Publications [#376096] of David B. Dunson

Papers Published

1. Talbot, A; Dunson, D; Dzirasa, K; Carlson, D, Estimating a brain network predictive of stress and genotype with supervised autoencoders., J R Stat Soc Ser C Appl Stat, vol. 72 no. 4 (August, 2023), pp. 912-936 [doi]
   (last updated on 2025/04/11)

   Abstract:
   Targeted brain stimulation has the potential to treat mental illnesses. We develop an approach to help design protocols by identifying relevant multi-region electrical dynamics. Our approach models these dynamics as a superposition of latent networks, where the latent variables predict a relevant outcome. We use supervised autoencoders (SAEs) to improve predictive performance in this context, describe the conditions where SAEs improve predictions, and provide modelling constraints to ensure biological relevance. We experimentally validate our approach by finding a network associated with stress that aligns with a previous stimulation protocol and characterizing a genotype associated with bipolar disorder.