Publications [#134808] of Randy L. Jirtle
Papers Published
- T Yamada, AT De Souza, S Finkelstein, RL Jirtle, Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis.,
Proceedings of the National Academy of Sciences of the United States of America, UNITED STATES, vol. 94 no. 19
(September, 1997),
pp. 10351-5, ISSN 0027-8424
(last updated on 2003/09/18)Abstract:
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 (61%) hepatocellular carcinomas (HCCs) associated with the high risk factors of hepatitis virus infection and liver cirrhosis. Mutations in the remaining allele were detected in 6/11 (55%) HCCs, including deletions in a polydeoxyguanosine region known to be a target of microsatellite instability. M6P/IGF2R allele loss was also found in cirrhotic tissue of clonal origin adjacent to these dysplastic lesions and HCCs, demonstrating that M6P/IGF2R inactivation occurs early in liver carcinogenesis. In conclusion, HCCs frequently develop from clonal expansions of phenotypically normal, M6P/IGF2R-mutated hepatocytes, providing further support for the idea that M6P/IGF2R functions as a liver tumor-suppressor gene.Keywords:
Aged • Carcinoma, Hepatocellular • Chromosome Deletion • Female • Heterozygote • Humans • Immunohistochemistry • Liver Neoplasms • Male • Middle Aged • Mutation • Receptor, IGF Type 2 • Risk Factors • genetics*