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Publications [#347201] of Peter A Ubel

Journal Articles

  1. Kratka, A; Ubel, PA; Scherr, K; Murray, B; Eyal, N; Kirby, C; Katz, MN; Holtzman, L; Pollak, K; Freedburg, K; Blumenthal-Barby, J, HIV Cure Research: Risks Patients Expressed Willingness to Accept., Ethics Hum Res, vol. 41 no. 6 (November, 2019), pp. 23-34 [doi]
    (last updated on 2024/03/29)

    Abstract:
    Despite doing well on antiretroviral therapy, many people living with HIV have expressed a willingness to accept substantial risks for an HIV cure. To date, few studies have assessed the specific quantitative maximal risk that future participants might take; probed whether, according to future participants, the risk can be offset by the benefits; and examined whether taking substantial risk is a reasonable decision. In this qualitative study, we interviewed 22 people living with HIV and used standard gamble methodology to assess the maximum chance of death a person would risk for an HIV cure. We probed participants' reasoning behind their risk-taking responses. Conventional inductive content analysis was used to categorize key themes regarding decision-making. We found that some people would be willing to risk even death for an HIV cure, and some of their reasons were plausible and went far beyond the health-related utility of an HIV cure. We contend that people's expressed willingness to take substantial risk for an HIV cure should not be dismissed out of hand.


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