Publications [#266800] of Randall Kramer

Papers Published

1. Kim, D; Fedak, K; Kramer, R, Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis., The American Journal of Tropical Medicine and Hygiene, vol. 87 no. 1 (July, 2012), pp. 117-124, ISSN 0002-9637 [repository], [doi]
   (last updated on 2023/04/30)

   Abstract:
   Indoor residual spraying (IRS) has become an increasingly popular method of insecticide use for malaria control, and many recent studies have reported on its effectiveness in reducing malaria burden in a single community or region. There is a need for systematic review and integration of the published literature on IRS and the contextual determining factors of its success in controlling malaria. This study reports the findings of a meta-regression analysis based on 13 published studies, which were chosen from more than 400 articles through a systematic search and selection process. The summary relative risk for reducing malaria prevalence was 0.38 (95% confidence interval = 0.31-0.46), which indicated a risk reduction of 62%. However, an excessive degree of heterogeneity was found between the studies. The meta-regression analysis indicates that IRS is more effective with high initial prevalence, multiple rounds of spraying, use of DDT, and in regions with a combination of Plasmodium falciparum and P. vivax malaria.