume = {33},
Number = {16},
Pages = {7011-7019},
Year = {2013},
Month = {April},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23595758},
Abstract = {Success in many decision-making scenarios depends on the
ability to maximize gains and minimize losses. Even if an
agent knows which cues lead to gains and which lead to
losses, that agent could still make choices yielding
suboptimal rewards. Here, by analyzing event-related
potentials (ERPs) recorded in humans during a probabilistic
gambling task, we show that individuals' behavioral
tendencies to maximize gains and to minimize losses are
associated with their ERP responses to the receipt of those
gains and losses, respectively. We focused our analyses on
ERP signals that predict behavioral adjustment: the
frontocentral feedback-related negativity (FRN) and two P300
(P3) subcomponents, the frontocentral P3a and the parietal
P3b. We found that, across participants, gain maximization
was predicted by differences in amplitude of the P3b for
suboptimal versus optimal gains (i.e., P3b amplitude
difference between the least good and the best gains).
Conversely, loss minimization was predicted by differences
in the P3b amplitude to suboptimal versus optimal losses
(i.e., difference between the worst and the least bad
losses). Finally, we observed that the P3a and P3b, but not
the FRN, predicted behavioral adjustment on subsequent
trials, suggesting a specific adaptive mechanism by which
prior experience may alter ensuing behavior. These findings
indicate that individual differences in gain maximization
and loss minimization are linked to individual differences
in rapid neural responses to monetary outcomes.},
Doi = {10.1523/JNEUROSCI.4242-12.2013},
Key = {fds252248}
}
@article{fds252249,
Author = {Libedinsky, C and Massar, SAA and Ling, A and Chee, W and Huettel, SA and Chee, MWL},
Title = {Sleep deprivation alters effort discounting but not delay
discounting of monetary rewards.},
Journal = {Sleep},
Volume = {36},
Number = {6},
Pages = {899-904},
Year = {2013},
Month = {June},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23729933},
Abstract = {<h4>Study objectives</h4>To determine whether sleep
deprivation would affect the discounting of delayed rewards,
of rewards entailing the expense of effort, or
both.<h4>Design</h4>We measured rates of two types of reward
discounting under conditions of rested wakefulness (RW) and
sleep deprivation (SD). Delay discounting was defined as the
willingness to accept smaller monetary rewards sooner rather
than larger monetary rewards later. Effort discounting was
defined as the willingness to accept smaller rewards that
require less effort to obtain (e.g., typing a small number
of letter strings backward) over larger but more effortful
rewards (e.g., typing more letter strings to receive the
reward). The first two experiments used a crossover design
in which one session was conducted after a normal night of
sleep (RW), and the other after a night without sleep (SD).
The first experiment evaluated only temporal discounting
whereas the second evaluated temporal and effort
discounting. In the second experiment, the discounting tasks
were repeatedly administered prior to the state comparisons
to minimize the effects of order and/or repeated testing. In
a third experiment, participants were studied only once in a
between-subject evaluation of discounting across
states.<h4>Setting</h4>The study took place in a research
laboratory.<h4>Participants</h4>Seventy-seven healthy young
adult participants: 20 in Experiment 1, 27 in Experiment 2,
and 30 in Experiment 3.<h4>Interventions</h4>N/A.<h4>Measurements
and results</h4>Sleep deprivation elicited increased effort
discounting but did not affect delay discounting.<h4>Conclusions</h4>The
dissociable effects of sleep deprivation on two forms of
discounting behavior suggest that they may have differing
underlying neural mechanisms.},
Doi = {10.5665/sleep.2720},
Key = {fds252249}
}
@article{fds252243,
Author = {Carter, RM and Huettel, SA},
Title = {A nexus model of the temporal-parietal junction.},
Journal = {Trends in Cognitive Sciences},
Volume = {17},
Number = {7},
Pages = {328-336},
Year = {2013},
Month = {July},
ISSN = {1364-6613},
url = {http://dx.doi.org/10.1016/j.tics.2013.05.007},
Abstract = {The temporal-parietal junction (TPJ) has been proposed to
support either specifically social functions or non-specific
processes of cognition such as memory and attention. To
account for diverse prior findings, we propose a nexus model
for TPJ function: overlap of basic processes produces novel
secondary functions at their convergence. We present
meta-analytic evidence that is consistent with the
anatomical convergence of attention, memory, language, and
social processing in the TPJ, leading to a higher-order role
in the creation of a social context for behavior. The nexus
model accounts for recent examples of TPJ contributions
specifically to decision making in a social context and
provides a potential reconciliation for competing claims
about TPJ function.},
Doi = {10.1016/j.tics.2013.05.007},
Key = {fds252243}
}
@article{fds252244,
Author = {Winecoff, A and Clithero, JA and Carter, RM and Bergman, SR and Wang, L and Huettel, SA},
Title = {Ventromedial prefrontal cortex encodes emotional
value.},
Journal = {Journal of Neuroscience},
Volume = {33},
Number = {27},
Pages = {11032-11039},
Year = {2013},
Month = {July},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23825408},
Abstract = {The ventromedial prefrontal cortex (vmPFC) plays a critical
role in processing appetitive stimuli. Recent investigations
have shown that reward value signals in the vmPFC can be
altered by emotion regulation processes; however, to what
extent the processing of positive emotion relies on neural
regions implicated in reward processing is unclear. Here, we
investigated the effects of emotion regulation on the
valuation of emotionally evocative images. Two independent
experimental samples of human participants performed a
cognitive reappraisal task while undergoing fMRI. The
experience of positive emotions activated the vmPFC, whereas
the regulation of positive emotions led to relative
decreases in vmPFC activation. During the experience of
positive emotions, vmPFC activation tracked participants'
own subjective ratings of the valence of stimuli.
Furthermore, vmPFC activation also tracked normative valence
ratings of the stimuli when participants were asked to
experience their emotions, but not when asked to regulate
them. A separate analysis of the predictive power of vmPFC
on behavior indicated that even after accounting for
normative stimulus ratings and condition, increased signal
in the vmPFC was associated with more positive valence
ratings. These results suggest that the vmPFC encodes a
domain-general value signal that tracks the value of not
only external rewards, but also emotional
stimuli.},
Doi = {10.1523/JNEUROSCI.4317-12.2013},
Key = {fds252244}
}
@article{fds252246,
Author = {De Bellis, MD and Wang, L and Bergman, SR and Yaxley, RH and Hooper, SR and Huettel, SA},
Title = {Neural mechanisms of risky decision-making and reward
response in adolescent onset cannabis use
disorder.},
Journal = {Drug Alcohol Depend},
Volume = {133},
Number = {1},
Pages = {134-145},
Year = {2013},
Month = {November},
ISSN = {0376-8716},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23773952},
Abstract = {BACKGROUND: Neural mechanisms of decision-making and reward
response in adolescent cannabis use disorder (CUD) are
underexplored. METHODS: Three groups of male adolescents
were studied: CUD in full remission (n=15); controls with
psychopathology without substance use disorder history
(n=23); and healthy controls (n=18). We investigated neural
processing of decision-making and reward under conditions of
varying risk and uncertainty with the Decision-Reward
Uncertainty Task while participants were scanned using
functional magnetic resonance imaging. RESULTS: Abstinent
adolescents with CUD compared to controls with
psychopathology showed hyperactivation in one cluster that
spanned left superior parietal lobule/left lateral occipital
cortex/precuneus while making risky decisions that involved
uncertainty, and hypoactivation in left orbitofrontal cortex
to rewarded outcomes compared to no-reward after making
risky decisions. Post hoc region of interest analyses
revealed that both control groups significantly differed
from the CUD group (but not from each other) during both the
decision-making and reward outcome phase of the
Decision-Reward Uncertainty Task. In the CUD group,
orbitofrontal activations to reward significantly and
negatively correlated with total number of individual drug
classes the CUD patients experimented with prior to
treatment. CUD duration significantly and negatively
correlated with orbitofrontal activations to no-reward.
CONCLUSIONS: The adolescent CUD group demonstrated
distinctly different activation patterns during risky
decision-making and reward processing (after risky
decision-making) compared to both the controls with
psychopathology and healthy control groups. These findings
suggest that neural differences in risky decision-making and
reward processes are present in adolescent addiction,
persist after remission from first CUD treatment, and may
contribute to vulnerability for adolescent
addiction.},
Doi = {10.1016/j.drugalcdep.2013.05.020},
Key = {fds252246}
}
@article{fds252230,
Author = {Smidts, A and Hsu, M and Sanfey, AG and Boksem, MAS and Ebstein, RB and Huettel, SA and Kable, JW and Karmarkar, UR and Kitayama, S and Knutson,
B and Liberzon, I and Lohrenz, T and Stallen, M and Yoon,
C},
Title = {Advancing consumer neuroscience},
Journal = {Marketing Letters},
Volume = {25},
Number = {3},
Pages = {257-267},
Publisher = {Springer Nature},
Year = {2014},
ISSN = {0923-0645},
url = {http://dx.doi.org/10.1007/s11002-014-9306-1},
Doi = {10.1007/s11002-014-9306-1},
Key = {fds252230}
}
@article{fds252219,
Author = {Li, R and Brannon, EM and Huettel, SA},
Title = {Children do not exhibit ambiguity aversion despite intact
familiarity bias.},
Journal = {Frontiers in Psychology},
Volume = {5},
Pages = {1519},
Year = {2014},
Month = {January},
url = {http://dx.doi.org/10.3389/fpsyg.2014.01519},
Abstract = {The phenomenon of ambiguity aversion, in which risky gambles
with known probabilities are preferred over ambiguous
gambles with unknown probabilities, has been thoroughly
documented in adults but never measured in children. Here,
we use two distinct tasks to investigate ambiguity
preferences of children (8- to 9-year-olds) and a comparison
group of adults (19- to 27-year-olds). Across three separate
measures, we found evidence for significant ambiguity
aversion in adults but not in children and for greater
ambiguity aversion in adults compared to children. As
ambiguity aversion in adults has been theorized to result
from a preference to bet on the known and avoid the
unfamiliar, we separately measured familiarity bias and
found that children, like adults, are biased towards the
familiar. Our findings indicate that ambiguity aversion
emerges across the course of development between childhood
and adolescence, while a familiarity bias is already present
in childhood.},
Doi = {10.3389/fpsyg.2014.01519},
Key = {fds252219}
}
@article{fds252221,
Author = {Kwak, Y and Pearson, J and Huettel, SA},
Title = {Differential reward learning for self and others predicts
self-reported altruism.},
Journal = {Plos One},
Volume = {9},
Number = {9},
Pages = {e107621},
Year = {2014},
Month = {January},
url = {http://dx.doi.org/10.1371/journal.pone.0107621},
Abstract = {In social environments, decisions not only determine rewards
for oneself but also for others. However, individual
differences in pro-social behaviors have been typically
studied through self-report. We developed a decision-making
paradigm in which participants chose from card decks with
differing rewards for themselves and charity; some decks
gave similar rewards to both, while others gave higher
rewards for one or the other. We used a reinforcement-learning
model that estimated each participant's relative weighting
of self versus charity reward. As shown both in choices and
model parameters, individuals who showed relatively better
learning of rewards for charity--compared to
themselves--were more likely to engage in pro-social
behavior outside of a laboratory setting indicated by
self-report. Overall rates of reward learning, however, did
not predict individual differences in pro-social tendencies.
These results support the idea that biases toward learning
about social rewards are associated with one's altruistic
tendencies.},
Doi = {10.1371/journal.pone.0107621},
Key = {fds252221}
}
@article{fds252226,
Author = {Smidts, A and Hsu, M and Sanfey, AG and Boksem, MAS and Ebstein, RB and Huettel, SA and Kable, JW and Karmarkar, UR and Kitayama, S and Knutson,
B and Liberzon, I and Lohrenz, T and Stallen, M and Yoon,
C},
Title = {Advancing consumer neuroscience},
Journal = {Marketing Letters},
Volume = {25},
Number = {3},
Pages = {257-267},
Year = {2014},
Month = {January},
ISSN = {0923-0645},
url = {http://dx.doi.org/10.1007/s11002-014-9306-1},
Abstract = {In the first decade of consumer neuroscience, strong
progress has been made in understanding how neuroscience can
inform consumer decision making. Here, we sketch the
development of this discipline and compare it to that of the
adjacent field of neuroeconomics. We describe three new
frontiers for ongoing progress at both theoretical and
applied levels. First, the field will broaden its boundaries
to include genetics and molecular neuroscience, each of
which will provide important new insights into individual
differences in decision making. Second, recent advances in
computational methods will improve the accuracy and
out-of-sample generalizability of predicting decisions from
brain activity. Third, sophisticated meta-analyses will help
consumer neuroscientists to synthesize the growing body of
knowledge, providing evidence for consistency and
specificity of brain activations and their reliability as
measurements of consumer behavior. © 2014 Springer
Science+Business Media New York.},
Doi = {10.1007/s11002-014-9306-1},
Key = {fds252226}
}
@article{fds252233,
Author = {Stanton, SJ and Reeck, C and Huettel, SA and LaBar,
KS},
Title = {Effects of induced moods on economic choices},
Journal = {Judgment and Decision Making},
Volume = {9},
Number = {2},
Pages = {167-175},
Year = {2014},
Month = {January},
ISSN = {1930-2975},
Abstract = {Emotions can shape decision processes by altering valuation
signals, risk perception, and strategic orientation.
Although multiple theories posit a role for affective
processes in mediating the influence of frames on decision
making, empirical studies have yet to demonstrate that
manipulated affect modulates framing phenomena. The present
study asked whether induced affective states alter gambling
propensity and the influence of frames on decision making.
In a between-subjects design, we induced mood (happy, sad,
or neutral) in subjects (N=91) via films that were
interleaved with the framing task. Happy mood induction
increased gambling and apparently accentuated framing
effects compared to sad mood induction, although the effect
on framing could have resulted from the fact that the
increased tendency to gamble made the framing measure more
sensitive. Happy mood induction increased gambling, but not
framing magnitude, compared to neutral mood induction.
Subjects experiencing a sad mood induction did not exhibit
behavioral differences from those experiencing a neutral
mood. For those subjects who experienced the happy mood
induction, both gambling propensity and framing magnitude
were positively correlated with the magnitude of the change
in their mood valence. We discuss the broader implications
of mood effects on real-world economic decisions. ©
2013.},
Key = {fds252233}
}
@misc{fds252238,
Author = {Utevsky, AV and Smith, DV and Huettel, SA},
Title = {Precuneus is a functional core of the default-mode
network.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {34},
Number = {3},
Pages = {932-940},
Year = {2014},
Month = {January},
ISSN = {0270-6474},
url = {http://dx.doi.org/10.1523/jneurosci.4227-13.2014},
Abstract = {Efforts to understand the functional architecture of the
brain have consistently identified multiple overlapping
large-scale neural networks that are observable across
multiple states. Despite the ubiquity of these networks, it
remains unclear how regions within these large-scale neural
networks interact to orchestrate behavior. Here, we
collected functional magnetic resonance imaging data from
188 human subjects who engaged in three cognitive tasks and
a resting-state scan. Using multiple tasks and a large
sample allowed us to use split-sample validations to test
for replication of results. We parceled the task-rest pairs
into functional networks using a probabilistic spatial
independent components analysis. We examined changes in
connectivity between task and rest states using
dual-regression analysis, which quantifies voxelwise
connectivity estimates for each network of interest while
controlling for the influence of signals arising from other
networks and artifacts. Our analyses revealed systematic
state-dependent functional connectivity in one brain region:
the precuneus. Specifically, task performance led to
increased connectivity (compared to rest) between the
precuneus and the left frontoparietal network (lFPN),
whereas rest increased connectivity between the precuneus
and the default-mode network (DMN). The absolute magnitude
of this effect was greater for DMN, suggesting a heightened
specialization for resting-state cognition. All results
replicated within the two independent samples. Our results
indicate that the precuneus plays a core role not only in
DMN, but also more broadly through its engagement under a
variety of processing states.},
Doi = {10.1523/jneurosci.4227-13.2014},
Key = {fds252238}
}
@article{fds252236,
Author = {Damiano, CR and Aloi, J and Dunlap, K and Burrus, CJ and Mosner, MG and Kozink, RV and McLaurin, RE and Mullette-Gillman, OA and Carter, RM and Huettel, SA and McClernon, FJ and Ashley-Koch, A and Dichter,
GS},
Title = {Association between the oxytocin receptor (OXTR) gene and
mesolimbic responses to rewards.},
Journal = {Molecular Autism},
Volume = {5},
Number = {1},
Pages = {7},
Year = {2014},
Month = {January},
url = {http://dx.doi.org/10.1186/2040-2392-5-7},
Abstract = {BACKGROUND: There has been significant progress in
identifying genes that confer risk for autism spectrum
disorders (ASDs). However, the heterogeneity of symptom
presentation in ASDs impedes the detection of ASD risk
genes. One approach to understanding genetic influences on
ASD symptom expression is to evaluate relations between
variants of ASD candidate genes and neural endophenotypes in
unaffected samples. Allelic variations in the oxytocin
receptor (OXTR) gene confer small but significant risk for
ASDs for which the underlying mechanisms may involve
associations between variability in oxytocin signaling
pathways and neural response to rewards. The purpose of this
preliminary study was to investigate the influence of
allelic variability in the OXTR gene on neural responses to
monetary rewards in healthy adults using functional magnetic
resonance imaging (fMRI). METHODS: The moderating effects of
three single nucleotide polymorphisms (SNPs) (rs1042778,
rs2268493 and rs237887) of the OXTR gene on mesolimbic
responses to rewards were evaluated using a monetary
incentive delay fMRI task. RESULTS: T homozygotes of the
rs2268493 SNP demonstrated relatively decreased activation
in mesolimbic reward circuitry (including the nucleus
accumbens, amygdala, insula, thalamus and prefrontal
cortical regions) during the anticipation of rewards but not
during the outcome phase of the task. Allelic variation of
the rs1042778 and rs237887 SNPs did not moderate mesolimbic
activation during either reward anticipation or outcomes.
CONCLUSIONS: This preliminary study suggests that the OXTR
SNP rs2268493, which has been previously identified as an
ASD risk gene, moderates mesolimbic responses during reward
anticipation. Given previous findings of decreased
mesolimbic activation during reward anticipation in ASD, the
present results suggest that OXTR may confer ASD risk via
influences on the neural systems that support reward
anticipation.},
Doi = {10.1186/2040-2392-5-7},
Key = {fds252236}
}
@article{fds252234,
Author = {Crozier, JC and Wang, L and Huettel, SA and De Bellis,
MD},
Title = {Neural correlates of cognitive and affective processing in
maltreated youth with posttraumatic stress symptoms: does
gender matter?},
Journal = {Dev Psychopathol},
Volume = {26},
Number = {2},
Pages = {491-513},
Year = {2014},
Month = {May},
ISSN = {0954-5794},
url = {http://dx.doi.org/10.1017/S095457941400008X},
Abstract = {We investigated the relationship of gender to cognitive and
affective processing in maltreated youth with posttraumatic
stress disorder symptoms using functional magnetic resonance
imaging. Maltreated (N = 29, 13 females, 16 males) and
nonmaltreated participants (N = 45, 26 females, 19 males)
performed an emotional oddball task that involved detection
of targets with fear or scrambled face distractors. Results
were moderated by gender. During the executive component of
this task, left precuneus/posterior middle cingulate
hypoactivation to fear versus calm or scrambled face targets
were seen in maltreated versus control males and may
represent dysfunction and less resilience in attentional
networks. Maltreated males also showed decreased activation
in the inferior frontal gyrus compared to control males. No
differences were found in females. Posterior cingulate
activations positively correlated with posttraumatic stress
disorder symptoms. While viewing fear faces, maltreated
females exhibited decreased activity in the dorsomedial
prefrontal cortex and cerebellum I-VI, whereas maltreated
males exhibited increased activity in the left hippocampus,
fusiform cortex, right cerebellar crus I, and visual cortex
compared to their same-gender controls. Gender by
maltreatment effects were not attributable to demographic,
clinical, or maltreatment parameters. Maltreated girls and
boys exhibited distinct patterns of neural activations
during executive and affective processing, a new finding in
the maltreatment literature.},
Doi = {10.1017/S095457941400008X},
Key = {fds252234}
}
@article{fds252235,
Author = {Smith, DV and Utevsky, AV and Bland, AR and Clement, N and Clithero, JA and Harsch, AEW and McKell Carter and R and Huettel, SA},
Title = {Characterizing individual differences in functional
connectivity using dual-regression and seed-based
approaches.},
Journal = {Neuroimage},
Volume = {95},
Pages = {1-12},
Year = {2014},
Month = {July},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2014.03.042},
Abstract = {A central challenge for neuroscience lies in relating
inter-individual variability to the functional properties of
specific brain regions. Yet, considerable variability exists
in the connectivity patterns between different brain areas,
potentially producing reliable group differences. Using sex
differences as a motivating example, we examined two
separate resting-state datasets comprising a total of 188
human participants. Both datasets were decomposed into
resting-state networks (RSNs) using a probabilistic spatial
independent component analysis (ICA). We estimated
voxel-wise functional connectivity with these networks using
a dual-regression analysis, which characterizes the
participant-level spatiotemporal dynamics of each network
while controlling for (via multiple regression) the
influence of other networks and sources of variability. We
found that males and females exhibit distinct patterns of
connectivity with multiple RSNs, including both visual and
auditory networks and the right frontal-parietal network.
These results replicated across both datasets and were not
explained by differences in head motion, data quality, brain
volume, cortisol levels, or testosterone levels.
Importantly, we also demonstrate that dual-regression
functional connectivity is better at detecting
inter-individual variability than traditional seed-based
functional connectivity approaches. Our findings
characterize robust-yet frequently ignored-neural
differences between males and females, pointing to the
necessity of controlling for sex in neuroscience studies of
individual differences. Moreover, our results highlight the
importance of employing network-based models to study
variability in functional connectivity.},
Doi = {10.1016/j.neuroimage.2014.03.042},
Key = {fds252235}
}
@article{fds252232,
Author = {Beam, E and Appelbaum, LG and Jack, J and Moody, J and Huettel,
SA},
Title = {Mapping the semantic structure of cognitive
neuroscience.},
Journal = {J Cogn Neurosci},
Volume = {26},
Number = {9},
Pages = {1949-1965},
Year = {2014},
Month = {September},
ISSN = {0898-929X},
url = {http://hdl.handle.net/10161/10645 Duke open
access},
Abstract = {Cognitive neuroscience, as a discipline, links the
biological systems studied by neuroscience to the processing
constructs studied by psychology. By mapping these relations
throughout the literature of cognitive neuroscience, we
visualize the semantic structure of the discipline and point
to directions for future research that will advance its
integrative goal. For this purpose, network text analyses
were applied to an exhaustive corpus of abstracts collected
from five major journals over a 30-month period, including
every study that used fMRI to investigate psychological
processes. From this, we generate network maps that
illustrate the relationships among psychological and
anatomical terms, along with centrality statistics that
guide inferences about network structure. Three
terms--prefrontal cortex, amygdala, and anterior cingulate
cortex--dominate the network structure with their high
frequency in the literature and the density of their
connections with other neuroanatomical terms. From network
statistics, we identify terms that are understudied compared
with their importance in the network (e.g., insula and
thalamus), are underspecified in the language of the
discipline (e.g., terms associated with executive function),
or are imperfectly integrated with other concepts (e.g.,
subdisciplines like decision neuroscience that are
disconnected from the main network). Taking these results as
the basis for prescriptive recommendations, we conclude that
semantic analyses provide useful guidance for cognitive
neuroscience as a discipline, both by illustrating
systematic biases in the conduct and presentation of
research and by identifying directions that may be most
productive for future research.},
Doi = {10.1162/jocn_a_00604},
Key = {fds252232}
}
@article{fds252228,
Author = {Murty, VP and Shermohammed, M and Smith, DV and Carter, RM and Huettel,
SA and Adcock, RA},
Title = {Resting state networks distinguish human ventral tegmental
area from substantia nigra.},
Journal = {Neuroimage},
Volume = {100},
Pages = {580-589},
Year = {2014},
Month = {October},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2014.06.047},
Abstract = {Dopaminergic networks modulate neural processing across a
spectrum of function from perception to learning to action.
Multiple organizational schemes based on anatomy and
function have been proposed for dopaminergic nuclei in the
midbrain. One schema originating in rodent models delineated
ventral tegmental area (VTA), implicated in complex
behaviors like addiction, from more lateral substantia nigra
(SN), preferentially implicated in movement. However,
because anatomy and function in rodent midbrain differs from
the primate midbrain in important ways, the utility of this
distinction for human neuroscience has been questioned. We
asked whether functional definition of networks within the
human dopaminergic midbrain would recapitulate this
traditional anatomical topology. We first developed a method
for reliably defining SN and VTA in humans at conventional
MRI resolution. Hand-drawn VTA and SN regions-of-interest
(ROIs) were constructed for 50 participants, using
individually-localized anatomical landmarks and signal
intensity. Individual segmentation was used in seed-based
functional connectivity analysis of resting-state functional
MRI data; results of this analysis recapitulated traditional
anatomical targets of the VTA versus SN. Next, we
constructed a probabilistic atlas of the VTA, SN, and the
dopaminergic midbrain region (comprised of SN plus VTA) from
individual hand-drawn ROIs. The combined probabilistic (SN
plus VTA) ROI was then used for connectivity-based
dual-regression analysis in two independent resting-state
datasets (n = 69 and n = 79). Results of the
connectivity-based, dual-regression functional segmentation
recapitulated results of the anatomical segmentation,
validating the utility of this probabilistic atlas for
future research.},
Doi = {10.1016/j.neuroimage.2014.06.047},
Key = {fds252228}
}
@article{fds252224,
Author = {Lighthall, NR and Huettel, SA and Cabeza, R},
Title = {Functional compensation in the ventromedial prefrontal
cortex improves memory-dependent decisions in older
adults.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {34},
Number = {47},
Pages = {15648-15657},
Year = {2014},
Month = {November},
ISSN = {0270-6474},
url = {http://dx.doi.org/10.1523/jneurosci.2888-14.2014},
Abstract = {Everyday consumer choices frequently involve memory, as when
we retrieve information about consumer products when making
purchasing decisions. In this context, poor memory may
affect decision quality, particularly in individuals with
memory decline, such as older adults. However, age
differences in choice behavior may be reduced if older
adults can recruit additional neural resources that support
task performance. Although such functional compensation is
well documented in other cognitive domains, it is presently
unclear whether it can support memory-guided decision making
and, if so, which brain regions play a role in compensation.
The current study engaged younger and older humans in a
memory-dependent choice task in which pairs of consumer
products from a popular online-shopping site were evaluated
with different delays between the first and second product.
Using functional imaging (fMRI), we found that the
ventromedial prefrontal cortex (vmPFC) supports compensation
as defined by three a priori criteria: (1) increased vmPFC
activation was observed in older versus younger adults; (2)
age-related increases in vmPFC activity were associated with
increased retrieval demands; and (3) increased vmPFC
activity was positively associated with performance in older
adults-evidence of successful compensation. Extending these
results, we observed evidence for compensation in
connectivity between vmPFC and the dorsolateral PFC during
memory-dependent choice. In contrast, we found no evidence
for age differences in value-related processing or
age-related compensation for choices without delayed
retrieval. Together, these results converge on the
conclusion that age-related decline in memory-dependent
choice performance can be minimized via functional
compensation in vmPFC.},
Doi = {10.1523/jneurosci.2888-14.2014},
Key = {fds252224}
}
@article{fds252225,
Author = {Venkatraman, V and Payne, JW and Huettel, SA},
Title = {An overall probability of winning heuristic for complex
risky decisions: Choice and eye fixation
evidence},
Journal = {Organizational Behavior and Human Decision
Processes},
Volume = {125},
Number = {2},
Pages = {73-87},
Year = {2014},
Month = {November},
ISSN = {0749-5978},
url = {http://dx.doi.org/10.1016/j.obhdp.2014.06.003},
Abstract = {When faced with multi-outcome gambles involving
possibilities of both gains and losses, people often use a
simple heuristic that maximizes the overall probability of
winning (Pwin). Across three different studies, using choice
data as well as process data from eye tracking, we
demonstrate that the Pwin heuristic is a frequently used
strategy for decisions involving complex (multiple outcome)
mixed gambles. Crucially, we show systematic contextual and
individual differences in the use of Pwin heuristic. We
discuss the implication of these findings in the context of
the broader debate about single versus multiple strategies
in risky choice, and the need to extend the study of risky
decision making from simple to more complex
gambles.},
Doi = {10.1016/j.obhdp.2014.06.003},
Key = {fds252225}
}
@article{fds252237,
Author = {Smith, DV and Clithero, JA and Boltuck, SE and Huettel,
SA},
Title = {Functional connectivity with ventromedial prefrontal cortex
reflects subjective value for social rewards.},
Journal = {Social Cognitive and Affective Neuroscience},
Volume = {9},
Number = {12},
Pages = {2017-2025},
Year = {2014},
Month = {December},
ISSN = {1749-5016},
url = {http://dx.doi.org/10.1093/scan/nsu005},
Abstract = {According to many studies, the ventromedial prefrontal
cortex (VMPFC) encodes the subjective value of disparate
rewards on a common scale. Yet, a host of other reward
factors-likely represented outside of VMPFC-must be
integrated to construct such signals for valuation. Using
functional magnetic resonance imaging (fMRI), we tested
whether the interactions between posterior VMPFC and
functionally connected brain regions predict subjective
value. During fMRI scanning, participants rated the
attractiveness of unfamiliar faces. We found that activation
in dorsal anterior cingulate cortex, anterior VMPFC and
caudate increased with higher attractiveness ratings. Using
data from a post-scan task in which participants spent money
to view attractive faces, we quantified each individual's
subjective value for attractiveness. We found that
connectivity between posterior VMPFC and regions frequently
modulated by social information-including the
temporal-parietal junction (TPJ) and middle temporal
gyrus-was correlated with individual differences in
subjective value. Crucially, these additional regions
explained unique variation in subjective value beyond that
extracted from value regions alone. These findings indicate
not only that posterior VMPFC interacts with additional
brain regions during valuation, but also that these
additional regions carry information employed to construct
the subjective value for social reward.},
Doi = {10.1093/scan/nsu005},
Key = {fds252237}
}
@article{fds252220,
Author = {Young, JS and Smith, DV and Coutlee, CG and Huettel,
SA},
Title = {Synchrony between sensory and cognitive networks is
associated with subclinical variation in autistic
traits},
Journal = {Frontiers in Human Neuroscience},
Volume = {9},
Number = {MAR},
Publisher = {FRONTIERS MEDIA SA},
Year = {2015},
Month = {March},
url = {http://hdl.handle.net/10161/10251 Duke open
access},
Abstract = {Individuals with autistic spectrum disorders exhibit
distinct personality traits linked to attentional, social,
and affective functions, and those traits are expressed with
varying levels of severity in the neurotypical and
subclinical population. Variation in autistic traits has
been linked to reduced functional and structural
connectivity (i.e., underconnectivity, or reduced synchrony)
with neural networks modulated by attentional, social, and
affective functions. Yet, it remains unclear whether reduced
synchrony between these neural networks contributes to
autistic traits. To investigate this issue, we used
functional magnetic resonance imaging to record brain
activation while neurotypical participants who varied in
their subclinical scores on the Autism-Spectrum Quotient
(AQ) viewed alternating blocks of social and nonsocial
stimuli (i.e., images of faces and of landscape scenes). We
used independent component analysis (ICA) combined with a
spatiotemporal regression to quantify synchrony between
neural networks. Our results indicated that decreased
synchrony between the executive control network (ECN) and a
face-scene network (FSN) predicted higher scores on the AQ.
This relationship was not explained by individual
differences in head motion, preferences for faces, or
personality variables related to social cognition. Our
findings build on clinical reports by demonstrating that
reduced synchrony between distinct neural networks
contributes to a range of subclinical autistic
traits.},
Doi = {10.3389/fnhum.2015.00146},
Key = {fds252220}
}
@article{fds252216,
Author = {Plassmann, H and Venkatraman, V and Huettel, S and Yoon,
C},
Title = {Consumer neuroscience: Applications, challenges, and
possible solutions},
Journal = {Journal of Marketing Research},
Volume = {52},
Number = {4},
Pages = {427-435},
Publisher = {SAGE Publications},
Year = {2015},
Month = {August},
ISSN = {0022-2437},
url = {http://dx.doi.org/10.1509/jmr.14.0048},
Abstract = {The first decade of consumer neuroscience research has
produced groundbreaking work in identifying the basic neural
processes underlying human judgment and decision making,
with the majority of such studies published in neuroscience
journals and influencing models of brain function. Yet for
the field of consumer neuroscience to thrive in the next
decade, the current emphasis on basic science research must
be extended into marketing theory and practice. The authors
suggest five concrete ways that neuroscientific methods can
be fruitfully applied to marketing. They then outline three
fundamental challenges facing consumer neuroscientists and
offer potential solutions for addressing them. The authors
conclude by describing how consumer neuroscience can become
an important complement to research and practice in
marketing.},
Doi = {10.1509/jmr.14.0048},
Key = {fds252216}
}
@article{fds252215,
Author = {Massar, SAA and Libedinsky, C and Weiyan, C and Huettel, SA and Chee,
MWL},
Title = {Separate and overlapping brain areas encode subjective value
during delay and effort discounting.},
Journal = {Neuroimage},
Volume = {120},
Pages = {104-113},
Year = {2015},
Month = {October},
ISSN = {1053-8119},
url = {http://dx.doi.org/10.1016/j.neuroimage.2015.06.080},
Abstract = {Making decisions about rewards that involve delay or effort
requires the integration of value and cost information. The
brain areas recruited in this integration have been well
characterized for delay discounting. However only a few
studies have investigated how effort costs are integrated
into value signals to eventually determine choice. In
contrast to previous studies that have evaluated fMRI
signals related to physical effort, we used a task that
focused on cognitive effort. Participants discounted the
value of delayed and effortful rewards. The value of
cognitively effortful rewards was represented in the
anterior portion of the inferior frontal gyrus and
dorsolateral prefrontal cortex. Additionally, the value of
the chosen option was encoded in the anterior cingulate
cortex, caudate, and cerebellum. While most brain regions
showed no significant dissociation between effort
discounting and delay discounting, the ACC was significantly
more activated in effort compared to delay discounting
tasks. Finally, overlapping regions within the right
orbitofrontal cortex and lateral temporal and parietal
cortices encoded the value of the chosen option during both
delay and effort discounting tasks. These results indicate
that encoding of rewards discounted by cognitive effort and
delay involves partially dissociable brain areas, but a
common representation of chosen value is present in the
orbitofrontal, temporal and parietal cortices.},
Doi = {10.1016/j.neuroimage.2015.06.080},
Key = {fds252215}
}
@article{fds252217,
Author = {Kwak, Y and Payne, JW and Cohen, AL and Huettel, SA},
Title = {The rational adolescent: Strategic information processing
during decision making revealed by eye tracking},
Journal = {Cognitive Development},
Volume = {36},
Pages = {20-30},
Year = {2015},
Month = {October},
ISSN = {0885-2014},
url = {http://hdl.handle.net/10161/10590 Duke open
access},
Abstract = {Abstract Adolescence is often viewed as a time of
irrational, risky decision-making—despite adolescents’
competence in other cognitive domains. In this study, we
examined the strategies used by adolescents (N = 30) and
young adults (N = 47) to resolve complex, multi-outcome
economic gambles. Compared to adults, adolescents were more
likely to make conservative, loss-minimizing choices
consistent with economic models. Eye-tracking data showed
that prior to decisions, adolescents acquired more
information in a more thorough manner; that is, they engaged
in a more analytic processing strategy indicative of
trade-offs between decision variables. In contrast, young
adults’ decisions were more consistent with heuristics
that simplified the decision problem, at the expense of
analytic precision. Collectively, these results demonstrate
a counter-intuitive developmental transition in economic
decision making: adolescents’ decisions are more
consistent with rational-choice models, while young adults
more readily engage task-appropriate heuristics.},
Doi = {10.1016/j.cogdev.2015.08.001},
Key = {fds252217}
}
@article{fds303797,
Author = {Knutson, B and Huettel, SA},
Title = {The risk matrix},
Journal = {Current Opinion in Behavioral Sciences},
Volume = {5},
Pages = {141-146},
Publisher = {Elsevier BV},
Year = {2015},
Month = {October},
ISSN = {2352-1546},
url = {http://dx.doi.org/10.1016/j.cobeha.2015.10.012},
Abstract = {Neuroimaging methods (e.g., functional magnetic resonance
imaging or FMRI) can now resolve momentary changes in deep
brain activity that not only correlate with but also predict
risky choice. Accumulating evidence beginning from financial
choice studies but extending into other domains indicates
that risk assessment recruits activity in multiple core
components which differentially promote (e.g., ventral
striatum) versus inhibit (e.g., anterior insula) risky
choice. Further, frontal control circuits may modulate the
influence of these core components on risky choice. These
findings point toward an emerging consensus about a 'risk
matrix' whose components unite previously disparate
literatures related to anticipation of reward versus pain
and whose measurement can improve the prediction of risky
choice.},
Doi = {10.1016/j.cobeha.2015.10.012},
Key = {fds303797}
}
@article{fds324438,
Author = {Lighthall, N and Pearson, JM and Huettel, S and Cabeza,
R},
Title = {THE IMPACT OF FEEDBACK TIMING ON VALUE LEARNING IN
AGING},
Journal = {Gerontologist},
Volume = {55},
Number = {Suppl_2},
Pages = {140-140},
Publisher = {Oxford University Press (OUP)},
Year = {2015},
Month = {November},
url = {http://dx.doi.org/10.1093/geront/gnv513.03},
Doi = {10.1093/geront/gnv513.03},
Key = {fds324438}
}
@article{fds292901,
Author = {Ngo, L and Kelly, M and Coutlee, CG and Carter, RM and Sinnott-Armstrong, W and Huettel, SA},
Title = {Two Distinct Moral Mechanisms for Ascribing and Denying
Intentionality},
Journal = {Scientific Reports},
Volume = {5},
Pages = {17390},
Publisher = {Macmillan Publishers Limited},
Year = {2015},
Month = {December},
url = {http://hdl.handle.net/10161/11093 Duke open
access},
Abstract = {Philosophers and legal scholars have long theorized about
how intentionality serves as a critical input for morality
and culpability, but the emerging field of experimental
philosophy has revealed a puzzling asymmetry. People judge
actions leading to negative consequences as being more
intentional than those leading to positive ones. The
implications of this asymmetry remain unclear because there
is no consensus regarding the underlying mechanism. Based on
converging behavioral and neural evidence, we demonstrate
that there is no single underlying mechanism. Instead, two
distinct mechanisms together generate the asymmetry. Emotion
drives ascriptions of intentionality for negative
consequences, while the consideration of statistical norms
leads to the denial of intentionality for positive
consequences. We employ this novel two-mechanism model to
illustrate that morality can paradoxically shape judgments
of intentionality. This is consequential for mens rea in
legal practice and arguments in moral philosophy pertaining
to terror bombing, abortion, and euthanasia among
others.},
Doi = {10.1038/srep17390},
Key = {fds292901}
}
@article{fds323690,
Author = {Coutlee, CG and Kiyonaga, A and Korb, FM and Huettel, SA and Egner,
T},
Title = {Reduced Risk-Taking following Disruption of the
Intraparietal Sulcus.},
Journal = {Frontiers in Neuroscience},
Volume = {10},
Pages = {588},
Year = {2016},
Month = {January},
url = {http://dx.doi.org/10.3389/fnins.2016.00588},
Abstract = {Decision makers frequently encounter opportunities to pursue
great gains-assuming they are willing to accept greater
risks. Previous neuroimaging studies have shown that
activity in the intraparietal sulcus (IPS) and the inferior
frontal junction (IFJ) are associated with individual
preferences for economic risk ("known unknowns," e.g., a 50%
chance of winning $5) and ambiguity ("unknown unknowns,"
e.g., an unknown chance of winning $5), respectively.
Whether processing in these regions causally enables
risk-taking for individual decisions, however, remains
unknown. To examine this question, we assessed the decision
to engage in risk-taking after disrupting neural processing
in the IPS and IFJ of healthy human participants using
repetitive transcranial magnetic stimulation. While
stimulation of the IFJ resulted in general slowing of
decision times, disrupting neural processing within the IPS
selectively suppressed risk-taking, biasing choices toward
certain options featuring both lower risks and lower
expected rewards. Our results are the first to demonstrate
the necessity of intact IPS function for choosing uncertain
outcomes when faced with calculable risks and rewards.
Engagement of IPS during decision making may support a
willingness to accept uncertain outcomes for a chance to
obtain greater gains.},
Doi = {10.3389/fnins.2016.00588},
Key = {fds323690}
}
@article{fds252218,
Author = {San Martín and R and Appelbaum, LG and Huettel, SA and Woldorff,
MG},
Title = {Cortical Brain Activity Reflecting Attentional Biasing
Toward Reward-Predicting Cues Covaries with Economic
Decision-Making Performance.},
Journal = {Cerebral Cortex},
Volume = {26},
Number = {1},
Pages = {1-11},
Year = {2016},
Month = {January},
ISSN = {1047-3211},
url = {http://hdl.handle.net/10161/12006 Duke open
access},
Abstract = {Adaptive choice behavior depends critically on identifying
and learning from outcome-predicting cues. We hypothesized
that attention may be preferentially directed toward certain
outcome-predicting cues. We studied this possibility by
analyzing event-related potential (ERP) responses in humans
during a probabilistic decision-making task. Participants
viewed pairs of outcome-predicting visual cues and then
chose to wager either a small (i.e., loss-minimizing) or
large (i.e., gain-maximizing) amount of money. The cues were
bilaterally presented, which allowed us to extract the
relative neural responses to each cue by using a
contralateral-versus-ipsilateral ERP contrast. We found an
early lateralized ERP response, whose features matched the
attention-shift-related N2pc component and whose amplitude
scaled with the learned reward-predicting value of the cues
as predicted by an attention-for-reward model. Consistently,
we found a double dissociation involving the N2pc. Across
participants, gain-maximization positively correlated with
the N2pc amplitude to the most reliable gain-predicting cue,
suggesting an attentional bias toward such cues. Conversely,
loss-minimization was negatively correlated with the N2pc
amplitude to the most reliable loss-predicting cue,
suggesting an attentional avoidance toward such stimuli.
These results indicate that learned stimulus-reward
associations can influence rapid attention allocation, and
that differences in this process are associated with
individual differences in economic decision-making
performance.},
Doi = {10.1093/cercor/bhu160},
Key = {fds252218}
}
@article{fds322016,
Author = {Kwak, Y and Huettel, SA},
Title = {Prosocial Reward Learning in Children and
Adolescents.},
Journal = {Frontiers in Psychology},
Volume = {7},
Number = {OCT},
Pages = {1539},
Publisher = {FRONTIERS MEDIA SA},
Year = {2016},
Month = {January},
url = {http://dx.doi.org/10.3389/fpsyg.2016.01539},
Abstract = {Adolescence is a period of increased sensitivity to social
contexts. To evaluate how social context sensitivity changes
over development-and influences reward learning-we
investigated how children and adolescents perceive and
integrate rewards for oneself and others during a dynamic
risky decision-making task. Children and adolescents
(<i>N</i> = 75, 8-16 years) performed the Social Gambling
Task (SGT, Kwak et al., 2014) and completed a set of
questionnaires measuring other-regarding behavior. In the
SGT, participants choose amongst four card decks that have
different payout structures for oneself and for a charity.
We examined patterns of choices, overall decision
strategies, and how reward outcomes led to trial-by-trial
adjustments in behavior, as estimated using a
reinforcement-learning model. Performance of children and
adolescents was compared to data from a previously collected
sample of adults (<i>N</i> = 102) performing the identical
task. We found that that children/adolescents were not only
more sensitive to rewards directed to the charity than self
but also showed greater prosocial tendencies on independent
measures of other-regarding behavior. Children and
adolescents also showed less use of a strategy that
prioritizes rewards for self at the expense of rewards for
others. These results support the conclusion that, compared
to adults, children and adolescents show greater sensitivity
to outcomes for others when making decisions and learning
about potential rewards.},
Doi = {10.3389/fpsyg.2016.01539},
Key = {fds322016}
}
@article{fds322017,
Author = {San Martín and R and Kwak, Y and Pearson, JM and Woldorff, MG and Huettel,
SA},
Title = {Altruistic traits are predicted by neural responses to
monetary outcomes for self vs charity.},
Journal = {Soc Cogn Affect Neurosci},
Volume = {11},
Number = {6},
Pages = {863-876},
Year = {2016},
Month = {June},
url = {http://dx.doi.org/10.1093/scan/nsw026},
Abstract = {Human altruism is often expressed through charitable
donation-supporting a cause that benefits others in society,
at cost to oneself. The underlying mechanisms of this
other-regarding behavior remain imperfectly understood. By
recording event-related-potential (ERP) measures of brain
activity from human participants during a social gambling
task, we identified markers of differential responses to
receipt of monetary outcomes for oneself vs for a charitable
cause. We focused our ERP analyses on the frontocentral
feedback-related negativity (FRN) and three subcomponents of
the attention-related P300 (P3) brain wave: the
frontocentral P2 and P3a and the parietal P3b. The FRN
distinguished between gains and losses for both self and
charity outcomes. Importantly, this effect of outcome
valence was greater for self than charity for both groups
and was independent of two altruism-related measures:
participants' pre-declared intended donations and the actual
donations resulting from their choices. In contrast,
differences in P3 subcomponents for outcomes for self vs
charity strongly predicted both of our laboratory measures
of altruism-as well as self-reported engagement in real-life
altruistic behaviors. These results indicate that individual
differences in altruism are linked to individual differences
in the relative deployment of attention (as indexed by the
P3) toward outcomes affecting other people.},
Doi = {10.1093/scan/nsw026},
Key = {fds322017}
}
@article{fds323990,
Author = {Meade, CS and Cordero, DM and Hobkirk, AL and Metra, BM and Chen, N-K and Huettel, SA},
Title = {Compensatory activation in fronto-parietal cortices among
HIV-infected persons during a monetary decision-making
task.},
Journal = {Hum Brain Mapp},
Volume = {37},
Number = {7},
Pages = {2455-2467},
Year = {2016},
Month = {July},
url = {http://dx.doi.org/10.1002/hbm.23185},
Abstract = {HIV infection can cause direct and indirect damage to the
brain and is consistently associated with neurocognitive
disorders, including impairments in decision-making
capacities. The tendency to devalue rewards that are delayed
(temporal discounting) is relevant to a range of health risk
behaviors. Making choices about delayed rewards engages the
executive control network of the brain, which has been found
to be affected by HIV. In this case-control study of 18
HIV-positive and 17 HIV-negative adults, we examined the
effects of HIV on brain activation during a temporal
discounting task. Functional MRI (fMRI) data were collected
while participants made choices between smaller, sooner
rewards and larger, delayed rewards. Choices were
individualized based on participants' unique discount
functions, so each participant experienced hard (similarly
valued), easy (disparately valued), and control choices.
fMRI data were analyzed using a mixed-effects model to
identify group-related differences associated with choice
difficulty. While there was no difference between groups in
behavioral performance, the HIV-positive group demonstrated
significantly larger increases in activation within left
parietal regions and bilateral prefrontal regions during
easy trials and within the right prefrontal cortex and
anterior cingulate during hard trials. Increasing activation
within the prefrontal regions was associated with lower
nadir CD4 cell count and risk-taking propensity. These
results support the hypothesis that HIV infection can alter
brain functioning in regions that support decision making,
providing further evidence for HIV-associated compensatory
activation within fronto-parietal cortices. A history of
immunosuppression may contribute to these brain changes. Hum
Brain Mapp 37:2455-2467, 2016. © 2016 Wiley Periodicals,
Inc.},
Doi = {10.1002/hbm.23185},
Key = {fds323990}
}
@article{fds322015,
Author = {Jenke, L and Huettel, SA},
Title = {Issues or Identity? Cognitive Foundations of Voter
Choice.},
Journal = {Trends in Cognitive Sciences},
Volume = {20},
Number = {11},
Pages = {794-804},
Year = {2016},
Month = {November},
url = {http://dx.doi.org/10.1016/j.tics.2016.08.013},
Abstract = {Voter choice is one of the most important problems in
political science. The most common models assume that voting
is a rational choice based on policy positions (e.g., key
issues) and nonpolicy information (e.g., social identity,
personality). Though such models explain macroscopic
features of elections, they also reveal important anomalies
that have been resistant to explanation. We argue for a new
approach that builds upon recent research in cognitive
science and neuroscience; specifically, we contend that
policy positions and social identities do not combine in
merely an additive manner, but compete to determine voter
preferences. This model not only explains several key
anomalies in voter choice, but also suggests new directions
for research in both political science and cognitive
science.},
Doi = {10.1016/j.tics.2016.08.013},
Key = {fds322015}
}
@article{fds322014,
Author = {Delgado, MR and Beer, JS and Fellows, LK and Huettel, SA and Platt, ML and Quirk, GJ and Schiller, D},
Title = {Viewpoints: Dialogues on the functional role of the
ventromedial prefrontal cortex.},
Journal = {Nat Neurosci},
Volume = {19},
Number = {12},
Pages = {1545-1552},
Year = {2016},
Month = {November},
url = {http://dx.doi.org/10.1038/nn.4438},
Doi = {10.1038/nn.4438},
Key = {fds322014}
}
@article{fds325991,
Author = {Li, R and Smith, DV and Clithero, JA and Venkatraman, V and Carter, RM and Huettel, SA},
Title = {Reason's Enemy Is Not Emotion: Engagement of Cognitive
Control Networks Explains Biases in Gain/Loss
Framing.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {37},
Number = {13},
Pages = {3588-3598},
Year = {2017},
Month = {March},
url = {http://dx.doi.org/10.1523/jneurosci.3486-16.2017},
Abstract = {In the classic gain/loss framing effect, describing a gamble
as a potential gain or loss biases people to make
risk-averse or risk-seeking decisions, respectively. The
canonical explanation for this effect is that frames
differentially modulate emotional processes, which in turn
leads to irrational choice behavior. Here, we evaluate the
source of framing biases by integrating functional magnetic
resonance imaging data from 143 human participants
performing a gain/loss framing task with meta-analytic data
from >8000 neuroimaging studies. We found that activation
during choices consistent with the framing effect were most
correlated with activation associated with the resting or
default brain, while activation during choices inconsistent
with the framing effect was most correlated with the
task-engaged brain. Our findings argue against the common
interpretation of gain/loss framing as a competition between
emotion and control. Instead, our study indicates that this
effect results from differential cognitive engagement across
decision frames.<b>SIGNIFICANCE STATEMENT</b> The biases
frequently exhibited by human decision makers have often
been attributed to the presence of emotion. Using a large
fMRI sample and analysis of whole-brain networks defined
with the meta-analytic tool Neurosynth, we find that neural
activity during frame-biased decisions was more
significantly associated with default behaviors (and the
absence of executive control) than with emotion. These
findings point to a role for neuroscience in shaping
long-standing psychological theories in decision
science.},
Doi = {10.1523/jneurosci.3486-16.2017},
Key = {fds325991}
}
@article{fds324858,
Author = {Cordero, DM and Towe, SL and Chen, N-K and Robertson, KR and Madden, DJ and Huettel, SA and Meade, CS},
Title = {Cocaine dependence does not contribute substantially to
white matter abnormalities in HIV infection.},
Journal = {J Neurovirol},
Volume = {23},
Number = {3},
Pages = {441-450},
Year = {2017},
Month = {June},
url = {http://dx.doi.org/10.1007/s13365-017-0512-5},
Abstract = {This study investigated the association of HIV infection and
cocaine dependence with cerebral white matter integrity
using diffusion tensor imaging (DTI). One hundred
thirty-five participants stratified by HIV and cocaine
status (26 HIV+/COC+, 37 HIV+/COC-, 37 HIV-/COC+, and 35
HIV-/COC-) completed a comprehensive substance abuse
assessment, neuropsychological testing, and MRI with DTI.
Among HIV+ participants, all were receiving HIV care and 46%
had an AIDS diagnosis. All COC+ participants were current
users and met criteria for cocaine use disorder. We used
tract-based spatial statistics (TBSS) to assess the relation
of HIV and cocaine to fractional anisotropy (FA) and mean
diffusivity (MD). In whole-brain analyses, HIV+ participants
had significantly reduced FA and increased MD compared to
HIV- participants. The relation of HIV and FA was widespread
throughout the brain, whereas the HIV-related MD effects
were restricted to the corpus callosum and thalamus. There
were no significant cocaine or HIV-by-cocaine effects. These
DTI metrics correlated significantly with duration of HIV
disease, nadir CD4+ cell count, and AIDS diagnosis, as well
as some measures of neuropsychological functioning. These
results suggest that HIV is related to white matter
integrity throughout the brain, and that HIV-related effects
are more pronounced with increasing duration of infection
and greater immune compromise. We found no evidence for
independent effects of cocaine dependence on white matter
integrity, and cocaine dependence did not appear to
exacerbate the effects of HIV.},
Doi = {10.1007/s13365-017-0512-5},
Key = {fds324858}
}
@article{fds325992,
Author = {Li, R and Roberts, RC and Huettel, SA and Brannon,
EM},
Title = {Five-year-olds do not show ambiguity aversion in a risk and
ambiguity task with physical objects.},
Journal = {Journal of Experimental Child Psychology},
Volume = {159},
Pages = {319-326},
Publisher = {ELSEVIER SCIENCE INC},
Year = {2017},
Month = {July},
url = {http://dx.doi.org/10.1016/j.jecp.2017.02.013},
Abstract = {Ambiguity aversion arises when a decision maker prefers
risky gambles with known probabilities over equivalent
ambiguous gambles with unknown probabilities. This
phenomenon has been consistently observed in adults across a
large body of empirical work. Evaluating ambiguity aversion
in young children, however, has posed methodological
challenges because probabilistic representations appropriate
for adults might not be understood by young children. Here,
we established a novel method for representing risk and
ambiguity with physical objects that overcomes previous
methodological limitations and allows us to measure
ambiguity aversion in young children. We found that
individual 5-year-olds exhibited consistent choice
preferences and, as a group, exhibited no ambiguity aversion
in a task that evokes ambiguity aversion in adults. Across
individuals, 5-year-olds exhibited greater variance in
ambiguity preferences compared with adults tested under
similar conditions. This suggests that ambiguity aversion is
absent during early childhood and emerges over the course of
development.},
Doi = {10.1016/j.jecp.2017.02.013},
Key = {fds325992}
}
@article{fds330179,
Author = {Kelly, M and Ngo, L and Chituc, V and Huettel, S and Sinnott-Armstrong,
W},
Title = {Moral conformity in online interactions: rational
justifications increase influence of peer opinions on moral
judgments},
Journal = {Social Influence},
Volume = {12},
Number = {2-3},
Pages = {57-68},
Publisher = {Informa UK Limited},
Year = {2017},
Month = {July},
url = {http://dx.doi.org/10.1080/15534510.2017.1323007},
Abstract = {Over the last decade, social media has increasingly been
used as a platform for political and moral discourse. We
investigate whether conformity, specifically concerning
moral attitudes, occurs in these virtual environments apart
from face-to-face interactions. Participants took an online
survey and saw either statistical information about the
frequency of certain responses, as one might see on social
media (Study 1), or arguments that defend the responses in
either a rational or emotional way (Study 2). Our results
show that social information shaped moral judgments, even in
an impersonal digital setting. Furthermore, rational
arguments were more effective at eliciting conformity than
emotional arguments. We discuss the implications of these
results for theories of moral judgment that prioritize
emotional responses.},
Doi = {10.1080/15534510.2017.1323007},
Key = {fds330179}
}
@article{fds329283,
Author = {Stanton, SJ and Sinnott-Armstrong, W and Huettel,
SA},
Title = {Neuromarketing: Ethical Implications of its Use and
Potential Misuse},
Journal = {Journal of Business Ethics},
Volume = {144},
Number = {4},
Pages = {799-811},
Publisher = {Springer Nature},
Year = {2017},
Month = {September},
url = {http://dx.doi.org/10.1007/s10551-016-3059-0},
Abstract = {Neuromarketing is an emerging field in which academic and
industry research scientists employ neuroscience techniques
to study marketing practices and consumer behavior. The use
of neuroscience techniques, it is argued, facilitates a more
direct understanding of how brain states and other
physiological mechanisms are related to consumer behavior
and decision making. Herein, we will articulate common
ethical concerns with neuromarketing as currently practiced,
focusing on the potential risks to consumers and the ethical
decisions faced by companies. We argue that the most
frequently raised concerns—threats to consumer autonomy,
privacy, and control—do not rise to meaningful ethical
issues given the current capabilities and implementation of
neuromarketing research. But, we identify how potentially
serious ethical issues may emerge from neuromarketing
research practices in industry, which are largely
proprietary and opaque. We identify steps that can mitigate
associated ethical risks and thus reduce the threats to
consumers. We conclude that neuromarketing has clear
potential for positive impact on society and consumers, a
fact rarely considered in the discussion on the ethics of
neuromarketing.},
Doi = {10.1007/s10551-016-3059-0},
Key = {fds329283}
}
@article{fds329566,
Author = {Utevsky, AV and Smith, DV and Young, JS and Huettel,
SA},
Title = {Large-Scale Network Coupling with the Fusiform Cortex
Facilitates Future Social Motivation.},
Journal = {Eneuro},
Volume = {4},
Number = {5},
Pages = {ENEURO.0084-ENEU17.2017},
Year = {2017},
Month = {September},
url = {http://dx.doi.org/10.1523/eneuro.0084-17.2017},
Abstract = {Large-scale functional networks, as identified through the
coordinated activity of spatially distributed brain regions,
have become central objects of study in neuroscience because
of their contributions to many processing domains. Yet, it
remains unclear how these domain-general networks interact
with focal brain regions to coordinate thought and action.
Here, we investigated how the default-mode network (DMN) and
executive control network (ECN), two networks associated
with goal-directed behavior, shape task performance through
their coupling with other cortical regions several seconds
in advance of behavior. We measured these networks'
connectivity during an adaptation of the monetary incentive
delay (MID) response-time task in which human participants
viewed social and nonsocial images (i.e., pictures of faces
and landscapes, respectively) while brain activity was
measured using fMRI. We found that participants displayed
slower reaction times (RTs) subsequent to social trials
relative to nonsocial trials. To examine the neural
mechanisms driving this subsequent-RT effect, we integrated
independent components analysis (ICA) and a network-based
psychophysiological interaction (nPPI) analysis; this
allowed us to investigate task-related changes in network
coupling that preceded the observed trial-to-trial variation
in RT. Strikingly, when subjects viewed social rewards, an
area of the fusiform gyrus (FG) consistent with the
functionally-defined fusiform face area (FFA) exhibited
increased coupling with the ECN (relative to the DMN), and
the relative magnitude of coupling tracked the slowing of RT
on the following trial. These results demonstrate how
large-scale, domain-general networks can interact with
focal, domain-specific cortical regions to orchestrate
subsequent behavior.},
Doi = {10.1523/eneuro.0084-17.2017},
Key = {fds329566}
}
@article{fds327383,
Author = {Meade, CS and Hobkirk, AL and Towe, SL and Chen, N-K and Bell, RP and Huettel, SA},
Title = {Cocaine dependence modulates the effect of HIV infection on
brain activation during intertemporal decision
making.},
Journal = {Drug Alcohol Depend},
Volume = {178},
Pages = {443-451},
Year = {2017},
Month = {September},
url = {http://dx.doi.org/10.1016/j.drugalcdep.2017.05.043},
Abstract = {BACKGROUND: Both HIV infection and chronic cocaine use alter
the neural circuitry of decision making, but the interactive
effects of these commonly comorbid conditions have not been
adequately examined. This study tested how cocaine moderates
HIV-related neural activation during an intertemporal
decision-making task. METHODS: The sample included 73
participants who differed on cocaine and HIV status (18
COC+/HIV+, 19 COC+/HIV-, 19 COC-/HIV+, 17 COC-/HIV-).
Participants made choices between smaller, sooner and
larger, delayed rewards while undergoing functional MRI.
Choices varied in difficulty based on subjective value: hard
(equivalently valued), easy (disparately valued), and
control choices. A mixed-effects model controlling for
education and smoking identified main and interactive
effects of HIV and COC during hard relative to easy choices
(difficulty contrast). RESULTS: COC+ status was associated
with lower activation in bilateral frontal gyri and right
insular and posterior parietal cortices. HIV+ status was
associated with higher activation in the visual cortex, but
lower activation in bilateral prefrontal cortices and
cerebellum and left posterior parietal cortex. COC moderated
the effects of HIV in several clusters centered in the
bilateral prefrontal cortices and cerebellum. In post-hoc
analyses, there were significant effects of HIV status on
activation for COC+, but not COC-, participants; interaction
effects remained after controlling for polysubstance use.
CONCLUSION: Cocaine use may diminish the compensatory neural
activation often seen among HIV+ samples during decision
making. Our results highlight the importance of examining
the neuropsychiatric effects of comorbid medical conditions
to identify potential neural targets for cognitive
remediation interventions.},
Doi = {10.1016/j.drugalcdep.2017.05.043},
Key = {fds327383}
}
@article{fds340129,
Author = {Sweitzer, MM and Watson, KK and Erwin, SR and Winecoff, AA and Datta, N and Huettel, S and Platt, ML and Zucker, NL},
Title = {Neurobiology of social reward valuation in adults with a
history of anorexia nervosa.},
Journal = {Plos One},
Volume = {13},
Number = {12},
Pages = {e0205085},
Year = {2018},
url = {http://dx.doi.org/10.1371/journal.pone.0205085},
Abstract = {OBJECTIVE: Anorexia nervosa (AN) is a disorder characterized
by atypical patterns of reward valuation (e.g. positive
valuation of hunger). Atypical reward processing may extend
into social domains. If so, such findings would be of
prognostic significance as impaired social functioning
predicts worse outcome. We explore neural circuits
implicated in social reward processing in individuals with a
history of AN who are weight-restored relative to controls
and examine the effects of illness course on the experience
of social value. METHOD: 20 weight-restored individuals with
a history of AN (AN-WR) and 24 healthy control (HC)
participants were assessed using fMRI tasks that tapped
social reward: smiling faces and full human figures that
varied in attractiveness and weight. RESULTS: AN-WR differed
from HC in attractiveness ratings by weight (negatively
correlated in AN-WR). While there were no significant
differences when viewing smiling faces, viewing full figures
resulted in decreased activation in regions implicated in
reward valuation (the right caudate) for AN-WR and this
region was negatively correlated with a sustained course of
the disorder. Exploratory whole brain analyses revealed
reduced activation in regions associated with social reward,
self-referential processing, and cognitive reappraisal
(e.g., medial prefrontal cortex, striatum, and nucleus
accumbens) with sustained disorder course. DISCUSSION: The
rewarding value of full body images decreases with a
sustained disorder course. This may reflect an extension of
atypical reward processing documented in AN-WR, perhaps as a
function of starvation dampening visceral motivational
signals; the deployment of cognitive strategies that lessen
the experience of reward; and/or the nature of the stimuli
themselves as provocative of eating disorder symptoms (e.g.,
thin bodies). These findings did not extend to smiling face
stimuli. Advances in technology (e.g., virtual avatars, text
messaging) may provide novel means to build relationships,
including therapeutic relationships, to support improved
social connections without threats to symptom
provocation.},
Doi = {10.1371/journal.pone.0205085},
Key = {fds340129}
}
@article{fds330849,
Author = {Kwak, Y and Huettel, S},
Title = {The order of information processing alters economic
gain-loss framing effects.},
Journal = {Acta Psychologica},
Volume = {182},
Pages = {46-54},
Year = {2018},
Month = {January},
url = {http://dx.doi.org/10.1016/j.actpsy.2017.11.013},
Abstract = {Adaptive decision making requires analysis of available
information during the process of choice. In many decisions
that information is presented visually - which means that
variations in visual properties (e.g., salience, complexity)
can potentially influence the process of choice. In the
current study, we demonstrate that variation in the
left-right positioning of risky and safe decision options
can influence the canonical gain-loss framing effect. Two
experiments were conducted using an economic framing task in
which participants chose between gambles and certain
outcomes. The first experiment demonstrated that the
magnitude of the gain-loss framing effect was greater when
the certain option signaling the current frame was presented
on the left side of the visual display. Eye-tracking data
during task performance showed a left-gaze bias for initial
fixations, suggesting that the option presented on the left
side was processed first. Combination of eye-tracking and
choice data revealed that there was a significant effect of
direction of first gaze (i.e. left vs. right) as well as an
interaction between gaze direction and identity of the first
fixated information (i.e. certain vs. gamble) regardless of
frame. A second experiment presented the gamble and certain
options in a random order, with a temporal delay between
their presentations. We found that the magnitude of
gain-loss framing was larger when the certain option was
presented first, regardless of left and right positioning,
only in individuals with lower risk-taking tendencies. The
effect of presentation order on framing was not present in
high risk-takers. These results suggest that the sequence of
visual information processing as well as their left-right
positioning can bias choices by changing the impact of the
presented information during risky decision
making.},
Doi = {10.1016/j.actpsy.2017.11.013},
Key = {fds330849}
}
@article{fds327384,
Author = {Meade, CS and Addicott, M and Hobkirk, AL and Towe, SL and Chen, N-K and Sridharan, S and Huettel, SA},
Title = {Cocaine and HIV are independently associated with neural
activation in response to gain and loss valuation during
economic risky choice.},
Journal = {Addict Biol},
Volume = {23},
Number = {2},
Pages = {796-809},
Year = {2018},
Month = {March},
url = {http://dx.doi.org/10.1111/adb.12529},
Abstract = {Stimulant abuse is disproportionately common in HIV-positive
persons. Both HIV and stimulants are independently
associated with deficits in reward-based decision making,
but their interactive and/or additive effects are poorly
understood despite their prevalent co-morbidity. Here, we
examined the effects of cocaine dependence and HIV infection
in 69 adults who underwent functional magnetic resonance
imaging while completing an economic loss aversion task. We
identified two neural networks that correlated with the
evaluation of the favorable characteristics of the gamble
(i.e. higher gains/lower losses: ventromedial prefrontal
cortex, anterior cingulate, anterior and posterior precuneus
and visual cortex) versus unfavorable characteristics of the
gamble (i.e. lower gains/higher losses: dorsal prefrontal,
lateral orbitofrontal, posterior parietal cortex, anterior
insula and dorsal caudate). Behaviorally, cocaine and HIV
had additive effects on loss aversion scores, with
HIV-positive cocaine users being the least loss averse.
Cocaine users had greater activation in brain regions that
tracked the favorability of gamble characteristics (i.e.
increased activation to gains, but decreased activation to
losses). In contrast, HIV infection was independently
associated with lesser activation in regions that tracked
the unfavorability of gamble characteristics. These results
suggest that cocaine is associated with an overactive
reward-seeking system, while HIV is associated with an
underactive cognitive control system. Together, these
alterations may leave HIV-positive cocaine users
particularly vulnerable to making unfavorable decisions when
outcomes are uncertain.},
Doi = {10.1111/adb.12529},
Key = {fds327384}
}
@article{fds332798,
Author = {Wing, EA and Iyengar, V and Hess, TM and LaBar, KS and Huettel, SA and Cabeza, R},
Title = {Neural mechanisms underlying subsequent memory for personal
beliefs:An fMRI study.},
Journal = {Cognitive, Affective & Behavioral Neuroscience},
Volume = {18},
Number = {2},
Pages = {216-231},
Year = {2018},
Month = {April},
url = {http://dx.doi.org/10.3758/s13415-018-0563-y},
Abstract = {Many fMRI studies have examined the neural mechanisms
supporting emotional memory for stimuli that generate
emotion rather automatically (e.g., a picture of a dangerous
animal or of appetizing food). However, far fewer studies
have examined how memory is influenced by emotion related to
social and political issues (e.g., a proposal for large
changes in taxation policy), which clearly vary across
individuals. In order to investigate the neural substrates
of affective and mnemonic processes associated with personal
opinions, we employed an fMRI task wherein participants
rated the intensity of agreement/disagreement to
sociopolitical belief statements paired with neural face
pictures. Following the rating phase, participants performed
an associative recognition test in which they distinguished
identical versus recombined face-statement pairs. The study
yielded three main findings: behaviorally, the intensity of
agreement ratings was linked to greater subjective emotional
arousal as well as enhanced high-confidence subsequent
memory. Neurally, statements that elicited strong (vs. weak)
agreement or disagreement were associated with greater
activation of the amygdala. Finally, a subsequent memory
analysis showed that the behavioral memory advantage for
statements generating stronger ratings was dependent on the
medial prefrontal cortex (mPFC). Together, these results
both underscore consistencies in neural systems supporting
emotional arousal and suggest a modulation of
arousal-related encoding mechanisms when emotion is
contingent on referencing personal beliefs.},
Doi = {10.3758/s13415-018-0563-y},
Key = {fds332798}
}
@article{fds338425,
Author = {Lighthall, NR and Pearson, JM and Huettel, SA and Cabeza,
R},
Title = {Feedback-Based Learning in Aging: Contributions and
Trajectories of Change in Striatal and Hippocampal
Systems.},
Journal = {The Journal of Neuroscience : the Official Journal of the
Society for Neuroscience},
Volume = {38},
Number = {39},
Pages = {8453-8462},
Year = {2018},
Month = {September},
url = {http://dx.doi.org/10.1523/jneurosci.0769-18.2018},
Abstract = {The striatum supports learning from immediate feedback by
coding prediction errors (PEs), whereas the hippocampus (HC)
plays a parallel role in learning from delayed feedback.
Both regions show evidence of decline in human aging, but
behavioral research suggests greater decline in HC versus
striatal functions. The present study included male and
female humans and used fMRI to examine younger and older
adults' brain activation patterns during a learning task
with choice feedback presented immediately or after a brief
delay. Participants then completed a surprise memory task
that tested their recognition of trial-unique feedback
stimuli, followed by assessments of postlearning cue
preference, outcome probability awareness, and willingness
to pay. The study yielded three main findings. First,
behavioral measures indicated similar rates of learning in
younger and older adults across conditions, but postlearning
measures indicated impairment in older adults' ability to
subsequently apply learning to discriminate between cues.
Second, PE signals in the striatum were greater for
immediate versus delayed feedback in both age groups, but PE
signals in the HC were greater for delayed versus immediate
feedback only in younger adults. Third, unlike younger
adults, older adults failed to exhibit enhanced episodic
memory for outcome stimuli in the delayed-feedback
condition. Together, these findings indicate that HC
circuits supporting learning and memory decline more than
striatal circuits in healthy aging, which suggests that
declines in HC learning signals may be an important
predictor of deficits in learning-dependent economic
decisions among older adults.SIGNIFICANCE STATEMENT The
hippocampus (HC) and striatum play distinct and critical
roles in learning. Substantial research suggests that
age-related decline in learning supported by the HC outpaces
decline in learning supported by the striatum; however, such
inferences have been drawn by comparing performance in tasks
with fundamentally different structures. The present study
overcomes this obstacle by implementing a single
fMRI-learning paradigm with a subtle variation in feedback
timing to examine differential age effects on memory
supported by the HC and striatum. Our results provide
converging behavioral and brain-imaging evidence showing
that HC circuits supporting learning and memory decline more
than striatal circuits in healthy aging and that declines in
HC learning signals may predict early deficits in
learning-dependent decisions among older
adults.},
Doi = {10.1523/jneurosci.0769-18.2018},
Key = {fds338425}
}
@article{fds339650,
Author = {Hobkirk, AL and Bell, RP and Utevsky, AV and Huettel, S and Meade,
CS},
Title = {Reward and executive control network resting-state
functional connectivity is associated with impulsivity
during reward-based decision making for cocaine
users.},
Journal = {Drug Alcohol Depend},
Volume = {194},
Pages = {32-39},
Year = {2019},
Month = {January},
url = {http://dx.doi.org/10.1016/j.drugalcdep.2018.09.013},
Abstract = {BACKGROUND: Cocaine addiction is related to impulsive
decision making that is mediated by brain circuitry involved
in reward processing and executive functions, such as
cognitive control and attentional salience. Resting-state
functional connectivity between reward and executive control
circuitry is altered among cocaine users, with concomitant
deficits in impulsivity and learning. Prior research has
examined how select brain regions interact to influence
impulsive decision making for drug users; however, research
examining interactions between large-scale brain networks
and impulsive behavior is limited. METHODS: The current
study compared reward and executive control network
resting-state functional connectivity and its relationship
to impulsive decision making between cocaine users
(n = 37) and non-cocaine using control participants
(n = 35). Participants completed computerized
decision-making tasks and a separate resting-state
functional magnetic resonance imaging scan. Data underwent
independent component, dual regression, and linear
regression moderation analyses. RESULTS: Higher impulsivity
on the Balloon Analogue Risk Task (BART) was associated with
inverse resting-state connectivity between the left
cognitive control and subgenual anterior cingulate extended
reward networks for cocaine users, while the opposite was
found for controls. Less impulsivity on the monetary choice
questionnaire was associated with stronger positive
resting-state connectivity between the attentional salience
and striatal core reward networks for controls, while
cocaine users showed no association between impulsivity and
resting-state connectivity of these networks. CONCLUSIONS:
Cocaine users show aberrant associations between
reward-executive control resting-state network coupling and
impulsive decision making. The findings support the
conclusion that an imbalance between reward and executive
control circuitry contributes to impulsivity in drug
use.},
Doi = {10.1016/j.drugalcdep.2018.09.013},
Key = {fds339650}
}
@article{fds339750,
Author = {Shelby, RA and Dorfman, CS and Bosworth, HB and Keefe, F and Sutton, L and Owen, L and Corsino, L and Erkanli, A and Reed, SD and Arthur, SS and Somers, T and Barrett, N and Huettel, S and Gonzalez, JM and Kimmick,
G},
Title = {Testing a behavioral intervention to improve adherence to
adjuvant endocrine therapy (AET).},
Journal = {Contemp Clin Trials},
Volume = {76},
Pages = {120-131},
Year = {2019},
Month = {January},
url = {http://dx.doi.org/10.1016/j.cct.2018.11.010},
Abstract = {Adjuvant endocrine therapy (AET) is used to prevent
recurrence and reduce mortality for women with hormone
receptor positive breast cancer. Poor adherence to AET is a
significant problem and contributes to increased medical
costs and mortality. A variety of problematic symptoms
associated with AET are related to non-adherence and early
discontinuation of treatment. The goal of this study is to
test a novel, telephone-based coping skills training that
teaches patients adherence skills and techniques for coping
with problematic symptoms (CST-AET). Adherence to AET will
be assessed in real-time for 18 months using wireless
smart pill bottles. Symptom interference (i.e., pain,
vasomotor symptoms, sleep problems, vaginal dryness) and
cost-effectiveness of the intervention protocol will be
examined as secondary outcomes. Participants (N = 400)
will be recruited from a tertiary care medical center or
community clinics in medically underserved or rural areas.
Participants will be randomized to receive CST-AET or a
general health education intervention (comparison
condition). CST-AET includes ten nurse-delivered calls
delivered over 6 months. CST-AET provides systematic
training in coping skills for managing symptoms that
interfere with adherence. Interactive voice messaging
provides reinforcement for skills use and adherence that is
tailored based on real-time adherence data from the wireless
smart pill bottles. Given the high rates of non-adherence
and recent recommendations that women remain on AET for
10 years, we describe a timely trial. If effective, the
CST-AET protocol may not only reduce the burden of AET use
but also lead to cost-effective changes in clinical care and
improve breast cancer outcomes. Trials registration:
ClinicalTrials.gov, NCT02707471, registered
3/3/2016.},
Doi = {10.1016/j.cct.2018.11.010},
Key = {fds339750}
}
@article{fds341051,
Author = {Sullivan, NJ and Fitzsimons, GJ and Platt, ML and Huettel,
SA},
Title = {Indulgent Foods Can Paradoxically Promote Disciplined
Dietary Choices.},
Journal = {Psychol Sci},
Volume = {30},
Number = {2},
Pages = {273-287},
Year = {2019},
Month = {February},
url = {http://dx.doi.org/10.1177/0956797618817509},
Abstract = {As obesity rates continue to rise, interventions promoting
healthful choices will become increasingly important. Here,
participants ( N = 79) made binary choices between familiar
foods; some trials contained a common consequence that had a
constant probability of receipt regardless of the
participant's choice. We theorized-on the basis of
simulations using a value-normalization model-that indulgent
common consequences potentiated disciplined choices by
shaping other options' perceived healthfulness and
tastiness. Our experimental results confirmed these
predictions: An indulgent common consequence more than
doubled the rate of disciplined choices. We used eye-gaze
data to provide insights into the underlying mechanisms,
finding that an indulgent common consequence biased eye gaze
toward healthful foods. Furthermore, attention toward the
common consequence predicted individual differences in
behavioral bias. Results were replicated across two
independent samples receiving distinct goal primes. These
results demonstrate that introducing an irrelevant indulgent
food can alter processing of healthier items-and thus
promote disciplined choices.},
Doi = {10.1177/0956797618817509},
Key = {fds341051}
}
@article{fds341890,
Author = {Amasino, DR and Sullivan, NJ and Kranton, RE and Huettel,
SA},
Title = {Amount and time exert independent influences on
intertemporal choice.},
Journal = {Nature Human Behaviour},
Volume = {3},
Number = {4},
Pages = {383-392},
Year = {2019},
Month = {April},
url = {http://dx.doi.org/10.1038/s41562-019-0537-2},
Abstract = {Intertemporal choices involve trade-offs between the value
of rewards and the delay before those rewards are
experienced. Canonical intertemporal choice models such as
hyperbolic discounting assume that reward amount and time
until delivery are integrated within each option prior to
comparison<sup>1,2</sup>. An alternative view posits that
intertemporal choice reflects attribute-wise processes in
which amount and time attributes are compared
separately<sup>3-6</sup>. Here, we use multi-attribute drift
diffusion modelling (DDM) to show that attribute-wise
comparison represents the choice process better than
option-wise comparison for intertemporal choice in a young
adult population. We find that, while accumulation rates for
amount and time information are uncorrelated, the difference
between those rates predicts individual differences in
patience. Moreover, patient individuals incorporate amount
earlier than time into the decision process. Using eye
tracking, we link these modelling results to attention,
showing that patience results from a rapid, attribute-wise
process that prioritizes amount over time information. Thus,
we find converging evidence that distinct evaluation
processes for amount and time determine intertemporal
financial choices. Because intertemporal decisions in the
lab have been linked to failures of patience ranging from
insufficient saving to addiction<sup>7-13</sup>,
understanding individual differences in the choice process
is important for developing more effective
interventions.},
Doi = {10.1038/s41562-019-0537-2},
Key = {fds341890}
}
@article{fds342482,
Author = {McDonald, KR and Broderick, WF and Huettel, SA and Pearson,
JM},
Title = {Bayesian nonparametric models characterize instantaneous
strategies in a competitive dynamic game.},
Journal = {Nature Communications},
Volume = {10},
Number = {1},
Pages = {1808},
Year = {2019},
Month = {April},
url = {http://dx.doi.org/10.1038/s41467-019-09789-4},
Abstract = {Previous studies of strategic social interaction in game
theory have predominantly used games with clearly-defined
turns and limited choices. Yet, most real-world social
behaviors involve dynamic, coevolving decisions by
interacting agents, which poses challenges for creating
tractable models of behavior. Here, using a game in which
humans competed against both real and artificial opponents,
we show that it is possible to quantify the instantaneous
dynamic coupling between agents. Adopting a reinforcement
learning approach, we use Gaussian Processes to model the
policy and value functions of participants as a function of
both game state and opponent identity. We found that
higher-scoring participants timed their final change in
direction to moments when the opponent's counter-strategy
was weaker, while lower-scoring participants less precisely
timed their final moves. This approach offers a natural set
of metrics for facilitating analysis at multiple timescales
and suggests new classes of experimental paradigms for
assessing behavior.},
Doi = {10.1038/s41467-019-09789-4},
Key = {fds342482}
}
@article{fds342483,
Author = {Zhang, X and Huettel, SA and Mullette-Gillman, OA and Guo, H and Wang,
L},
Title = {Exploring common changes after acute mental stress and acute
tryptophan depletion: Resting-state fMRI
studies.},
Journal = {J Psychiatr Res},
Volume = {113},
Pages = {172-180},
Year = {2019},
Month = {June},
url = {http://dx.doi.org/10.1016/j.jpsychires.2019.03.025},
Abstract = {Stress and low serotonin levels are important biological
factors in depression and anxiety etiologies. Although
studies indicate that low serotonin levels, stress, and
other factors may interact in depression/anxiety
psychopathology, few studies have investigated the
potentially shared neural substrates. We conducted
resting-state fMRI scans pre- and post-stress task, and
under control and tryptophan depletion condition, to explore
the common changes induced by acute mental stress (AMS) and
acute tryptophan depletion (ATD). The present study targeted
regions within core brain networks - default mode network,
salience network, executive control network, and emotion
network - reported altered in AMS and ATD, and used regional
homogeneity (ReHo) and functional connectivity (FC) analyses
to explore their overlapped effects. We additionally
examined the relationships among core neural networks -
operationalized as an index of resource allocation bias that
quantifies the shift from internal to external modes of
processing. We found both manipulations induced increased
ReHo of the amygdala and decreased ReHo of the posterior
cingulate cortex (PCC). The PCC-amygdala FC was negatively
correlated with the change of negative affect, whereas the
right dorsolateral prefrontal cortex and right anterior
insula FC was positively associated with anxiety level. In
addition, we found that a greater shift to an external mode
was correlated with higher anxiety level under both
conditions. Common changes induced by acute mental stress
and acute tryptophan depletion confirmed our hypothesis that
AMS and ATD induce changes in common neural pathways, which
in turn might mark vulnerability to depression and
anxiety.},
Doi = {10.1016/j.jpsychires.2019.03.025},
Key = {fds342483}
}
@article{fds344828,
Author = {Warwick, H and Hutyra, C and Politzer, C and Francis, A and Risoli, T and Green, C and Verma, N and Huettel, S and Mather, RC},
Title = {Small Social Incentives Did Not Improve the Survey Response
Rate of Patients Who Underwent Orthopaedic Surgery: A
Randomized Trial.},
Journal = {Clinical Orthopaedics and Related Research},
Volume = {477},
Number = {7},
Pages = {1648-1656},
Year = {2019},
Month = {July},
url = {http://dx.doi.org/10.1097/CORR.0000000000000732},
Abstract = {BACKGROUND: The generalizability of data derived from
patient-reported outcome measures (PROMs) depends largely on
the proportion of the relevant population that completes
PROM surveys. However, PROM survey responses remain low,
despite efforts to increase participation. Social
incentives, such as the offer to make a charitable donation
on behalf of the survey respondent, have generally not been
effective where online surveys are concerned, but this has
not been extensively tested in medicine. QUESTIONS/PURPOSES:
(1) Do personalized social incentives increase response
rates or response completeness for postoperative PROM
surveys in an orthopaedic population? (2) Are there
demographic factors associated with response and nonresponse
to postoperative PROM surveys? (3) Are some demographic
factors associated with increased response to social
incentive offers? METHODS: Participants were selected from
an institutional orthopaedics database. Patients were older
than 18 years, had an email address on file, and had
undergone one of the following procedures 1 to 2 years ago:
Achilles tendon repair, ACL reconstruction, meniscectomy,
hip arthroscopy, TKA, or THA. Of 4685 eligible patients,
3000 (64%) were randomly selected for inclusion in the
study. Participants were randomized to one of four groups:
(1) control: no incentive (n = 750); (2) patient donation:
offer of a USD 5 donation to provide medical supplies to a
pediatric orthopaedic patient (n = 751); (3) research
donation: offer of a USD 5 donation to a procedure-specific
research program (n = 749); or (4) explanation: explanation
that response supports quality improvement (n = 750). The
four groups did not differ regarding patient age, gender,
race, procedure type, or time since procedure. All patients
were sent an email invitation with the same PROM survey
link. The proportion of patients who responded (defined here
as the response rate) was measured at 4 weeks and compared
between intervention groups. We used a logistic regression
analysis to identify demographic factors associated with
response while controlling for confounding variables and
performed subgroup analyses to determine any demographic
factors associated with increased response to social
incentives. RESULTS: There was no difference in the overall
response rate (research donation: 49% [353 of 725], patient
donation: 45% [333 of 734], control: 45% [322 of 723],
explanation: 44% [314 of 719]; p = 0.239) or response
completeness (research donation: 89% [315 of 353], patient
donation: 90% [301 of 333], control: 89% [287 of 322],
explanation: 87% [274 of 314]; p = 0.647) between the four
groups. Women (odds ratio [OR], 1.175; p = 0.042), older
patients (< 58 years: OR, 1.016 per 1-year increase; p =
0.001; 58-64 years: OR, 1.023 per 1-year increase; p <
0.001; > 64 years: OR, 1.021 per 1-year increase; p <
0.001), and white patients (OR 2.034 compared with black
patients, p < 0.001) were slightly more likely to respond,
after controlling for potential confounding variables such
as gender, age, race, and procedure type. In subgroup
analyses, men (research donation: 49% [155 of 316], patient
donation: 45% [146 of 328], control: 40% [130 of 325],
explanation: 39% [127 of 325]; p = 0.041) and patients
younger than 58 years (research donation: 40% [140 of 351],
control: 35% [130 of 371], patient donation: 32% [113 of
357], explanation: 27% [93 of 340]; p = 0.004) were slightly
more likely to respond to the research donation than those
with other interventions were. CONCLUSIONS: Despite small
effects in specific subgroups, personalized social
incentives did not increase the overall response to
postoperative orthopaedic surveys. Novel and targeted
strategies will be necessary to reach response thresholds
that enable healthcare stakeholders to use PROMs
effectively. LEVEL OF EVIDENCE: Level I, therapeutic
study.},
Doi = {10.1097/CORR.0000000000000732},
Key = {fds344828}
}
@article{fds343502,
Author = {Li, R and Utevsky, AV and Huettel, SA and Braams, BR and Peters, S and Crone, EA and van Duijvenvoorde, ACK},
Title = {Developmental Maturation of the Precuneus as a Functional
Core of the Default Mode Network.},
Journal = {Journal of Cognitive Neuroscience},
Volume = {31},
Number = {10},
Pages = {1506-1519},
Year = {2019},
Month = {October},
url = {http://dx.doi.org/10.1162/jocn_a_01426},
Abstract = {Efforts to map the functional architecture of the developing
human brain have shown that connectivity between and within
functional neural networks changes from childhood to
adulthood. Although prior work has established that the
adult precuneus distinctively modifies its connectivity
during task versus rest states [Utevsky, A. V., Smith, D.
V., & Huettel, S. A. Precuneus is a functional core of the
default-mode network. Journal of Neuroscience, 34, 932-940,
2014], it remains unknown how these connectivity patterns
emerge over development. Here, we use fMRI data collected at
two longitudinal time points from over 250 participants
between the ages of 8 and 26 years engaging in two cognitive
tasks and a resting-state scan. By applying independent
component analysis to both task and rest data, we identified
three canonical networks of interest-the rest-based default
mode network and the task-based left and right
frontoparietal networks (LFPN and RFPN, respectively)-which
we explored for developmental changes using dual regression
analyses. We found systematic state-dependent functional
connectivity in the precuneus, such that engaging in a task
(compared with rest) resulted in greater precuneus-LFPN and
precuneus-RFPN connectivity, whereas being at rest (compared
with task) resulted in greater precuneus-default mode
network connectivity. These cross-sectional results
replicated across both tasks and at both developmental time
points. Finally, we used longitudinal mixed models to show
that the degree to which precuneus distinguishes between
task and rest states increases with age, due to age-related
increasing segregation between precuneus and LFPN at rest.
Our results highlight the distinct role of the precuneus in
tracking processing state, in a manner that is both present
throughout and strengthened across development.},
Doi = {10.1162/jocn_a_01426},
Key = {fds343502}
}
@article{fds338534,
Author = {Meade, CS and Bell, RP and Towe, SL and Chen, N-K and Hobkirk, AL and Huettel, SA},
Title = {Synergistic effects of marijuana abuse and HIV infection on
neural activation during a cognitive interference
task.},
Journal = {Addict Biol},
Volume = {24},
Number = {6},
Pages = {1235-1244},
Year = {2019},
Month = {November},
url = {http://dx.doi.org/10.1111/adb.12678},
Abstract = {Marijuana use, which is disproportionately prevalent among
human immunodeficiency virus (HIV)-infected persons, can
alter activity in fronto-parietal regions during cognitively
demanding tasks. While HIV is also associated with altered
neural activation, it is not known how marijuana may further
affect brain function in this population. Our study examined
the independent and additive effects of HIV infection and
regular marijuana use on neural activation during a
cognitive interference task. The sample included 93 adults
who differed on marijuana (MJ) and HIV statuses
(20 MJ+/HIV+, 19 MJ+/HIV-, 29 MJ-/HIV+, 25 MJ-/HIV-).
Participants completed a counting Stroop task during a
functional magnetic resonance imaging scan. Main and
interactive effects on neural activation during interference
versus neutral blocks were examined using a mixed-effects
analysis. The sample showed the expected Stroop effect for
both speed and accuracy. There were main effects of MJ in
the right and left inferior parietal lobules, with the left
cluster extending into the posterior middle temporal gyrus
and a main effect of HIV in the dorsal anterior cingulate
cortex. There was an interaction in the left fronto-insular
cortex, such that the MJ+/HIV+ group had the largest
increase in activation compared with other groups. Among
MJ+, signal change in this cluster correlated positively
with cumulative years of regular marijuana use. These
results suggest that comorbid HIV and marijuana use is
associated with complex neural alterations in multiple brain
regions during cognitive interference. Follow-up research is
needed to determine how marijuana-related characteristics
may moderate HIV neurologic disease and impact real-world
functioning.},
Doi = {10.1111/adb.12678},
Key = {fds338534}
}
@article{fds348349,
Author = {Bachman, MD and Huettel, SA},
Title = {Motivated control as a bridge between neuroeconomics and
cognitive neuroscience.},
Journal = {Nature Human Behaviour},
Volume = {4},
Number = {4},
Pages = {332-333},
Year = {2020},
Month = {April},
url = {http://dx.doi.org/10.1038/s41562-019-0794-0},
Doi = {10.1038/s41562-019-0794-0},
Key = {fds348349}
}
@article{fds349865,
Author = {Botvinik-Nezer, R and Holzmeister, F and Camerer, CF and Dreber, A and Huber, J and Johannesson, M and Kirchler, M and Iwanir, R and Mumford,
JA and Adcock, RA and Avesani, P and Baczkowski, BM and Bajracharya, A and Bakst, L and Ball, S and Barilari, M and Bault, N and Beaton, D and Beitner, J and Benoit, RG and Berkers, RMWJ and Bhanji, JP and Biswal,
BB and Bobadilla-Suarez, S and Bortolini, T and Bottenhorn, KL and Bowring, A and Braem, S and Brooks, HR and Brudner, EG and Calderon, CB and Camilleri, JA and Castrellon, JJ and Cecchetti, L and Cieslik, EC and Cole, ZJ and Collignon, O and Cox, RW and Cunningham, WA and Czoschke,
S and Dadi, K and Davis, CP and Luca, AD and Delgado, MR and Demetriou, L and Dennison, JB and Di, X and Dickie, EW and Dobryakova, E and Donnat, CL and Dukart, J and Duncan, NW and Durnez, J and Eed, A and Eickhoff, SB and Erhart, A and Fontanesi, L and Fricke, GM and Fu, S and Galván, A and Gau,
R and Genon, S and Glatard, T and Glerean, E and Goeman, JJ and Golowin,
SAE and González-García, C and Gorgolewski, KJ and Grady, CL and Green, MA and Guassi Moreira and JF and Guest, O and Hakimi, S and Hamilton, JP and Hancock, R and Handjaras, G and Harry, BB and Hawco, C and Herholz, P and Herman, G and Heunis, S and Hoffstaedter, F and Hogeveen,
J and Holmes, S and Hu, C-P and Huettel, SA and Hughes, ME and Iacovella,
V and Iordan, AD and Isager, PM and Isik, AI and Jahn, A and Johnson, MR and Johnstone, T and Joseph, MJE and Juliano, AC and Kable, JW and Kassinopoulos, M and Koba, C and Kong, X-Z and Koscik, TR and Kucukboyaci, NE and Kuhl, BA and Kupek, S and Laird, AR and Lamm, C and Langner, R and Lauharatanahirun, N and Lee, H and Lee, S and Leemans, A and Leo, A and Lesage, E and Li, F and Li, MYC and Lim, PC and Lintz, EN and Liphardt, SW and Losecaat Vermeer and AB and Love, BC and Mack, ML and Malpica, N and Marins, T and Maumet, C and McDonald, K and McGuire, JT and Melero, H and Méndez Leal and AS and Meyer, B and Meyer, KN and Mihai, G and Mitsis, GD and Moll, J and Nielson, DM and Nilsonne, G and Notter, MP and Olivetti, E and Onicas, AI and Papale, P and Patil, KR and Peelle, JE and Pérez, A and Pischedda, D and Poline, J-B and Prystauka, Y and Ray, S and Reuter-Lorenz, PA and Reynolds, RC and Ricciardi, E and Rieck, JR and Rodriguez-Thompson, AM and Romyn, A and Salo, T and Samanez-Larkin,
GR and Sanz-Morales, E and Schlichting, ML and Schultz, DH and Shen, Q and Sheridan, MA and Silvers, JA and Skagerlund, K and Smith, A and Smith,
DV and Sokol-Hessner, P and Steinkamp, SR and Tashjian, SM and Thirion,
B and Thorp, JN and Tinghög, G and Tisdall, L and Tompson, SH and Toro-Serey, C and Torre Tresols and JJ and Tozzi, L and Truong, V and Turella, L and van 't Veer, AE and Verguts, T and Vettel, JM and Vijayarajah, S and Vo, K and Wall, MB and Weeda, WD and Weis, S and White,
DJ and Wisniewski, D and Xifra-Porxas, A and Yearling, EA and Yoon, S and Yuan, R and Yuen, KSL and Zhang, L and Zhang, X and Zosky, JE and Nichols,
TE and Poldrack, RA and Schonberg, T},
Title = {Variability in the analysis of a single neuroimaging dataset
by many teams.},
Journal = {Nature},
Volume = {582},
Number = {7810},
Pages = {84-88},
Year = {2020},
Month = {June},
url = {http://dx.doi.org/10.1038/s41586-020-2314-9},
Abstract = {Data analysis workflows in many scientific domains have
become increasingly complex and flexible. Here we assess the
effect of this flexibility on the results of functional
magnetic resonance imaging by asking 70 independent teams
to analyse the same dataset, testing the same 9 ex-ante
hypotheses1. The flexibility of analytical approaches is
exemplified by the fact that no two teams chose identical
workflows to analyse the data. This flexibility resulted in
sizeable variation in the results of hypothesis tests, even
for teams whose statistical maps were highly correlated at
intermediate stages of the analysis pipeline. Variation in
reported results was related to several aspects of analysis
methodology. Notably, a meta-analytical approach that
aggregated information across teams yielded a significant
consensus in activated regions. Furthermore, prediction
markets of researchers in the field revealed an
overestimation of the likelihood of significant findings,
even by researchers with direct knowledge of the dataset2-5.
Our findings show that analytical flexibility can have
substantial effects on scientific conclusions, and identify
factors that may be related to variability in the analysis
of functional magnetic resonance imaging. The results
emphasize the importance of validating and sharing complex
analysis workflows, and demonstrate the need for performing
and reporting multiple analyses of the same data. Potential
approaches that could be used to mitigate issues related to
analytical variability are discussed.},
Doi = {10.1038/s41586-020-2314-9},
Key = {fds349865}
}
@article{fds353842,
Author = {McDonald, KR and Pearson, JM and Huettel, SA},
Title = {Dorsolateral and dorsomedial prefrontal cortex track
distinct properties of dynamic social behavior.},
Journal = {Social Cognitive and Affective Neuroscience},
Volume = {15},
Number = {4},
Pages = {383-393},
Year = {2020},
Month = {June},
url = {http://dx.doi.org/10.1093/scan/nsaa053},
Abstract = {Understanding how humans make competitive decisions in
complex environments is a key goal of decision neuroscience.
Typical experimental paradigms constrain behavioral
complexity (e.g. choices in discrete-play games), and thus,
the underlying neural mechanisms of dynamic social
interactions remain incompletely understood. Here, we
collected fMRI data while humans played a competitive
real-time video game against both human and computer
opponents, and then, we used Bayesian non-parametric methods
to link behavior to neural mechanisms. Two key cognitive
processes characterized behavior in our task: (i) the
coupling of one's actions to another's actions (i.e.
opponent sensitivity) and (ii) the advantageous timing of a
given strategic action. We found that the dorsolateral
prefrontal cortex displayed selective activation when the
subject's actions were highly sensitive to the opponent's
actions, whereas activation in the dorsomedial prefrontal
cortex increased proportionally to the advantageous timing
of actions to defeat one's opponent. Moreover, the
temporoparietal junction tracked both of these behavioral
quantities as well as opponent social identity, indicating a
more general role in monitoring other social agents. These
results suggest that brain regions that are frequently
implicated in social cognition and value-based
decision-making also contribute to the strategic tracking of
the value of social actions in dynamic, multi-agent
contexts.},
Doi = {10.1093/scan/nsaa053},
Key = {fds353842}
}
@article{fds350801,
Author = {Bell, RP and Towe, SL and Lalee, Z and Huettel, SA and Meade,
CS},
Title = {Neural sensitivity to risk in adults with co-occurring HIV
infection and cocaine use disorder.},
Journal = {Cogn Affect Behav Neurosci},
Volume = {20},
Number = {4},
Pages = {859-872},
Year = {2020},
Month = {August},
url = {http://dx.doi.org/10.3758/s13415-020-00806-4},
Abstract = {Persons with co-occurring HIV infection and cocaine use
disorder tend to engage in riskier decision-making. However,
the neural correlates of sensitivity to risk are not
well-characterized in this population. The purpose of this
study was to examine the neural interaction effects of HIV
infection and cocaine use disorder to sensitivity to risk.
The sample included 79 adults who differed on HIV status and
cocaine use disorder. During functional magnetic resonance
imaging (fMRI), participants completed a Wheel of Fortune
(WoF) task that assessed neural activation in response to
variations of monetary risk (i.e., lower probability of
winning a larger reward). Across groups, neural activation
to increasing risk was in cortical and subcortical regions
similar to previous investigations using the WoF in
nondrug-using populations. Our analyses showed that there
was a synergistic effect between HIV infection and cocaine
use in the left precuneus/posterior cingulate cortex and
hippocampus, and right postcentral gyrus, lateral occipital
cortex, cerebellum, and posterior parietal cortex. HIV+
individuals with cocaine use disorder displayed neural
hyperactivation to increasing risk that was not observed in
the other groups. These results support a synergistic effect
of co-occurring HIV infection and cocaine dependence in
neural processing of risk probability that may reflect
compensation. Future studies can further investigate and
validate how neural activation to increasing risk is
associated with risk-taking behavior.},
Doi = {10.3758/s13415-020-00806-4},
Key = {fds350801}
}
@article{fds351438,
Author = {Kranton, R and Pease, M and Sanders, S and Huettel,
S},
Title = {Deconstructing bias in social preferences reveals groupy and
not-groupy behavior.},
Journal = {Proceedings of the National Academy of Sciences of the
United States of America},
Volume = {117},
Number = {35},
Pages = {21185-21193},
Year = {2020},
Month = {September},
url = {http://dx.doi.org/10.1073/pnas.1918952117},
Abstract = {Group divisions are a continual feature of human history,
with biases toward people's own groups shown in both
experimental and natural settings. Using a within-subject
design, this paper deconstructs group biases to find
significant and robust individual differences; some
individuals consistently respond to group divisions, while
others do not. We examined individual behavior in two
treatments in which subjects make pairwise decisions that
determine own and others' incomes. In a political treatment,
which divided subjects into groups based on their political
leanings, political party members showed more in-group bias
than Independents who professed the same political opinions.
However, this greater bias was also present in a minimal
group treatment, showing that stronger group identification
was not the driver of higher favoritism in the political
setting. Analyzing individual choices across the experiment,
we categorize participants as "groupy" or "not groupy," such
that groupy participants have social preferences that change
for in-group and out-group recipients, while not-groupy
participants' preferences do not change across group
context. Demonstrating further that the group identity of
the recipient mattered less to their choices, strongly
not-groupy subjects made allocation decisions faster. We
conclude that observed in-group biases build on a foundation
of heterogeneity in individual groupiness.},
Doi = {10.1073/pnas.1918952117},
Key = {fds351438}
}
@article{fds353059,
Author = {Jenke, L and Huettel, SA},
Title = {Voter Preferences Reflect a Competition Between Policy and
Identity},
Journal = {Frontiers in Psychology},
Volume = {11},
Year = {2020},
Month = {October},
url = {http://dx.doi.org/10.3389/fpsyg.2020.566020},
Abstract = {Canonical rational choice models of voter preferences assume
that voters select candidates whose policy positions most
closely match their own. Yet, much of the electorate often
appears to prioritize identity variables (e.g., social
categories, group membership) over policy considerations.
Here, we report an empirical test of policy-identity
interactions using surveys of likely voters conducted in the
24 hours before the 2016 United States presidential election
and the 2018 United States senatorial elections. Each
respondent indicated not only their policy preferences but
also key social group identities and how those identities
would be reinforced by voting. We observed striking evidence
for a competition between policy and social group
identification: For voters who exhibited the maximal effects
of identity, policy positions were essentially irrelevant to
their candidate preferences. These results account for
dissociations between voters’ stated policy preferences
and their voting behavior, while linking empirical
observations of political behavior to new models derived
from psychology and neuroscience.},
Doi = {10.3389/fpsyg.2020.566020},
Key = {fds353059}
}
@article{fds358689,
Author = {Bachman, MD and Hunter, MN and Huettel, SA and Woldorff,
MG},
Title = {Disruptions of Sustained Spatial Attention Can Be Resistant
to the Distractor's Prior Reward Associations.},
Journal = {Frontiers in Human Neuroscience},
Volume = {15},
Pages = {666731},
Year = {2021},
url = {http://dx.doi.org/10.3389/fnhum.2021.666731},
Abstract = {Attention can be involuntarily biased toward
reward-associated distractors (value-driven attentional
capture, VDAC). Yet past work has primarily demonstrated
this distraction phenomenon during a particular set of
circumstances: transient attentional orienting to
potentially relevant stimuli occurring in our visual
environment. Consequently, it is not well-understood if
reward-based attentional capture can occur under other
circumstances, such as during sustained visuospatial
attention. Using EEG, we investigated whether associating
transient distractors with reward value would increase their
distractibility and lead to greater decrements in concurrent
sustained spatial attention directed elsewhere. Human
participants learned to associate three differently colored,
laterally presented squares with rewards of varying
magnitude (zero, small, and large). These colored squares
were then periodically reintroduced as distractors at the
same lateral locations during a demanding
sustained-attention rapid-serial-visual-presentation (RSVP)
task at the midline. Behavioral and neural evidence
indicated that participants had successfully learned and
maintained the reward associations to the distractors.
During the RSVP task, consistent with prior work, we found
that the distractors generated dips in the instantaneous
amplitude of the steady-state visual evoked potentials
(SSVEPs) elicited by the midline RSVP stimuli, indicating
that the distractors were indeed transiently disrupting
sustained spatial attention. Contrary to our hypotheses,
however, the magnitude of this dip did not differ by the
magnitude of the distractor's reward associations. These
results indicate that while sustained spatial attention can
be impaired by the introduction of distractors at another
location, the main distraction process is resistant to the
distractors' reward associations, thus providing evidence of
an important boundary condition to value-driven attentional
capture.},
Doi = {10.3389/fnhum.2021.666731},
Key = {fds358689}
}
@article{fds356409,
Author = {Hall, SA and Towe, SL and Nadeem, MT and Hobkirk, AL and Hartley, BW and Li, R and Huettel, SA and Meade, CS},
Title = {Hypoactivation in the precuneus and posterior cingulate
cortex during ambiguous decision making in individuals with
HIV.},
Journal = {J Neurovirol},
Volume = {27},
Number = {3},
Pages = {463-475},
Year = {2021},
Month = {June},
url = {http://dx.doi.org/10.1007/s13365-021-00981-1},
Abstract = {People with human immunodeficiency virus (HIV) often have
neurocognitive impairment. People with HIV make riskier
decisions when the outcome probabilities are known, and have
abnormal neural architecture underlying risky decision
making. However, ambiguous decision making, when the outcome
probabilities are unknown, is more common in daily life, but
the neural architecture underlying ambiguous decision making
in people with HIV is unknown. Eighteen people with HIV and
20 controls completed a decision making task while
undergoing functional magnetic resonance imaging scanning.
Participants chose between a certain reward and uncertain
reward with a known (risky) or unknown (ambiguous)
probability of winning. There were three levels of risk:
high, medium, and low. Ambiguous > risky brain activity
was compared between groups. Ambiguous > risky brain
activity was correlated with emotional/psychiatric
functioning in people with HIV. Both groups were similarly
ambiguity-averse. People with HIV were more risk-averse than
controls and chose the high-risk uncertain option less
often. People with HIV had hypoactivity in the precuneus,
posterior cingulate cortex (PCC), and fusiform gyrus during
ambiguous > medium risk decision making.
Ambiguous > medium risk brain activity was negatively
correlated with emotional/psychiatric functioning in
individuals with HIV. To make ambiguous decisions, people
with HIV underrecruit key regions of the default mode
network, which are thought to integrate internally and
externally derived information to come to a decision. These
regions and related cognitive processes may be candidates
for interventions to improve decision-making outcomes in
people with HIV.},
Doi = {10.1007/s13365-021-00981-1},
Key = {fds356409}
}
@article{fds356410,
Author = {Khaw, MW and Kranton, R and Huettel, S},
Title = {Oversampling of minority categories drives misperceptions of
group compositions.},
Journal = {Cognition},
Volume = {214},
Pages = {104756},
Year = {2021},
Month = {September},
url = {http://dx.doi.org/10.1016/j.cognition.2021.104756},
Abstract = {The ability to estimate proportions informs our immediate
impressions of social environments (e.g., of the diversity
of races or genders within a crowded room). This study
examines how the distribution of attention during brief
glances shapes estimates of group gender proportions.
Performance-wise, subjects exhibit a canonical pattern of
judgment errors: small proportions are overestimated while
large values are underestimated. Subjects' eye movements at
sub-second timescales reveal that these biases follow from a
tendency to visually oversample members of the gender
minority. Rates of oversampling dovetail with average levels
of error magnitudes, response variability, and response
times. Visual biases are thus associated with the inherent
difficulty in estimating particular proportions. All results
are replicated at a within-subjects level with non-human
ensembles using natural scene stimuli; the observed
attentional patterns and judgment biases are thus not
exclusively guided by face-specific visual properties. Our
results reveal the biased distribution of attention
underlying typical judgment errors of group
proportions.},
Doi = {10.1016/j.cognition.2021.104756},
Key = {fds356410}
}
@article{fds358766,
Author = {Lee, VK and Kranton, RE and Conzo, P and Huettel,
SA},
Title = {The hidden cost of humanization: Individuating information
reduces prosocial behavior toward in-group
members},
Journal = {Journal of Economic Psychology},
Volume = {86},
Year = {2021},
Month = {October},
url = {http://dx.doi.org/10.1016/j.joep.2021.102424},
Abstract = {This paper reports robust experimental evidence that
humanization—in the form of individuating information
about another's personal preferences—leads to decreased
prosocial behavior toward in-group members. Previous
research shows that individuating information increases
prosocial behavior toward dehumanized out-group members. Its
consequences for in-group members, however, are less well
understood. Using methods from social psychology and
behavioral economics, four experiments show that
individuating information decreases pro-social behavior
toward in-group members in a variety of settings (charitable
giving, altruistic punishment, and trust games). Moreover,
this effect results from decreased reliance on group
membership labels, and not from other potential explanations
like the induction of new group identities. Understanding
these effects sheds light on the motives behind intergroup
conflict, which may not result from a difference in social
perception (i.e., humanized in-groups and dehumanized
out-groups), but rather from biases associated with group
membership (i.e., in-group favoritism and out-group
discrimination) that are eliminated by individuating
information. Together, these results indicate that
humanization carries a hidden cost for in-group members by
disrupting group identities that would otherwise make them
targets of altruistic actions.},
Doi = {10.1016/j.joep.2021.102424},
Key = {fds358766}
}
@article{fds358765,
Author = {Blankenstein, NE and Huettel, SA and Li, R},
Title = {Resolving ambiguity: Broadening the consideration of risky
decision making over adolescent development},
Journal = {Developmental Review},
Volume = {62},
Year = {2021},
Month = {December},
url = {http://dx.doi.org/10.1016/j.dr.2021.100987},
Abstract = {Popular culture often portrays adolescence as a period of
peak risk-taking, but that developmental trend is not
consistently found across laboratory studies. Instead,
meta-analytic evidence shows that while adolescents take
more risks compared to adults, children and adolescents
actually take similar levels of risk. Furthermore,
developmental trajectories vary across different measures of
laboratory decision making and everyday risky behavior.
Indeed, the psychological concept of “risk” is
multifactorial, such that its different factors exhibit
different developmental trajectories. Here, we examine how
economic risk preference, or the propensity to gamble on
uncertain outcomes with known probabilities, is distinct
from economic ambiguity preference, or the propensity to
gamble on uncertain outcomes with unknown probabilities –
and how economic risk and ambiguity may differentially
influence adolescent decision making. Economic ambiguity
engages distinct neural mechanisms from economic risk –
both in adults and adolescents – and differentially
relates to everyday risk-taking. However, to date, it
remains elusive how economic ambiguity aversion develops
across adolescence, as the relative paucity of such work
limits the conclusions that can be drawn. We propose that
developmental research into adolescent decision making
should consider economic ambiguity as a distinct component
within the multifactorial construct of adolescent
risk-taking. This will set the stage for future work on
economic ambiguity preferences as an explanatory mechanism
for behaviors beyond risk taking, such as learning and
prosocial behavior.},
Doi = {10.1016/j.dr.2021.100987},
Key = {fds358765}
}
@article{fds357561,
Author = {Sullivan, NJ and Huettel, SA},
Title = {Healthful choices depend on the latency and rate of
information accumulation.},
Journal = {Nature Human Behaviour},
Volume = {5},
Number = {12},
Pages = {1698-1706},
Year = {2021},
Month = {December},
url = {http://dx.doi.org/10.1038/s41562-021-01154-0},
Abstract = {The drift diffusion model provides a parsimonious
explanation of decisions across neurobiological,
psychological and behavioural levels of analysis. Although
most drift diffusion model implementations assume that only
a single value guides decisions, choices often involve
multiple attributes that could make separable contributions
to choice. Here we fit incentive-compatible dietary choices
to a multi-attribute, time-dependent drift diffusion model,
in which taste and health could differentially influence the
evidence accumulation process. We find that these attributes
shaped both the relative value signal and the latency of
evidence accumulation in a manner consistent with
participants' idiosyncratic preferences. Moreover, by using
a dietary prime, we showed how a healthy choice intervention
alters multi-attribute, time-dependent drift diffusion model
parameters that in turn predict prime-dependent choices. Our
results reveal that different decision attributes make
separable contributions to the strength and timing of
evidence accumulation, providing new insights into the
construction of interventions to alter the processes of
choice.},
Doi = {10.1038/s41562-021-01154-0},
Key = {fds357561}
}
@article{fds364335,
Author = {Xu, S and Liu, W and Yang, X and Jönsson, J and Qian, R and McKee, P and Kim,
K and Konda, PC and Zhou, KC and Kreiß, L and Wang, H and Berrocal, E and Huettel, SA and Horstmeyer, R},
Title = {Transient Motion Classification Through Turbid Volumes
via Parallelized Single-Photon Detection and Deep
Contrastive Embedding.},
Journal = {Frontiers in Neuroscience},
Volume = {16},
Pages = {908770},
Year = {2022},
Month = {January},
url = {http://dx.doi.org/10.3389/fnins.2022.908770},
Abstract = {Fast noninvasive probing of spatially varying decorrelating
events, such as cerebral blood flow beneath the human skull,
is an essential task in various scientific and clinical
settings. One of the primary optical techniques used is
diffuse correlation spectroscopy (DCS), whose classical
implementation uses a single or few single-photon detectors,
resulting in poor spatial localization accuracy and
relatively low temporal resolution. Here, we propose a
technique termed <i><b>C</b></i> <i>lassifying</i>
<i><b>R</b></i> <i>apid decorrelation</i> <i><b>E</b></i>
<i>vents via</i> <i><b>P</b></i> <i>arallelized single
photon d</i> <i><b>E</b></i> <i>tection (CREPE)</i>, a new
form of DCS that can probe and classify different
decorrelating movements hidden underneath turbid volume with
high sensitivity using parallelized speckle detection from a
32 × 32 pixel SPAD array. We evaluate our setup by
classifying different spatiotemporal-decorrelating patterns
hidden beneath a 5 mm tissue-like phantom made with rapidly
decorrelating dynamic scattering media. Twelve multi-mode
fibers are used to collect scattered light from different
positions on the surface of the tissue phantom. To validate
our setup, we generate perturbed decorrelation patterns by
both a digital micromirror device (DMD) modulated at
multi-kilo-hertz rates, as well as a vessel phantom
containing flowing fluid. Along with a deep contrastive
learning algorithm that outperforms classic unsupervised
learning methods, we demonstrate our approach can accurately
detect and classify different transient decorrelation events
(happening in 0.1-0.4 s) underneath turbid scattering media,
without any data labeling. This has the potential to be
applied to non-invasively monitor deep tissue motion
patterns, for example identifying normal or abnormal
cerebral blood flow events, at multi-Hertz rates within a
compact and static detection probe.},
Doi = {10.3389/fnins.2022.908770},
Key = {fds364335}
}
@article{fds362418,
Author = {Breslav, ADS and Zucker, NL and Schechter, JC and Majors, A and Bidopia,
T and Fuemmeler, BF and Kollins, SH and Huettel, SA},
Title = {Shuffle the Decks: Children Are Sensitive to Incidental
Nonrandom Structure in a Sequential-Choice
Task.},
Journal = {Psychol Sci},
Volume = {33},
Number = {4},
Pages = {550-562},
Year = {2022},
Month = {April},
url = {http://dx.doi.org/10.1177/09567976211042007},
Abstract = {As children age, they can learn increasingly complex
features of environmental structure-a key prerequisite for
adaptive decision-making. Yet when we tested children (N =
304, 4-13 years old) in the Children's Gambling Task, an
age-appropriate variant of the Iowa Gambling Task, we found
that age was negatively associated with performance.
However, this paradoxical effect of age was found only in
children who exhibited a maladaptive deplete-replenish bias,
a tendency to shift choices after positive outcomes and
repeat choices after negative outcomes. We found that this
bias results from sensitivity to incidental nonrandom
structure in the canonical, deterministic forms of these
tasks-and that it would actually lead to optimal outcomes if
the tasks were not deterministic. Our results illustrate
that changes in decision-making across early childhood
reflect, in part, increasing sensitivity to environmental
structure.},
Doi = {10.1177/09567976211042007},
Key = {fds362418}
}
@article{fds362933,
Author = {Sullivan, NJ and Li, R and Huettel, SA},
Title = {Peer presence increases the prosocial behavior of
adolescents by speeding the evaluation of outcomes for
others.},
Journal = {Scientific Reports},
Volume = {12},
Number = {1},
Pages = {6477},
Year = {2022},
Month = {April},
url = {http://dx.doi.org/10.1038/s41598-022-10115-0},
Abstract = {Peer presence can elicit maladaptive adolescent
decision-making, potentially by increasing sensitivity to
the rewards one receives. It remains unknown whether peer
presence also increases adolescents' sensitivity to others'
outcomes, which could have an adaptive effect in contexts
allowing pro-social behaviors. Here, we combine social
utility modeling and real-time decision process modeling to
characterize how peer presence alters adolescents'
processing of self and other outcomes. We found that
adolescents behaved selfishly when privately allocating
monetary rewards for themselves and a peer in an
incentive-compatible task. In peer presence, however,
adolescents became more altruistic. Real-time decision
process estimates collected using computer mouse tracking
showed that altruistic behavior was associated with
relatively earlier influence of peer-outcomes relative to
self-outcomes, and that peer presence sped the influence of
peer-outcomes without altering the time at which
self-outcomes began to influence the decision process. Our
results indicate a mechanism through which peer presence
prompts greater prosocial behavior by altering how
adolescents process prosocial outcomes.},
Doi = {10.1038/s41598-022-10115-0},
Key = {fds362933}
}
@article{fds364055,
Author = {Molter, F and Thomas, AW and Huettel, SA and Heekeren, HR and Mohr,
PNC},
Title = {Gaze-dependent evidence accumulation predicts
multi-alternative risky choice behaviour.},
Journal = {Plos Computational Biology},
Volume = {18},
Number = {7},
Pages = {e1010283},
Year = {2022},
Month = {July},
url = {http://dx.doi.org/10.1371/journal.pcbi.1010283},
Abstract = {Choices are influenced by gaze allocation during
deliberation, so that fixating an alternative longer leads
to increased probability of choosing it. Gaze-dependent
evidence accumulation provides a parsimonious account of
choices, response times and gaze-behaviour in many simple
decision scenarios. Here, we test whether this framework can
also predict more complex context-dependent patterns of
choice in a three-alternative risky choice task, where
choices and eye movements were subject to attraction and
compromise effects. Choices were best described by a
gaze-dependent evidence accumulation model, where subjective
values of alternatives are discounted while not fixated.
Finally, we performed a systematic search over a large model
space, allowing us to evaluate the relative contribution of
different forms of gaze-dependence and additional mechanisms
previously not considered by gaze-dependent accumulation
models. Gaze-dependence remained the most important
mechanism, but participants with strong attraction effects
employed an additional similarity-dependent inhibition
mechanism found in other models of multi-alternative
multi-attribute choice.},
Doi = {10.1371/journal.pcbi.1010283},
Key = {fds364055}
}
@article{fds365123,
Author = {Sullivan, NJ and Li, R and Huettel, SA},
Title = {Author Correction: Peer presence increases the prosocial
behavior of adolescents by speeding the evaluation of
outcomes for others.},
Journal = {Scientific Reports},
Volume = {12},
Number = {1},
Pages = {13177},
Year = {2022},
Month = {August},
url = {http://dx.doi.org/10.1038/s41598-022-17425-3},
Doi = {10.1038/s41598-022-17425-3},
Key = {fds365123}
}
%% Papers Published
@article{fds136700,
Title = {Huettel SA, Lockhead GR. Psychologically Rational Choice:
Selection between alternatives in a multiple-equilibrium
game. Cognitive Sys Res. 2000; 1(3):143-160.},
Year = {2000},
Key = {fds136700}
}
@article{fds136714,
Author = {B Bucur and DJ Madden and J Spaniol and JM Provenzale and R Cabeza and LE
White, SA Huettel},
Title = {Age-related slowing of memory retrieval: Contributions of
perceptual speed and cerebral white matter
integrity.},
Journal = {Neurobiol Aging},
Year = {2007},
Month = {March},
ISSN = {1558-1497},
Abstract = {Previous research suggests that, in reaction time (RT)
measures of episodic memory retrieval, the unique effects of
adult age are relatively small compared to the effects aging
shares with more elementary abilities such as perceptual
speed. Little is known, however, regarding the mechanisms of
perceptual speed. We used diffusion tensor imaging (DTI) to
test the hypothesis that white matter integrity, as indexed
by fractional anisotropy (FA), serves as one mechanism of
perceptual slowing in episodic memory retrieval. Results
indicated that declines in FA in the pericallosal frontal
region and in the genu of the corpus callosum, but not in
other regions, mediated the relationship between perceptual
speed and episodic retrieval RT. This relation held, though
to a different degree, for both hits and correct rejections.
These findings suggest that white matter integrity in
prefrontal regions is one mechanism underlying the relation
between individual differences in perceptual speed and
episodic retrieval.},
Key = {fds136714}
}
@article{fds149957,
Author = {DJ Madden and J Spaniol and MC Costello and B Bucur and LE White and R
Cabeza, SW Davis and NA Dennis and JM Provenzale and SA
Huettel},
Title = {Cerebral White Matter Integrity Mediates Adult Age
Differences in Cognitive Performance.},
Journal = {Journal of cognitive neuroscience},
Year = {2008},
Month = {June},
ISSN = {0898-929X},
Abstract = {Abstract Previous research has established that age-related
decline occurs in measures of cerebral white matter
integrity, but the role of this decline in age-related
cognitive changes is not clear. To conclude that white
matter integrity has a mediating (causal) contribution, it
is necessary to demonstrate that statistical control of the
white matter-cognition relation reduces the magnitude of
age-cognition relation. In this research, we tested the
mediating role of white matter integrity, in the context of
a task-switching paradigm involving word categorization.
Participants were 20 healthy, community-dwelling older
adults (60-85 years), and 20 younger adults (18-27 years).
From diffusion tensor imaging tractography, we obtained
fractional anisotropy (FA) as an index of white matter
integrity in the genu and splenium of the corpus callosum
and the superior longitudinal fasciculus (SLF). Mean FA
values exhibited age-related decline consistent with a
decrease in white matter integrity. From a model of reaction
time distributions, we obtained independent estimates of the
decisional and nondecisional (perceptual-motor) components
of task performance. Age-related decline was evident in both
components. Critically, age differences in task performance
were mediated by FA in two regions: the central portion of
the genu, and splenium-parietal fibers in the right
hemisphere. This relation held only for the decisional
component and was not evident in the nondecisional
component. This result is the first demonstration that the
integrity of specific white matter tracts is a mediator of
age-related changes in cognitive performance.},
Key = {fds149957}
}
%% Books
@book{fds183692,
Author = {Purves, D. and Brannon, E. and Cabeza, R. and Huettel, S. and LaBar, K. and Platt, M. and Woldorff, M.},
Title = {Principles of Cognitive Neuroscience},
Publisher = {Sinauer Associates},
Year = {2009},
Key = {fds183692}
}
@book{fds150850,
Author = {S.A. Huettel and Allen W. Song and Gregory McCarthy},
Title = {Functional Magnetic Resonance Imaging, 2nd
Edition},
Publisher = {Sinauer Associates},
Year = {2009},
Month = {January},
url = {http://www.sinauer.com/detail.php?id=2863},
Key = {fds150850}
}
@book{fds211720,
Author = {Purves, D. and Cabeza, R. and Huettel, S. and LaBar, K. and Platt, M. and Woldorff, M.},
Title = {Principles of Cognitive Neuroscience, 2nd
Edition},
Year = {2012},
Key = {fds211720}
}
%% Chapters in Books
@misc{fds252213,
Author = {Madden, DJ and Whiting, WL and Huettel, SA},
Title = {Age-related changes in neural activity during visual
perception and attention},
Pages = {157-185},
Booktitle = {Cognitive Neuroscience of Aging: Linking cognitive and
cerebral aging},
Publisher = {Oxford University Press},
Year = {2005},
Month = {May},
ISBN = {9780195156744},
url = {http://dx.doi.org/10.1093/acprof:oso/9780195156744.003.0007},
Abstract = {© 2005 by Oxford University Press, Inc. All rights
reserved. This chapter presents an overview of age-related
changes in sensory systems that alter the identification of
objects and events in the environment. It reviews the
behavioral literature on perception and attention,
documenting decreases in sensory function with age and the
centrality of theories of decreased speed of processing in
accounting for many age differences in perception and
attention. It discusses age differences in attention, as
well as the instances when some types of attentional
processes remain age invariant. The chapter then reviews the
neurobiological underpinnings of attention and perception in
young adults, which sets the stage for a detailed discussion
of what has been learned about age differences in neural
activation and pathways for object recognition and
attention. The picture presented is one of decreased
efficiency and less differentiation of neural pathways
mediating object recognition and higher order visual
processes, along with instances of compensatory
activation.},
Doi = {10.1093/acprof:oso/9780195156744.003.0007},
Key = {fds252213}
}
@misc{fds154465,
Author = {S.A. Huettel},
Title = {Imaging techniques: BOLD Functional Magnetic Resonance
Imaging},
Booktitle = {The New Encyclopedia of Neuroscience},
Editor = {Squire et al.},
Year = {2008},
Key = {fds154465}
}
@misc{fds154466,
Author = {S.A. Huettel},
Title = {Magnetic resonance: Functional MRI (fMRI)},
Booktitle = {Encyclopedia of Spectroscopy and Spectrometry, 2nd
Edition},
Editor = {Lindon et al.},
Year = {2008},
Key = {fds154466}
}
@misc{fds170450,
Author = {S.A. Huettel},
Title = {Decisions are not so simple},
Booktitle = {Cerebrum 2010: Emerging Ideas in Brain Science},
Year = {2010},
Key = {fds170450}
}
@misc{fds183476,
Author = {S.A. Huettel},
Title = {Decision making: Neural Underpinnings},
Booktitle = {Sage Encyclopedia of the Mind},
Year = {2010},
Key = {fds183476}
}
@misc{fds323841,
Author = {Venkatraman, V and Huettel, SA and Libedinsky, C and Chee,
MWL},
Title = {Economic decision-making and the sleep-deprived
brain},
Pages = {145-153},
Booktitle = {Neuroimaging of Sleep and Sleep Disorders},
Publisher = {Cambridge University Press},
Year = {2010},
Month = {January},
ISBN = {9781107018631},
url = {http://dx.doi.org/10.1017/CBO9781139088268},
Abstract = {Introduction As acceptable temporal boundaries of business
and social activities gradually disappear with pervasive
connectivity, an increasing number of persons will be called
upon to make decisions at times that our predecessors
reserved for sleep. In the last decade, there has been a
surge in interest in the neural underpinnings of
decision-making, particularly when individuals are faced
with risk [1, 2]. Yet, despite the steady increase in
numbers of persons who make decisions following chronic or
acute sleep loss, there remains relatively little work about
how sleep deprivation (SD) alters decision-making. Risky
decisions are those where the outcomes of one or more
potential choices are probabilistic; that is, different
outcomes might occurwith knownor estimated probabilities
(e.g., gambling on roulette). The broad appeal, detailed
characterization, ease of experimental design, and ready
incentive compatibility have made risky decision-making a
common target for research in decision neuroscience or
“neuroeconomics” [1, 3, 4].Moreover, risky decisions
often must be made under conditions of reduced sleep (and/or
other deleterious states), as in the cases of emergency
personnel, physicians, financial markets, and even policy
makers. For these reasons, an improved understanding of
risky decision-making in sleep-deprived persons could have
important real-world consequences.},
Doi = {10.1017/CBO9781139088268},
Key = {fds323841}
}
@misc{fds198098,
Author = {S.A. Huettel},
Title = {Novel developments in cognitive fMRI},
Booktitle = {fMRI: From Nuclear Spins to Brain Function},
Year = {2011},
Key = {fds198098}
}
@misc{fds252222,
Author = {Venkatraman, V and Payne, JW and Huettel, SA},
Title = {Neuroeconomics of risky decisions: From variables to
strategies},
Pages = {153-172},
Booktitle = {Decision Making, Affect, and Learning: Attention and
Performance XXIII},
Publisher = {Oxford University Press},
Year = {2011},
Month = {May},
ISBN = {9780199600434},
url = {http://dx.doi.org/10.1093/acprof:oso/9780199600434.003.0007},
Abstract = {We make a variety of decisions throughout our lives. Some
decisions involve outcomes whose values can be readily
compared, especially when those outcomes are simple,
immediate, and familiar. Other decisions involve imperfect
knowledge about their potential consequences. Understanding
the choice process when consequences are uncertain - often
called the study of decision making under risk - remains a
key goal of behavioural economics, cognitive psychology, and
now neuroscience. An ongoing challenge, however, lies in the
substantial individual differences in how people approach
risky decisions. Using a novel choice paradigm, this chapter
demonstrates that people vary in whether they adopt
compensatory rules (i.e., tradeoffs between decision
variables) or noncompensatory rules (i.e., a simplification
of the choice problem) in economic decision making. The
chapter shows that distinct neural mechanisms support
variability in choices and variability in strategic
preferences. Specifically, compensatory choices are
associated with activation in the anterior insula and the
ventromedial prefrontal cortex, while noncompensatory
choices are associated with increased activation in the
dorsolateral prefrontal cortex and the posterior parietal
cortex. The dorsomedial prefrontal cortex shaped decision
making at a strategic level through its functional
connectivity with these regions. Individual-difference
analyses are a key direction through which neuroscience can
influence models of choice behaviour.},
Doi = {10.1093/acprof:oso/9780199600434.003.0007},
Key = {fds252222}
}
@misc{fds211721,
Author = {Venkatraman, V. and Huettel, S.A. and Libedinsky, C. and Chee,
M.W.L},
Title = {Economic decision making and the sleep-deprived
brain},
Booktitle = {Neuroimaging of Sleep & Sleep Disorders},
Editor = {Nofzinger et al.},
Year = {2013},
Key = {fds211721}
}
@misc{fds220101,
Author = {S.A. Huettel},
Title = {Neuroeconomics},
Booktitle = {The Cognitive Neurosciences V},
Editor = {Gazzaniga, M.},
Year = {2013},
Key = {fds220101}
}
@misc{fds220102,
Author = {Reyna, V.F. and Huettel, S.A.},
Title = {A theoretical framework for the neuroscience of risky
decision making},
Booktitle = {The Neuroscience of Risky Decision Making},
Editor = {Reyna, V.F. and Zayas, V.},
Year = {2013},
Key = {fds220102}
}
@misc{fds252212,
Author = {San Martin and R and Huettel, SA},
Title = {Cognitive functions as revealed by imaging of the human
brain},
Pages = {2213-2238},
Booktitle = {Neuroscience in the 21st Century: From Basic to
Clinical},
Publisher = {Springer New York},
Editor = {Pfaff, D.},
Year = {2013},
Month = {November},
ISBN = {1461419964},
url = {http://dx.doi.org/10.1007/978-1-4614-1997-6_82},
Abstract = {Functional neuroimaging techniques allow neuroscientists to
map the processes of perception, cognition, memory, and
action onto the human brain. The core techniques used in
current research either measure neuronal activity directly
(e.g., electroencephalography, magnetoencephalography) or
measure aspects of brain metabolism that provide indirect
measures of neuronal activity (e.g., functional magnetic
resonance imaging, positron emission tomography). Each
technique presents a distinct set of strengths and
limitations; some have superior ability to localize
processing within the brain (spatial resolution), while
others have better capability for evaluating the timing of
processing (temporal resolution). As these techniques have
matured, they have been applied to an increasingly diverse
range of research questions. This chapter highlights some
key advances associated with functional neuroimaging, with a
focus on research that studies higher cognition and decision
making. The chapter ends with speculations about the future
directions for functional neuroimaging research, including
the roles these techniques will play within
neuroscience.},
Doi = {10.1007/978-1-4614-1997-6_82},
Key = {fds252212}
}
@misc{fds366951,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Combining fMRI with Other Techniques},
Pages = {485-532},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366951}
}
@misc{fds366952,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {The Future of fMRI: Practical and Ethical
Issues},
Pages = {533-573},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366952}
}
@misc{fds366953,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Statistical Analysis II: Advanced Approaches},
Pages = {411-462},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366953}
}
@misc{fds366954,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Advanced fMRI Methods},
Pages = {463-483},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366954}
}
@misc{fds366955,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Statistical Analysis I: Basic Analyses},
Pages = {363-410},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366955}
}
@misc{fds366956,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Experimental Design},
Pages = {323-361},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366956}
}
@misc{fds366957,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {BOLD fMRI: Origins and Properties},
Pages = {211-270},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366957}
}
@misc{fds366958,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {From Neuronal to Hemodynamic Activity},
Pages = {159-210},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366958}
}
@misc{fds366959,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Signal, Noise, and Preprocessing of fMRI
Data},
Pages = {271-321},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366959}
}
@misc{fds366960,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {MRI Contrast Mechanisms and Acquisition Techniques},
Pages = {123-157},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366960}
}
@misc{fds366961,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Basic Principles of MR Image Formation},
Pages = {89-121},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366961}
}
@misc{fds366962,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {Basic Principles of MR Signal Generation},
Pages = {57-88},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366962}
}
@misc{fds366963,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {MRI Scanners},
Pages = {31-55},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366963}
}
@misc{fds366964,
Author = {Huettel, SA and Song, AW and McCarthy, G},
Title = {An Introduction to fMRI},
Pages = {1-30},
Booktitle = {FUNCTIONAL MAGNETIC RESONANCE IMAGING, THIRD
EDITION},
Year = {2014},
ISBN = {978-0-87893-627-4},
Key = {fds366964}
}
@misc{fds303798,
Author = {Coutlee, CG and Huettel, SA},
Title = {Rules, rewards, and responsibility: A reinforcement learning
approach to action control},
Pages = {327-334},
Booktitle = {Moral Psychology, Volume 4: Free Will And Moral
Responsibility},
Editor = {Sinnott-Armstrong, W.},
Year = {2014},
Month = {January},
ISBN = {9780262525473},
Key = {fds303798}
}
@misc{fds252214,
Author = {Utevsky, AV and Huettel, SA},
Title = {Social Decision Making},
Volume = {3},
Pages = {231-234},
Booktitle = {Brain Mapping: An Encyclopedic Reference},
Year = {2015},
Month = {February},
ISBN = {9780123973160},
url = {http://dx.doi.org/10.1016/B978-0-12-397025-1.00185-8},
Doi = {10.1016/B978-0-12-397025-1.00185-8},
Key = {fds252214}
}
@misc{fds322018,
Author = {Huettel, SA},
Title = {Novel developments in cognitive fMRI},
Pages = {557-579},
Booktitle = {fMRI: From Nuclear Spins to Brain Functions},
Publisher = {Springer US},
Year = {2015},
Month = {September},
ISBN = {9781489975904},
url = {http://dx.doi.org/10.1007/978-1-4899-7591-1_19},
Doi = {10.1007/978-1-4899-7591-1_19},
Key = {fds322018}
}
@misc{fds366406,
Author = {Huettel, SA},
Title = {Functional MRI (fMRI)},
Pages = {778-784},
Booktitle = {Encyclopedia of Spectroscopy and Spectrometry},
Year = {2016},
Month = {January},
ISBN = {9780128032244},
url = {http://dx.doi.org/10.1016/B978-0-12-803224-4.00053-4},
Abstract = {Functional magnetic resonance imaging (fMRI) allows
researchers to investigate the mechanisms underlying
information processing in the human brain. Most fMRI studies
use standard MRI scanners to collect images sensitive to
changes in blood oxygenation level-dependent (BOLD)
contrast, which provides an indirect measure of neuronal
activity. The images collected in BOLD fMRI experiments
generally have spatial resolution on the order of several
millimeters and temporal resolution on the order of several
seconds. fMRI provides several advantages over other human
neuroimaging techniques: it is noninvasive, can be adapted
to a wide range of experiments, and allows good localization
of activation. Because of these and other strengths, fMRI
has grown over the past two decades to become the dominant
technique in human cognitive neuroscience. However, fMRI
also has significant limitations, especially regarding the
conclusions that can be drawn from individual studies. This
article introduces the basic physical and physiological
principles of fMRI, followed by a consideration of the core
concepts involved in fMRI experimentation.},
Doi = {10.1016/B978-0-12-803224-4.00053-4},
Key = {fds366406}
}
@misc{fds326932,
Author = {Martin, RS and Huettel, SA},
Title = {Cognitive functions as revealed by imaging of the human
brain},
Pages = {2727-2753},
Booktitle = {Neuroscience in the 21st Century: From Basic to Clinical,
Second Edition},
Publisher = {Springer New York},
Year = {2016},
Month = {January},
ISBN = {9781493934737},
url = {http://dx.doi.org/10.1007/978-1-4939-3474-4_82},
Abstract = {Functional neuroimaging techniques allow neuroscientists to
map the processes of perception, cognition, memory, and
action onto the human brain. The core techniques used in
current research either measure neuronal activity directly
(e.g., electroencephalography, magnetoencephalography) or
measure aspects of brain metabolism that provide indirect
measures of neuronal activity (e.g., functional magnetic
resonance imaging, positron emission tomography). Each
technique presents a distinct set of strengths and
limitations; some have superior ability to localize
processing within the brain (spatial resolution), while
others have better capability for evaluating the timing of
processing (temporal resolution). As these techniques have
matured, they have been applied to an increasingly diverse
range of research questions. This chapter highlights some
key advances associated with functional neuroimaging, with a
focus on research that studies higher cognition and decision
making. The chapter ends with speculations about the future
directions for functional neuroimaging research, including
the roles these techniques will play within
neuroscience.},
Doi = {10.1007/978-1-4939-3474-4_82},
Key = {fds326932}
}
@misc{fds330540,
Author = {Jack, J and Appelbaum, LG and Beam, E and Moody, J and Huettel,
SA},
Title = {Mapping rhetorical topologies in cognitive
neuroscience},
Pages = {125-150},
Booktitle = {Topologies as Techniques for a Post-Critical
Rhetoric},
Publisher = {Springer International Publishing},
Year = {2017},
Month = {January},
ISBN = {9783319512679},
url = {http://dx.doi.org/10.1007/978-3-319-51268-6_7},
Abstract = {Many tools that neuroscientists use to trace the complex
topography of the human brain draw on the neuroscience
literature to yield “metanalyses” or “syntheses of
data.” These approaches conflate rhetorical connections in
the literature with physical connections in the brain. By
contrast, the model presented in this chapter seeks not a
topography of the brain but a topology of neuroscience. A
social network analysis of titles and abstracts for
cognitive neuroscience articles yields a topology of brain
regions and functions. This map can help researchers
identify underresearched areas (e.g., the thalamus) or areas
that are oversaturated (e.g., the amygdala). The map also
helps researchers identify subdisciplines, such as
“neuroeconomics,” that have not yet integrated with the
broader field–“islands” where rhetorical work could
yield benefits.},
Doi = {10.1007/978-3-319-51268-6_7},
Key = {fds330540}
}
@misc{fds341007,
Author = {Huettel, SA},
Title = {Functional MRI (fMRI)},
Pages = {778-784},
Booktitle = {Encyclopedia of Spectroscopy and Spectrometry},
Year = {2017},
Month = {January},
ISBN = {9780128032244},
url = {http://dx.doi.org/10.1016/B978-0-12-803224-4.00053-4},
Abstract = {Functional magnetic resonance imaging (fMRI) allows
researchers to investigate the mechanisms underlying
information processing in the human brain. Most fMRI studies
use standard MRI scanners to collect images sensitive to
changes in blood oxygenation level-dependent (BOLD)
contrast, which provides an indirect measure of neuronal
activity. The images collected in BOLD fMRI experiments
generally have spatial resolution on the order of several
millimeters and temporal resolution on the order of several
seconds. fMRI provides several advantages over other human
neuroimaging techniques: it is noninvasive, can be adapted
to a wide range of experiments, and allows good localization
of activation. Because of these and other strengths, fMRI
has grown over the past two decades to become the dominant
technique in human cognitive neuroscience. However, fMRI
also has significant limitations, especially regarding the
conclusions that can be drawn from individual studies. This
article introduces the basic physical and physiological
principles of fMRI, followed by a consideration of the core
concepts involved in fMRI experimentation.},
Doi = {10.1016/B978-0-12-803224-4.00053-4},
Key = {fds341007}
}
@misc{fds342365,
Author = {Massar, SAA and Lim, J and Huettel, SA},
Title = {Sleep deprivation, effort allocation and
performance.},
Volume = {246},
Pages = {1-26},
Booktitle = {Progress in Brain Research},
Year = {2019},
Month = {January},
ISBN = {9780444642509},
url = {http://dx.doi.org/10.1016/bs.pbr.2019.03.007},
Abstract = {Sleep deprivation causes physiological alterations (e.g.,
decreased arousal, intrusion of micro-sleeps), that
negatively affect performance on a wide range of cognitive
domains. These effects indicate that cognitive performance
relies on a capacity-limited system that may be more
challenged in the absence of sleep. Additionally, sleep loss
can result in a lower willingness to exert effort in the
pursuit of performance goals. Such deficits in motivation
may interact with the effects of capacity limitations to
further stifle cognitive performance. When sleep-deprived,
cognitive performance is experienced as more effortful, and
intrinsic motivation to perform dwindles. On the other hand,
increasing motivation extrinsically (e.g., by monetary
incentives) can inspire individuals to allocate more
task-related effort, and can partially counter performance
deficits associated with sleep deprivation. In this chapter,
we review current research on the interplay between sleep
deprivation, effort and performance. We integrate these
findings into an effort-based decision-making framework in
which sleep-related performance impairments may result from
a voluntary decision to withdraw effort. We conclude with
practical implications of this framework for performance in
healthy populations (e.g., work productivity) and clinical
conditions.},
Doi = {10.1016/bs.pbr.2019.03.007},
Key = {fds342365}
}
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