|
| Publications [#140748] of John D Hamilton
Papers Published
- FM Gordin, PM Hartigan, NG Klimas, SB Zolla-Pazner, MS Simberkoff, JD Hamilton, Delayed-type hypersensitivity skin tests are an independent predictor of human immunodeficiency virus disease progression. Department of Veterans Affairs Cooperative Study Group.,
The Journal of infectious diseases, UNITED STATES, vol. 169 no. 4
(April, 1994),
pp. 893-7, ISSN 0022-1899
(last updated on 2007/12/26)
Abstract:
Delayed-type hypersensitivity (DTH) testing was evaluated as a predictor of human immunodeficiency virus (HIV) disease progression in 336 symptomatic patients with baseline CD4 cell counts of 200-500/mm3 who were participating in a randomized trial of early versus late therapy with zidovudine. Patients with a response of > 2 mm to any of seven antigens were categorized as reactive; those without were anergic. Anergic patients were significantly more likely than reactive patients to have HIV disease progression as evidenced by decrease in CD4 cell count (52% vs. 27%), development of AIDS (33% vs. 17%), or death (18% vs. 9%) (P < or = .02), irrespective of time of zidovudine initiation. By multivariate analysis, DTH results were an independent predictor of HIV progression separate from CD4 cell count, p24 antigen positivity, or level of beta 2-microglobulin. DTH skin tests are an independent predictor of HIV disease progression and may be of value in the evaluation of a patient's immune status.
Keywords:
Acquired Immunodeficiency Syndrome • Adult • Age Factors • CD4-Positive T-Lymphocytes • Cohort Studies • Double-Blind Method • Female • HIV Infections • Humans • Hypersensitivity, Delayed* • Leukocyte Count • Male • Prognosis • Proportional Hazards Models • Risk Factors • Skin Tests • Survival Rate • Treatment Outcome • Zidovudine • analysis • beta 2-Microglobulin • drug therapy • etiology • immunology* • mortality • therapeutic use
|
