Publications [#385908] of Kathleen A. Welsh-Bohmer

Journal Articles

1. Rajabli, F; Benchek, P; Tosto, G; Kushch, N; Sha, J; Bazemore, K; Zhu, C; Lee, W-P; Haut, J; Hamilton-Nelson, KL; Wheeler, NR; Zhao, Y; Farrell, JJ; Grunin, MA; Leung, YY; Kuksa, PP; Li, D; da Fonseca, EL; Mez, JB; Palmer, EL; Pillai, J; Sherva, RM; Song, YE; Zhang, X; Ikeuchi, T; Iqbal, T; Pathak, O; Valladares, O; Reyes-Dumeyer, D; Kuzma, AB; Abner, E; Adams, LD; Adams, PM; Aguirre, A; Albert, MS; Albin, RL; Allen, M; Alvarez, L; Apostolova, LG; Arnold, SE; Asthana, S; Atwood, CS; Auerbach, S; Ayres, G; Baldwin, CT; Barber, RC; Barnes, LL; Barral, S; Beach, TG; Becker, JT; Beecham, GW; Beekly, D; Benitez, BA; Bennett, D; Bertelson, J; Bird, TD; Blacker, D; Boeve, BF; Bowen, JD; Boxer, A; Brewer, J; Burke, JR; Burns, JM; Buxbaum, JD; Cairns, NJ; Cantwell, LB; Cao, C; Carlson, CS; Carlsson, CM; Carney, RM; Carrasquillo, MM; Chasse, S; Chesselet, M-F; Chin, NA; Chui, HC; Chung, J; Craft, S; Crane, PK; Cribbs, DH; Crocco, EA; Cruchaga, C; Cuccaro, ML; Cullum, M; Darby, E; Davis, B; De Jager, PL; DeCarli, C; DeToledo, J; Dick, M; Dickson, DW; Dombroski, BA; Doody, RS; Duara, R; Ertekin-Taner, N; Evans, DA; Faber, KM; Fairchild, TJ; Fallon, KB; Fardo, DW; Farlow, MR; Fernandez-Hernandez, V; Ferris, S; Friedland, RP; Foroud, TM; Frosch, MP; Fulton-Howard, B; Galasko, DR; Gamboa, A; Gearing, M; Geschwind, DH; Ghetti, B; Gilbert, JR; Go, RCP; Goate, AM; Grabowski, TJ; Graff-Radford, NR; Green, RC; Growdon, JH; Hakonarson, H; Hall, J; Hamilton, RL; Harari, O; Hardy, J; Harrell, LE; Head, E; Henderson, VW; Hernandez, M; Hohman, T; Honig, LS; Huebinger, RM; Huentelman, MJ; Hulette, CM; Hyman, BT; Hynan, LS; Ibanez, L; Jarvik, GP; Jayadev, S; Jin, L-W; Johnson, K; Johnson, L; Kamboh, MI; Karydas, AM; Katz, MJ; Kauwe, JS; Kaye, JA; Keene, CD; Khaleeq, A; Kikuchi, M; Kim, R; Knebl, J; Kowall, NW; Kramer, JH; Kukull, WA; LaFerla, FM; Lah, JJ; Larson, EB; Lerner, A; Leverenz, JB; Levey, AI; Lieberman, AP; Lipton, RB; Logue, M; Lopez, OL; Lunetta, KL; Lyketsos, CG; Mains, D; Margaret, FE; Marson, DC; Martin, ER; Martiniuk, F; Mash, DC; Masliah, E; Massman, P; Masurkar, A; McCormick, WC; McCurry, SM; McDavid, AN; McDonough, S; McKee, AC; Mesulam, M; Miller, BL; Miller, CA; Miller, JW; Montine, TJ; Monuki, ES; Morris, JC; Mukherjee, S; Myers, AJ; Nguyen, T; Obisesan, T; O'Bryant, S; Olichney, JM; Ory, M; Palmer, R; Parisi, JE; Paulson, HL; Pavlik, V; Paydarfar, D; Perez, V; Peskind, E; Petersen, RC; Petrovitch, H; Pierce, A; Polk, M; Poon, WW; Potter, H; Qu, L; Quiceno, M; Quinn, JF; Raj, A; Raskind, M; Reiman, EM; Reisberg, B; Reisch, JS; Ringman, JM; Roberson, ED; Rodriguear, M; Rogaeva, E; Rosen, HJ; Rosenberg, RN; Royall, DR; Sabbagh, M; Sadovnick, AD; Sager, MA; Sano, M; Saykin, AJ; Schneider, JA; Schneider, LS; Seeley, WW; Slifer, SH; Small, S; Smith, AG; Smith, JP; Sonnen, JA; Spina, S; George-Hyslop, PS; Starks, TD; Stern, RA; Stevens, AB; Strittmatter, SM; Sultzer, D; Swerdlow, RH; Tanzi, RE; Tilson, JL; Trojanowski, JQ; Troncoso, JC; Tsolaki, M; Tsuang, DW; Van Deerlin, VM; van Eldik, LJ; Vance, JM; Vardarajan, BN; Vassar, R; Vinters, HV; Vonsattel, J-P; Weintraub, S; Welsh-Bohmer, KA; Whitehead, PL; Wijsman, EM; Wilhelmsen, KC; Williams, B; Williamson, J; Wilms, H; Wingo, TS; Wisniewski, T; Woltjer, RL; Woon, M; Wright, CB; Wu, C-K; Younkin, SG; Yu, C-E; Yu, L; Zhu, X; Kunkle, BW; Bush, WS; Miyashita, A; Byrd, GS; Wang, L-S; Farrer, LA; Haines, JL; Mayeux, R; Pericak-Vance, MA; Schellenberg, GD; Jun, GR; Reitz, C; Naj, AC; Alzheimer’s Disease Genetics Consortium (ADGC) (2025). Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.. Genome Biol, 26(1), 210. [doi]
   (last updated on 2025/12/31)

   Abstract:
   BACKGROUND: Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We construct and analyze a multi-ancestry GWAS dataset in the Alzheimer's Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer's disease (LOAD) susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6728 African American, 8899 Hispanic (HIS), and 3232 East Asian individuals, performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. RESULTS: We identify 13 loci with cross-population associations including known loci at/near CR1, BIN1, TREM2, CD2AP, PTK2B, CLU, SHARPIN, MS4A6A, PICALM, ABCA7, APOE, and two novel loci not previously reported at 11p12 (LRRC4C) and 12q24.13 (LHX5-AS1). We additionally identify three population-specific loci with genome-wide significance at/near PTPRK and GRB14 in HIS and KIAA0825 in NHW. Pathway analysis implicates multiple amyloid regulation pathways and the classical complement pathway. Genes at/near our novel loci have known roles in neuronal development (LRRC4C, LHX5-AS1, and PTPRK) and insulin receptor activity regulation (GRB14). CONCLUSIONS: Using cross-population GWAS meta-analyses, we identify novel LOAD susceptibility loci in/near LRRC4C and LHX5-AS1, both with known roles in neuronal development, as well as several novel population-unique loci. Reflecting the power of diverse ancestry in GWAS, we detect the SHARPIN locus with only 13.7% of the sample size of the NHW GWAS study (n = 409,589) in which this locus was first observed. Continued expansion into larger multi-ancestry studies will provide even more power for further elucidating the genomics of late-onset Alzheimer's disease.