Publications [#375282] of David B. Dunson

Papers Published

1. Jin, B; Dunson, DB; Rager, JE; Reif, DM; Engel, SM; Herring, AH, Bayesian matrix completion for hypothesis testing., Journal of the Royal Statistical Society. Series C, Applied statistics, vol. 72 no. 2 (May, 2023), pp. 254-270 [doi]
   (last updated on 2026/01/15)

   Abstract:
   We aim to infer bioactivity of each chemical by assay endpoint combination, addressing sparsity of toxicology data. We propose a Bayesian hierarchical framework which borrows information across different chemicals and assay endpoints, facilitates out-of-sample prediction of activity for chemicals not yet assayed, quantifies uncertainty of predicted activity, and adjusts for multiplicity in hypothesis testing. Furthermore, this paper makes a novel attempt in toxicology to simultaneously model heteroscedastic errors and a nonparametric mean function, leading to a broader definition of activity whose need has been suggested by toxicologists. Real application identifies chemicals most likely active for neurodevelopmental disorders and obesity.