Publications [#345457] of Tuan Vo-Dinh

Papers Published

1. Jiang, Z; Zhou, X; Tao, M; Yuan, F; Liu, L; Wu, F; Wu, X; Xiang, Y; Niu, Y; Liu, F; Li, C; Ye, R; Byeon, B; Xue, Y; Zhao, H; Wang, H-N; Crawford, BM; Johnson, DM; Hu, C; Pei, C; Zhou, W; Swift, GB; Zhang, H; Vo-Dinh, T; Hu, Z; Siedow, JN; Pei, Z-M, Plant cell-surface GIPC sphingolipids sense salt to trigger Ca²⁺ influx., Nature, vol. 572 no. 7769 (August, 2019), pp. 341-346 [doi]
   (last updated on 2024/04/23)

   Abstract:
   Salinity is detrimental to plant growth, crop production and food security worldwide. Excess salt triggers increases in cytosolic Ca²⁺ concentration, which activate Ca²⁺-binding proteins and upregulate the Na⁺/H⁺ antiporter in order to remove Na⁺. Salt-induced increases in Ca²⁺ have long been thought to be involved in the detection of salt stress, but the molecular components of the sensing machinery remain unknown. Here, using Ca²⁺-imaging-based forward genetic screens, we isolated the Arabidopsis thaliana mutant monocation-induced [Ca^2+]_i increases 1 (moca1), and identified MOCA1 as a glucuronosyltransferase for glycosyl inositol phosphorylceramide (GIPC) sphingolipids in the plasma membrane. MOCA1 is required for salt-induced depolarization of the cell-surface potential, Ca²⁺ spikes and waves, Na⁺/H⁺ antiporter activation, and regulation of growth. Na⁺ binds to GIPCs to gate Ca²⁺ influx channels. This salt-sensing mechanism might imply that plasma-membrane lipids are involved in adaption to various environmental salt levels, and could be used to improve salt resistance in crops.