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Publications [#275114] of John S. March

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Papers Published

  1. DE May, CJ Kratochvil, SE Puumala, SG Silva, AJ Rezac, MJ Hallin, MA Reinecke, B Vitiello, EB Weller, S Pathak, AD Simons and JS March (2007). A manual-based intervention to address clinical crises and retain patients in the Treatment of Adolescents With Depression Study (TADS).. J Am Acad Child Adolesc Psychiatry, 46(5), 573-581. [17450048], [doi]
    (last updated on 2016/01/27)

    OBJECTIVE: To describe a manual-based intervention to address clinical crises and retain participants in the Treatment for Adolescents With Depression Study (TADS). METHOD: The use of adjunct services for attrition prevention (ASAP) is described for adolescents (ages 12-17 years) during the 12-week acute treatment in TADS, from 2000 to 2003. Logistic regression, controlling for site, was used to predict use. RESULTS: Of 439 enrolled participants, 17.8% (n = 78) used ASAP primarily for suicidality or worsening of depression. Of these, 46.2% continued in their assigned treatment through week 12, 47.4% received out-of-protocol treatment but continued participating in assessments, and 10.3% withdrew consent, including 3 who terminated treatment and withdrew consent on the same date. ASAP use did not differ between treatments (p =.97) and typically occurred early in treatment. At the end of the 12 weeks, 37.2% of participants using ASAP remained in their assigned treatment, although 80.8% continued participating in assessments. ASAP was associated with, at baseline, a higher severity of depression (p <.01), substance use (p <.01), and precontemplation level of change (p <.02). CONCLUSIONS: ASAP may be useful to retain adolescent participants and as a safety intervention in placebo-controlled trials. In clinical practice ASAP-like procedures may be useful to encourage adherence in patients engaging in long-term treatment. Clinical trial registration information-URL: Unique identifier: NCT00006286.

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