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Publications [#274964] of John S. March

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Papers Published

  1. JH Greist, JW Jefferson, R Rosenfeld, LD Gutzmann, JS March and NE Barklage (1990). Clomipramine and obsessive compulsive disorder: A placebo-controlled double-blind study of 32 patients. Journal of Clinical Psychiatry, 51(7), 292-297.
    (last updated on 2016/01/27)

    Abstract:
    Thirty-two nondepressed patients with obsessive impulsive disorder were randomly assigned to treatment with clomipramine (N=16) or placebo (N=16) in a 10 week double-blind study. Of the 15 patients who received at least 3 weeks of clomipramine treatment, 11 (73%) improved, 5 (33%) improved by more than 50%, and none worsened. Clomipramine treatment was associated with statistically significant improvement on several measures of obsessive compulsive symptoms. Side effects were more frequent and severe with clomipramine than with placebo. Although most patients tolerated clomipramine well, 3 discontinued treatment because of side effects.


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