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Publications [#275068] of John S. March

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Papers Published

  1. J March, S Silva, S Petrycki, J Curry, K Wells, J Fairbank, B Burns, M Domino, S McNulty, B Vitiello, J Severe, C Casat, J Kolker, K Riedal, M Goldman, N Feeny, R Findling, S Stull, N McNamara, E Weller, M Robins, R Weller, N Jessani, B Waslick, M Sweeney, R Kandel, D Schoenholz, J Walkup, G Ginsburg, E Kastelic, H Koo, C Kratochvil, D May, R LaGrone, M Harrington, AM Albano, G Hirsch, T Knibbs, E Capili, M Reinecke, B Leventhal, C Nageotte, G Rogers, S Pathak, J Wells, S Arszman, A Danielyan, A Simons, P Rohde, J Grimm, L Nguyen, G Emslie, B Kennard, C Hughes, M Ruberu, D Rosenberg, N Benazon, M Butkus, M Bartoi, G Clarke, D Brent and G Koch (2005). The Treatment for Adolescents with Depression Study (TADS): Demographic and clinical characteristics. Journal of the American Academy of Child and Adolescent Psychiatry, 44(1), 28-40. [doi]
    (last updated on 2016/01/27)

    Objective: The Treatment for Adolescents With Depression Study is a multicenter, randomized clinical trial sponsored by the NIMH. This study is designed to evaluate the short- and long-term effectiveness of four treatments for adolescents with major depressive disorder: fluoxetine, cognitive-behavioral therapy, their combination, and, acutely, pill placebo. This report describes the demographic and clinical characteristics of the sample and addresses external validity. Method: Participants are 439 adolescents, aged 12-17 years inclusively, with a primary DSM-IV diagnosis of current major depressive disorder. Baseline data are summarized and compared with those from national samples and previous trials. Results: The sample composition is 54.4% girls, 73.8% white, 12.5% African American, and 8.9% Hispanic. The mean Child Depression Rating Scale-Revised total score is 60.1 (SD = 10.4, range 45-98) with 86.0% experiencing their first major depressive episode. The most common concurrent diagnoses are generalized anxiety disorder (15.3%), attention-deficit/hyperactivity disorder (13.7%), oppositional defiant disorder (13.2%), social phobia (10.7%), and dysthymia (10.5%). Demographic results are consistent with data from national samples and large psychopharmacology trials involving depressed adolescents. Conclusions: The Treatment for Adolescents With Depression Study provides a large, diverse, and representative sample of depressed adolescents that highlights the complexity of major depressive disorder in adolescents and provides a rich source for explicating the effects of moderator and mediator variables on baseline psychopathology and treatment outcome.

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