Abstract:
A two-dimensional mapping model of a paced, isolated cardiac cell, which relates the duration of the action potential to the two preceding diastolic intervals as well as the preceding action potential duration, was studied. The model that was used displayed a rate-dependent restitution and memory. A control was initiated by carrying forward small adjustments to the pacing interval in order to suppress the alternans and stabilize the 1:1 response pattern displayed by the model. The gain that is necessary to establish control was shown to vary siginificantly depending on the value of the slope of the standard restitution curve.
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