Publications [#143940] of James A. Blumenthal

Papers Published

1. JA Blumenthal, WC Siegel, M Appelbaum (1991). Failure of exercise to reduce blood pressure in patients with mild hypertension. Results of a randomized controlled trial.. JAMA : the journal of the American Medical Association, 266(15), 2098-104.
   (last updated on 2013/05/16)

   Abstract:
   OBJECTIVE: --To assess the effects of physical exercise training on blood pressure in patients with mild hypertension. METHODS: --Randomized controlled trial. METHODS: --Hospital-based cardiac rehabilitation program. METHODS: --Ninety-nine men and women with untreated mild hypertension (systolic blood pressure, 140 to 180 mm Hg; diastolic blood pressure, 90 to 105 mm Hg) were included in the volunteer sample. METHODS: --Subjects were randomly assigned to a 4-month program of aerobic exercise training, strength and flexibility training, or to a waiting list control group. METHODS: --The main outcome measures were systolic and diastolic blood pressures measured four times with a random zero sphygmomanometer on 3 separate days in a clinic setting. RESULTS: --After 4 months of exercise training, subjects in the aerobic exercise group did not exhibit greater reductions in blood pressure than subjects in the control group. We expected a differential decline of 5 mm Hg between the aerobic exercise and waiting list control groups and found a difference of -1.0 +/- 16 mm Hg and -1.2 +/- 10 mm Hg at alpha = .05 for systolic and diastolic blood pressure, respectively. CONCLUSIONS: --Moderate aerobic exercise alone should not be considered a replacement for pharmacologic therapy in nonobese patients with mild hypertension.