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| Publications of John F. Curry :chronological alphabetical combined listing:%% Journal Articles @article{fds358373, Author = {Curry, JF and Kaminer, Y and Goldston, DB and Chan, G and Wells, KC and Burke, RH and Inscoe, AB and Meyer, AE and Cheek, SM}, Title = {Adaptive Treatment for Youth With Substance Use and Depression: Early Depression Response and Short-term Outcomes.}, Journal = {J Am Acad Child Adolesc Psychiatry}, Volume = {61}, Number = {4}, Pages = {508-519}, Year = {2022}, Month = {April}, url = {http://dx.doi.org/10.1016/j.jaac.2021.07.807}, Abstract = {OBJECTIVE: To investigate prevalence and predictors of early depression response (EDR) in adolescents with substance use and depression receiving cognitive-behavioral therapy (CBT) for substance use and to test the efficacy of supplemental CBT targeting depression (CBT-D) for non-EDR adolescents in an adaptive treatment approach. METHOD: At 2 sites, 95 youths (ages 14-21, mean [SD] = 17.4 [1.8]) with alcohol or cannabis use and depressive symptoms received up to 12 sessions of CBT for substance use over 14 weeks. Assessments were at baseline and weeks 4, 9, and 14. The Children's Depression Rating Scale-Revised was the primary depression measure, with a reduction of 50% or more on this scale at week 4 defining EDR. The primary substance use outcomes of alcohol use, heavy alcohol use, and cannabis use frequency were assessed via interview report on the Alcohol Consumption Questionnaire and the Drug Checklist. Urinalysis provided a secondary measure of cannabis use. Non-EDR adolescents were randomly assigned to supplemental CBT-D or enhanced treatment as usual (ETAU). RESULTS: Thirty-five adolescents (37%; 95% CI, 27%-47%) demonstrated EDR. Fewer days of cannabis use (odds ratio 0.977; 95% CI, 0.961-0.992) and absence of conduct disorder (odds ratio 0.149; 95% CI, 0.031-0.716) predicted EDR. Frequency of drinking (F1,82 = 11.09, η2 = 0.119, p = .001), heavy drinking (F1,82 = 19.91, η2 = 0.195, p < .0001), and cannabis use (F1,220 = 35.01, η2 = 0.137, p < .001) decreased over time for EDR, CBT-D, and ETAU adolescents, with EDR adolescents evidencing earlier lower cannabis use (F2,220 = 4.16, η2 = 0.036, p = .0169). Negative (clean) urine screens increased over time (F1,219 = 5.10, η2 = 0.023, p = .0249). Comparison of CBT-D and ETAU indicated that depression significantly decreased over time in both groups (F1,48 = 64.20, η2 = 0.572, p < .001), with no advantage for CBT-D. CONCLUSION: Approximately one-third of adolescents with substance use and depression attain EDR during substance use treatment. Less frequent cannabis use facilitates depression response. The relatively small sample may have precluded identification of additional EDR predictors. CLINICAL TRIAL REGISTRATION INFORMATION: Treatment for Teens With Alcohol Abuse and Depression; https://clinicaltrials.gov/; NCT02227589.}, Doi = {10.1016/j.jaac.2021.07.807}, Key = {fds358373} } @article{fds359587, Author = {Liu, Q and Martin, NC and Findling, RL and Youngstrom, EA and Garber, J and Curry, JF and Hyde, JS and Essex, MJ and Compas, BE and Goodyer, IM and Rohde, P and Stark, KD and Slattery, MJ and Forehand, R and Cole, DA}, Title = {Hopelessness and depressive symptoms in children and adolescents: An integrative data analysis.}, Journal = {J Abnorm Psychol}, Volume = {130}, Number = {6}, Pages = {594-607}, Year = {2021}, Month = {August}, url = {http://dx.doi.org/10.1037/abn0000667}, Abstract = {Although hopelessness has been linked to depression for centuries, the diagnostic criteria for depression are inconsistent with regard to the status of hopelessness. Most research on hopelessness and depression has focused on adults. The current study examined this relation in children and adolescents. Integrative data analyses with a pooled sample (N = 2466) showed that clinical levels of hopelessness multiplied the odds of having a clinical diagnosis of depression 10-fold. Conversely, not having clinical levels of hopelessness multiplied the odds of endorsing no clinical level of depressive symptoms 28-fold. Moreover, results differed by levels of depression: (a) among youths with clinical levels of depression, hopelessness was associated with six depressive symptoms; (b) among youths without clinical levels of depression, hopelessness was associated with nine depressive symptoms. We found that hopelessness helps to explain the heterogeneity of depressive presentations. Our finding supports the consideration of hopelessness in the diagnosis (if not treatment and prevention) of depression in children and adolescents. (PsycInfo Database Record (c) 2021 APA, all rights reserved).}, Doi = {10.1037/abn0000667}, Key = {fds359587} } @article{fds347363, Author = {Curry, JF and Shepherd-Banigan, M and Van Voorhees and E and Wagner, HR and Kelley, ML and Strauss, J and Naylor, J and Veterans Affairs Mid-Atlantic MIRECC Women Veterans Work Group, and Veterans Affairs Mid-Atlantic MIRECC Work Group}, Title = {Sex differences in predictors of recurrent major depression among current-era military veterans.}, Journal = {Psychol Serv}, Volume = {18}, Number = {2}, Pages = {275-284}, Year = {2021}, Month = {May}, url = {http://dx.doi.org/10.1037/ser0000397}, Abstract = {Although major depressive disorder (MDD) is a frequent diagnosis among women seeking care in the Veterans Health Administration, little is known about its course. For example, recurrence of MDD and its predictors have been investigated in civilians, but not among female veterans. Because female veterans differ from their civilian counterparts and from male veterans on demographic variables, including race, ethnicity, marital status, and educational level, it is important to identify factors affecting MDD course within this population. We investigated frequency and correlates of recurrent MDD among female veterans and their male counterparts. From a postdeployment research registry of 3,247 participants (660 women and 2,587 men), we selected those with a current episode of MDD (141 women and 462 men). For each sex, we compared those diagnosed with recurrent MDD with those experiencing a single episode on demographics, comorbid diagnoses, family history of mental illness, traumatic experiences, combat exposure, and social support. In contrast to findings in most civilian samples, recurrent MDD was significantly more frequent in female (70.2%) than in male (45.2%) depressed veterans, χ²(1) = 26.96, p < .001. In multivariable analyses, recurrence among women was associated with greater experiences of childhood abuse and more trauma during military service and with lower rates of posttraumatic stress disorder. Among men, recurrence was associated with older age, family history of psychiatric hospitalization, more postmilitary trauma, and lifetime anxiety disorder and with lower likelihood of war zone deployment. Trauma was associated with recurrence in both sexes, but the features of traumatic events differed in women and men. (PsycInfo Database Record (c) 2021 APA, all rights reserved).}, Doi = {10.1037/ser0000397}, Key = {fds347363} } @article{fds351496, Author = {Doyle, O and Weller, BE and Goldston, DB and Breland-Noble, AM and Estroff, SE and Daniel, SS and Curry, JF and Wells, KC}, Title = {Coping in the Aftermath of Youth's Suicidal Behaviors: A Comparison of Black Mothers and White Mothers}, Journal = {Family Relations}, Volume = {70}, Number = {1}, Pages = {77-89}, Year = {2021}, Month = {February}, url = {http://dx.doi.org/10.1111/fare.12484}, Abstract = {Objective: To better understand Black mothers' and White mothers' qualitative reactions to their adolescents' hospitalizations due to suicide attempts. Background: Caregivers of youth with suicidal behaviors play a vital role in youth's subsequent treatment and recovery. Yet little attention has been paid to how they are affected by youth's psychiatric hospitalizations or how their reactions may be influenced by race. Method: Twenty Black mothers (Mage = 42.50; SD = 8.48) and 20 White mothers (Mage = 44.85; SD = 6.86) were randomly selected from data originally collected for a larger longitudinal, mixed method, multisite study. Data analysis was informed by grounded theory methodology. Results: Four themes emerged from the data: mothers' emotional distress; mothers' coping, needs, and supports; mothers' perceived need for increased monitoring; and improved mother–child relationships. Conclusions: Black mothers and White mothers largely had similar reactions to youth's hospitalizations; however, nuanced differences also were noted regarding how they described their experiences and what they emphasized. Implications: During discharge planning, mothers need additional support (beyond referrals) in their roles as caregivers and for their own coping. Additional clinical and research implications are discussed.}, Doi = {10.1111/fare.12484}, Key = {fds351496} } @article{fds359063, Author = {Goldston, DB and Curry, JF and Wells, KC and Kaminer, Y and Daniel, SS and Esposito-Smythers, C and Doyle, O and Sapyta, J and Tunno, AM and Heilbron, NC and Roley-Roberts, M}, Title = {Feasibility of an Integrated Treatment Approach for Youth with Depression, Suicide Attempts, and Substance Use Problems.}, Journal = {Evid Based Pract Child Adolesc Ment Health}, Volume = {6}, Number = {2}, Pages = {155-172}, Year = {2021}, url = {http://dx.doi.org/10.1080/23794925.2021.1888664}, Abstract = {Depression, suicidal behaviors and substance use problems frequently co-occur, and treatment for youth with these co-occurring problems is often fragmented and challenging. An integrated cognitive-behavioral treatment approach that builds upon a relapse prevention framework and applies common core skills, language, and approach for treating these related problems may be clinically beneficial. Following a description of the integrated approach, we present results of a pilot trial (n = 13) to examine the acceptability and feasibility of the Cognitive-Behavioral Therapy - Relapse Prevention (CBT-RP) intervention plus enhanced treatment as usual (TAU) compared to enhanced TAU alone. The feasibility of the CBT-RP + TAU intervention was reflected by high rates of retention (86%). The acceptability was reflected in positive evaluations regarding the helpfulness of the intervention by adolescents and families. The majority of youth in both CBT-RP + TAU and TAU alone groups evidenced reductions in depression and suicide ideation from study entry to Week 20. Patterns of reduction were more consistent, however, for youth receiving CBT-RP + TAU, and reductions were slower to emerge for some youth receiving TAU alone. Reductions in alcohol and marijuana problems were similar, but half of the youth in TAU alone (and none in the CBT-RP + TAU group) had emergency department visits related to psychiatric crises or substance related problems. These findings, although based on a small sample, underscore the feasibility and acceptability of an integrated cognitive-behavioral relapse prevention approach for youth with depression, suicide attempt histories, and substance use problems.}, Doi = {10.1080/23794925.2021.1888664}, Key = {fds359063} } @article{fds352042, Author = {Meyer, AE and Curry, JF}, Title = {Moderators of Treatment for Adolescent Depression.}, Journal = {J Clin Child Adolesc Psychol}, Volume = {50}, Number = {4}, Pages = {486-497}, Year = {2021}, url = {http://dx.doi.org/10.1080/15374416.2020.1796683}, Abstract = {Objective: This brief report reviews the literature on moderators of treatment for adolescent depression. Treatment moderators can help to guide the process of personalizing intervention to individual patient characteristics.Method: We conducted a systematic search in PsycInfo and PubMed. We also reviewed references of previous reviews and searched for moderator analyses conducted secondary to published efficacy studies.Results: We review 27 studies that address the following categories of moderators: demographics, severity indices, comorbidity, contextual factors, history of abuse or trauma, and cognition and coping. We found limited evidence that demographic, contextual, or cognitive variables consistently moderated treatment for adolescent depression. There was some indication of moderation by race/ethnicity, presence of some comorbid disorders, greater depression severity, and a history of trauma.Conclusion: Our review found inconsistent findings across studies, likely due to the strong impact of predictors relative to moderators and limited statistical power. More research using innovative statistical approaches is necessary before treatment tailoring can be an empirically-based process.}, Doi = {10.1080/15374416.2020.1796683}, Key = {fds352042} } @article{fds351215, Author = {Arias, AJ and Hammond, CJ and Burleson, JA and Kaminer, Y and Feinn, R and Curry, JF and Dennis, ML}, Title = {Temporal dynamics of the relationship between change in depressive symptoms and cannabis use in adolescents receiving psychosocial treatment for cannabis use disorder.}, Journal = {J Subst Abuse Treat}, Volume = {117}, Pages = {108087}, Year = {2020}, Month = {October}, url = {http://dx.doi.org/10.1016/j.jsat.2020.108087}, Abstract = {AIMS: Cannabis use disorder (CUD) and depression frequently co-occur in youth. How depressive symptoms change over the course of CUD treatment and how they impact substance use treatment outcomes is unknown. In the current study, we examine the temporal relationships between cannabis use and depression in adolescents receiving evidence-based treatments for CUD as part of a multisite clinical trial. DESIGN: Six hundred adolescents (age 12-18) with a CUD were randomly assigned to substance use treatment from one of five evidence-based psychosocial interventions. We assessed self-reported cannabis use frequency and depressive symptoms at baseline (BL) and again at 3-, 6-, 9, and 12-months. A bivariate latent change model assessed bidirectional effects of baseline levels and time-lagged changes in depressive symptoms and cannabis use on depression and cannabis use outcomes. FINDINGS: Depressive symptoms (72%) and major depressive disorder (MDD) (18%) were common at BL. Both depression and cannabis use decreased over time and change in cannabis use was significantly associated with change in depressive symptoms (b = 1.22, p = .003). Time-lag analyses showed that within-subject change in depression (from one time point to the next) was predicted by previous depression (b = -0.71, p < .001) but not cannabis use (p = .068), and change (decrease) in cannabis use was predicted by previous (greater) depressive symptoms (b = -1.47, p < .001) but not cannabis use (p = .158), respectively. CONCLUSION: These findings indicate an enduring relationship between decreasing cannabis use and decreasing depression among adolescents lasting for 9-months after receiving psychosocial interventions for CUD. The presence of depressive symptoms did not appear to interfere with substance use treatment or attenuate improvements in cannabis use frequency. A decrease in cannabis use was not contingent upon a reduction in depressive symptoms. These findings are limited by the possibility of regression to the mean for both cannabis use and depressive symptoms, and the lack of a nonintervention control group.}, Doi = {10.1016/j.jsat.2020.108087}, Key = {fds351215} } @article{fds350346, Author = {Zhou, X and Teng, T and Zhang, Y and Del Giovane and C and Furukawa, TA and Weisz, JR and Li, X and Cuijpers, P and Coghill, D and Xiang, Y and Hetrick, SE and Leucht, S and Qin, M and Barth, J and Ravindran, AV and Yang, L and Curry, J and Fan, L and Silva, SG and Cipriani, A and Xie, P}, Title = {Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis.}, Journal = {Lancet Psychiatry}, Volume = {7}, Number = {7}, Pages = {581-601}, Year = {2020}, Month = {July}, url = {http://dx.doi.org/10.1016/S2215-0366(20)30137-1}, Abstract = {BACKGROUND: Depressive disorders are common in children and adolescents. Antidepressants, psychotherapies, and their combination are often used in routine clinical practice; however, available evidence on the comparative efficacy and safety of these interventions is inconclusive. Therefore, we sought to compare and rank all available treatment interventions for the acute treatment of depressive disorders in children and adolescents. METHODS: We did a systematic review and network meta-analysis. We searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, PsycINFO, ProQuest, CINAHL, LiLACS, international trial registries, and the websites of regulatory agencies for published and unpublished randomised controlled trials from database inception until Jan 1, 2019. We included placebo-controlled and head-to-head trials of 16 antidepressants, seven psychotherapies, and five combinations of antidepressant and psychotherapy that are used for the acute treatment of children and adolescents (≤18 years old and of both sexes) with depressive disorder diagnosed according to standard operationalised criteria. Trials recruiting participants with treatment-resistant depression, bipolar disorder, psychotic depression, treatment duration of less than 4 weeks, or an overall sample size of fewer than ten patients were excluded. We extracted data following a predefined hierarchy of outcome measures, and assessed risk of bias and certainty of evidence using validated methods. Primary outcomes were efficacy (change in depressive symptoms) and acceptability (treatment discontinuation due to any cause). We estimated summary standardised mean differences (SMDs) or odds ratios (ORs) with credible intervals (CrIs) using network meta-analysis with random effects. This study was registered with PROSPERO, number CRD42015020841. FINDINGS: From 20 366 publications, we included 71 trials (9510 participants). Depressive disorders in most studies were moderate to severe. In terms of efficacy, fluoxetine plus cognitive behavioural therapy (CBT) was more effective than CBT alone (-0·78, 95% CrI -1·55 to -0·01) and psychodynamic therapy (-1·14, -2·20 to -0·08), but not more effective than fluoxetine alone (-0·22, -0·86 to 0·42). No pharmacotherapy alone was more effective than psychotherapy alone. Only fluoxetine plus CBT and fluoxetine were significantly more effective than pill placebo or psychological controls (SMDs ranged from -1·73 to -0·51); and only interpersonal therapy was more effective than all psychological controls (-1·37 to -0·66). Nortriptyline (SMDs ranged from 1·04 to 2·22) and waiting list (SMDs ranged from 0·67 to 2·08) were less effective than most active interventions. In terms of acceptability, nefazodone and fluoxetine were associated with fewer dropouts than sertraline, imipramine, and desipramine (ORs ranged from 0·17 to 0·50); imipramine was associated with more dropouts than pill placebo, desvenlafaxine, fluoxetine plus CBT, and vilazodone (2·51 to 5·06). Most of the results were rated as "low" to "very low" in terms of confidence of evidence according to Confidence In Network Meta-Analysis. INTERPRETATION: Despite the scarcity of high-quality evidence, fluoxetine (alone or in combination with CBT) seems to be the best choice for the acute treatment of moderate-to-severe depressive disorder in children and adolescents. However, the effects of these interventions might vary between individuals, so patients, carers, and clinicians should carefully balance the risk-benefit profile of efficacy, acceptability, and suicide risk of all active interventions in young patients with depression on a case-by-case basis. FUNDING: National Key Research and Development Program of China.}, Doi = {10.1016/S2215-0366(20)30137-1}, Key = {fds350346} } @article{fds337454, Author = {Donoho, CJ and LeardMann, C and O'Malley, CA and Walter, KH and Riviere, LA and Curry, JF and Adler, AB}, Title = {Depression among military spouses: Demographic, military, and service member psychological health risk factors.}, Journal = {Depress Anxiety}, Volume = {35}, Number = {12}, Pages = {1137-1144}, Year = {2018}, Month = {December}, url = {http://dx.doi.org/10.1002/da.22820}, Abstract = {BACKGROUND: More than a decade of war has strained service members and their families and the psychological health of military spouses is a concern. This study uses data from the largest study of military families in the United States to examine the demographic, military-specific, and service member mental health correlates of probable diagnosis of major depressive disorder (MDD) among military spouses. METHODS: Data were from service member-spouse dyads from all branches of the U.S. military. Demographic and military-specific factors were assessed using administrative personnel records and survey data. RESULTS: Of the 9,038 spouses, 4.9% had a probable diagnosis of MDD. In unadjusted models, spouses of service members who deployed and experiencecd combat-related events, were enlisted, had a probable posttraumatic stress disorder (PTSD) diagnosis, or screened positive for alcohol misuse were more likely to screen positive for MDD. In adjusted models, only spouses married to enlisted service members or those with PTSD had increased risk for MDD. Other demographic and military-related factors associated with MDD in spouses included less educational attainment, unemployment, having four or more children, and having prior military service (although not currently serving in the military) in the adjusted models. CONCLUSIONS: Findings characterize demographic, military, and service member psychological health factors that are associated with depression among military spouses. These findings imply that deployment alone may not negatively affect military spouses, but rather it may be the mental health impact on the service member, especially PTSD that increases the odds for MDD among military spouses.}, Doi = {10.1002/da.22820}, Key = {fds337454} } @article{fds336065, Author = {Curry, JF and Kiser, LJ and Fernandez, PE and Elliott, AV and Dowling, LVM}, Title = {Development and initial piloting of a measure of post-deployment parenting reintegration experiences}, Journal = {Professional Psychology: Research and Practice}, Volume = {49}, Number = {2}, Pages = {159-166}, Publisher = {American Psychological Association (APA)}, Year = {2018}, Month = {April}, url = {http://dx.doi.org/10.1037/pro0000185}, Abstract = {Each phase of the deployment cycle poses challenges to military parents and children, with the post-deployment family reintegration period requiring returning military parents to resume such roles as direct caretaking and child discipline. Although veterans often report concerns about this domain of reintegration, existing measures permit only limited assessment of their parenting experiences. The authors initiated development of a self-report checklist to improve such assessment through two pilot studies. In the first, they generated a 30-item checklist of positive and challenging veteran parenting experiences, by interviewing nine clinicians experienced in assessment or intervention with veterans. In the second, 20 male veterans (mean age = 40.5 years) rated each parenting item based on their experiences during post-deployment family reintegration. They also indicated whether they had experienced any of 11 possible personal problems during this period and completed a family functioning measure. Results indicated that checklist items were relevant for the returning parents, that positive parenting experiences were endorsed by a higher percentage of veterans than challenging experiences, and that challenging experiences were associated with several personal problems and poorer family functioning. Further psychometric testing with larger, more representative samples of male and female veterans is needed, to establish the validity and utility of the measure.}, Doi = {10.1037/pro0000185}, Key = {fds336065} } @article{fds328869, Author = {Meyer, AE and Curry, JF}, Title = {Pathways from anxiety to stressful events: An expansion of the stress generation hypothesis.}, Journal = {Clin Psychol Rev}, Volume = {57}, Pages = {93-116}, Publisher = {Elsevier}, Year = {2017}, Month = {November}, url = {http://dx.doi.org/10.1016/j.cpr.2017.08.003}, Doi = {10.1016/j.cpr.2017.08.003}, Key = {fds328869} } @article{fds327307, Author = {Shepherd-Banigan, M and Kelley, ML and Katon, JG and Curry, JF and Goldstein, KM and Brancu, M and Wagner, HR and Fecteau, TE and VA Mid-Atlantic MIRECC Women Veterans Workgroup, and VA Mid-Atlantic MIRECC Workgroup, and Van Houtven, CH}, Title = {Paternal history of mental illness associated with posttraumatic stress disorder among veterans.}, Journal = {Psychiatry Research}, Volume = {256}, Pages = {461-468}, Year = {2017}, Month = {October}, url = {http://dx.doi.org/10.1016/j.psychres.2017.06.053}, Abstract = {This study examined the association between parent and family reported history of non-PTSD mental illness (MI), PTSD specifically, and substance use problems, and participant clinical diagnosis of PTSD. Participants were drawn from the US Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC) Post-Deployment Mental Health (PDMH) study (n = 3191), an ongoing multi-site cohort study of US Afghanistan and Iraq conflict era veterans. Participants who recalled a father history of PTSD had a 26-percentage point higher likelihood of meeting criteria for PTSD; while participants reporting any family history of PTSD had a 15-percentage point higher probability of endorsing symptoms consistent with PTSD. Mother history of substance use problems was associated with Veteran current PTSD, but results were sensitive to model specification. Current PTSD was not associated with family/parent history of non-PTSD mental illness, mother history of PTSD, or family/father history of substance use problems. Family history of PTSD may increase PTSD risk among veterans exposed to trauma, particularly when a father history is reported. Knowledge of family history could improve clinical decision-making for trauma-exposed individuals and allow for more effective targeting of programs and clinical services.}, Doi = {10.1016/j.psychres.2017.06.053}, Key = {fds327307} } @article{fds300118, Author = {Peters, AT and Jacobs, RH and Feldhaus, C and Henry, DB and Albano, AM and Langenecker, SA and Reinecke, MA and Silva, SG and Curry, JF}, Title = {Trajectories of Functioning Into Emerging Adulthood Following Treatment for Adolescent Depression.}, Journal = {J Adolesc Health}, Volume = {58}, Number = {3}, Pages = {253-259}, Year = {2016}, Month = {March}, ISSN = {1054-139X}, url = {http://dx.doi.org/10.1016/j.jadohealth.2015.09.022}, Abstract = {PURPOSE: It is well established that empirically supported treatments reduce depressive symptoms for most adolescents; however, it is not yet known whether these interventions lead to sustained improvements in global functioning. The goal of this study is to assess the clinical characteristics and trajectories of long-term psychosocial functioning among emerging adults who have experienced adolescent-onset major depressive disorder. METHODS: Global functioning was assessed using the Clinical Global Assessment Scale for children (participants ≤18 years), the Global Assessment of Functioning (participants ≥ 19 years) and the Health of the Nation Outcome Scales for Adolescents among 196 adolescents who elected to complete 3.5 years of naturalistic follow-up subsequent to their participation in the Treatment for Adolescents with Depression Study. The Treatment for Adolescents with Depression Study examined the efficacy of cognitive behavior therapy, fluoxetine, and the combination of cognitive behavior therapy and fluoxetine (combination treatment) over the course of 36 weeks. Mixed-effects regression models were used to identify trajectories and clinical predictors of functioning over the naturalistic follow-up. RESULTS: Global functioning and achievement of developmental milestones (college, employment) improved over the course of follow-up for most adolescents. Depressive relapse, initial randomization to the placebo group, and the presence of multiple psychiatric comorbidities conferred risk for relatively poorer functioning. CONCLUSIONS: Functioning generally improves among most adolescents who have received empirically supported treatments. However, the presence of recurrent major depressive disorder and multiple psychiatric comorbidities is associated with poorer functioning trajectories, offering targets for maintenance treatment or secondary prevention.}, Doi = {10.1016/j.jadohealth.2015.09.022}, Key = {fds300118} } @article{fds314974, Author = {Curry, JF and Meyer, AE}, Title = {Can Less Yield More? Behavioral Activation for Adolescent Depression}, Journal = {Clinical Psychology: Science and Practice}, Volume = {23}, Number = {1}, Pages = {62-65}, Publisher = {WILEY}, Year = {2016}, Month = {March}, ISSN = {0969-5893}, url = {http://dx.doi.org/10.1111/cpsp.12141}, Abstract = {The report by Ritschel et al. (2016) demonstrates that Behavioral Activation (BA) has significant promise as an effective intervention for adolescent major depression. At a minimum, confirmation of this finding in controlled trials would increase the available treatments for depression in young people. BA may also be more attractive to adolescents, especially younger adolescents, than models of cognitive-behavior therapy (CBT) that place greater emphasis on cognitive change. A more general attraction of BA is its relative simplicity, in comparison with the CBT models used in recent major trials, all of which involved multiple skill-training modules. The theoretical basis of BA lends itself to studies of mechanisms of therapeutic change, and may also prove to be useful within a Research Domain Criteria (RDoC) framework.}, Doi = {10.1111/cpsp.12141}, Key = {fds314974} } @article{fds300291, Author = {Rush, CC and Curry, JF and Looney, JG}, Title = {Alcohol expectancies and drinking behaviors among college students with disordered eating.}, Journal = {J Am Coll Health}, Volume = {64}, Number = {3}, Pages = {195-204}, Year = {2016}, ISSN = {0744-8481}, url = {http://dx.doi.org/10.1080/07448481.2015.1107837}, Abstract = {OBJECTIVE: The authors investigated binge drinking, alcohol expectancies, and risky and protective drinking behaviors in relation to disordered eating behaviors in male and female college students. PARTICIPANTS: The full sample consisted of 7,720 undergraduate students, 18 to 22 years of age. Drinking behaviors were analyzed in 4,592 recent drinkers. METHODS: Participants anonymously completed a survey as part of a universal alcohol abuse prevention program between September 2007 and April 2008. RESULTS: Co-occurring disordered eating behaviors and binge drinking characterized 17.1% of males and 19.0% of females. Rates of binge drinking were higher in those with disordered eating behaviors. Students with disordered eating behaviors also had more positive and negative alcohol expectancies and engaged in more risky and fewer protective drinking behaviors than their counterparts. CONCLUSIONS: Students with disordered eating behaviors have outcome expectancies and behavior patterns associated with problematic drinking. These findings may enhance prevention and intervention programs.}, Doi = {10.1080/07448481.2015.1107837}, Key = {fds300291} } @article{fds300119, Author = {Curry, JF}, Title = {Training implications of psychology's approach to conscience clause cases}, Journal = {Training and Education in Professional Psychology}, Volume = {9}, Number = {4}, Pages = {275-278}, Publisher = {American Psychological Association (APA)}, Year = {2015}, Month = {November}, ISSN = {1931-3918}, url = {http://dx.doi.org/10.1037/tep0000102}, Abstract = {The Board of Education Virtual Working Group on Restrictions Affecting Diversity Training has generated a thoughtful approach to the challenge of conscience clauses. In this commentary short-term and longer-term implications of their publications are considered, as these might affect training programs seeking to implement the Working Group tenets. Among the short-term issues that need to be addressed by faculty members in professional psychology training programs are (a) whether to focus broadly or more narrowly in policies and program statements, (b) how to define a minimal level of competence in students' ability to work with diverse clients, (c) how to provide effective supervision when conflicts arise between a trainee's values and clinical needs of diverse clients, and (d) how to disclose policy in a manner likely to be understood by program applicants. Among the longer-term implications of the Working Groups statements are (a) how to reach a deeper understanding of what is meant by diversity in clinical training, (b) how to integrate the focus on differences with a developing appreciation of common humanity, (c) how to base diversity training and practice on psychological science, and (d) how to reduce judgmental thinking while facilitating the growth of clinical judgment.}, Doi = {10.1037/tep0000102}, Key = {fds300119} } @article{fds271707, Author = {Kelley, ML and Brancu, M and Robbins, AT and D'Lima, GM and Strauss, JL and Curry, JF and Fairbank, JA and Runnals, J and VA Mid-Atlantic MIRECC Women Veterans Workgroup and VA Mid-Atlantic MIRECC Workgroup}, Title = {Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.}, Journal = {Drug Alcohol Depend}, Volume = {152}, Pages = {201-208}, Year = {2015}, Month = {July}, ISSN = {0376-8716}, url = {http://dx.doi.org/10.1016/j.drugalcdep.2015.03.038}, Abstract = {BACKGROUND: The current study was undertaken to examine whether posttraumatic stress symptoms (PTSS) and depressive symptoms mediated the association between trauma exposure (combat-related trauma and non-combat traumas occurring before, during, and after military service), and drug abuse symptoms use among male and female veterans. METHODS: Participants were 2304 (1851 male, 453 female) veterans who took part in a multi-site research study conducted through the Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (VISN 6 MIRECC). Path analytic models were used to determine the association between problematic past-year drug use and combat-related and non-combat trauma experienced before, during, or after the military and whether current post-traumatic stress symptoms or depressive symptoms mediated these associations. RESULTS: For both male and female veterans, depressive symptoms significantly mediated the effects of pre- and post-military trauma on drug abuse symptoms. CONCLUSION: Mental health providers who work with trauma-exposed Iraq and Afghanistan era veterans should assess for drug use, depressive symptoms, and life-span trauma (i.e., not only combat-related traumas) as part of a thorough trauma-based assessment for both men and women.}, Doi = {10.1016/j.drugalcdep.2015.03.038}, Key = {fds271707} } @article{fds271708, Author = {Curry, JF}, Title = {Good news in the battle against military suicide.}, Journal = {American Journal of Psychiatry}, Volume = {172}, Number = {5}, Pages = {406-407}, Year = {2015}, Month = {May}, ISSN = {0002-953X}, url = {http://dx.doi.org/10.1176/appi.ajp.2015.15020172}, Doi = {10.1176/appi.ajp.2015.15020172}, Key = {fds271708} } @article{fds271709, Author = {Goldman, EE and Bauer, D and Newman, DL and Kalka, E and Lochman, JE and Silverman, WK and Jensen, PS and Curry, J and Stark, K and Wells, KC and Bannon, WM and Integrated Psychotheraphy Consortium}, Title = {A school-based post-Katrina therapeutic intervention.}, Journal = {Adm Policy Ment Health}, Volume = {42}, Number = {3}, Pages = {363-372}, Year = {2015}, Month = {May}, ISSN = {0894-587X}, url = {http://dx.doi.org/10.1007/s10488-014-0576-y}, Abstract = {The current study presents the implementation of a set of school based interventions in a greater New Orleans school district one year following Hurricane Katrina. The interventions included adaptation and implementation of evidence based treatments in a crisis situation with at-risk youth which involved training and clinical challenges. 386 students found to have significant depressive and/or disruptive disorder symptoms received treatment from the School Therapeutic Enhancement Program (STEP). Further, a district-wide mental health needs assessment of middle and high school students (N = 11,861) screened for behavioral and emotional difficulties at the beginning and end of the school year provided a benchmark for community youth's emotional and behavioral distress. High-need intervention students demonstrated clinically significant lower levels of emotional and behavioral problems, depression and inattention in comparison to pre-treatment levels as indicated by multiple informants (i.e., self, parent, teacher). Self-reported distress levels were also lower than screening group students at post-test. These findings support the efficacy of a school-based intervention for youth struggling with the aftereffects of a highly disruptive natural disaster. Implications for utilizing a flexible adaptation of an evidence-based training model involving coaching and consultation are discussed.}, Doi = {10.1007/s10488-014-0576-y}, Key = {fds271709} } @article{fds271705, Author = {Crosskey, LB and Curry, JF and Leary, MR}, Title = {Role Transgressions, Shame, and Guilt Among Clergy}, Journal = {Pastoral Psychology}, Volume = {64}, Number = {6}, Pages = {783-801}, Publisher = {Springer Nature}, Year = {2015}, Month = {April}, ISSN = {0031-2789}, url = {http://dx.doi.org/10.1007/s11089-015-0644-6}, Abstract = {After committing an error or transgression, people may experience shame (they feel badly about themselves) or guilt (they feel badly about their action or inaction). This study investigated the possibility that people experience more shame in domains that are relevant to their self-concept and that shame in these domains is more strongly associated with distress. Work or vocation is one domain in which self-concept is often entangled. For instance, many clergy fail to differentiate between who they are and what they do in their role as pastor, raising the question of whether transgressions that are relevant to the pastoral role evoke greater shame than transgressions in other domains. Across two studies, seminary students generated scenarios involving failures that clergy may experience in their role as clergy, and seminarians and clergy rated their reactions to these scenarios and completed a measure of burnout. Results demonstrated that higher shame, both in ministry situations and in secular situations, was associated with higher negative affect among seminarians and less satisfaction and more emotional exhaustion in ministry among clergy. Contrary to expectations, clergy did not experience more ministry shame than general shame, nor was ministry shame more strongly associated with clergy burnout than was general shame. Implications for the mental health of ministers are explored.}, Doi = {10.1007/s11089-015-0644-6}, Key = {fds271705} } @article{fds271713, Author = {Brenner, SL and Burns, BJ and Curry, JF and Silva, SG and Kratochvil, CJ and Domino, ME}, Title = {Mental health service use among adolescents following participation in a randomized clinical trial for depression.}, Journal = {J Clin Child Adolesc Psychol}, Volume = {44}, Number = {4}, Pages = {551-558}, Year = {2015}, ISSN = {1537-4416}, url = {http://dx.doi.org/10.1080/15374416.2014.881291}, Abstract = {Major depressive disorder (MDD) is a common disorder among adolescents. The Treatment for Adolescents with Depression Study (TADS) was a randomized controlled trial to examine the efficacy of fluoxetine and cognitive-behavioral therapy (CBT), separately and together, compared with placebo, in adolescents 12 to 17 years of age. The Survey of Outcomes Following Treatment for Adolescent Depression (SOFTAD) was designed as a naturalistic follow-up of participants in TADS. The aims of the current analyses are to describe mental health service use during the SOFTAD period. There were 196 adolescents recruited from 12 TADS sites. The Schedule for Affective Disorders and Schizophrenia for School-Age-Children-Present and Lifetime Version was used for clinical diagnoses. Participants completed a psychiatric treatment log and the Child and Adolescent Services Assessment to assess service use. 58% received psychotherapy or nonstimulant psychotropic medication during SOFTAD. Youth with recurrent MDD had higher rates of treatment compared to youth without recurrent MDD (71% vs. 45%). However, nearly one third of the adolescents in the study did not receive treatment for a recurrent episode of depression. Service use differed by gender for those with recurrent MDD, with female participants (79%) receiving treatment at higher rates than male participants (55%), although there was no significant difference in depression severity between genders. Younger participants with recurrent MDD had higher odds of receiving psychotherapy. Use of psychotherapy and psychotropics following recurrence of depression appears to be influenced by age and gender. Even when youth respond well to treatment, a sizeable percentage are likely to experience a subsequent episode that may go untreated.}, Doi = {10.1080/15374416.2014.881291}, Key = {fds271713} } @article{fds271711, Author = {Freeman, J and Sapyta, J and Garcia, A and Compton, S and Khanna, M and Flessner, C and FitzGerald, D and Mauro, C and Dingfelder, R and Benito, K and Harrison, J and Curry, J and Foa, E and March, J and Moore, P and Franklin, M}, Title = {Family-based treatment of early childhood obsessive-compulsive disorder: the Pediatric Obsessive-Compulsive Disorder Treatment Study for Young Children (POTS Jr)--a randomized clinical trial.}, Journal = {Jama Psychiatry}, Volume = {71}, Number = {6}, Pages = {689-698}, Year = {2014}, Month = {June}, ISSN = {2168-622X}, url = {http://dx.doi.org/10.1001/jamapsychiatry.2014.170}, Abstract = {IMPORTANCE: Cognitive behavior therapy (CBT) has been established as efficacious for obsessive-compulsive disorder (OCD) among older children and adolescents, yet its effect on young children has not been evaluated sufficiently. OBJECTIVE: To examine the relative efficacy of family-based CBT (FB-CBT) involving exposure plus response prevention vs an FB relaxation treatment (FB-RT) control condition for children 5 to 8 years of age. DESIGN, SETTING, AND PARTICIPANTS: A 14-week randomized clinical trial (Pediatric Obsessive-Compulsive Disorder Treatment Study for Young Children [POTS Jr]) conducted at 3 academic medical centers between 2006 and 2011, involving 127 pediatric outpatients 5 to 8 years of age who received a primary diagnosis of OCD and a Children's Yale-Brown Obsessive Compulsive Scale total score of 16 or higher. INTERVENTIONS: Participants were randomly assigned to 14 weeks of (1) FB-CBT, including exposure plus response prevention, or (2) FB-RT. MAIN OUTCOMES AND MEASURES: Responder status defined as an independent evaluator-rated Clinical Global Impression-Improvement scale score of 1 (very much improved) or 2 (much improved) and change in independent evaluator-rated continuous Children's Yale-Brown Obsessive Compulsive Scale total score. RESULTS Family-based CBT was superior to FB-RT on both primary outcome measures. The percentages of children who were rated as 1 (very much improved) or 2 (much improved) on the Clinical Global Impression-Improvement scale at 14 weeks were 72% for FB-CBT and 41% for FB-RT. The effect size difference between FB-CBT and FB-RT on the Clinical Global Impression-Improvement scale was 0.31 (95% CI, 0.17-0.45). The number needed to treat (NNT) with FB-CBT vs FB-RT was estimated as 3.2 (95% CI, 2.2-5.8). The effect size difference between FB-CBT and FB-RT on the Children's Yale-Brown Obsessive Compulsive Scale at week 14 was 0.84 (95% CI, 0.62-1.06). CONCLUSIONS AND RELEVANCE: A comprehensive FB-CBT program was superior to a relaxation program with a similar format in reducing OCD symptoms and functional impairment in young children (5-8 years of age) with OCD. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00533806.}, Doi = {10.1001/jamapsychiatry.2014.170}, Key = {fds271711} } @article{fds271716, Author = {Becker, SJ and Curry, JF}, Title = {Testing the effects of peer socialization versus selection on alcohol and marijuana use among treated adolescents.}, Journal = {Subst Use Misuse}, Volume = {49}, Number = {3}, Pages = {234-242}, Year = {2014}, Month = {February}, ISSN = {1082-6084}, url = {http://dx.doi.org/10.3109/10826084.2013.824479}, Abstract = {This study examined the relative influence of peer socialization and selection on alcohol and marijuana use among 106 adolescents who received a brief intervention. Adolescents were recruited between 2003 and 2007 and followed for 12 months as part of a SAMHSA-funded study. Cross-lagged panel models using four assessment points examined the longitudinal relationship between adolescent substance use and peer substance involvement separately for alcohol and marijuana. Consistent with community studies, there was evidence of both peer socialization and peer selection for alcohol use, and only evidence of peer selection for marijuana use. Implications for research and intervention are discussed.}, Doi = {10.3109/10826084.2013.824479}, Key = {fds271716} } @article{fds271715, Author = {Curry, JF and Hersh, J}, Title = {Development and Evolution of Cognitive Behavior Therapy for Depressed Adolescents}, Journal = {Journal of Rational Emotive & Cognitive Behavior Therapy}, Volume = {32}, Number = {1}, Pages = {15-30}, Publisher = {Springer Nature}, Year = {2014}, Month = {January}, ISSN = {0894-9085}, url = {http://dx.doi.org/10.1007/s10942-014-0180-9}, Abstract = {Since the 1980's cognitive behavior therapy (CBT) has been developed and tested with adolescents experiencing depression. Early studies demonstrated that CBT was more effective than no intervention for young people with depressive symptoms. Beginning in the 1990's CBT has been proven to be efficacious for adolescents with diagnosed depressive disorders, specifically Major Depressive Disorder (MDD). A series of increasingly challenging and methodologically rigorous trials showed that CBT was an effective intervention for mild to moderate MDD, and enhanced the benefits of anti-depressant medication, even for those adolescents who had already failed to respond to an initial medication. Simultaneously, some limitations of CBT were suggested by these studies. Results of CBT alone were not encouraging with severely depressed adolescents, and the combination of CBT plus medication was not uniformly supported. As CBT investigators worked with more challenging, complex clinical cases, such as depressed adolescents who were abusing substances or engaging in suicidal or self-harm behaviors, standard components of CBT were augmented by increased emphasis placed on emotion regulation, safety planning, and by more intensive outpatient treatment models. Newer developments include "third wave" models, which have shown initial promise. © 2014 Springer Science+Business Media New York.}, Doi = {10.1007/s10942-014-0180-9}, Key = {fds271715} } @article{fds271719, Author = {Curry, JF and Aubuchon-Endsley, N and Brancu, M and Runnals, JJ and VA Mid-Atlantic Mirecc Women Veterans Research Workgroup, and VA Mid-Atlantic Mirecc Registry Workgroup, and Fairbank, JA}, Title = {Lifetime major depression and comorbid disorders among current-era women veterans.}, Journal = {J Affect Disord}, Volume = {152-154}, Number = {1}, Pages = {434-440}, Year = {2014}, Month = {January}, ISSN = {0165-0327}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24210623}, Abstract = {BACKGROUND: Most research on women veterans' mental health has focused on postraumatic stress disorder (PTSD) or reactions to military sexual trauma. Although depression is also a frequent diagnosis among women veterans, little is known about its characteristics, including comorbid conditions and patterns of disorder onset. We investigated lifetime diagnoses of major depressive disorder (MDD) and comorbid conditions in a primarily treatment-seeking research sample of male and female veterans to determine frequency of lifetime MDD, comorbid disorders and their temporal onset. METHOD: The 1700 veterans (346 women; 1354 men) completed diagnostic interviews as participants in a research registry. Rates of and gender differences in lifetime MDD and comorbid conditions (PTSD, other anxiety disorders, substance use and eating disorders) were calculated. We assessed the percentage of cases in which MDD preceded the comorbid condition (primary onset MDD). RESULTS: Lifetime MDD was frequent in this sample, and significantly more common in women (46.5%) than in men (36.3%). Gender differences in comorbidity were found for anxiety and eating disorders (more common in women); and for alcohol and nicotine use disorders (more common in men). However, primary onset MDD was no more common among women than among men, and was in neither case the predominant pattern of comorbid lifetime disorder onset. LIMITATIONS: The sample is not representative of all veterans, and lifetime diagnoses were based on retrospective recall. CONCLUSIONS: MDD usually follows the onset of other comorbid disorders among women veterans, indicating the need to assess for earlier lifetime disorders in veterans with MDD.}, Doi = {10.1016/j.jad.2013.10.012}, Key = {fds271719} } @article{fds271710, Author = {Hersh, J and Curry, JF and Kaminer, Y}, Title = {What is the impact of comorbid depression on adolescent substance abuse treatment?}, Journal = {Subst Abus}, Volume = {35}, Number = {4}, Pages = {364-375}, Year = {2014}, ISSN = {0889-7077}, url = {http://dx.doi.org/10.1080/08897077.2014.956164}, Abstract = {BACKGROUND: Substance use disorders (SUDs) are among the most common psychiatric diagnoses in adolescents. Some research suggests that comorbid depression in adolescents with SUD is associated with increased likelihood of alcohol dependence, poorer social competence, and greater risk for suicide attempts. However, little is known about how depression influences adolescent substance abuse treatment retention and outcomes. METHODS: This review aimed to summarize the effects of comorbid depression on treatment retention and outcomes across 13 adolescent SUD treatment studies. RESULTS: RESULTS indicated that depression has a mixed relationship with treatment retention and outcomes, exerting a negative, positive, or nonsignificant effect depending on aspects of the study. CONCLUSIONS: More research needs to be done, particularly addressing the potential mediators and moderators of the relationship between depression and SUD outcomes. Importantly, recognizing that the studies varied widely in hypotheses and research methods, the field needs to develop more standardized methods to allow for a clearer understanding of the role of comorbid depression.}, Doi = {10.1080/08897077.2014.956164}, Key = {fds271710} } @article{fds271712, Author = {Curry, JF}, Title = {Future directions in research on psychotherapy for adolescent depression.}, Journal = {J Clin Child Adolesc Psychol}, Volume = {43}, Number = {3}, Pages = {510-526}, Year = {2014}, ISSN = {1537-4416}, url = {http://dx.doi.org/10.1080/15374416.2014.904233}, Abstract = {Research over the past 3 decades has shown that psychotherapy can successfully address adolescent depression. Cognitive behavioral models have been most extensively and rigorously tested, with evidence also supporting interpersonal psychotherapy and attachment-based family therapy. However, the vast majority of studies have focused on short-term treatment of depressive episodes, even as evidence accumulates that depression is frequently a recurring condition extending into adulthood. Moreover, treatment studies indicate that better longer term outcomes are attained by adolescents who respond earlier and more completely to intervention. Given what has been learned to date about adolescent depression treatment, future psychotherapy research should adopt a longer term perspective and focus on the following key challenges: (a) preventing relapse and recurrent episodes, while improving speed and thoroughness of initial treatment response; (b) identifying the necessary treatment components and learning processes that lead to successful and enduring recovery from depression; (c) determining whether-and, if so, how-to address comorbid disorders within depression treatment; (d) addressing the dilemma of simplicity versus complexity in treatment models. Given the relatively small number of evidence-based treatment models, newer approaches warrant investigation. These should be tested against existing models and also compared to medication and combined (psychotherapy plus medication) treatment. Advances in technology now enable investigators to improve dissemination, to conduct experimental psychotherapeutics and to expand application of Internet-based interventions to the goals of relapse and recurrence prevention.}, Doi = {10.1080/15374416.2014.904233}, Key = {fds271712} } @article{fds271714, Author = {Jacobs, RH and Becker, SJ and Curry, JF and Silva, SG and Ginsburg, GS and Henry, DB and Reinecke, MA}, Title = {Increasing Positive Outlook Partially Mediates the Effect of Empirically Supported Treatments on Depression Symptoms Among Adolescents.}, Journal = {Journal of Cognitive Psychotherapy}, Volume = {28}, Number = {1}, Pages = {3-19}, Year = {2014}, ISSN = {0889-8391}, url = {http://dx.doi.org/10.1891/0889-8391.28.1.3}, Abstract = {Among adolescents there is evidence that cognitive change partially mediates the effect of cognitive behavioral therapy (CBT) on depression outcome. However, prior studies have been limited by small samples, narrow measures of cognition, and failure to compare cognitive change following CBT to cognitive change following antidepressant medication. This study examined whether change in four cognitive constructs (cognitive distortions, cognitive avoidance, positive outlook, and solution-focused thinking) mediated change in depression severity in a sample of 291 adolescents who participated in the Treatment for Adolescents with Depression Study (TADS). TADS assessed the effects of CBT, fluoxetine, and their combination on depression severity. All three treatments were associated with change in the cognitive constructs and combination treatment produced the greatest change. Furthermore, change in the cognitive constructs partially mediated change in depression severity within all three treatments. Results implicated positive outlook as the construct most associated with change in depression severity over 36 weeks.}, Doi = {10.1891/0889-8391.28.1.3}, Key = {fds271714} } @article{fds271717, Author = {Hersh, J and Curry, JF and Becker, SJ}, Title = {The Influence of Comorbid Depression and Conduct Disorder on MET/CBT Treatment Outcome for Adolescent Substance Use Disorders.}, Journal = {International Journal of Cognitive Therapy}, Volume = {6}, Number = {4}, Pages = {325-341}, Year = {2013}, Month = {December}, ISSN = {1937-1209}, url = {http://dx.doi.org/10.1521/ijct.2013.6.4.325}, Abstract = {Although depression and conduct disorder frequently co-occur with substance use disorders (SUDs), few studies have investigated the individual and interactive effects of these conditions on SUD treatment outcome. Data were collected from 90 adolescents aged 13-21 (M = 17.1, SD = 2.07) who received a brief evidence-based intervention for SUD. Hierarchical regressions assessed the relationship among demographic variables, depression, conduct disorder, and two substance use outcomes (frequency and problems) at two intervals (three months, six months). Results revealed that higher baseline substance use and lower socioeconomic status significantly predicted higher substance problems and frequency at three-months. At six months, higher three month substance problems and lower depressive symptoms predicted substance problems. In addition, an interaction indicated that the effect of conduct disorder on substance problems was greatest at lower levels of depression. Results are discussed in the context of previous research indicating mixed effects of depression on SUD treatment outcome.}, Doi = {10.1521/ijct.2013.6.4.325}, Key = {fds271717} } @article{fds300120, Author = {de Luise, C and Kolitsopoulos, F and Nieto, AE and Curry, JF and March, JS}, Title = {Pediatric Pharmacoepidemiology Safety Study with Long-Term Use of Sertraline: The SPRITES Study}, Journal = {Pharmacoepidemiology and Drug Safety}, Volume = {22}, Pages = {333-334}, Publisher = {WILEY-BLACKWELL}, Year = {2013}, Month = {October}, ISSN = {1053-8569}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334876101234&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Key = {fds300120} } @article{fds225130, Author = {J. Hersh and J.F. Curry and S.J. Becker}, Title = {The influence of comorbid depression and conduct disorder on MET/CBT outcome for adolescent substance use disorders}, Journal = {Journal of Cognitive Therapy}, Volume = {6}, Pages = {325-341}, Year = {2013}, Key = {fds225130} } @article{fds271721, Author = {Cole, DA and Cho, S-J and Martin, NC and Youngstrom, EA and March, JS and Findling, RL and Compas, BE and Goodyer, IM and Rohde, P and Weissman, M and Essex, MJ and Hyde, JS and Curry, JF and Forehand, R and Slattery, MJ and Felton, JW and Maxwell, MA}, Title = {Are increased weight and appetite useful indicators of depression in children and adolescents?}, Journal = {J Abnorm Psychol}, Volume = {121}, Number = {4}, Pages = {838-851}, Year = {2012}, Month = {November}, ISSN = {0021-843X}, url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000311527700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=47d3190e77e5a3a53558812f597b0b92}, Abstract = {During childhood and adolescence, physiological, psychological, and behavioral processes strongly promote weight gain and increased appetite while also inhibiting weight loss and decreased appetite. The Diagnostic and Statistical Manual-IV (DSM-IV) treats both weight-gain/increased-appetite and weight-loss/decreased-appetite as symptoms of major depression during these developmental periods, despite the fact that one complements typical development and the other opposes it. To disentangle the developmental versus pathological correlates of weight and appetite disturbance in younger age groups, the current study examined symptoms of depression in an aggregated sample of 2307 children and adolescents, 47.25% of whom met criteria for major depressive disorder. A multigroup, multidimensional item response theory model generated three key results. First, weight loss and decreased appetite loaded strongly onto a general depression dimension; in contrast, weight gain and increased appetite did not. Instead, weight gain and increased appetite loaded onto a separate dimension that did not correlate strongly with general depression. Second, inclusion or exclusion of weight gain and increased appetite affected neither the nature of the general depression dimension nor the fidelity of major depressive disorder diagnosis. Third, the general depression dimension and the weight-gain/increased-appetite dimension showed different patterns across age and gender. In child and adolescent populations, these results call into question the utility of weight gain and increased appetite as indicators of depression. This has serious implications for the diagnostic criteria of depression in children and adolescents. These findings inform a revision of the DSM, with implications for the diagnosis of depression in this age group and for research on depression.}, Doi = {10.1037/a0028175}, Key = {fds271721} } @article{fds271732, Author = {Barnard, LK and Curry, JF}, Title = {The Relationship of Clergy Burnout to Self-Compassion and Other Personality Dimensions}, Journal = {Pastoral Psychology}, Volume = {61}, Number = {2}, Pages = {149-163}, Publisher = {Springer Nature}, Year = {2012}, Month = {April}, ISSN = {0031-2789}, url = {http://dx.doi.org/10.1007/s11089-011-0377-0}, Abstract = {Religious leaders often experience burnout, which is characterized by emotional exhaustion and/or low satisfaction. Clergy with high emotional exhaustion feel drained and discouraged. Clergy with high satisfaction report that the ministry gives purpose and meaning to their lives. Hierarchichal regression was used to examine if current clergy's desire to please others, guilt or shame orientation, ability to be self-compassionate, and ability to differentiate self from role uniquely predicted variation in burnout. Although all personality dimensions explained significant variation in emotional satisfaction when examined individually, due to inter-correlations among predictors only self-compassion was significant in the full model. Higher self-compassion was also related to increased satisfaction in ministry. Increasing self-compassion may prevent clergy burnout. © 2011 Springer Science+Business Media, LLC.}, Doi = {10.1007/s11089-011-0377-0}, Key = {fds271732} } @article{fds271733, Author = {Becker, SJ and Stein, GL and Curry, JF and Hersh, J}, Title = {Ethnic differences among substance-abusing adolescents in a treatment dissemination project.}, Journal = {J Subst Abuse Treat}, Volume = {42}, Number = {3}, Pages = {328-336}, Year = {2012}, Month = {April}, ISSN = {0740-5472}, url = {http://dx.doi.org/10.1016/j.jsat.2011.08.007}, Abstract = {Despite evidence of ethnic differences in substance use patterns among adolescents in community samples, clinical studies have not found ethnic differences in posttreatment outcomes. Prior clinical studies have been limited by small samples, focus on broad treatment modalities, and lack of consideration of important covariates. We investigated ethnic differences in substance use frequency and problems in a large sample of White (60%), African American (12%), and Latino (28%) adolescents prior to and following an evidence-based treatment. Participants included 4,502 adolescents (29% female), with ages 13-18 years, who received Motivational Enhancement Therapy/Cognitive Behavior Therapy 5 Sessions. At baseline, African American adolescents demonstrated less frequent use, fewer problems, and less comorbidity than Whites or Latinos. Consistent with prior research, there were no ethnic differences in substance use outcomes among assessment completers (71%) when controlling for baseline differences. However, African Americans, older adolescents, and males were less likely to complete the posttreatment assessment. Implications for clinical service and effectiveness research are discussed.}, Doi = {10.1016/j.jsat.2011.08.007}, Key = {fds271733} } @article{fds271738, Author = {Curry, J and Silva, S and Rohde, P and Ginsburg, G and Kennard, B and Kratochvil, C and Simons, A and Kirchner, J and May, D and Mayes, T and Feeny, N and Albano, AM and Lavanier, S and Reinecke, M and Jacobs, R and Becker-Weidman, E and Weller, E and Emslie, G and Walkup, J and Kastelic, E and Burns, B and Wells, K and March, J}, Title = {Onset of alcohol or substance use disorders following treatment for adolescent depression.}, Journal = {J Consult Clin Psychol}, Volume = {80}, Number = {2}, Pages = {299-312}, Year = {2012}, Month = {April}, ISSN = {0022-006X}, url = {http://dx.doi.org/10.1037/a0026929}, Abstract = {OBJECTIVE: This study tested whether positive response to short-term treatment for adolescent major depressive disorder (MDD) would have the secondary benefit of preventing subsequent alcohol use disorders (AUD) or substance use disorders (SUD). METHOD: For 5 years, we followed 192 adolescents (56.2% female; 20.8% minority) who had participated in the Treatment for Adolescents with Depression Study (TADS; TADS Team, 2004) and who had no prior diagnoses of AUD or SUD. TADS initial treatments were cognitive behavior therapy (CBT), fluoxetine alone (FLX), the combination of CBT and FLX (COMB), or clinical management with pill placebo (PBO). We used both the original TADS treatment response rating and a more restrictive symptom count rating. During follow-up, diagnostic interviews were completed at 6- or 12-month intervals to assess onset of AUD or SUD as well as MDD recovery and recurrence. RESULTS: Achieving a positive response to MDD treatment was unrelated to subsequent AUD but predicted a lower rate of subsequent SUD, regardless of the measure of positive response (11.65% vs. 24.72%, or 10.0% vs. 24.5%, respectively). Type of initial MDD treatment was not related to either outcome. Prior to depression treatment, greater involvement with alcohol or drugs predicted later AUD or SUD, as did older age (for AUD) and more comorbid disorders (for SUD). Among those with recurrent MDD and AUD, AUD preceded MDD recurrence in 24 of 25 cases. CONCLUSION: Effective short-term adolescent depression treatment significantly reduces the rate of subsequent SUD but not AUD. Alcohol or drug use should be assessed prior to adolescent MDD treatment and monitored even after MDD recovery.}, Doi = {10.1037/a0026929}, Key = {fds271738} } @article{fds271720, Author = {Simons, AD and Marti, CN and Rohde, P and Lewis, CC and Curry, J and March, J}, Title = {Does homework "matter" in cognitive behavioral therapy for adolescent depression?}, Journal = {Journal of Cognitive Psychotherapy}, Volume = {26}, Number = {4}, Pages = {390-404}, Publisher = {Springer Publishing Company}, Year = {2012}, Month = {January}, ISSN = {0889-8391}, url = {http://dx.doi.org/10.1891/0889-8391.26.4.390}, Abstract = {Objective: Examine the degree to which homework completion is associated with various indices of clinical improvement in adolescents with depression treated with cognitive behavioral therapy (CBT) either as a monotherapy and in combination with antidepressant medication. Method: This study used data from the Treatment of Adolescents with Depression Study (TADS), which compared the efficacy of CBT, fluoxetine (FLX), the combination of CBT and FLX (COMB), and a pill placebo (PBO; TADS Team, 2003, 2004, 2005). Current analyses included only TADS participants in the CBT (n 5 111) or COMB (n 5 107) conditions. Analyses focused on the relations between partial and full homework completion and a dichotomized measure of clinical response, evaluator and self-report ratings of depressive symptoms, hopelessness, and suicidality. Results: Homework completion significantly predicted clinical improvement, decrease in self-reported hopelessness, suicidality, and depression-but not in evaluator-rated depressive symptoms-in adolescents treated with CBT only. These relationships were almost completely absent in the COMB condition. The only significant COMB finding was that partially completed homework was related to decrease in hopelessness over time. Conclusions: These findings suggest that the ability of therapists and clients to collaboratively develop and complete between-session assignments is associated with response to CBT, self-report of severity of depressive symptoms, hopelessness, and suicidality and may be integral to optimizing the effects of CBT when delivered as a monotherapy. © 2012 Springer Publishing Company.}, Doi = {10.1891/0889-8391.26.4.390}, Key = {fds271720} } @article{fds271730, Author = {Cole, DA and Cai, L and Martin, NC and Findling, RL and Youngstrom, EA and Garber, J and Curry, JF and Hyde, JS and Essex, MJ and Compas, BE and Goodyer, IM and Rohde, P and Stark, KD and Slattery, MJ and Forehand, R}, Title = {Structure and measurement of depression in youths: applying item response theory to clinical data.}, Journal = {Psychol Assess}, Volume = {23}, Number = {4}, Pages = {819-833}, Year = {2011}, Month = {December}, ISSN = {1040-3590}, url = {http://dx.doi.org/10.1037/a0023518}, Abstract = {Our goals in this article were to use item response theory (IRT) to assess the relation of depressive symptoms to the underlying dimension of depression and to demonstrate how IRT-based measurement strategies can yield more reliable data about depression severity than conventional symptom counts. Participants were 3,403 children and adolescents from 12 contributing clinical and nonclinical samples; all participants had received the Kiddie Schedule of Affective Disorders and Schizophrenia for School-Aged Children. Results revealed that some symptoms reflected higher levels of depression and were more discriminating than others. Furthermore, use of IRT-based information about symptom severity and discriminability in the measurement of depression severity was shown to reduce measurement error and increase measurement fidelity.}, Doi = {10.1037/a0023518}, Key = {fds271730} } @article{fds271731, Author = {Barnard, LK and Curry, JF}, Title = {Self-Compassion: Conceptualizations, Correlates, & Interventions}, Journal = {Review of General Psychology}, Volume = {15}, Number = {4}, Pages = {289-303}, Publisher = {American Psychological Association (APA)}, Year = {2011}, Month = {December}, ISSN = {1089-2680}, url = {http://dx.doi.org/10.1037/a0025754}, Abstract = {Within American psychology, there has been a recent surge of interest in self-compassion, a construct from Buddhist thought. Self-compassion entails: (a) being kind and understanding toward oneself in times of pain or failure, (b) perceiving one's own suffering as part of a larger human experience, and (c) holding painful feelings and thoughts in mindful awareness. In this article we review findings from personality, social, and clinical psychology related to self-compassion. First, we define self-compassion and distinguish it from other self-constructs such as self-esteem, self-pity, and self-criticism. Next, we review empirical work on the correlates of self-compassion, demonstrating that self-compassion has consistently been found to be related to well-being. These findings support the call for interventions that can raise self-compassion. We then review the theory and empirical support behind current interventions that could enhance self-compassion including compassionate mind training (CMT), imagery work, the gestalt two-chair technique, mindfulness based stress reduction (MBSR), dialectical behavior therapy (DBT), and acceptance and commitment therapy (ACT). Directions for future research are also discussed. © 2011 American Psychological Association.}, Doi = {10.1037/a0025754}, Key = {fds271731} } @article{fds271729, Author = {Becker, SJ and Curry, JF and Yang, C}, Title = {Factors that influence trajectories of change in frequency of substance use and quality of life among adolescents receiving a brief intervention.}, Journal = {J Subst Abuse Treat}, Volume = {41}, Number = {3}, Pages = {294-304}, Year = {2011}, Month = {October}, ISSN = {0740-5472}, url = {http://dx.doi.org/10.1016/j.jsat.2011.04.004}, Abstract = {This study aimed to identify factors influencing trajectories of change in two outcome domains, frequency of substance use and quality of life (QOL), among adolescents receiving a brief evidence-based intervention. Participants were 106 adolescents, aged 13 to 21 years, who met criteria for a substance use disorder. The adolescents received a five-session intervention and completed four assessments over 12 months. Based upon a theoretical and empirical review, five putative predictors were tested: gender, age, severity of conduct disorder, severity of depression, and peer substance involvement. Results of a parallel-process latent growth curve model indicated that higher peer substance involvement and conduct severity predicted higher frequency of use at baseline, whereas higher peer substance involvement and depression severity predicted poorer QOL at baseline. Counter to predictions, higher depression severity predicted greater improvements in QOL following substance use treatment. The implications of baseline risk factors on adolescents' response to intervention are discussed.}, Doi = {10.1016/j.jsat.2011.04.004}, Key = {fds271729} } @article{fds271728, Author = {Curry, JF}, Title = {Now that we have a strong building, let's add a few floors}, Journal = {Clinical Psychology: Science and Practice}, Volume = {18}, Number = {2}, Pages = {178-181}, Publisher = {WILEY}, Year = {2011}, Month = {June}, ISSN = {0969-5893}, url = {http://dx.doi.org/10.1111/j.1468-2850.2011.01249.x}, Abstract = {The new review by Chorpita and colleagues (2011) indicates an expanded number of evidence-based interventions for child and adolescent disorders. Notably, some of the best new treatments combine psychotherapy and medication. The new review wisely includes promising interventions with emerging or lower levels of empirical support. Overall, the evidence base for child and adolescent interventions is broad and strong. Future reviews should provide further differentiation among interventions with higher levels of support. Specifically, the notion of treatment equivalence needs more rigorous justification, effect sizes should be interpreted in the context of trial designs, and reviews should emphasize indices of the quality of supportive evidence. © 2011 American Psychological Association. Published by Wiley Periodicals, Inc., on behalf of the American Psychological Association.}, Doi = {10.1111/j.1468-2850.2011.01249.x}, Key = {fds271728} } @article{fds271737, Author = {Curry, J and Silva, S and Rohde, P and Ginsburg, G and Kratochvil, C and Simons, A and Kirchner, J and May, D and Kennard, B and Mayes, T and Feeny, N and Albano, AM and Lavanier, S and Reinecke, M and Jacobs, R and Becker-Weidman, E and Weller, E and Emslie, G and Walkup, J and Kastelic, E and Burns, B and Wells, K and March, J}, Title = {Recovery and recurrence following treatment for adolescent major depression.}, Journal = {Arch Gen Psychiatry}, Volume = {68}, Number = {3}, Pages = {263-269}, Year = {2011}, Month = {March}, ISSN = {0003-990X}, url = {http://dx.doi.org/10.1001/archgenpsychiatry.2010.150}, Abstract = {CONTEXT: Major depressive disorder in adolescents is common and impairing. Efficacious treatments have been developed, but little is known about longer-term outcomes, including recurrence. OBJECTIVES: To determine whether adolescents who responded to short-term treatments or who received the most efficacious short-term treatment would have lower recurrence rates, and to identify predictors of recovery and recurrence. DESIGN: Naturalistic follow-up study. SETTING: Twelve academic sites in the United States. PARTICIPANTS: One hundred ninety-six adolescents (86 males and 110 females) randomized to 1 of 4 short-term interventions (fluoxetine hydrochloride treatment, cognitive behavioral therapy, their combination, or placebo) in the Treatment for Adolescents With Depression Study were followed up for 5 years after study entry (44.6% of the original Treatment for Adolescents With Depression Study sample). MAIN OUTCOME MEASURES: Recovery was defined as absence of clinically significant major depressive disorder symptoms on the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version interview for at least 8 weeks, and recurrence was defined as a new episode of major depressive disorder following recovery. RESULTS: Almost all participants (96.4%) recovered from their index episode of major depressive disorder during the follow-up period. Recovery by 2 years was significantly more likely for short-term treatment responders (96.2%) than for partial responders or nonresponders (79.1%) (P < .001) but was not associated with having received the most efficacious short-term treatment (the combination of fluoxetine and cognitive behavioral therapy). Of the 189 participants who recovered, 88 (46.6%) had a recurrence. Recurrence was not predicted by full short-term treatment response or by original treatment. However, full or partial responders were less likely to have a recurrence (42.9%) than were nonresponders (67.6%) (P = .03). Sex predicted recurrence (57.0% among females vs 32.9% among males; P = .02). CONCLUSIONS: Almost all depressed adolescents recovered. However, recurrence occurs in almost half of recovered adolescents, with higher probability in females in this age range. Further research should identify and address the vulnerabilities to recurrence that are more common among young women.}, Doi = {10.1001/archgenpsychiatry.2010.150}, Key = {fds271737} } @article{fds271739, Author = {Stein, GL and Curry, JF and Hersh, J and Breland-Noble, A and March, J and Silva, SG and Reinecke, MA and Jacobs, R}, Title = {Ethnic differences among adolescents beginning treatment for depression.}, Journal = {Cultural Diversity & Ethnic Minority Psychology}, Volume = {16}, Number = {2}, Pages = {152-158}, Year = {2010}, Month = {April}, ISSN = {1099-9809}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20438153}, Abstract = {This study examines ethnic/racial differences at the start of treatment among participants in the Treatment for Adolescents with Depression Study (TADS). African American and Latino youth were compared to Caucasian youth on symptom presentation and cognitive variables associated with depression. Contrary to hypothesis, there were no significant differences in symptom presentation as measured by the interview-based items of the Children's Depression Rating Scale--Revised (CDRS-R). However, African American and Latino youth were both rated as demonstrating more severe symptoms on the observational items of the CDRS-R compared to Caucasian youth. In terms of cognitive variables associated with depression, African Americans reported fewer negative cognitive biases compared to Caucasians, but cognitive biases were significantly correlated with depression severity across ethnic groups.}, Doi = {10.1037/a0018666}, Key = {fds271739} } @article{fds271740, Author = {Kratochvil, CJ and May, DE and Silva, SG and Madaan, V and Puumula, SE and Curry, JF and Walkup, J and Kepley, H and Vitiello, B and March, JS}, Title = {Treatment response in depressed adolescents with and without comorbid attention deficit/hyperactivity disorder}, Journal = {Journal of Child and Adolescent Psychopharmacology}, Year = {2010}, Key = {fds271740} } @article{fds271725, Author = {Reinecke, MA and Curry, JF and March, JS}, Title = {Findings from the Treatment for Adolescents with Depression Study (TADS): what have we learned? What do we need to know?}, Journal = {J Clin Child Adolesc Psychol}, Volume = {38}, Number = {6}, Pages = {761-767}, Year = {2009}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20183660}, Abstract = {This introduction to the special section on findings from the Treatment for Adolescents with Depression Study provides a review of the rationale for the study, its design, and principal findings to date. Findings with regard to acute effectiveness of alternative treatments, relapse, recurrence, maintenance of gains, and the effects of treatment on suicidal ideations and suicidal behavior are reviewed. We conclude with a brief discussion of unresolved clinical issues, including treatment resistance, management of partial response, moderators and predictors of long-term response, and mediators of clinical change. The articles of the special section address a range of issues including relations between cognitive factors associated with depression, relations between maladaptive beliefs and treatment response, cognitive mediators of therapeutic improvement, relations between family conflict and treatment response, and the economic costs of adolescent depression.}, Doi = {10.1080/15374410903258991}, Key = {fds271725} } @article{fds271741, Author = {Feeny, NC and Silva, SG and Reinecke, MA and McNulty, S and Findling, RL and Rohde, P and Curry, JF and Ginsburg, GS and Kratochvil, CJ and Pathak, SM and May, DE and Kennard, BD and Simons, AD and Wells, KC and Robins, M and Rosenberg, D and March, JS}, Title = {An exploratory analysis of the impact of family functioning on treatment for depression in adolescents.}, Journal = {J Clin Child Adolesc Psychol}, Volume = {38}, Number = {6}, Pages = {814-825}, Year = {2009}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20183665}, Abstract = {This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments.}, Doi = {10.1080/15374410903297148}, Key = {fds271741} } @article{fds271742, Author = {Jacobs, RH and Silva, SG and Reinecke, MA and Curry, JF and Ginsburg, GS and Kratochvil, CJ and March, JS}, Title = {Dysfunctional attitudes scale perfectionism: a predictor and partial mediator of acute treatment outcome among clinically depressed adolescents.}, Journal = {J Clin Child Adolesc Psychol}, Volume = {38}, Number = {6}, Pages = {803-813}, Year = {2009}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20183664}, Abstract = {The effect of perfectionism on acute treatment outcomes was explored in a randomized controlled trial of 439 clinically depressed adolescents (12-17 years of age) enrolled in the Treatment for Adolescents with Depression Study (TADS) who received cognitive behavior therapy (CBT), fluoxetine, a combination of CBT and FLX, or pill placebo. Measures included the Children's Depression Rating Scale-Revised, the Suicidal Ideation Questionnaire-Grades 7-9, and the perfectionism subscale from the Dysfunctional Attitudes Scale (DAS). Predictor results indicate that adolescents with higher versus lower DAS perfectionism scores at baseline, regardless of treatment, continued to demonstrate elevated depression scores across the acute treatment period. In the case of suicidality, DAS perfectionism impeded improvement. Treatment outcomes were partially mediated by the change in DAS perfectionism across the 12-week period.}, Doi = {10.1080/15374410903259031}, Key = {fds271742} } @article{fds271743, Author = {Ginsburg, GS and Silva, SG and Jacobs, RH and Tonev, S and Hoyle, RH and Kingery, JN and Reinecke, MA and Curry, JF and March, JS}, Title = {Cognitive measures of adolescent depression: unique or unitary constructs?}, Journal = {J Clin Child Adolesc Psychol}, Volume = {38}, Number = {6}, Pages = {790-802}, Year = {2009}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20183663}, Abstract = {The factor structure of several self-report questionnaires assessing depression-relevant cognitions frequently employed in clinical research was examined in a sample of 390 adolescents (M age = 14.54; 216 girls; 74% Caucasian) with current major depressive disorder enrolled in the Treatment of Adolescents with Depression Study. A four-factor solution resulted, accounting for 65% of the total variance. The factors were labeled (a) Cognitive Distortions and Maladaptive Beliefs, (b) Cognitive Avoidance, (c) Positive Outlook, and (d) Solution-Focused Thinking. Internal consistencies for the factor-based composite scores were .83, .85, .84, and .82, respectively. Girls endorsed more negative cognitions than boys on three of the four factors. Maladaptive cognitions were positively related to severity of depression and predicted treatment response. Taken together, findings indicated that there are four distinct domains of cognitions that are present among adolescents with depression that are tapped by several widely used self-report measures of cognitions.}, Doi = {10.1080/15374410903259015}, Key = {fds271743} } @article{fds271744, Author = {Rogers, GM and Park, J-H and Essex, MJ and Klein, MH and Silva, SG and Hoyle, RH and Curry, JF and Feeny, NC and Kennard, B and Kratochvil, CJ and Pathak, S and Reinecke, MA and Rosenberg, DR and Weller, EB and March, JS}, Title = {The dysfunctional attitudes scale: psychometric properties in depressed adolescents.}, Journal = {J Clin Child Adolesc Psychol}, Volume = {38}, Number = {6}, Pages = {781-789}, Year = {2009}, Month = {November}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20183662}, Abstract = {The psychometric properties and factor structure of the Dysfunctional Attitudes Scale were examined in a sample of 422 male and female adolescents (ages 12-17) with current major depressive disorder. The scale demonstrated high internal consistency (alpha = .93) and correlated significantly with self-report and interview-based measures of depression. Confirmatory factor analysis indicated that a correlated 2-factor model, with scales corresponding to perfectionism and need for social approval, provided a satisfactory fit to the data. The goodness-of-fit was equivalent across sexes and age groups. The findings support the use of the Dysfunctional Attitudes Scale and its subscales in the assessment of clinically depressed adolescents.}, Doi = {10.1080/15374410903259007}, Key = {fds271744} } @article{fds271727, Author = {Kratochvil, CJ and May, DE and Silva, SG and Madaan, V and Puumala, SE and Curry, JF and Walkup, J and Kepley, H and Vitiello, B and March, JS}, Title = {Treatment response in depressed adolescents with and without co-morbid attention-deficit/hyperactivity disorder in the Treatment for Adolescents with Depression Study.}, Journal = {J Child Adolesc Psychopharmacol}, Volume = {19}, Number = {5}, Pages = {519-527}, Year = {2009}, Month = {October}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19877976}, Abstract = {OBJECTIVE: In the Treatment for Adolescents with Depression Study (TADS), fluoxetine (FLX) and the combination of fluoxetine with cognitive-behavioral therapy (COMB) had superior improvement trajectories compared to pill placebo (PBO), whereas cognitive-behavioral therapy (CBT) was not significantly different from PBO. Because attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD) frequently co-exist, we examined whether ADHD moderated these outcomes in TADS. METHOD: A total of 439 adolescents with MDD, 12-17 years old, were randomized to FLX, CBT, COMB, or PBO. Random coefficients regression models examined depression improvement in 377 depressed youths without ADHD and 62 with ADHD, including 20 who were treated with a psychostimulant. RESULTS: Within the ADHD group, the improvement trajectories of the three active treatments were similar, all with rates of improvement greater than PBO. For those without ADHD, only COMB had a rate of improvement that was superior to PBO. CONCLUSIONS: Co-morbid ADHD moderated treatment of MDD. CBT alone or FLX alone may offer benefits similar to COMB in the treatment of MDD in youths with co-morbid MDD and ADHD, whereas monotherapy may not match the benefits of COMB for those without ADHD. The ADHD subgroup analysis presented in this paper is exploratory in nature because of the small number of youths with ADHD in the sample. CLINICAL TRIAL REGISTRY: www.clinicaltrials.gov Identifier: NCT00006286. The TADS protocol and all of the TADS manuals are available on the Internet at https://trialweb.dcri.duke.edu/tads/index.html .}, Doi = {10.1089/cap.2008.0143}, Key = {fds271727} } @article{fds271736, Author = {Treatment for Adolescents With Depression Study (TADS) Team, and March, J and Silva, S and Curry, J and Wells, K and Fairbank, J and Burns, B and Domino, M and Vitiello, B and Severe, J and Riedal, K and Goldman, M and Feeny, N and Findling, R and Stull, S and Baab, S and Weller, EB and Robbins, M and Weller, RA and Jessani, N and Waslick, B and Sweeney, M and Dublin, R and Walkup, J and Ginsburg, G and Kastelic, E and Koo, H and Kratochvil, C and May, D and LaGrone, R and Vaughan, B and Albano, AM and Hirsch, GS and Podniesinki, E and Chu, A and Reincecke, M and Leventhal, B and Rogers, G and Jacobs, R and Pathak, S and Wells, J and Lavanier, SA and Danielyan, A and Rohde, P and Simons, A and Grimm, J and Frank, S and Emslie, G and Kennard, B and Hughes, C and Mayes, TL and Rosenberg, D and Benazon, N and Butkus, M and Bartoi, M}, Title = {The Treatment for Adolescents With Depression Study (TADS): outcomes over 1 year of naturalistic follow-up.}, Journal = {American Journal of Psychiatry}, Volume = {166}, Number = {10}, Pages = {1141-1149}, Year = {2009}, Month = {October}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19723787}, Abstract = {OBJECTIVE: The Treatment for Adolescents With Depression Study (TADS) evaluates the effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), and their combination in adolescents with major depressive disorder. The authors report effectiveness outcomes across a 1-year naturalistic follow-up period. METHOD: The randomized, controlled trial was conducted in 13 academic and community sites in the United States. Stages I, II, and III consisted of 12, 6, and 18 weeks of acute, consolidation, and continuation treatment, respectively. Following discontinuation of TADS treatments at the end of stage III, stage IV consisted of 1 year of naturalistic follow-up. The participants were 327 subjects between the ages of 12 and 17 with a primary DSM-IV diagnosis of major depressive disorder. No TADS treatment was provided during the follow-up period; treatment was available in the community. The primary dependent measures, rated by an independent evaluator blind to treatment status, were the total score on the Children's Depression Rating Scale-Revised and the rate of response, defined as a rating of much or very much improved on the Clinical Global Impressions improvement measure. RESULTS: Sixty-six percent of the eligible subjects participated in at least one stage IV assessment. The benefits seen at the end of active treatment (week 36) persisted during follow-up on all measures of depression and suicidality. CONCLUSIONS: In contrast to earlier reports on short-term treatments, in which worsening after treatment is the rule, the longer treatment in the TADS was associated with persistent benefits over 1 year of naturalistic follow-up.}, Doi = {10.1176/appi.ajp.2009.08111620}, Key = {fds271736} } @article{fds271746, Author = {Stanley, B and Brown, G and Brent, DA and Wells, K and Poling, K and Curry, J and Kennard, BD and Wagner, A and Cwik, MF and Klomek, AB and Goldstein, T and Vitiello, B and Barnett, S and Daniel, S and Hughes, J}, Title = {Cognitive-behavioral therapy for suicide prevention (CBT-SP): treatment model, feasibility, and acceptability.}, Journal = {J Am Acad Child Adolesc Psychiatry}, Volume = {48}, Number = {10}, Pages = {1005-1013}, Year = {2009}, Month = {October}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/CHI.0b013e3181b5dbfe}, Abstract = {OBJECTIVE: To describe the elements of a manual-based cognitive-behavioral therapy for suicide prevention (CBT-SP) and to report its feasibility in preventing the recurrence of suicidal behavior in adolescents who have recently attempted suicide. METHOD: The CBT-SP was developed using a risk reduction and relapse prevention approach and theoretically grounded in principles of cognitive-behavioral therapy, dialectical behavioral therapy, and targeted therapies for suicidal youths with depression. The CBT-SP consists of acute and continuation phases, each lasting about 12 sessions, and includes a chain analysis of the suicidal event, safety plan development, skill building, psychoeducation, family intervention, and relapse prevention. RESULTS: The CBT-SP was administered to 110 recent suicide attempters with depression aged 13 to 19 years (mean 15.8 years, SD 1.6) across five academic sites. Twelve or more sessions were completed by 72.4% of the sample. CONCLUSIONS: A specific intervention for adolescents at high risk for repeated suicide attempts has been developed and manual based, and further testing of its efficacy seems feasible.}, Doi = {10.1097/CHI.0b013e3181b5dbfe}, Key = {fds271746} } @article{fds271747, Author = {Vitiello, B and Brent, DA and Greenhill, LL and Emslie, G and Wells, K and Walkup, JT and Stanley, B and Bukstein, O and Kennard, BD and Compton, S and Coffey, B and Cwik, MF and Posner, K and Wagner, A and March, JS and Riddle, M and Goldstein, T and Curry, J and Capasso, L and Mayes, T and Shen, S and Gugga, SS and Turner, JB and Barnett, S and Zelazny, J}, Title = {Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study.}, Journal = {J Am Acad Child Adolesc Psychiatry}, Volume = {48}, Number = {10}, Pages = {997-1004}, Year = {2009}, Month = {October}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20854770}, Abstract = {OBJECTIVE: To examine the course of depression during the treatment of adolescents with depression who had recently attempted suicide. METHOD: Adolescents (N = 124), ages 12 to 18 years, with a 90-day history of suicide attempt, a current diagnosis of depressive disorder (96.0% had major depressive disorder), and a Children's Depression Rating Scale-Revised (CDRS-R) score of 36 or higher, entered a 6-month treatment with antidepressant medication, cognitive-behavioral therapy focused on suicide prevention, or their combination (Comb), at five academic sites. Treatment assignment could be either random or chosen by study participants. Intent-to-treat, mixed effects regression models of depression and other relevant ratings were estimated. Improvement and remission rates were computed with the last observation carried forward. RESULTS: Most patients (n = 104 or 84%) chose treatment assignment, and overall, three fourths (n = 93) received Comb. In Comb, CDRS-R declined from a baseline adjusted mean of 49.6 (SD 12.3) to 38.3 (8.0) at week 12 and to 27.0 (10.1) at week 24 (p < .0001), with a Clinical Global Impression -defined improvement rate of 58.0% at week 12 and 72.2% at week 24 and a remission (CDRS-R ≤ 28) rate of 32.5% at week 12 and 50.0% at week 24. The CDRS-R and the Scale for Suicidal Ideation scores were correlated at baseline (r = 0.43, p < .0001) and declined in parallel. CONCLUSIONS: When vigorously treated with a combination of medication and psychotherapy, adolescents with depression who have recently attempted suicide show rates of improvement and remission of depression that seem comparable to those observed in nonsuicidal adolescents with depression.}, Doi = {10.1097/CHI.0b013e3181b5db66}, Key = {fds271747} } @article{fds271748, Author = {Brent, DA and Greenhill, LL and Compton, S and Emslie, G and Wells, K and Walkup, JT and Vitiello, B and Bukstein, O and Stanley, B and Posner, K and Kennard, BD and Cwik, MF and Wagner, A and Coffey, B and March, JS and Riddle, M and Goldstein, T and Curry, J and Barnett, S and Capasso, L and Zelazny, J and Hughes, J and Shen, S and Gugga, SS and Turner, JB}, Title = {The Treatment of Adolescent Suicide Attempters study (TASA): predictors of suicidal events in an open treatment trial.}, Journal = {J Am Acad Child Adolesc Psychiatry}, Volume = {48}, Number = {10}, Pages = {987-996}, Year = {2009}, Month = {October}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19730274}, Abstract = {OBJECTIVE: To identify the predictors of suicidal events and attempts in adolescent suicide attempters with depression treated in an open treatment trial. METHOD: Adolescents who had made a recent suicide attempt and had unipolar depression (n =124) were either randomized (n = 22) or given a choice (n = 102) among three conditions. Two participants withdrew before treatment assignment. The remaining 124 youths received a specialized psychotherapy for suicide attempting adolescents (n = 17), a medication algorithm (n = 14), or the combination (n = 93). The participants were followed up 6 months after intake with respect to rate, timing, and predictors of a suicidal event (attempt or acute suicidal ideation necessitating emergency referral). RESULTS: The morbid risks of suicidal events and attempts on 6-month follow-up were 0.19 and 0.12, respectively, with a median time to event of 44 days. Higher self-rated depression, suicidal ideation, family income, greater number of previous suicide attempts, lower maximum lethality of previous attempt, history of sexual abuse, and lower family cohesion predicted the occurrence, and earlier time to event, with similar findings for the outcome of attempts. A slower decline in suicidal ideation was associated with the occurrence of a suicidal event. CONCLUSIONS: In this open trial, the 6-month morbid risks for suicidal events and for reattempts were lower than those in other comparable samples, suggesting that this intervention should be studied further. Important treatment targets include suicidal ideation, family cohesion, and sequelae of previous abuse. Because 40% of events occurred with 4 weeks of intake, an emphasis on safety planning and increased therapeutic contact early in treatment may be warranted.}, Doi = {10.1097/CHI.0b013e3181b5dbe4}, Key = {fds271748} } @article{fds271749, Author = {Curry, JF}, Title = {Research psychotherapy: Aspirin or music?}, Journal = {Clinical Psychology: Science and Practice}, Volume = {16}, Number = {3}, Pages = {318-322}, Publisher = {WILEY}, Year = {2009}, Month = {September}, ISSN = {0969-5893}, url = {http://dx.doi.org/10.1111/j.1468-2850.2009.01169.x}, Abstract = {Beutler's call for an expanded psychotherapy agenda is appropriate but does not require downgrading the role of randomized clinical trials (RCTs). Large-scale RCTs are necessary to address questions of general public health importance. Within RCTs, psychotherapy can be conducted in a flexible, creative manner, similar to the practice of good clinicians. The aspirin analogy drawn from Klerman is not illustrative of how psychotherapy is actually conducted in contemporary clinical trials. A better analogy is that of music, which not only involves known ingredients and trainable, replicable skills, but also permits tailoring and improvisation. By conducting large RCTs, secondary analyses of these studies, and smaller controlled trials, psychotherapy researchers can address many clinically relevant questions. © 2009 Society of Clinical Psychology.}, Doi = {10.1111/j.1468-2850.2009.01169.x}, Key = {fds271749} } @article{fds271750, Author = {Becker, SJ and Curry, JF and Yang, C}, Title = {Longitudinal association between frequency of substance use and quality of life among adolescents receiving a brief outpatient intervention.}, Journal = {Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors}, Volume = {23}, Number = {3}, Pages = {482-490}, Year = {2009}, Month = {September}, ISSN = {0893-164X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19769432}, Abstract = {Recognition of the broad consequences of adolescent substance abuse has led to increased emphasis on balancing traditional measures of treatment effectiveness, such as frequency of substance use, with measures of patient functioning and quality of life (QOL). This study evaluated the longitudinal association between frequency of use and QOL among adolescent substance abusers receiving a brief outpatient intervention. Participants were 106 adolescents, aged 13 to 21 years, who met criteria for substance abuse or dependence and completed 4 assessments over a 12 month period. Results of a parallel-process latent growth curve model indicated a moderate longitudinal association, such that reduced frequency of use was associated with QOL improvement. Elaboration of the temporal ordering of this association via a cross-lagged panel model revealed that frequency of substance use predicted subsequent QOL, but that QOL did not predict subsequent frequency of use. Implications pertaining to the assessment of comprehensive outcomes and the setting of treatment expectations are discussed.}, Doi = {10.1037/a0016579}, Key = {fds271750} } @article{fds271726, Author = {Rush, CC and Becker, SJ and Curry, JF}, Title = {Personality factors and styles among college students who binge eat and drink.}, Journal = {Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors}, Volume = {23}, Number = {1}, Pages = {140-145}, Year = {2009}, Month = {March}, ISSN = {0893-164X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19290698}, Abstract = {Elevated rates of comorbidity between binge eating and alcohol use problems have been widely documented. Prior studies have examined specific personality traits associated with the co-occurrence of these problems. The current study explores comprehensive personality factors that are associated with the co-occurrence of binge eating and binge drinking among a diverse sample of 208 college undergraduates. Using the Five Factor Model of personality, the authors assessed both comprehensive personality factors and style of impulse control, a personality style defined by different combinations of neuroticism and conscientiousness. On the basis of responses to a screening instrument, college students were assigned to one of four groups: binge eat, binge drink, binge eat and drink, and non-binge. The binge eat and drink group reported a higher level of neuroticism than did students in the binge drink and non-binge groups. Additionally, the binge eat and drink group was more likely to report an undercontrolled style of impulse control than were other groups. (PsycINFO Database Record (c) 2009 APA, all rights reserved).}, Doi = {10.1037/a0013167}, Key = {fds271726} } @article{fds271751, Author = {Kennard, BD and Silva, SG and Mayes, TL and Rohde, P and Hughes, JL and Vitiello, B and Kratochvil, CJ and Curry, JF and Emslie, GJ and Reinecke, MA and March, JS and TADS}, Title = {Assessment of safety and long-term outcomes of initial treatment with placebo in TADS.}, Journal = {American Journal of Psychiatry}, Volume = {166}, Number = {3}, Pages = {337-344}, Year = {2009}, Month = {March}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19147693}, Abstract = {OBJECTIVE: The authors examined whether initial assignment to receive placebo for 12 weeks followed by open active treatment as clinically indicated was associated with different levels of benefit and risk of harm across 36 weeks as compared with initial assignment to receive active treatments. METHOD: Adolescents with major depressive disorder (N=439) were randomly assigned to receive an initial 12 weeks of treatment with fluoxetine, cognitive-behavioral therapy (CBT), combination treatment with fluoxetine and CBT, or clinical management with placebo; those assigned to placebo received open active treatment as clinically indicated after 12 weeks of placebo. Assessments were conducted every 6 weeks for 36 weeks. The primary outcome measures were response and remission based on scores on the Children's Depression Rating Scale-Revised and the Clinical Global Impression improvement subscale. RESULTS: At week 36, the response rate was 82% in the placebo/open group and 83% in the active treatment groups. The remission rate was 48% in the placebo/open group and 59% in the active treatment groups, a difference that approached statistical significance. Patients who responded to placebo generally retained their response. Those who did not respond to placebo subsequently responded to active treatment at the same rate as those initially assigned to active treatments. There were no differences between groups in rates of suicidal events, study retention, or symptom worsening. CONCLUSIONS: Remission rates at 9 months were lower in patients treated initially with placebo, but 3 months of placebo treatment was not associated with any harm or diminished response to subsequent treatment.}, Doi = {10.1176/appi.ajp.2008.08040487}, Key = {fds271751} } @article{fds271752, Author = {Kennard, BD and Silva, SG and Tonev, S and Rohde, P and Hughes, JL and Vitiello, B and Kratochvil, CJ and Curry, JF and Emslie, GJ and Reinecke, M and March, J}, Title = {Remission and recovery in the Treatment for Adolescents with Depression Study (TADS): acute and long-term outcomes.}, Journal = {J Am Acad Child Adolesc Psychiatry}, Volume = {48}, Number = {2}, Pages = {186-195}, Year = {2009}, Month = {February}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/CHI.0b013e31819176f9}, Abstract = {OBJECTIVE: We examine remission rate probabilities, recovery rates, and residual symptoms across 36 weeks in the Treatment for Adolescents with Depression Study (TADS). METHOD: The TADS, a multisite clinical trial, randomized 439 adolescents with major depressive disorder to 12 weeks of treatment with fluoxetine, cognitive-behavioral therapy, their combination, or pill placebo. The pill placebo group, treated openly after week 12, was not included in the subsequent analyses. Treatment differences in remission rates and probabilities of remission over time are compared. Recovery rates in remitters at weeks 12 (acute phase remitters) and 18 (continuation phase remitters) are summarized. We also examined whether residual symptoms at the end of 12 weeks of acute treatment predicted later remission. RESULTS: At week 36, the estimated remission rates for intention-to-treat cases were as follows: combination, 60%; fluoxetine, 55%; cognitive-behavioral therapy, 64%; and overall, 60%. Paired comparisons reveal that, at week 24, all active treatments converge on remission outcomes. The recovery rate at week 36 was 65% for acute phase remitters and 71% for continuation phase remitters, with no significant between-treatment differences in recovery rates. Residual symptoms at the end of acute treatment predicted failure to achieve remission at weeks 18 and 36. CONCLUSIONS: Most depressed adolescents in all three treatment modalities achieved remission at the end of 9 months of treatment.}, Doi = {10.1097/CHI.0b013e31819176f9}, Key = {fds271752} } @article{fds271745, Author = {Reinecke, MA and Curry, JF and March, JS}, Title = {Findings from the Treatment for Adolescents with Depression Study (TADS)}, Journal = {Journal of Clinical Child and Adolescent Psychology}, Volume = {38}, Pages = {761-767}, Year = {2009}, Key = {fds271745} } @article{fds271724, Author = {Becker, SJ and Sanchez, CC and Curry, JF and Silva, S and Tonev, S}, Title = {Cognitive-behavioral therapy for adolescent depression}, Journal = {Psychiatric Times}, Volume = {25}, Number = {14}, Pages = {46-48}, Year = {2008}, Month = {December}, ISSN = {0893-2905}, Abstract = {Cognitive variables that predict favorable treatment outcomes in adolescents with depression include higher levels of rational thoughts, less hopelessness, fewer negative thoughts, and fewer cognitive distortions at baseline. 10,14,22 In an analysis of TADS data, cognitive distortions at baseline were also shown to moderate the effects of combined CBT and fluoxetine, such that adolescents with high levels of cognitive distortion were more likely to experience incremental benefits from CBT as part of combination treatment. 31 In an analysis of the Brent study, hopelessness was found to mediate the predictive effects of referral source on outcome across 3 types of psychotherapy. 14 The only variables that have been found to mediate the results of CBT specifically are negative automatic thoughts, and in a small subclinical sample, dysfunctional attitudes, which suggests that a reduction in these variables may be important mechanisms of change in CBT. 17,23 Mediational analyses have not yet been conducted on the TADS data, which precludes conclusions about the mechanisms of change in pharmacological and combination treatments. Further research is needed to uncover the specific strategies used in therapy that reframe negative cognition, modify dysfunctional beliefs, and improve depressive symptoms.}, Key = {fds271724} } @article{fds271754, Author = {Becker, SJ and Curry, JF}, Title = {Outpatient interventions for adolescent substance abuse: a quality of evidence review.}, Journal = {J Consult Clin Psychol}, Volume = {76}, Number = {4}, Pages = {531-543}, Year = {2008}, Month = {August}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18665683}, Abstract = {Previous reviews of outpatient interventions for adolescent substance abuse have been limited in the extent to which they considered the methodological quality of individual studies. The authors assessed 31 randomized trials of outpatient interventions for adolescent substance abuse on 14 attributes of trial quality. A quality of evidence score was calculated for each study and used to compare the evidence in support of different outpatient interventions. Across studies, frequently reported methodological attributes included presence of an active comparison condition, reporting of baseline data, use of treatment manuals, and verification of self-reported outcomes. Infrequently reported attributes included power and determination of sample size, techniques to randomize participants to condition, specification of hypotheses and primary outcomes, use of treatment adherence ratings, blind assessment, and inclusion of dropouts in the analysis. Treatment models with evidence of immediate superiority in 2 or more methodologically stronger studies included ecological family therapy, brief motivational interventions, and cognitive-behavioral therapy.}, Doi = {10.1037/0022-006X.76.4.531}, Key = {fds271754} } @article{fds271723, Author = {Rohde, P and Silva, SG and Tonev, ST and Kennard, BD and Vitiello, B and Kratochvil, CJ and Reinecke, MA and Curry, JF and Simons, AD and March, JS}, Title = {Achievement and maintenance of sustained response during the Treatment for Adolescents With Depression Study continuation and maintenance therapy.}, Journal = {Arch Gen Psychiatry}, Volume = {65}, Number = {4}, Pages = {447-455}, Year = {2008}, Month = {April}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18391133}, Abstract = {CONTEXT: The Treatment for Adolescents With Depression Study evaluated fluoxetine (FLX), cognitive behavioral therapy (CBT), and FLX/CBT combination (COMB) vs pill placebo in 439 adolescents with major depressive disorder. Treatment consisted of 3 stages: (1) acute (12 weeks), (2) continuation (6 weeks), and (3) maintenance (18 weeks). OBJECTIVE: To examine rates of achieving and maintaining sustained response during continuation and maintenance treatments. DESIGN: Randomized controlled trial. Response was determined by blinded independent evaluators. SETTING: Thirteen US sites. PATIENTS: Two hundred forty-two FLX, CBT, and COMB patients in their assigned treatment at the end of stage 1. INTERVENTIONS: Stage 2 treatment varied based on stage 1 response. Stage 3 consisted of 3 CBT and/or pharmacotherapy sessions and, if applicable, continued medication. MAIN OUTCOME MEASURES: Sustained response was defined as 2 consecutive Clinical Global Impression-Improvement ratings of 1 or 2 ("full response"). Patients achieving sustained response were classified on subsequent nonresponse status. RESULTS: Among 95 patients (39.3%) who had not achieved sustained response by week 12 (29.1% COMB, 32.5% FLX, and 57.9% CBT), sustained response rates during stages 2 and 3 were 80.0% COMB, 61.5% FLX, and 77.3% CBT (difference not significant). Among the remaining 147 patients (60.7%) who achieved sustained response by week 12, CBT patients were more likely than FLX patients to maintain sustained response through week 36 (96.9% vs 74.1%; P = .007; 88.5% of COMB patients maintained sustained response through week 36). Total rates of sustained response by week 36 were 88.4% COMB, 82.5% FLX, and 75.0% CBT. CONCLUSIONS: Most adolescents with depression who had not achieved sustained response during acute treatment did achieve that level of improvement during continuation and maintenance therapies. The possibility that CBT may help the subset of adolescents with depression who achieve early sustained response maintain their response warrants further investigation. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00006286.}, Doi = {10.1001/archpsyc.65.4.447}, Key = {fds271723} } @article{fds271753, Author = {Kaminer, Y and Connor, DF and Curry, JF}, Title = {Treatment of comorbid adolescent cannabis use and major depressive disorder}, Journal = {Psychiatry}, Volume = {5}, Pages = {43-48}, Year = {2008}, Key = {fds271753} } @article{fds271755, Author = {Rohde, P and Silva, S and Tonev, ST and Kennard, BD and Vitiello, B and Kratochvil, CJ and Reinecke, MA and Curry, JF and Simons, AD and March, JS}, Title = {Achievement and maintenance of sustained response during TADS continuation and maintenance therapy}, Journal = {Archives of General Psychaitry}, Volume = {65}, Pages = {447-455}, Year = {2008}, Key = {fds271755} } @article{fds271757, Author = {Vitiello, B and Kratochvil, CJ and Silva, S and Curry, J and Reinecke, M and Pathak, S and Waslick, B and Hughes, CW and Prentice, ED and May, DE and March, JS}, Title = {Research knowledge among the participants in the Treatment for Adolescents With Depression Study (TADS).}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {46}, Number = {12}, Pages = {1642-1650}, Year = {2007}, Month = {December}, ISSN = {0890-8567}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18030086}, Abstract = {OBJECTIVE: We examined the extent to which parents and adolescents participating in the Treatment for Adolescents With Depression Study (TADS) understood key aspects of the study. METHOD: TADS was a clinical trial comparing the effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), their combination, and placebo in 439 adolescents (12-17 years old) with major depressive disorder. Six weeks after starting treatment, adolescents and their parents were asked to complete a questionnaire about critical elements of the trial. RESULTS: Completion rate was 67.2% for adolescents (N = 295) and 73.6% for parents (N = 323). More than 90% of the completers knew of the main purpose of the trial, possible assignment to placebo, and their right to withdraw participation at any time. However, about one third overall (and 49% in the CBT group) described TADS as "education" rather than "research." Of 12 questions, the mean number of correct answers was 10.3 (SD 1.7) among adolescents and 11.2 (SD 1.2) among parents (p <.0001). The most frequently stated reason for TADS participation was the pursuit of high-quality care. CONCLUSIONS: Most parents and adolescents were well-informed research participants. Difficulties in appreciating the research nature of the trial, however, emerged, especially among participants assigned to psychotherapy. Parents were overall better informed than adolescents.}, Doi = {10.1097/chi.0b013e318153f8c7}, Key = {fds271757} } @article{fds271758, Author = {March, JS and Silva, S and Petrycki, S and Curry, J and Wells, K and Fairbank, J and Burns, B and Domino, M and McNulty, S and Vitiello, B and Severe, J}, Title = {The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes.}, Journal = {Archives of General Psychiatry}, Volume = {64}, Number = {10}, Pages = {1132-1143}, Year = {2007}, Month = {October}, ISSN = {0003-990X}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17909125}, Abstract = {CONTEXT: The Treatment for Adolescents With Depression Study evaluates the effectiveness of fluoxetine hydrochloride therapy, cognitive behavior therapy (CBT), and their combination in adolescents with major depressive disorder. OBJECTIVE: To report effectiveness outcomes across 36 weeks of randomized treatment. DESIGN AND SETTING: Randomized, controlled trial conducted in 13 academic and community sites in the United States. Cognitive behavior and combination therapies were not masked, whereas administration of placebo and fluoxetine was double-blind through 12 weeks, after which treatments were unblinded. Patients assigned to placebo were treated openly after week 12, and the placebo group is not included in these analyses by design. PARTICIPANTS: Three hundred twenty-seven patients aged 12 to 17 years with a primary DSM-IV diagnosis of major depressive disorder. INTERVENTIONS: All treatments were administered per protocol. MAIN OUTCOME MEASURES: The primary dependent measures rated blind to treatment status by an independent evaluator were the Children's Depression Rating Scale-Revised total score and the response rate, defined as a Clinical Global Impressions-Improvement score of much or very much improved. RESULTS: Intention-to-treat analyses on the Children's Depression Rating Scale-Revised identified a significant time x treatment interaction (P < .001). Rates of response were 73% for combination therapy, 62% for fluoxetine therapy, and 48% for CBT at week 12; 85% for combination therapy, 69% for fluoxetine therapy, and 65% for CBT at week 18; and 86% for combination therapy, 81% for fluoxetine therapy, and 81% for CBT at week 36. Suicidal ideation decreased with treatment, but less so with fluoxetine therapy than with combination therapy or CBT. Suicidal events were more common in patients receiving fluoxetine therapy (14.7%) than combination therapy (8.4%) or CBT (6.3%). CONCLUSIONS: In adolescents with moderate to severe depression, treatment with fluoxetine alone or in combination with CBT accelerates the response. Adding CBT to medication enhances the safety of medication. Taking benefits and harms into account, combined treatment appears superior to either monotherapy as a treatment for major depression in adolescents.}, Doi = {10.1001/archpsyc.64.10.1132}, Key = {fds271758} } @article{fds271763, Author = {Hughes, CW and Emslie, GJ and Crismon, ML and Posner, K and Birmaher, B and Ryan, N and Jensen, P and Curry, J and Vitiello, B and Lopez, M and Shon, SP and Pliszka, SR and Trivedi, MH and TEXAS CONSENSUS CONFERENCE PANEL ON MEDICATION TREATMENT OF CHILDHOOD MAJOR DEPRESSIVE DISORDER}, Title = {Texas Children's Medication Algorithm Project: update from Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive Disorder.}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {46}, Number = {6}, Pages = {667-686}, Year = {2007}, Month = {June}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/chi.0b013e31804a859b}, Abstract = {OBJECTIVE: To revise and update consensus guidelines for medication treatment algorithms for childhood major depressive disorder based on new scientific evidence and expert clinical consensus when evidence is lacking. METHOD: A consensus conference was held January 13-14, 2005, that included academic clinicians and researchers, practicing clinicians, administrators, consumers, and families. The focus was to review, update, and incorporate the most current data to inform and recommend specific pharmacological approaches and clinical guidance for treatment of major depressive disorder in children and adolescents. RESULTS: Consensually agreed on medication algorithms for major depression (with and without psychosis) and comorbid attention-deficit disorders were updated. These revised algorithms also incorporated approaches to address issues of suicidality, aggression, and irritability. Stages 1, 2, and 3 of the algorithm consist of selective serotonin reuptake inhibitor and norepinephrine serotonin reuptake inhibitor medications whose use is supported by controlled, acute clinical trials and clinical experience. Recent studies provide support that selective serotonin reuptake inhibitors in addition to fluoxetine are still encouraged as first-line interventions. The need for additional assessments, precautions, and monitoring is emphasized, as well as continuation and maintenance treatment. CONCLUSIONS: Evidence and expert clinical consensus support the use of selected antidepressants in the treatment of depression in youths. The use of the recommended antidepressant medications requires appropriate monitoring of suicidality and potential adverse effects and consideration of other evidence-based treatment alternatives such as cognitive behavioral therapies.}, Doi = {10.1097/chi.0b013e31804a859b}, Key = {fds271763} } @article{fds271756, Author = {Kaminer, Y and Connor, DF and Curry, JF}, Title = {Comorbid adolescent substance use and major depressive disorders: A review}, Journal = {Psychiatry}, Volume = {4}, Pages = {32-43}, Year = {2007}, Key = {fds271756} } @article{fds271760, Author = {Becker, SJ and Curry, JF}, Title = {Interactive effect of substance abuse and depression on adolescent social competence.}, Journal = {Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53}, Volume = {36}, Number = {3}, Pages = {469-475}, Year = {2007}, ISSN = {1537-4416}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17658989}, Abstract = {This study explored the interactive effect of substance abuse and depression on social competence among 106 adolescent inpatients (57% female, 86% Caucasian). Substance abuse and depression were conceptualized using dimensional ratings of illness severity based on adolescent interviews, whereas social competence was conceptualized using parent ratings of adolescent behavior. Cross-sectional analyses revealed that substance abuse and depression had a negative interactive effect on adolescent social competence: Higher severity levels of both dimensions were associated with lower levels of competence than accounted for by the additive effects of the two dimensions. These findings persisted when controlling for gender, race, and other common dimensions of psychopathology. Significant impairment in social competence occurred at subdiagnostic levels of substance abuse when depression severity was high, highlighting the value of assessing outcomes across the full range of severity.}, Doi = {10.1080/15374410701448638}, Key = {fds271760} } @article{fds271761, Author = {Kratochvil, C and Emslie, G and Silva, S and McNulty, S and Walkup, J and Curry, J and Reinecke, M and Vitiello, B and Rohde, P and Feeny, N and Casat, C and Pathak, S and Weller, E and May, D and Mayes, T and Robins, M and March, J and TADS Team}, Title = {Acute time to response in the Treatment for Adolescents with Depression Study (TADS).}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {45}, Number = {12}, Pages = {1412-1418}, Year = {2006}, Month = {December}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/01.chi.0000237710.73755.14}, Abstract = {OBJECTIVE: To examine the time to response for both pharmacotherapy and psychotherapy in the Treatment for Adolescents with Depression Study (TADS). METHOD: Adolescents (N = 439, ages 12 to 17 years) with major depressive disorder were randomized to fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or pill placebo (PBO). Defining response as very much improved or much improved on the Clinical Global Impression-Improvement Scale (CGI-I), survival analyses using Cox proportional hazards models, and Kaplan-Meier curves were conducted to evaluate time to first response and time to stable response for subjects receiving pharmacotherapy (COMB, FLX, PBO) as well as for subjects receiving CBT (COMB, CBT). Direct comparisons between pharmacotherapy and CBT were not made because of differences in visit schedules. RESULTS: Based on pharmacotherapist CGI-I scores, COMB and FLX showed faster onset of benefit than PBO on time to response and time to stable response (p < .001), and COMB was faster than FLX on time to stable response (p = .034). The probability of sustained early response was approximately threefold greater for COMB than PBO, twofold greater for FLX than PBO, and 1.5-fold greater for COMB than FLX. On the psychotherapist CGI-I scores, both first response and stable response occurred faster in COMB than CBT (p < .001), with a probability of sustained early response approximately threefold greater for COMB than CBT. CONCLUSIONS: In the acute treatment of depressed adolescents, FLX and COMB accelerate response relative to PBO, and COMB accelerates response relative to CBT alone.}, Doi = {10.1097/01.chi.0000237710.73755.14}, Key = {fds271761} } @article{fds271762, Author = {Kennard, B and Silva, S and Vitiello, B and Curry, J and Kratochvil, C and Simons, A and Hughes, J and Feeny, N and Weller, E and Sweeney, M and Reinecke, M and Pathak, S and Ginsburg, G and Emslie, G and March, J and TADS Team}, Title = {Remission and residual symptoms after short-term treatment in the Treatment of Adolescents with Depression Study (TADS).}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {45}, Number = {12}, Pages = {1404-1411}, Year = {2006}, Month = {December}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/01.chi.0000242228.75516.21}, Abstract = {OBJECTIVE: To ascertain remission rates in depressed youth participating in the Treatment for Adolescents With Depression Study (TADS), a multisite clinical trial that randomized 439 adolescents with major depressive disorder (MDD) to a 12-week treatment of fluoxetine (FLX), cognitive-behavioral therapy (CBT), their combination (COMB), or clinical management with pill placebo (PBO). METHOD: Using an end-of-treatment Children's Depression Rating Scale-Revised (CDRS-R) total score of 28 or below as the criterion for remission, rates of remission were examined with logistic regression, controlling for site. Loss of MDD diagnosis and residual symptoms in responders (defined as Clinical Global Impressions-Improvement (CGI-I) score of 1 (very much improved) or 2 (much improved) were also examined across treatment groups. RESULTS: After 12 weeks of treatment, 102 (23%) of 439 youths had reached remission. The remission rate was significantly higher in the COMB group (37%) relative to the other treatment groups (FLX, 23%; CBT, 16%; PBO, 17%), with odds ratios of 2.1 for COMB versus FLX, 3.3 for COMB versus CBT, and 3.0 for COMB versus PBO. In addition, 71% of subjects across treatment groups no longer met criteria for MDD at the end of acute treatment. Fifty percent of the youths who responded by CGI-I criteria continued to have residual symptoms, such as sleep or mood disturbances, fatigue, and poor concentration. CONCLUSIONS: The combination of FLX and CBT was superior to both monotherapy and PBO in terms of remission rates, but overall rates of remission remain low and residual symptoms are common at the end of 12 weeks of treatment.}, Doi = {10.1097/01.chi.0000242228.75516.21}, Key = {fds271762} } @article{fds271764, Author = {Curry, J and Rohde, P and Simons, A and Silva, S and Vitiello, B and Kratochvil, C and Reinecke, M and Feeny, N and Wells, K and Pathak, S and Weller, E and Rosenberg, D and Kennard, B and Robins, M and Ginsburg, G and March, J and TADS Team}, Title = {Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS).}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {45}, Number = {12}, Pages = {1427-1439}, Year = {2006}, Month = {December}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/01.chi.0000240838.78984.e2}, Abstract = {OBJECTIVE: To identify predictors and moderators of response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive-behavioral therapy (CBT), both fluoxetine and CBT, or clinical management with pill placebo in the Treatment for Adolescents With Depression Study (TADS). METHOD: Potential baseline predictors and moderators were identified by a literature review. The outcome measure was a week 12 predicted score derived from the Children's Depression Rating Scale-Revised (CDRS-R). For each candidate moderator or predictor, a general linear model was conducted to examine main and interactive effects of treatment and the candidate variable on the CDRS-R predicted scores. RESULTS: Adolescents who were younger, less chronically depressed, higher functioning, and less hopeless with less suicidal ideation, fewer melancholic features or comorbid diagnoses, and greater expectations for improvement were more likely to benefit acutely than their counterparts. Combined treatment, under no condition less effective than monotherapy, was more effective than fluoxetine for mild to moderate depression and for depression with high levels of cognitive distortion, but not for severe depression or depression with low levels of cognitive distortion. Adolescents from high-income families were as likely to benefit from CBT alone as from combined treatment. CONCLUSIONS: Younger and less severely impaired adolescents are likely to respond better to acute treatment than older, more impaired, or multiply comorbid adolescents. Family income level, cognitive distortions, and severity of depression may help clinicians to choose among acute interventions, but combined treatment proved robust in the presence of moderators.}, Doi = {10.1097/01.chi.0000240838.78984.e2}, Key = {fds271764} } @article{fds271735, Author = {Chrisman, A and Egger, H and Compton, SN and Curry, J and Goldston, DB}, Title = {Assessment of Childhood Depression.}, Journal = {Child and Adolescent Mental Health}, Volume = {11}, Number = {2}, Pages = {111-116}, Publisher = {WILEY}, Year = {2006}, Month = {May}, ISSN = {1475-357X}, url = {http://dx.doi.org/10.1111/j.1475-3588.2006.00395.x}, Abstract = {Depression as a disorder in childhood began to be increasingly recognised in the 1970s. Epidemiologic community and clinic-based studies have characterised the prevalence, clinical course, and complications of this illness throughout childhood and adolescence into adulthood. This paper reviews two instruments for assessing depression in prepubertal children - the Dominic Interactive and The Preschool Age Psychiatric Assessment. Both instruments are useful in screening for psychiatric disorders and reliably identifying the presence of depressive symptoms in young children.}, Doi = {10.1111/j.1475-3588.2006.00395.x}, Key = {fds271735} } @article{fds271767, Author = {Hervey, AS and Epstein, JN and Curry, JF and Tonev, S and Eugene Arnold, L and Keith Conners and C and Hinshaw, SP and Swanson, JM and Hechtman, L}, Title = {Reaction time distribution analysis of neuropsychological performance in an ADHD sample.}, Journal = {Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence}, Volume = {12}, Number = {2}, Pages = {125-140}, Year = {2006}, Month = {April}, ISSN = {0929-7049}, url = {http://dx.doi.org/10.1080/09297040500499081}, Abstract = {Differences in reaction time (RT) variability have been documented between children with and without Attention Deficit Hyperactivity Disorder (ADHD). Most previous research has utilized estimates of normal distributions to examine variability. Using a nontraditional approach, the present study evaluated RT distributions on the Conners' Continuous Performance Test in children and adolescents from the Multimodal Treatment Study of ADHD sample compared to a matched sample of normal controls (n = 65 pairs). The ex-Gaussian curve was used to model RT and RT variability. Children with ADHD demonstrated faster RT associated with the normal portion of the curve and a greater proportion of abnormally slow responses associated with the exponential portion of the curve. These results contradict previous interpretation that children with ADHD have slower than normal responding and demonstrate why slower RT is found when estimates of variability assume normal Gaussian distributions. Further, results of this study suggest that the greater number of abnormally long RTs of children with ADHD reflect attentional lapses on some but not all trials.}, Doi = {10.1080/09297040500499081}, Key = {fds271767} } @article{fds271734, Author = {Chabrol, H}, Title = {CBT versus supportive therapy for depression.}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {44}, Number = {9}, Pages = {841}, Year = {2005}, Month = {September}, url = {http://dx.doi.org/10.1097/01.chi.0000170555.00551.37}, Doi = {10.1097/01.chi.0000170555.00551.37}, Key = {fds271734} } @article{fds271722, Author = {Curry, JF and Wells, KC}, Title = {Striving for effectiveness in the treatment of adolescent depression: Cognitive behavior therapy for multisite community intervention}, Journal = {Cognitive and Behavioral Practice}, Volume = {12}, Number = {2}, Pages = {177-185}, Publisher = {Elsevier BV}, Year = {2005}, Month = {January}, url = {http://dx.doi.org/10.1016/S1077-7229(05)80023-9}, Abstract = {The Treatment for Adolescents With Depression Study (TADS) was designed to compare the relative and combined effectiveness of cognitive, behavior therapy (CBT) and fluoxetine, each of which had demonstrated efficacy in carefully controlled single-site studies. Models of CBT from these efficacy studies served as the foundation for the TADS psychosocial intervention. When interpreting the acute and long-term outcomes of TADS treatment in the context of other studies of CBT for major depression, it is critical to understand the process and the decision making that formed the TADS CBT intervention. The TADS CBT Committee reviewed meta-analyses of child and adolescent psychotherapy as well as studies of CBT for childhood and, adolescent depression, relied on expert consultants, and evaluated the treatment process in a feasibility study to derive the essential components of TADS CBT. In this article we describe the rationale for the TADS CBT, the process of treatment design, and the. immediate sources of the TADS treatment. Key decisions were made involving the degree of treatment structure, therapist flexibility versus cross-site consistency, duration and intensity of treatment, the involvement of family members in treatment, and core versus optional elements of the intevention. Copyright © 2005 by Association for Advancement of Behavior Therapy. All rights of reproduction in any form reserved.}, Doi = {10.1016/S1077-7229(05)80023-9}, Key = {fds271722} } @article{fds271765, Author = {Rogers, GM and Reinecke, MA and Curry, JF}, Title = {Case formulation in TADS CBT}, Journal = {Cognitive and Behavioral Practice}, Volume = {12}, Number = {2}, Pages = {198-208}, Publisher = {Elsevier BV}, Year = {2005}, Month = {January}, ISSN = {1077-7229}, url = {http://dx.doi.org/10.1016/S1077-7229(05)80025-2}, Abstract = {For the Treatment for Adolescents With Depression Study (TADS), a cognitive-behavioral therapy (CBT) manual was developed with the aim of balancing standardization and flexibility. In this article, we describe the manual's case formulation procedures, which served as one major mechanism of flexibility in TADS CBT. We first describe the essential components of a cognitive-behavioral case formulation. We then present a rationale for including individualized case formulation in manual-based treatments and clinical effectiveness studies, and discuss the specific case of TADS. We illustrate case formulation in an effectiveness study with a composite "case" of a 15-year-old male treated with TADS CBT Clinical implications and future directions are discussed. Copyright © 2005 by Association for Advancement of Behavior Therapy. All rights of reproduction in any form reserved.}, Doi = {10.1016/S1077-7229(05)80025-2}, Key = {fds271765} } @article{fds271768, Author = {Treatment for Adolescents and Depression Study (TADS) Team}, Title = {The Treatment for Adolescents With Depression Study (TADS): demographic and clinical characteristics.}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {44}, Number = {1}, Pages = {28-40}, Year = {2005}, Month = {January}, ISSN = {0890-8567}, url = {http://dx.doi.org/10.1097/01.chi.0000145807.09027.82}, Abstract = {OBJECTIVE: The Treatment for Adolescents With Depression Study is a multicenter, randomized clinical trial sponsored by the NIMH. This study is designed to evaluate the short- and long-term effectiveness of four treatments for adolescents with major depressive disorder: fluoxetine, cognitive-behavioral therapy, their combination, and, acutely, pill placebo. This report describes the demographic and clinical characteristics of the sample and addresses external validity. METHOD: Participants are 439 adolescents, aged 12-17 years inclusively, with a primary DSM-IV diagnosis of current major depressive disorder. Baseline data are summarized and compared with those from national samples and previous trials. RESULTS: The sample composition is 54.4% girls, 73.8% white, 12.5% African American, and 8.9% Hispanic. The mean Child Depression Rating Scale-Revised total score is 60.1 (SD = 10.4, range 45-98) with 86.0% experiencing their first major depressive episode. The most common concurrent diagnoses are generalized anxiety disorder (15.3%), attention-deficit/hyperactivity disorder (13.7%), oppositional defiant disorder (13.2%), social phobia (10.7%), and dysthymia (10.5%). Demographic results are consistent with data from national samples and large psychopharmacology trials involving depressed adolescents. CONCLUSIONS: The Treatment for Adolescents With Depression Study provides a large, diverse, and representative sample of depressed adolescents that highlights the complexity of major depressive disorder in adolescents and provides a rich source for explicating the effects of moderator and mediator variables on baseline psychopathology and treatment outcome.}, Doi = {10.1097/01.chi.0000145807.09027.82}, Key = {fds271768} } @article{fds271766, Author = {Curry, JF and Wells, KC}, Title = {Striving for effectiveness in the treatment of adolescent depression}, Journal = {Cognitive & Behavioral Practice}, Volume = {12}, Pages = {177-185}, Year = {2005}, Key = {fds271766} } @article{fds271771, Author = {Compton, SN and March, JS and Brent, D and Albano, AM and Weersing, R and Curry, J}, Title = {Cognitive-behavioral psychotherapy for anxiety and depressive disorders in children and adolescents: an evidence-based medicine review.}, Journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, Volume = {43}, Number = {8}, Pages = {930-959}, Year = {2004}, Month = {August}, ISSN = {0890-8567}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15266189}, Abstract = {OBJECTIVE: To review the literature on the cognitive-behavioral treatment of children and adolescents with anxiety and depressive disorders within the conceptual framework of evidence-based medicine. METHOD: The psychiatric and psychological literature was systematically searched for controlled trials applying cognitive-behavioral treatment to pediatric anxiety and depressive disorders. RESULTS: For both anxiety and depression, substantial evidence supports the efficacy of problem-specific cognitive-behavioral interventions. Comparisons with wait-list, inactive control, and active control conditions suggest medium to large effects for symptom reduction in primary outcome domains. CONCLUSIONS: From an evidence-based perspective, cognitive-behavioral therapy is currently the treatment of choice for anxiety and depressive disorders in children and adolescents. Future research in this area will need to focus on comparing cognitive-behavioral psychotherapy with other treatments, component analyses, and the application of exportable protocol-driven treatments to divergent settings and patient populations.}, Doi = {10.1097/01.chi.0000127589.57468.bf}, Key = {fds271771} } @article{fds271800, Author = {Hervey, AS and Epstein, JN and Curry, JF}, Title = {Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review.}, Journal = {Neuropsychology}, Volume = {18}, Number = {3}, Pages = {485-503}, Year = {2004}, Month = {July}, ISSN = {0894-4105}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15291727}, Keywords = {Adult • Attention • Attention Deficit Disorder with Hyperactivity • Humans • Inhibition (Psychology) • Memory, Short-Term • Neuropsychological Tests* • Psychomotor Performance • Reaction Time • diagnosis* • psychology}, Abstract = {A comprehensive, empirically based review of the published studies addressing neuropsychological performance in adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) was conducted to identify patterns of performance deficits. Findings from 33 published studies were submitted to a meta-analytic procedure producing sample-size-weighted mean effect sizes across test measures. Results suggest that neuropsychological deficits are expressed in adults with ADHD across multiple domains of functioning, with notable impairments in attention, behavioral inhibition, and memory, whereas normal performance is noted in simple reaction time. Theoretical and developmental considerations are discussed, including the role of behavioral inhibition and working memory impairment. Future directions for research based on these findings are highlighted, including further exploration of specific impairments and an emphasis on particular tests and testing conditions.}, Doi = {10.1037/0894-4105.18.3.485}, Key = {fds271800} } @article{fds271799, Author = {Curry, JF}, Title = {Future directions in residential treatment outcome research.}, Journal = {Child and Adolescent Psychiatric Clinics of North America}, Volume = {13}, Number = {2}, Pages = {429-440}, Year = {2004}, Month = {April}, ISSN = {1056-4993}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15062355}, Keywords = {Adolescent • Child • Forecasting • Humans • Mental Disorders • Residential Treatment • Treatment Outcome • therapy* • trends*}, Abstract = {Future outcome research on residential treatment will be influenced positively by major trends in the helping professions. These trends include the transfer of empirically supported interventions into the residential treatment setting, the targeting of specific problems or disorders that burden children and adolescents,and more sophisticated tests of positive and negative outcomes. It is also likely that future research will use recent developments in statistics that permit study of trajectories of change in children or adolescents before, during, and after residential treatment. Continued emphasis must be placed on improving and studying postresidential transitions, comparing residential to less restrictive models of treatment, and qualitative investigations of successful and unsuccessful cases.}, Doi = {10.1016/S1056-4993(03)00127-5}, Key = {fds271799} } @article{fds137878, Title = {The Treatment for Adolescents with Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression. Journal of the American Medical Association, 2004, 292, 807-820. | |
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