Publications [#379904] of Dorothy Buck

Papers Published

1. Buck, D; O’donnol, D, Knotting of replication intermediates is narrowly restricted, Contemporary Mathematics, vol. 746 (January, 2020), pp. 85-100 [doi]
   (last updated on 2026/01/21)

   Abstract:
   The fundamental biological process of DNA replication contains several potential topological pitfalls. These, if not properly managed, lead to cell death. The enzymes (topoisomerases) responsible for averting these topological death warrants can inadvertently knot the same DNA they are supposed to be simplifying. These knotted DNA replication intermediates are still poorly understood. Here, we characterize which knotted forms these DNA molecules can take. Surprisingly, these forms are very narrowly restricted, representing a small fraction of possible entangled configurations.